The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located... See more...

Aliases for S100A9 Gene

Aliases for S100A9 Gene

  • S100 Calcium Binding Protein A9 2 3 5
  • Migration Inhibitory Factor-Related Protein 14 3 4
  • Leukocyte L1 Complex Heavy Chain 3 4
  • Calprotectin L1H Subunit 3 4
  • Protein S100-A9 3 4
  • Calgranulin B 2 3
  • MRP-14 3 4
  • MRP14 3 4
  • CAGB 3 4
  • CFAG 3 4
  • P14 3 4
  • S100 Calcium-Binding Protein A9 (Calgranulin B) 2
  • S100 Calcium-Binding Protein A9 4
  • Calgranulin-B 4
  • 60B8AG 3
  • MAC387 3
  • CGLB 3
  • L1AG 3
  • LIAG 3
  • MIF 3
  • NIF 3

External Ids for S100A9 Gene

Previous HGNC Symbols for S100A9 Gene

  • CAGB
  • CFAG

Previous GeneCards Identifiers for S100A9 Gene

  • GC01P151146
  • GC01P149113
  • GC01P150105
  • GC01P150546
  • GC01P150143
  • GC01P151596
  • GC01P153330
  • GC01P124693

Summaries for S100A9 Gene

Entrez Gene Summary for S100A9 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for S100A9 Gene

S100A9 (S100 Calcium Binding Protein A9) is a Protein Coding gene. Diseases associated with S100A9 include Cystic Fibrosis and Crohn's Disease. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and microtubule binding. An important paralog of this gene is S100A12.

UniProtKB/Swiss-Prot Summary for S100A9 Gene

  • S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.

Gene Wiki entry for S100A9 Gene

Additional gene information for S100A9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A9 Gene

Genomics for S100A9 Gene

GeneHancer (GH) Regulatory Elements for S100A9 Gene

Promoters and enhancers for S100A9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153357 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 750.6 +1.7 1672 6.6 POLR2A SP1 CEBPG IKZF1 CEBPA RXRA SMARCC1 NFE2L2 CEBPB ZNF316 S100A9 S100A15A S100A8 RNU6-160P S100A14 S100A16 S100A12 LOC101928009
GH01J153358 Promoter/Enhancer 0.9 Ensembl dbSUPER 750.6 -2.0 -1953 0.2 CTCF RAD21 ARID2 ZNF143 ZNF24 TRIM22 DEK ZBTB17 ZKSCAN1 SKIL S100A9 PGLYRP4
GH01J153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 +207.7 207707 8.8 SIN3A CTCF SREBF1 RBPJ SMARCE1 POLR2A ZNF217 ZNF362 RUNX1 CC2D1A S100A3 S100A2 HSALNG0007314 CHTOP S100A4 S100A6 S100A5 ENSG00000238279 S100A16 UBAP2L
GH01J153384 Enhancer 0.6 FANTOM5 ENCODE 23.3 +28.4 28427 2 POLR2A MAX S100A12 S100A9 S100A8 PGLYRP4 RNU6-160P S100A4 lnc-S100A12-2 LAPTM4BP1
GH01J153489 Enhancer 1 ENCODE dbSUPER 10.8 +133.0 132973 2.1 HLF SP7 ZSCAN21 PRDM1 ZNF547 ZIC2 POLR2A PRDM10 ZEB2 CEBPB PGLYRP4 S100A9 RNU6-160P S100A1 CHTOP S100A13 PGLYRP3 RN7SL44P S100A3 RF00017-350
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A9 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CP2
  • HTF

Genomic Locations for S100A9 Gene

Genomic Locations for S100A9 Gene
chr1:153,357,854-153,361,027
(GRCh38/hg38)
Size:
3,174 bases
Orientation:
Plus strand
chr1:153,330,330-153,333,503
(GRCh37/hg19)
Size:
3,174 bases
Orientation:
Plus strand

Genomic View for S100A9 Gene

Genes around S100A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A9 Gene

Proteins for S100A9 Gene

  • Protein details for S100A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06702-S10A9_HUMAN
    Recommended name:
    Protein S100-A9
    Protein Accession:
    P06702
    Secondary Accessions:
    • D3DV36
    • Q6FGA1
    • Q9NYM0
    • Q9UCJ1

    Protein attributes for S100A9 Gene

    Size:
    114 amino acids
    Molecular mass:
    13242 Da
    Quaternary structure:
    • Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A8 known as calprotectin (S100A8/A9). S100A9 interacts with ATP2A2 (By similarity). S100A9 interacts with AGER, and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. S100A9 binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions. S100A9 interacts with amyloid-beta protein 40. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. Calprotectin (S100A8/9) interacts with NCF2/P67PHOX, RAC1, RAC2, CYBA and CYBB. Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex; induced by LDL(ox) (PubMed:25417112).

    Three dimensional structures from OCA and Proteopedia for S100A9 Gene

neXtProt entry for S100A9 Gene

Post-translational modifications for S100A9 Gene

  • Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.
  • S-nitrosylation of Cys-3 is implicated in LDL(ox)-induced S-nitrosylation of GAPDH at 'Cys-247' through a transnitrosylase mechanism involving a iNOS-S100A8/9 complex (PubMed:25417112).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S100A9 Gene

Domains & Families for S100A9 Gene

Gene Families for S100A9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for S100A9 Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein A9 (S10A9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06702

UniProtKB/Swiss-Prot:

S10A9_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A9: view

Function for S100A9 Gene

Molecular function for S100A9 Gene

UniProtKB/Swiss-Prot Function:
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.
GENATLAS Biochemistry:
S100 calcium binding protein A9,calgranulin B,epidermal differentiation complex expressed in monocytes and granulocytes

Phenotypes From GWAS Catalog for S100A9 Gene

Gene Ontology (GO) - Molecular Function for S100A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding TAS 22489132
GO:0005515 protein binding IPI 9867828
GO:0008017 microtubule binding TAS 22489132
GO:0008270 zinc ion binding TAS 22489132
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with S100A9: view
genes like me logo Genes that share phenotypes with S100A9: view

Animal Models for S100A9 Gene

MGI Knock Outs for S100A9:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A9 Gene

Localization for S100A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A9 Gene

Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A9 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Cytosol (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,HDA 22489132
GO:0005615 extracellular space IDA 21805676
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 12874352
genes like me logo Genes that share ontologies with S100A9: view

Pathways & Interactions for S100A9 Gene

genes like me logo Genes that share pathways with S100A9: view

Pathways by source for S100A9 Gene

SIGNOR curated interactions for S100A9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for S100A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production TAS 22489132
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002523 leukocyte migration involved in inflammatory response IDA 12626582
GO:0006914 autophagy IDA,IEA 19935772
genes like me logo Genes that share ontologies with S100A9: view

Drugs & Compounds for S100A9 Gene

(14) Drugs for S100A9 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra Target 7773
Zinc Approved, Investigational Pharma Target 2741
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(17) Additional Compounds for S100A9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A9: view

Transcripts for S100A9 Gene

mRNA/cDNA for S100A9 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(244) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A9 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for S100A9 Gene

GeneLoc Exon Structure for
S100A9
ECgene alternative splicing isoforms for
S100A9

Expression for S100A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A9 Gene

This gene is overexpressed in Whole Blood (x31.8) and Esophagus - Mucosa (x9.3).

Protein differential expression in normal tissues from HIPED for S100A9 Gene

This gene is overexpressed in Neutrophil (14.7), Monocytes (9.1), Lavage (7.2), and Cervix (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A9 Gene



Protein tissue co-expression partners for S100A9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A9 Gene:

S100A9

SOURCE GeneReport for Unigene cluster for S100A9 Gene:

Hs.112405

mRNA Expression by UniProt/SwissProt for S100A9 Gene:

P06702-S10A9_HUMAN
Tissue specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.

Evidence on tissue expression from TISSUES for S100A9 Gene

  • Blood(4.8)
  • Lung(4.7)
  • Skin(4.7)
  • Liver(4.5)
  • Bone marrow(3.9)
  • Spleen(3.7)
  • Heart(3.3)
  • Intestine(3.3)
  • Nervous system(2.9)
  • Gall bladder(2.8)
  • Lymph node(2.8)
  • Muscle(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with S100A9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A9 Gene

Orthologs for S100A9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A9 33 32
  • 98.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia S100A9 33 32
  • 78.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia S100A9 33 32
  • 75.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia S100a9 17 33 32
  • 71.7 (n)
rat
(Rattus norvegicus)
Mammalia S100a9 32
  • 71.7 (n)
oppossum
(Monodelphis domestica)
Mammalia S100A9 33
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves S100A9 32
  • 58.89 (n)
-- 33
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 47 (a)
ManyToMany
-- 33
  • 44 (a)
ManyToMany
Species where no ortholog for S100A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A9 Gene

ENSEMBL:
Gene Tree for S100A9 (if available)
TreeFam:
Gene Tree for S100A9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A9: view image

Paralogs for S100A9 Gene

(18) SIMAP similar genes for S100A9 Gene using alignment to 1 proteins:

  • S10A9_HUMAN
genes like me logo Genes that share paralogs with S100A9: view

Variants for S100A9 Gene

Sequence variations from dbSNP and Humsavar for S100A9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000484791 -- 153,358,502(+) T/C intron_variant
rs1000538901 -- 153,359,408(+) C/T intron_variant
rs1001510694 -- 153,360,998(+) G/T 3_prime_UTR_variant
rs1001562416 -- 153,359,044(+) C/T intron_variant
rs1001611542 -- 153,358,738(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S100A9 Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958
nsv7184 OTHER inversion 18451855

Variation tolerance for S100A9 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A9 Gene

Disorders for S100A9 Gene

MalaCards: The human disease database

(21) MalaCards diseases for S100A9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • cf
crohn's disease
  • ileitis
juvenile rheumatoid arthritis
  • rheumatoid arthritis, systemic juvenile
inflammatory bowel disease
  • inflammatory bowel diseases
psoriasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A9 Gene

Publications for S100A9 Gene

  1. A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway. (PMID: 19534726) Li C … Liu Z (The Biochemical journal 2009) 3 4 23 56
  2. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. (PMID: 19087201) Sroussi HY … Palefsky JM (FEMS immunology and medical microbiology 2009) 3 4 23 56
  3. Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils. (PMID: 15905572) Lominadze G … McLeish KR (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 23 56
  4. Target-selective protein S-nitrosylation by sequence motif recognition. (PMID: 25417112) Jia J … Fox PL (Cell 2014) 3 4 56
  5. MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization. (PMID: 22457725) Zhang C … van der Maarel JR (PloS one 2012) 3 4 56

Products for S100A9 Gene

Sources for S100A9 Gene