The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located... See more...

Aliases for S100P Gene

Aliases for S100P Gene

  • S100 Calcium Binding Protein P 2 3 5
  • Migration-Inducing Gene 9 Protein 3 4
  • S100 Calcium-Binding Protein P 2 4
  • Protein S100-P 3 4
  • Protein S100-E 3 4
  • MIG9 3 4
  • S100P 5
  • S100E 4

External Ids for S100P Gene

Previous GeneCards Identifiers for S100P Gene

  • GC04M006590
  • GC04P006816
  • GC04P006687
  • GC04P006759
  • GC04P006812
  • GC04P006695
  • GC04P006628
  • GC04P006696
  • GC04P006698

Summaries for S100P Gene

Entrez Gene Summary for S100P Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100P Gene

S100P (S100 Calcium Binding Protein P) is a Protein Coding gene. Diseases associated with S100P include Geographic Tongue and Atrophic Glossitis. Among its related pathways are Innate Immune System and Gastric Cancer Network 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100Z.

UniProtKB/Swiss-Prot Summary for S100P Gene

  • May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

Gene Wiki entry for S100P Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100P Gene

Genomics for S100P Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for S100P Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100P on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100P

Top Transcription factor binding sites by QIAGEN in the S100P gene promoter:
  • AREB6
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for S100P Gene

Latest Assembly
chr4:6,693,878-6,697,170
(GRCh38/hg38)
Size:
3,293 bases
Orientation:
Plus strand

Previous Assembly
chr4:6,695,605-6,698,897
(GRCh37/hg19 by Entrez Gene)
Size:
3,293 bases
Orientation:
Plus strand

chr4:6,694,796-6,698,897
(GRCh37/hg19 by Ensembl)
Size:
4,102 bases
Orientation:
Plus strand

Genomic View for S100P Gene

Genes around S100P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100P Gene

Proteins for S100P Gene

  • Protein details for S100P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25815-S100P_HUMAN
    Recommended name:
    Protein S100-P
    Protein Accession:
    P25815
    Secondary Accessions:
    • Q5J7W2

    Protein attributes for S100P Gene

    Size:
    95 amino acids
    Molecular mass:
    10400 Da
    Quaternary structure:
    • Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
    SequenceCaution:
    • Sequence=AAS00487.1; Type=Miscellaneous discrepancy; Note=Sequencing error in Met-1 codon.; Evidence={ECO:0000305};
    Miscellaneous:
    • This protein binds two calcium ions.

    Three dimensional structures from OCA and Proteopedia for S100P Gene

neXtProt entry for S100P Gene

Post-translational modifications for S100P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100P Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100P Gene

Domains & Families for S100P Gene

Gene Families for S100P Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for S100P Gene

InterPro:
Blocks:
  • Calcium-binding protein, S-100/ICaBP type

Suggested Antigen Peptide Sequences for S100P Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein P (S100P_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25815

UniProtKB/Swiss-Prot:

S100P_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100P: view

Function for S100P Gene

Molecular function for S100P Gene

UniProtKB/Swiss-Prot Function:
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
GENATLAS Biochemistry:
S100 calcium binding protein P

Phenotypes From GWAS Catalog for S100P Gene

Gene Ontology (GO) - Molecular Function for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 15632002
GO:0005509 calcium ion binding TAS,IBA 21873635
GO:0005515 protein binding IPI 11747429
GO:0042803 protein homodimerization activity IDA 11747429
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with S100P: view
genes like me logo Genes that share phenotypes with S100P: view

miRNA for S100P Gene

miRTarBase miRNAs that target S100P

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100P

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100P Gene

Localization for S100P Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100P Gene

Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100P gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 4
cytosol 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 15632002
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 15632002
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with S100P: view

Pathways & Interactions for S100P Gene

genes like me logo Genes that share pathways with S100P: view

Pathways by source for S100P Gene

1 BioSystems pathway for S100P Gene
3 Reactome pathways for S100P Gene
1 Cell Signaling Technology pathway for S100P Gene

Gene Ontology (GO) - Biological Process for S100P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance IEP 17486081
GO:0043312 neutrophil degranulation TAS --
GO:0043542 endothelial cell migration IBA,IMP 15313892
genes like me logo Genes that share ontologies with S100P: view

No data available for SIGNOR curated interactions for S100P Gene

Drugs & Compounds for S100P Gene

(2) Drugs for S100P Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cromoglicic acid Approved Pharma Target, antagonist 0
Calcium Nutra 6959
genes like me logo Genes that share compounds with S100P: view

Transcripts for S100P Gene

mRNA/cDNA for S100P Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100P

Alternative Splicing Database (ASD) splice patterns (SP) for S100P Gene

No ASD Table

Relevant External Links for S100P Gene

GeneLoc Exon Structure for
S100P

Expression for S100P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100P Gene

mRNA differential expression in normal tissues according to GTEx for S100P Gene

This gene is overexpressed in Whole Blood (x17.4), Bladder (x10.6), Stomach (x9.6), and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for S100P Gene

This gene is overexpressed in Nasal epithelium (28.7), Placenta (10.3), and Breast (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100P Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100P

SOURCE GeneReport for Unigene cluster for S100P Gene:

Hs.2962

mRNA Expression by UniProt/SwissProt for S100P Gene:

P25815-S100P_HUMAN
Tissue specificity: Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.

Evidence on tissue expression from TISSUES for S100P Gene

  • Stomach(3.1)
  • Intestine(2.9)
  • Blood(2.9)
  • Pancreas(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with S100P: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100P Gene

Orthologs for S100P Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100P Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia S100P 29 30
  • 98.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia S100P 29 30
  • 81.56 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia S100P 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia s100p 29
  • 69.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii icn 30
  • 44 (a)
OneToMany
icn2 30
  • 42 (a)
OneToMany
s100t 30
  • 38 (a)
OneToMany
s100s 30
  • 36 (a)
OneToMany
Species where no ortholog for S100P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for S100P Gene

ENSEMBL:
Gene Tree for S100P (if available)
TreeFam:
Gene Tree for S100P (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100P: view image
Alliance of Genome Resources:
Additional Orthologs for S100P

Paralogs for S100P Gene

(20) SIMAP similar genes for S100P Gene using alignment to 1 proteins:

  • S100P_HUMAN
genes like me logo Genes that share paralogs with S100P: view

Variants for S100P Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100P Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs73089273 Benign: not provided 6,694,007(+) G/A
NM_005980.3(S100P):c.75G>A (p.Thr25=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for S100P Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for S100P Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER inversion 12058347
nsv829849 CNV loss 17160897

Variation tolerance for S100P Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100P
Leiden Open Variation Database (LOVD)
S100P

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100P Gene

Disorders for S100P Gene

MalaCards: The human disease database

(3) MalaCards diseases for S100P Gene - From: COP and GCD

Disorder Aliases PubMed IDs
geographic tongue
  • benign migratory glossitis
atrophic glossitis
  • atrophy of tongue papillae
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search S100P in MalaCards View complete list of genes associated with diseases

Additional Disease Information for S100P

genes like me logo Genes that share disorders with S100P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100P Gene

Publications for S100P Gene

  1. Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein. (PMID: 14672411) Jin G … Mao Y (Molecular biology reports 2003) 3 4 22
  2. Generation and characterization of a novel, permanently active S100P mutant. (PMID: 19111582) Austermann J … Gerke V (Biochimica et biophysica acta 2009) 3 4
  3. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. (PMID: 15632002) Dowen SE … Lemoine NR (The American journal of pathology 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Heterodimeric interaction and interfaces of S100A1 and S100P. (PMID: 15171681) Wang G … Barraclough R (The Biochemical journal 2004) 3 4

Products for S100P Gene

Sources for S100P Gene