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Aliases for S100PBP Gene

Aliases for S100PBP Gene

  • S100P Binding Protein 2 3 5
  • S100P Binding Protein 1 2 3
  • S100PBPR 3 4
  • S100P-Binding Protein Riken 4
  • S100P-Binding Protein 3

External Ids for S100PBP Gene

Previous GeneCards Identifiers for S100PBP Gene

  • GC01P032954
  • GC01P033055
  • GC01P033283
  • GC01P031399

Summaries for S100PBP Gene

Entrez Gene Summary for S100PBP Gene

  • This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

GeneCards Summary for S100PBP Gene

S100PBP (S100P Binding Protein) is a Protein Coding gene. Diseases associated with S100PBP include Charcot-Marie-Tooth Disease, Dominant Intermediate C. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding.

Additional gene information for S100PBP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100PBP Gene

Genomics for S100PBP Gene

GeneHancer (GH) Regulatory Elements for S100PBP Gene

Promoters and enhancers for S100PBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 691 +0.5 475 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS RBBP4 TXLNA KHDRBS1 TSSK3 ZBTB8A TMEM39B EIF3I FAM229A
GH01J032821 Promoter 0.5 EPDnew 650.7 +4.8 4827 0.1 S100PBP YARS FNDC5
GH01J031924 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 43.3 -880.9 -880934 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1
GH01J033336 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.4 +527.0 526969 15.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZNF610 GLIS1 NBN PHC2 PIR53170 S100PBP A3GALT2 RBBP4 ENSG00000225313 FAM229A TRIM62 ZSCAN20 ENSG00000270115
GH01J032331 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.5 -480.6 -480630 8.6 HDGF ARID4B SIN3A ZBTB7B IRF4 SLC30A9 POLR2B ZNF766 ZNF207 ZNF143 MARCKSL1 RBBP4 S100PBP KHDRBS1 TMEM39B DCDC2B FAM229A ENSG00000224066 TXLNA MTMR9LP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100PBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100PBP gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • E2F-5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for S100PBP Gene

Genomic Locations for S100PBP Gene
42,113 bases
Plus strand
42,109 bases
Plus strand

Genomic View for S100PBP Gene

Genes around S100PBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100PBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100PBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100PBP Gene

Proteins for S100PBP Gene

  • Protein details for S100PBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S100P-binding protein
    Protein Accession:
    Secondary Accessions:
    • B3KR04
    • D3DPQ5
    • Q5HYH3
    • Q9H997

    Protein attributes for S100PBP Gene

    408 amino acids
    Molecular mass:
    45582 Da
    Quaternary structure:
    • Interacts with S100P.
    • Sequence=BAB14335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for S100PBP Gene


neXtProt entry for S100PBP Gene

Post-translational modifications for S100PBP Gene

  • Ubiquitination at isoforms=2322 and posLast=305305
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for S100PBP Gene

Domains & Families for S100PBP Gene

Gene Families for S100PBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for S100PBP Gene


Suggested Antigen Peptide Sequences for S100PBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with S100PBP: view

No data available for UniProtKB/Swiss-Prot for S100PBP Gene

Function for S100PBP Gene

Gene Ontology (GO) - Molecular Function for S100PBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048306 calcium-dependent protein binding IEA,IPI 15632002
genes like me logo Genes that share ontologies with S100PBP: view
genes like me logo Genes that share phenotypes with S100PBP: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100PBP Gene

Localization for S100PBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100PBP Gene

Nucleus. Note=Colocalizes with S100P in the nucleus. {ECO:0000269 PubMed:15632002}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100PBP gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100PBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15632002
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with S100PBP: view

Pathways & Interactions for S100PBP Gene

SuperPathways for S100PBP Gene

No Data Available

Interacting Proteins for S100PBP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96BU1-S1PBP_HUMAN ENSP00000362574 for S100PBP Gene via IID STRING

Gene Ontology (GO) - Biological Process for S100PBP Gene


No data available for Pathways by source and SIGNOR curated interactions for S100PBP Gene

Drugs & Compounds for S100PBP Gene

No Compound Related Data Available

Transcripts for S100PBP Gene

Unigene Clusters for S100PBP Gene

S100P binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100PBP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: -
SP8: -

Relevant External Links for S100PBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100PBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100PBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for S100PBP Gene

This gene is overexpressed in Cervix (34.4) and Adrenal (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100PBP Gene

Protein tissue co-expression partners for S100PBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100PBP Gene:


SOURCE GeneReport for Unigene cluster for S100PBP Gene:


mRNA Expression by UniProt/SwissProt for S100PBP Gene:

Tissue specificity: Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).

Evidence on tissue expression from TISSUES for S100PBP Gene

  • Nervous system(4.4)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with S100PBP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100PBP Gene

Orthologs for S100PBP Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100PBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100PBP 34 33
  • 99.26 (n)
(Canis familiaris)
Mammalia S100PBP 34 33
  • 86.49 (n)
(Bos Taurus)
Mammalia S100PBP 34 33
  • 85.19 (n)
(Mus musculus)
Mammalia S100pbp 16 34 33
  • 82.86 (n)
(Rattus norvegicus)
Mammalia S100pbp 33
  • 82.42 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
-- 34
  • 40 (a)
Species where no ortholog for S100PBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100PBP Gene

Gene Tree for S100PBP (if available)
Gene Tree for S100PBP (if available)
Evolutionary constrained regions (ECRs) for S100PBP: view image

Paralogs for S100PBP Gene

No data available for Paralogs for S100PBP Gene

Variants for S100PBP Gene

Sequence variations from dbSNP and Humsavar for S100PBP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1057515442 uncertain-significance, Charcot-Marie-Tooth, Intermediate 32,817,577(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1057515514 uncertain-significance, Charcot-Marie-Tooth, Intermediate 32,817,411(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1057515550 uncertain-significance, Charcot-Marie-Tooth, Intermediate 32,817,864(+) T/G genic_upstream_transcript_variant, intron_variant
rs112104823 uncertain-significance, Charcot-Marie-Tooth, Intermediate 32,817,906(+) C/T genic_upstream_transcript_variant, intron_variant
rs113748028 uncertain-significance, Charcot-Marie-Tooth, Intermediate 32,817,527(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for S100PBP Gene

Variant ID Type Subtype PubMed ID
esv3577803 CNV loss 25503493
nsv1145333 CNV deletion 24896259
nsv516302 CNV loss 19592680

Variation tolerance for S100PBP Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100PBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100PBP Gene

Disorders for S100PBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100PBP Gene - From: GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, dominant intermediate c
  • cmtdic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100PBP

genes like me logo Genes that share disorders with S100PBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100PBP Gene

Publications for S100PBP Gene

  1. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. (PMID: 15632002) Dowen SE … Lemoine NR (The American journal of pathology 2005) 3 4 22 58
  2. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. (PMID: 18089492) Deng H … Lin F (American journal of clinical pathology 2008) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for S100PBP Gene

Sources for S100PBP Gene

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