S100A8 Gene (Protein Coding)

S100 Calcium Binding Protein A8

GC01M153391
GIFtS:
44
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located... See more...

Aliases for S100A8 Gene

Aliases for S100A8 Gene

  • S100 Calcium Binding Protein A8 2 3 5
  • Migration Inhibitory Factor-Related Protein 8 3 4
  • Leukocyte L1 Complex Light Chain 3 4
  • Urinary Stone Protein Band A 3 4
  • Calprotectin L1L Subunit 3 4
  • Cystic Fibrosis Antigen 3 4
  • Protein S100-A8 3 4
  • Calgranulin A 2 3
  • CAGA 3 4
  • CFAG 3 4
  • MRP8 3 4
  • P8 3 4
  • S100 Calcium-Binding Protein A8 (Calgranulin A) 2
  • S100 Calcium-Binding Protein A8 4
  • Calgranulin-A 4
  • 60B8AG 3
  • CP-10 3
  • MA387 3
  • MRP-8 4
  • CGLA 3
  • L1Ag 3
  • MIF 3
  • NIF 3

External Ids for S100A8 Gene

Previous HGNC Symbols for S100A8 Gene

  • CAGA
  • CFAG

Previous GeneCards Identifiers for S100A8 Gene

  • GC01M151178
  • GC01M149145
  • GC01M150137
  • GC01M150579
  • GC01M150175
  • GC01M151629
  • GC01M153362
  • GC01M124725

Summaries for S100A8 Gene

Entrez Gene Summary for S100A8 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for S100A8 Gene

S100A8 (S100 Calcium Binding Protein A8) is a Protein Coding gene. Diseases associated with S100A8 include Duodenal Ulcer and Cystic Fibrosis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A12.

UniProtKB/Swiss-Prot Summary for S100A8 Gene

  • S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.

Gene Wiki entry for S100A8 Gene

Additional gene information for S100A8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A8 Gene

Genomics for S100A8 Gene

GeneHancer (GH) Regulatory Elements for S100A8 Gene

Promoters and enhancers for S100A8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J153389 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 750.3 +32.0 31977 2.4 NFIB CEBPG CTBP1 CEBPB RCOR1 MAX EP300 PKNOX1 ZFHX2 CTCF lnc-S100A12-2 S100A8 S100A12 LAPTM4BP1
GH01J153422 Enhancer 0.8 Ensembl 750.6 -0.1 -75 0.5 ZBTB40 ATF1 CREB1 MIXL1 ZNF362 HLF CSDE1 ZNF384 TFE3 NCOA6 S100A8 UBAP2L CHTOP S100A9 PGLYRP3 RNU6-160P GATAD2B S100A7A S100A7P1 lnc-S100A7L2-1
GH01J153363 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 24.7 +56.6 56642 4.3 TCF7L2 ZNF217 MNT CEBPG CREB1 TARDBP RFX1 CTBP1 CEBPB MAX S100A8 S100A12 S100A15A RNU6-160P S100A9
GH01J153357 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 11.1 +63.1 63052 6.6 POLR2A SP1 CEBPG IKZF1 CEBPA RXRA SMARCC1 NFE2L2 CEBPB ZNF316 S100A9 S100A15A S100A8 RNU6-160P S100A14 S100A16 S100A12 LOC101928009
GH01J153384 Enhancer 0.6 FANTOM5 ENCODE 22.6 +36.3 36297 2 POLR2A MAX S100A12 S100A9 S100A8 PGLYRP4 RNU6-160P S100A4 lnc-S100A12-2 LAPTM4BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A8 gene promoter:
  • AML1a
  • E47
  • GATA-1
  • HOXA5
  • LCR-F1
  • Lmo2
  • MyoD
  • RFX1
  • Tal-1
  • TGIF

Genomic Locations for S100A8 Gene

Genomic Locations for S100A8 Gene
chr1:153,390,032-153,422,578
(GRCh38/hg38)
Size:
32,547 bases
Orientation:
Minus strand
chr1:153,362,508-153,363,664
(GRCh37/hg19)
Size:
1,157 bases
Orientation:
Minus strand

Genomic View for S100A8 Gene

Genes around S100A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for S100A8 Gene

Proteins for S100A8 Gene

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  • Protein details for S100A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05109-S10A8_HUMAN
    Recommended name:
    Protein S100-A8
    Protein Accession:
    P05109
    Secondary Accessions:
    • A8K5L3
    • D3DV37
    • Q5SY70
    • Q9UC84
    • Q9UC92
    • Q9UCJ0
    • Q9UCM6

    Protein attributes for S100A8 Gene

    Size:
    93 amino acids
    Molecular mass:
    10835 Da
    Quaternary structure:
    • Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A9 known as calprotectin (S100A8/A9). S100A8 interacts with AGER, ATP2A2 and with the heterodimeric complex formed by TLR4 and LY96 (By similarity). Interacts with GAPDH. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. S100A8 and calprotectin (S100A8/9) interact with NCF2/P67PHOX, RAC1 and RAC2. Calprotectin (S100A8/9) interacts with CYBA and CYBB. Calprotectin (S100A8/9) interacts with NOS2 to form the iNOS-S100A8/A9 transnitrosylase complex; induced by LDL(ox) (PubMed:25417112).
    Miscellaneous:
    • Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.

    Three dimensional structures from OCA and Proteopedia for S100A8 Gene

neXtProt entry for S100A8 Gene

Protein Expression for S100A8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for S100A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for S100A8

Protein Products

  • Abcam proteins for S100A8

Assay Products

  • Abcam assays for S100A8

No data available for DME Specific Peptides for S100A8 Gene

Domains & Families for S100A8 Gene

Gene Families for S100A8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for S100A8 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for S100A8 Gene

GenScript: Design optimal peptide antigens:
  • Urinary stone protein band A (S10A8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05109

UniProtKB/Swiss-Prot:

S10A8_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A8: view

Function for S100A8 Gene

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Molecular function for S100A8 Gene

UniProtKB/Swiss-Prot Function:
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
GENATLAS Biochemistry:
S100 calcium binding protein A8,calgranulin A,epidermal differentiation complex

Phenotypes From GWAS Catalog for S100A8 Gene

Gene Ontology (GO) - Molecular Function for S100A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding TAS 22489132
GO:0005515 protein binding IPI 9867828
GO:0008017 microtubule binding TAS 22489132
GO:0008270 zinc ion binding TAS 22489132
GO:0035662 Toll-like receptor 4 binding TAS 22489132
genes like me logo Genes that share ontologies with S100A8: view
genes like me logo Genes that share phenotypes with S100A8: view

Animal Models for S100A8 Gene

MGI Knock Outs for S100A8:

Animal Model Products

CRISPR Products

miRNA for S100A8 Gene

miRTarBase miRNAs that target S100A8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A8 Gene

Localization for S100A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A8 Gene

Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A8 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,HDA 22489132
GO:0005615 extracellular space IDA 21805676
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS 22489132
genes like me logo Genes that share ontologies with S100A8: view

Pathways & Interactions for S100A8 Gene

genes like me logo Genes that share pathways with S100A8: view

Pathways by source for S100A8 Gene

1 KEGG pathway for S100A8 Gene

Gene Ontology (GO) - Biological Process for S100A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production TAS 22489132
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002523 leukocyte migration involved in inflammatory response IDA 12626582
GO:0002526 acute inflammatory response IEA --
genes like me logo Genes that share ontologies with S100A8: view

No data available for SIGNOR curated interactions for S100A8 Gene

Drugs & Compounds for S100A8 Gene

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  1. Drug

(29) Drugs for S100A8 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra Target 7773
Zinc Approved, Investigational Pharma Target 2741
Copper Approved, Investigational Pharma Target 227
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(26) Additional Compounds for S100A8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A8: view

Transcripts for S100A8 Gene

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mRNA/cDNA for S100A8 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(431) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A8 Gene

No ASD Table

Relevant External Links for S100A8 Gene

GeneLoc Exon Structure for
S100A8
ECgene alternative splicing isoforms for
S100A8

Expression for S100A8 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A8 Gene

mRNA expression in normal human tissues for S100A8 Gene
mRNA expression by BioGPS for S100A8 GenemRNA expression by GTEx for S100A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A8 Gene

This gene is overexpressed in Whole Blood (x17.2), Esophagus - Mucosa (x17.1), Vagina (x6.7), and Cervix - Ectocervix (x4.2).

Protein differential expression in normal tissues from HIPED for S100A8 Gene

This gene is overexpressed in Neutrophil (19.4), Monocytes (12.5), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S100A8 Gene



Protein tissue co-expression partners for S100A8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A8 Gene:

S100A8

SOURCE GeneReport for Unigene cluster for S100A8 Gene:

Hs.416073

mRNA Expression by UniProt/SwissProt for S100A8 Gene:

P05109-S10A8_HUMAN
Tissue specificity: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.

Evidence on tissue expression from TISSUES for S100A8 Gene

  • Blood(4.8)
  • Skin(4.6)
  • Liver(4.5)
  • Muscle(4.4)
  • Bone marrow(3.6)
  • Stomach(3.6)
  • Intestine(3.3)
  • Spleen(3.1)
  • Lung(3)
  • Heart(2.6)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with S100A8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A8 Gene

Orthologs for S100A8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia S100A8 33 32
  • 98.57 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia S100A8 33 32
  • 82.77 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia S100A8 33 32
  • 80.52 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia S100a8 32
  • 71.91 (n)
mouse
(Mus musculus)
 Mammalia S100a8 17 33 32
  • 70.79 (n)
oppossum
(Monodelphis domestica)
 Mammalia S100A8 33
  • 49 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia S100A8 33
  • 46 (a)
 OneToOne
Species where no ortholog for S100A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A8 Gene

ENSEMBL:
Gene Tree for S100A8 (if available)
TreeFam:
Gene Tree for S100A8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A8: view image

Paralogs for S100A8 Gene

Paralogs for S100A8 Gene

(22) SIMAP similar genes for S100A8 Gene using alignment to 1 proteins:

  • S10A8_HUMAN
genes like me logo Genes that share paralogs with S100A8: view

Variants for S100A8 Gene

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Sequence variations from dbSNP and Humsavar for S100A8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000277856 -- 153,402,358(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000278785 -- 153,415,717(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000322639 -- 153,401,082(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000325715 -- 153,391,146(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000353643 -- 153,415,604(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S100A8 Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958

Variation tolerance for S100A8 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A8 Gene

Disorders for S100A8 Gene

MalaCards: The human disease database

(17) MalaCards diseases for S100A8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenal ulcer
  • curling ulcer
cystic fibrosis
  • cf
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
gastritis
  • acute gastric mucosal erosion
atrophic gastritis
  • gastric atrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A8 Gene

Publications for S100A8 Gene

  1. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. (PMID: 19087201) Sroussi HY … Palefsky JM (FEMS immunology and medical microbiology 2009) 3 4 23 56
  2. Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation. (PMID: 1326551) Lemarchand P … Markert M (The Journal of biological chemistry 1992) 3 4 23 56
  3. Target-selective protein S-nitrosylation by sequence motif recognition. (PMID: 25417112) Jia J … Fox PL (Cell 2014) 3 4 56
  4. Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation. (PMID: 22808130) Berthier S … Morel F (PloS one 2012) 3 4 56
  5. Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway. (PMID: 22363402) Atallah M … Mevorach D (PloS one 2012) 3 4 56

ExternalLinks

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