Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008] See more...

Aliases for S100Z Gene

Aliases for S100Z Gene

  • S100 Calcium Binding Protein Z 2 3 5
  • S100 Calcium Binding Protein, Zeta 2 3
  • Protein S100-Z 3 4
  • S100 Calcium-Binding Protein Z 4
  • S100-Zeta 3
  • Gm625 3

External Ids for S100Z Gene

Previous GeneCards Identifiers for S100Z Gene

  • GC05P074951
  • GC05P076380
  • GC05P076184
  • GC05P076229
  • GC05P076181
  • GC05P071353

Summaries for S100Z Gene

Entrez Gene Summary for S100Z Gene

  • Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]

GeneCards Summary for S100Z Gene

S100Z (S100 Calcium Binding Protein Z) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A1.

Additional gene information for S100Z Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100Z Gene

Genomics for S100Z Gene

GeneHancer (GH) Regulatory Elements for S100Z Gene

Promoters and enhancers for S100Z Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J076849 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 503.8 +1.4 1414 4.1 NRF1 PHB2 ZBTB11 TRIM28 TARDBP HES1 TOE1 MYC CTBP1 HDAC3 S100Z F2RL1 IQGAP2 piR-46381-063 RF00017-4732 RF00017-4734 RF00017-4735
GH05J076865 Promoter 0.3 EPDnew 500.4 +15.2 15202 0.1 S100Z piR-41245-222 piR-46381-063 RF00017-4732 RF00017-4735
GH05J076847 Enhancer 0.3 Ensembl 500.7 -2.0 -2000 1.2 HLF S100Z ENSG00000225407 F2R CRHBP F2RL1 RF00017-4737 RF00017-4732 RF00017-4734 RF00017-4735
GH05J077231 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.8 +382.5 382500 3.8 CTCF RFX1 ZBTB17 SPI1 BMI1 ZSCAN16 RAD21 ZNF449 ZBTB20 ZSCAN4 PDE8B ZBED3-AS1 S100Z HSALNG0042825 ENSG00000284762
GH05J076467 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -373.7 -373701 20.6 CTCF TCF12 NCOR1 TEAD4 ZIC2 ZBTB11 TCF7 SKI TEAD1 ZNF341 IQGAP2 ENSG00000249713 S100Z piR-33804-025 piR-57133-481
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100Z on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100Z

Top Transcription factor binding sites by QIAGEN in the S100Z gene promoter:
  • AML1a
  • CBF(2)
  • deltaCREB
  • ER-alpha
  • FOXC1
  • GATA-1
  • NF-Y
  • Nkx6-1
  • p53
  • STAT5B

Genomic Locations for S100Z Gene

Genomic Locations for S100Z Gene
102,882 bases
Plus strand
71,650 bases
Plus strand

Genomic View for S100Z Gene

Genes around S100Z on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100Z Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100Z Gene

Proteins for S100Z Gene

  • Protein details for S100Z Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-Z
    Protein Accession:

    Protein attributes for S100Z Gene

    99 amino acids
    Molecular mass:
    11620 Da
    Quaternary structure:
    • Homodimer (PubMed:28074300). Interacts with S100P (PubMed:11747429).
    • This protein binds two calcium ions.

    Three dimensional structures from OCA and Proteopedia for S100Z Gene

neXtProt entry for S100Z Gene

Post-translational modifications for S100Z Gene

No Post-translational modifications

No data available for DME Specific Peptides for S100Z Gene

Domains & Families for S100Z Gene

Gene Families for S100Z Gene

Protein Domains for S100Z Gene

  • Calcium-binding protein, S-100/ICaBP type

Suggested Antigen Peptide Sequences for S100Z Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein Z (S100Z_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100Z: view

Function for S100Z Gene

Phenotypes From GWAS Catalog for S100Z Gene

Gene Ontology (GO) - Molecular Function for S100Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 11747429
GO:0005515 protein binding IPI 11747429
GO:0042803 protein homodimerization activity IDA 11747429
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100Z: view
genes like me logo Genes that share phenotypes with S100Z: view

Animal Model Products

CRISPR Products

miRNA for S100Z Gene

miRTarBase miRNAs that target S100Z

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100Z Gene

Localization for S100Z Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100Z gene
Compartment Confidence
cytosol 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for S100Z Gene

Pathways & Interactions for S100Z Gene

PathCards logo

SuperPathways for S100Z Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with S100Z: view

No data available for Pathways by source and SIGNOR curated interactions for S100Z Gene

Drugs & Compounds for S100Z Gene

(1) Drugs for S100Z Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with S100Z: view

Transcripts for S100Z Gene

mRNA/cDNA for S100Z Gene

4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100Z Gene

No ASD Table

Relevant External Links for S100Z Gene

GeneLoc Exon Structure for

Expression for S100Z Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100Z Gene

mRNA differential expression in normal tissues according to GTEx for S100Z Gene

This gene is overexpressed in Whole Blood (x19.4) and Spleen (x7.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100Z

SOURCE GeneReport for Unigene cluster for S100Z Gene:


mRNA Expression by UniProt/SwissProt for S100Z Gene:

Tissue specificity: Highest level of expression in spleen and leukocytes.
genes like me logo Genes that share expression patterns with S100Z: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100Z Gene

Orthologs for S100Z Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100Z Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100Z 31 30
  • 99.66 (n)
(Bos Taurus)
Mammalia S100Z 31 30
  • 88.55 (n)
(Mus musculus)
Mammalia S100z 17 31 30
  • 87.21 (n)
(Canis familiaris)
Mammalia S100Z 30
  • 86.23 (n)
-- 31
  • 45 (a)
(Rattus norvegicus)
Mammalia S100z 30
  • 86.2 (n)
(Monodelphis domestica)
Mammalia S100Z 31
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia S100Z 31
  • 71 (a)
(Gallus gallus)
Aves S100Z 31 30
  • 72.57 (n)
(Anolis carolinensis)
Reptilia S100Z 31
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia s100z 30
  • 76.77 (n)
(Danio rerio)
Actinopterygii s100z 31 30
  • 68.69 (n)
Species where no ortholog for S100Z was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100Z Gene

Gene Tree for S100Z (if available)
Gene Tree for S100Z (if available)
Evolutionary constrained regions (ECRs) for S100Z: view image

Paralogs for S100Z Gene

(25) SIMAP similar genes for S100Z Gene using alignment to 1 proteins:

  • S100Z_HUMAN
genes like me logo Genes that share paralogs with S100Z: view

Variants for S100Z Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100Z Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1320308 - p.Glu23Ala

Additional dbSNP identifiers (rs#s) for S100Z Gene

Structural Variations from Database of Genomic Variants (DGV) for S100Z Gene

Variant ID Type Subtype PubMed ID
esv2762526 CNV loss 21179565
esv34133 CNV loss 18971310
esv3605476 CNV loss 21293372
nsv1027236 CNV gain 25217958
nsv1143312 CNV deletion 24896259
nsv524024 CNV loss 19592680
nsv830355 CNV gain 17160897

Variation tolerance for S100Z Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100Z Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100Z Gene

Disorders for S100Z Gene

Additional Disease Information for S100Z

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for S100Z Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100Z Gene

Publications for S100Z Gene

  1. Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. (PMID: 11747429) Gribenko AV … Makhatadze GI (Biochemistry 2001) 2 3 4 23 54
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen EA … Weersma RK (The American journal of gastroenterology 2010) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Reviewing the Crystal Structure of S100Z and Other Members of the S100 Family: Implications in Calcium-Regulated Quaternary Structure. (PMID: 30710292) Calderone V … Luchinat C (Methods in molecular biology (Clifton, N.J.) 2019) 3 54
  5. Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds. (PMID: 28074300) Calderone V … Luchinat C (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2017) 4 54

Products for S100Z Gene

Sources for S100Z Gene