Aliases for S100A7A Gene

Aliases for S100A7A Gene

  • S100 Calcium Binding Protein A7A 2 3 5
  • S100 Calcium-Binding Protein A7-Like 1 3 4
  • S100 Calcium-Binding Protein A15 3 4
  • Protein S100-A7A 3 4
  • Koebnerisin 2 3
  • S100A7L1 3 4
  • S100A15 3 4
  • S100 Calcium Binding Protein A7-Like 1 2
  • S100 Calcium-Binding Protein A7A 4
  • S100 Calcium Binding Protein A15 2
  • S100A7f 3
  • NICE-2 3
  • NICE2 3

External Ids for S100A7A Gene

Previous HGNC Symbols for S100A7A Gene

  • S100A15
  • S100A7L1

Previous GeneCards Identifiers for S100A7A Gene

  • GC01P151655
  • GC01P124752

Summaries for S100A7A Gene

GeneCards Summary for S100A7A Gene

S100A7A (S100 Calcium Binding Protein A7A) is a Protein Coding gene. Diseases associated with S100A7A include Psoriasis and Macular Degeneration, Age-Related, 13. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein self-association. An important paralog of this gene is S100A7.

UniProtKB/Swiss-Prot Summary for S100A7A Gene

  • May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Gene Wiki entry for S100A7A Gene

Additional gene information for S100A7A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A7A Gene

Genomics for S100A7A Gene

GeneHancer (GH) Regulatory Elements for S100A7A Gene

Promoters and enhancers for S100A7A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153413 Enhancer 0.4 Ensembl 500.7 -1.5 -1519 2.8 MEF2C TCF12 MEF2A ZSCAN4 S100A7A RNU6-160P CHTOP S100A3 S100A8 S100A15A
GH01J153416 Promoter 0.3 EPDnew 500.7 0.0 -17 0.1 S100A7A S100A8 S100A15A
GH01J153606 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 +195.9 195939 11.6 ZNF217 CTCF POLR2G NCOR1 PHF8 JUND FOS ZFX ZIC2 POLR2A S100A16 S100A14 lnc-S100A16-1 S100A1 ILF2 CREB3L4 SLC27A3 ENSG00000272030 CHTOP CRTC2
GH01J153422 Enhancer 0.8 Ensembl 0.4 +6.1 6133 0.5 NRF1 REST AFF1 CUX1 ZBTB25 TGIF2 ATF2 ZSCAN9 MIER1 CREB1 S100A8 S100A9 PGLYRP3 RNU6-160P S100A7A S100A7P1 lnc-S100A7L2-1
GH01J153404 Enhancer 0.7 ENCODE 0.4 -11.7 -11660 0.1 CTCF USF1 REST TOE1 MYC SMC3 HDAC2 MIER1 CREB3L1 USF2 CHTOP S100A15A S100A7A S100A8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A7A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100A7A

Top Transcription factor binding sites by QIAGEN in the S100A7A gene promoter:
  • C/EBPalpha
  • Chx10
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA5
  • Lhx3a
  • LHX3b

Genomic Locations for S100A7A Gene

Genomic Locations for S100A7A Gene
chr1:153,416,520-153,423,225
(GRCh38/hg38)
Size:
6,706 bases
Orientation:
Plus strand
chr1:153,389,000-153,395,701
(GRCh37/hg19)
Size:
6,702 bases
Orientation:
Plus strand

Genomic View for S100A7A Gene

Genes around S100A7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7A Gene

Proteins for S100A7A Gene

  • Protein details for S100A7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SG5-S1A7A_HUMAN
    Recommended name:
    Protein S100-A7A
    Protein Accession:
    Q86SG5
    Secondary Accessions:
    • D3DV38
    • Q5SY69

    Protein attributes for S100A7A Gene

    Size:
    101 amino acids
    Molecular mass:
    11305 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S100A7A Gene

neXtProt entry for S100A7A Gene

Post-translational modifications for S100A7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A7A Gene

Domains & Families for S100A7A Gene

Gene Families for S100A7A Gene

Protein Domains for S100A7A Gene

Blocks:
  • Calcium-binding protein, S-100/ICaBP type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for S100A7A Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein A7A (S1A7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86SG5

UniProtKB/Swiss-Prot:

S1A7A_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A7A: view

Function for S100A7A Gene

Molecular function for S100A7A Gene

UniProtKB/Swiss-Prot Function:
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Phenotypes From GWAS Catalog for S100A7A Gene

Gene Ontology (GO) - Molecular Function for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0043621 protein self-association IDA 21148126
GO:0046872 metal ion binding IEA --
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A7A: view
genes like me logo Genes that share phenotypes with S100A7A: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A7A Gene

Localization for S100A7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A7A gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with S100A7A: view

Pathways & Interactions for S100A7A Gene

genes like me logo Genes that share pathways with S100A7A: view

Pathways by source for S100A7A Gene

Gene Ontology (GO) - Biological Process for S100A7A Gene

None

No data available for SIGNOR curated interactions for S100A7A Gene

Drugs & Compounds for S100A7A Gene

(1) Drugs for S100A7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with S100A7A: view

Transcripts for S100A7A Gene

mRNA/cDNA for S100A7A Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7A Gene

No ASD Table

Relevant External Links for S100A7A Gene

GeneLoc Exon Structure for
S100A7A

Expression for S100A7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A7A Gene

mRNA differential expression in normal tissues according to GTEx for S100A7A Gene

This gene is overexpressed in Esophagus - Mucosa (x38.1) and Minor Salivary Gland (x4.7).

Protein differential expression in normal tissues from HIPED for S100A7A Gene

This gene is overexpressed in Oral epithelium (35.2), Heart (12.1), Saliva (8.1), and Urine (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S100A7A Gene



Protein tissue co-expression partners for S100A7A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100A7A

SOURCE GeneReport for Unigene cluster for S100A7A Gene:

Hs.442337

mRNA Expression by UniProt/SwissProt for S100A7A Gene:

Q86SG5-S1A7A_HUMAN
Tissue specificity: Overexpressed in psoriasis.

Evidence on tissue expression from TISSUES for S100A7A Gene

  • Skin(4.5)
genes like me logo Genes that share expression patterns with S100A7A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A7A Gene

Orthologs for S100A7A Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A7A 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 66 (a)
ManyToMany
S100A7 31
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia S100a7a 31
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 29 (a)
OneToMany
Species where no ortholog for S100A7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A7A Gene

ENSEMBL:
Gene Tree for S100A7A (if available)
TreeFam:
Gene Tree for S100A7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A7A: view image

Paralogs for S100A7A Gene

(12) SIMAP similar genes for S100A7A Gene using alignment to 1 proteins:

  • S1A7A_HUMAN
genes like me logo Genes that share paralogs with S100A7A: view

Variants for S100A7A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100A7A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3006414 - p.Ala84Thr
rs55985140 - p.Arg23His

Additional dbSNP identifiers (rs#s) for S100A7A Gene

Structural Variations from Database of Genomic Variants (DGV) for S100A7A Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958
nsv946398 CNV duplication 23825009
nsv952211 CNV deletion 24416366

Variation tolerance for S100A7A Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A7A Gene

Disorders for S100A7A Gene

MalaCards: The human disease database

(3) MalaCards diseases for S100A7A Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A7A

genes like me logo Genes that share disorders with S100A7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A7A Gene

Publications for S100A7A Gene

  1. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PMID: 12923069) Wolf R … Ruzicka T (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4 23 54
  2. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PMID: 12664160) Kulski JK … Bellgard M (Journal of molecular evolution 2003) 3 4 23 54
  3. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding. (PMID: 22747601) Murray JI … Boulanger MJ (BMC structural biology 2012) 3 4 54
  4. Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PMID: 17620096) Wolf R … Ruzicka T (Experimental dermatology 2007) 3 23 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for S100A7A Gene

Sources for S100A7A Gene