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Aliases for S100Z Gene

Aliases for S100Z Gene

  • S100 Calcium Binding Protein Z 2 3 5
  • S100 Calcium Binding Protein, Zeta 2 3
  • S100 Calcium-Binding Protein Z 4
  • Protein S100-Z 3
  • S100-Zeta 3
  • Gm625 3

External Ids for S100Z Gene

Previous GeneCards Identifiers for S100Z Gene

  • GC05P074951
  • GC05P076380
  • GC05P076184
  • GC05P076229
  • GC05P076181
  • GC05P071353

Summaries for S100Z Gene

Entrez Gene Summary for S100Z Gene

  • Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]

GeneCards Summary for S100Z Gene

S100Z (S100 Calcium Binding Protein Z) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is S100A1.

Additional gene information for S100Z Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100Z Gene

Genomics for S100Z Gene

GeneHancer (GH) Regulatory Elements for S100Z Gene

Promoters and enhancers for S100Z Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I076849 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.9 +1.4 1414 4.1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 NCOA1 ZNF592 S100Z F2RL1 IQGAP2 PIR54977 GC05P076755
GH05I076865 Promoter 0.5 EPDnew 550.4 +15.2 15202 0.1 S100Z PIR54977 GC05P076755
GH05I077231 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.8 +381.6 381595 0.9 CTCF ZBTB20 ZBTB17 ZBED3-AS1 S100Z GC05M077218 GC05M077268 PDE8B
GH05I076580 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -267.9 -267925 2.8 BMI1 BATF IRF4 ZNF143 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 EGR2 IQGAP2 LOC101929109 F2RL2 S100Z GC05M076583 GC05M076503
GH05I076401 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.2 -445.0 -444962 8 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 IQGAP2 S100Z GC05P076385 LOC101060043
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around S100Z on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100Z gene promoter:

Genomic Locations for S100Z Gene

Genomic Locations for S100Z Gene
102,882 bases
Plus strand

Genomic View for S100Z Gene

Genes around S100Z on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100Z Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100Z Gene

Proteins for S100Z Gene

  • Protein details for S100Z Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-Z
    Protein Accession:

    Protein attributes for S100Z Gene

    99 amino acids
    Molecular mass:
    11620 Da
    Quaternary structure:
    • Homodimer (PubMed:28074300). Interacts with S100P (PubMed:11747429).
    • This protein binds two calcium ions.

    Three dimensional structures from OCA and Proteopedia for S100Z Gene

neXtProt entry for S100Z Gene

Post-translational modifications for S100Z Gene

No Post-translational modifications

No data available for DME Specific Peptides for S100Z Gene

Domains & Families for S100Z Gene

Gene Families for S100Z Gene

Suggested Antigen Peptide Sequences for S100Z Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100Z: view

Function for S100Z Gene

Phenotypes From GWAS Catalog for S100Z Gene

Gene Ontology (GO) - Molecular Function for S100Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 11747429
GO:0005515 protein binding IPI 11747429
GO:0042803 protein homodimerization activity IDA 11747429
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100Z: view
genes like me logo Genes that share phenotypes with S100Z: view

miRNA for S100Z Gene

miRTarBase miRNAs that target S100Z

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100Z Gene

Localization for S100Z Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100Z gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for S100Z Gene

Pathways & Interactions for S100Z Gene

SuperPathways for S100Z Gene

No Data Available

Interacting Proteins for S100Z Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WXG8-S100Z_HUMAN ENSP00000320430 for S100Z Gene via IID STRING

Gene Ontology (GO) - Biological Process for S100Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with S100Z: view

No data available for Pathways by source and SIGNOR curated interactions for S100Z Gene

Drugs & Compounds for S100Z Gene

(1) Drugs for S100Z Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with S100Z: view

Transcripts for S100Z Gene

mRNA/cDNA for S100Z Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100Z Gene

S100 calcium binding protein Z:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100Z Gene

No ASD Table

Relevant External Links for S100Z Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100Z Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100Z Gene

mRNA differential expression in normal tissues according to GTEx for S100Z Gene

This gene is overexpressed in Whole Blood (x19.4) and Spleen (x7.5).

NURSA nuclear receptor signaling pathways regulating expression of S100Z Gene:


SOURCE GeneReport for Unigene cluster for S100Z Gene:


mRNA Expression by UniProt/SwissProt for S100Z Gene:

Tissue specificity: Highest level of expression in spleen and leukocytes.
genes like me logo Genes that share expression patterns with S100Z: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100Z Gene

Orthologs for S100Z Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100Z Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100Z 33 34
  • 99.66 (n)
(Bos Taurus)
Mammalia S100Z 33 34
  • 88.55 (n)
(Mus musculus)
Mammalia S100z 33 16 34
  • 87.21 (n)
(Canis familiaris)
Mammalia S100Z 33
  • 86.23 (n)
-- 34
  • 45 (a)
(Rattus norvegicus)
Mammalia S100z 33
  • 86.2 (n)
(Monodelphis domestica)
Mammalia S100Z 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia S100Z 34
  • 71 (a)
(Gallus gallus)
Aves S100Z 33 34
  • 72.57 (n)
(Anolis carolinensis)
Reptilia S100Z 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia s100z 33
  • 76.77 (n)
(Danio rerio)
Actinopterygii s100z 33 34
  • 68.69 (n)
Species where no ortholog for S100Z was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100Z Gene

Gene Tree for S100Z (if available)
Gene Tree for S100Z (if available)

Paralogs for S100Z Gene

Paralogs for S100Z Gene

genes like me logo Genes that share paralogs with S100Z: view

Variants for S100Z Gene

Sequence variations from dbSNP and Humsavar for S100Z Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000046815 -- 76,919,902(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000054257 -- 76,889,227(+) T/C intron_variant
rs1000179105 -- 76,866,003(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000246505 -- 76,913,947(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000268652 -- 76,871,445(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S100Z Gene

Variant ID Type Subtype PubMed ID
nsv830355 CNV gain 17160897
nsv524024 CNV loss 19592680
nsv1143312 CNV deletion 24896259
nsv1027236 CNV gain 25217958
esv3605476 CNV loss 21293372
esv34133 CNV loss 18971310
esv2762526 CNV loss 21179565

Variation tolerance for S100Z Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100Z Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100Z Gene

Disorders for S100Z Gene

Additional Disease Information for S100Z

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for S100Z Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100Z Gene

Publications for S100Z Gene

  1. Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins. (PMID: 11747429) Gribenko AV … Makhatadze GI (Biochemistry 2001) 2 3 4 22 58
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen EA … Weersma RK (The American journal of gastroenterology 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds. (PMID: 28074300) Calderone V … Luchinat C (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2017) 4 58
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 58

Products for S100Z Gene

Sources for S100Z Gene

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