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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
S100B (S100 Calcium Binding Protein B) is a Protein Coding gene. Diseases associated with S100B include Malignant Peripheral Nerve Sheath Tumor and Neurofibroma. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005509 | calcium ion binding | TAS,NAS | 9519411 |
GO:0005515 | protein binding | IPI | 3111527 |
GO:0008270 | zinc ion binding | ISS | -- |
GO:0042802 | identical protein binding | IPI | 10913138 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001726 | ruffle | IDA | 10913138 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005634 | nucleus | IEA,IDA | 10913138 |
GO:0005654 | nucleoplasm | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Cytosolic sensors of pathogen-associated DNA | ||
3 | Innate Immune System |
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4 | Signaling by ERBB4 | ||
5 | Ca, cAMP and Lipid Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007409 | axonogenesis | TAS | 8202493 |
GO:0007417 | central nervous system development | TAS | 8202493 |
GO:0007611 | learning or memory | ISS | -- |
GO:0007613 | memory | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Olopatadine | Approved | Pharma | Target, other/unknown | 0 | ||
Calcium citrate | Approved, Investigational | Pharma | Target, ligand | 0 | ||
Calcium Phosphate | Approved | Pharma | Target, ligand | 0 | ||
Calcium phosphate dihydrate | Approved | Pharma | Target | 0 | ||
(Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
B2 |
|
115687-05-3 |
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Nogo-66 (1-40) |
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475221-20-6 |
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||
PLP (139-151) |
|
122018-58-0 |
|
|
||
TCS PrP Inhibitor 13 |
|
34320-83-7 |
|
|
Compound | Action | Cas Number |
---|---|---|
B2 | Promotes inclusion formation in Huntington's and Parkinson's diseases | 115687-05-3 |
MOG (35-55) | Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 149635-73-4 |
Nogo-66 (1-40) | Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration | 475221-20-6 |
PLP (139-151) | Encephalitogenic myelin proteolipid fragment | 122018-58-0 |
TCS PrP Inhibitor 13 | Antiprion agent; potently inhibits PrP-res accumulation | 34320-83-7 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | S100B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | S100B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | S100b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | S100b 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | S100B 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | S100B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | S100B 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | s100b 30 31 |
|
OneToOne | |
wufq18b10 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4441n100 | CNV | gain | 25217958 |
dgv4442n100 | CNV | gain | 25217958 |
dgv4443n100 | CNV | gain | 25217958 |
dgv4444n100 | CNV | gain | 25217958 |
dgv4445n100 | CNV | gain | 25217958 |
dgv4446n100 | CNV | gain | 25217958 |
esv2758822 | CNV | gain | 17122850 |
esv2760700 | CNV | gain | 21179565 |
esv34393 | CNV | gain | 17911159 |
esv3647171 | CNV | gain | 21293372 |
esv3647172 | CNV | loss | 21293372 |
esv3647173 | CNV | gain | 21293372 |
nsv1057566 | CNV | loss | 25217958 |
nsv1065227 | CNV | gain | 25217958 |
nsv470910 | CNV | gain | 18288195 |
nsv527542 | CNV | loss | 19592680 |
nsv528495 | CNV | loss | 19592680 |
nsv528947 | CNV | gain | 19592680 |
nsv587999 | CNV | gain | 21841781 |
nsv588002 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
malignant peripheral nerve sheath tumor |
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neurofibroma |
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syringoma |
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amelanotic melanoma |
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myxopapillary ependymoma |
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