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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
S100A8 (S100 Calcium Binding Protein A8) is a Protein Coding gene. Diseases associated with S100A8 include Peptic Ulcer Disease and Duodenal Ulcer. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A12.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | TAS | 22489132 |
GO:0005515 | protein binding | IPI | 9867828 |
GO:0008017 | microtubule binding | TAS | 22489132 |
GO:0008270 | zinc ion binding | TAS | 22489132 |
GO:0035662 | Toll-like receptor 4 binding | TAS | 22489132 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | 22489132 |
GO:0005615 | extracellular space | IDA | 21805676 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
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2 | Defensins | ||
3 | Activated TLR4 signalling | ||
4 | IL-17 Family Signaling Pathways |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001816 | cytokine production | TAS | 22489132 |
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002523 | leukocyte migration involved in inflammatory response | IDA | 12626582 |
GO:0002526 | acute inflammatory response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
Copper | Approved, Investigational | Pharma | Target | 249 | ||
zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
Zinc chloride | Approved, Investigational | Pharma | Target, regulator | 0 | ||
Zinc sulfate, unspecified form | Approved, Experimental | Pharma | Target, regulator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | S100A8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | S100A8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | S100A8 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | S100a8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | S100a8 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | S100A8 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | S100A8 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1002705 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
peptic ulcer disease |
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duodenal ulcer |
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atrophic gastritis |
|
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cystic fibrosis |
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gastritis |
|