Aliases for S100P Gene
External Ids for S100P Gene
Previous GeneCards Identifiers for S100P Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for S100P Gene
S100P (S100 Calcium Binding Protein P) is a Protein Coding gene. Diseases associated with S100P include Geographic Tongue and Atrophic Glossitis. Among its related pathways are Innate Immune System and Gastric Cancer Network 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100Z.
UniProtKB/Swiss-Prot Summary for S100P Gene
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).