Aliases for S100A7A Gene

Aliases for S100A7A Gene

  • S100 Calcium Binding Protein A7A 2 3 5
  • S100 Calcium-Binding Protein A7-Like 1 3 4
  • S100 Calcium-Binding Protein A15 3 4
  • Protein S100-A7A 3 4
  • Koebnerisin 2 3
  • S100A7L1 3 4
  • S100A15 3 4
  • S100A7f 2 3
  • S100 Calcium Binding Protein A7-Like 1 2
  • S100 Calcium Binding Protein A15 2
  • S100 Calcium-Binding Protein A7A 4
  • S100A7A 5
  • NICE-2 3
  • NICE2 3

External Ids for S100A7A Gene

Previous HGNC Symbols for S100A7A Gene

  • S100A15
  • S100A7L1

Previous GeneCards Identifiers for S100A7A Gene

  • GC01P151655
  • GC01P153392
  • GC01P124752

Summaries for S100A7A Gene

GeneCards Summary for S100A7A Gene

S100A7A (S100 Calcium Binding Protein A7A) is a Protein Coding gene. Diseases associated with S100A7A include Psoriasis and Macular Degeneration, Age-Related, 13. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein self-association. An important paralog of this gene is S100A7.

UniProtKB/Swiss-Prot Summary for S100A7A Gene

  • May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Gene Wiki entry for S100A7A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A7A Gene

Genomics for S100A7A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for S100A7A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153413 Enhancer 0.3 Ensembl 250.7 -1.5 -1519 2.8 TCF12 ZSCAN4 S100A7A RNU6-160P CHTOP S100A3 S100A8 HSALNG0007297 S100A12
GH01J153416 Promoter 0.3 EPDnew 250.7 0.0 -17 0.1 S100A7A S100A8 HSALNG0007297 S100A12
GH01J153606 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.3 +195.9 195939 11.6 MYC IKZF1 NCOR1 JUND ZNF592 ATF3 BRCA1 NFIC ZIC2 YY1 S100A16 S100A14 lnc-S100A16-1 S100A1 ILF2 CREB3L4 SLC27A3 ENSG00000272030 CHTOP CRTC2
GH01J153388 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 0.3 -26.2 -26201 3 CTCF CEBPB MAX EP300 CTBP1 SPI1 PKNOX1 POLR2A REST NFIB S100A8 HSALNG0007295 MN308807 lnc-S100A12-2 S100A12 S100A9 S100A7L2 S100A7A
GH01J153422 Enhancer 0.8 Ensembl 0.4 +6.1 6122 0.5 ATF2 BRCA1 REST KLF11 THAP11 NBN ZNF511 SAP130 CUX1 RFX5 S100A8 S100A9 PGLYRP3 RNU6-160P HSALNG0007298 S100A7A S100A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A7A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100A7A

Top Transcription factor binding sites by QIAGEN in the S100A7A gene promoter:
  • C/EBPalpha
  • Chx10
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA5
  • Lhx3a
  • LHX3b

Genomic Locations for S100A7A Gene

Latest Assembly
6,703 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
6,703 bases
Plus strand

(GRCh37/hg19 by Ensembl)
6,702 bases
Plus strand

Genomic View for S100A7A Gene

Genes around S100A7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7A Gene

Proteins for S100A7A Gene

  • Protein details for S100A7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A7A
    Protein Accession:
    Secondary Accessions:
    • D3DV38
    • Q5SY69

    Protein attributes for S100A7A Gene

    101 amino acids
    Molecular mass:
    11305 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S100A7A Gene

neXtProt entry for S100A7A Gene

Post-translational modifications for S100A7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7A Gene

No data available for DME Specific Peptides for S100A7A Gene

Domains & Families for S100A7A Gene

Gene Families for S100A7A Gene

Protein Domains for S100A7A Gene

  • Calcium-binding protein, S-100/ICaBP type

Suggested Antigen Peptide Sequences for S100A7A Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein A7A (S1A7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A7A: view

Function for S100A7A Gene

Molecular function for S100A7A Gene

UniProtKB/Swiss-Prot Function:
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Phenotypes From GWAS Catalog for S100A7A Gene

Gene Ontology (GO) - Molecular Function for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0043621 protein self-association IDA 21148126
GO:0046872 metal ion binding IEA --
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A7A: view
genes like me logo Genes that share phenotypes with S100A7A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100A7A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A7A Gene

Localization for S100A7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A7A gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S100A7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with S100A7A: view

Pathways & Interactions for S100A7A Gene

genes like me logo Genes that share pathways with S100A7A: view

Pathways by source for S100A7A Gene

Gene Ontology (GO) - Biological Process for S100A7A Gene


No data available for SIGNOR curated interactions for S100A7A Gene

Drugs & Compounds for S100A7A Gene

(1) Drugs for S100A7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with S100A7A: view

Transcripts for S100A7A Gene

mRNA/cDNA for S100A7A Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100A7A

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7A Gene

No ASD Table

Relevant External Links for S100A7A Gene

GeneLoc Exon Structure for

Expression for S100A7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A7A Gene

mRNA differential expression in normal tissues according to GTEx for S100A7A Gene

This gene is overexpressed in Esophagus - Mucosa (x38.1) and Minor Salivary Gland (x4.7).

Protein differential expression in normal tissues from HIPED for S100A7A Gene

This gene is overexpressed in Oral epithelium (35.2), Heart (12.1), Saliva (8.1), and Urine (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S100A7A Gene

Protein tissue co-expression partners for S100A7A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100A7A

SOURCE GeneReport for Unigene cluster for S100A7A Gene:


mRNA Expression by UniProt/SwissProt for S100A7A Gene:

Tissue specificity: Overexpressed in psoriasis.

Evidence on tissue expression from TISSUES for S100A7A Gene

  • Skin(4.5)
genes like me logo Genes that share expression patterns with S100A7A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A7A Gene

Orthologs for S100A7A Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A7A 30
  • 95 (a)
(Bos Taurus)
Mammalia -- 30
  • 66 (a)
S100A7 30
  • 63 (a)
(Mus musculus)
Mammalia S100a7a 30
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 31 (a)
(Canis familiaris)
Mammalia -- 30
  • 29 (a)
Species where no ortholog for S100A7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for S100A7A Gene

Gene Tree for S100A7A (if available)
Gene Tree for S100A7A (if available)
Evolutionary constrained regions (ECRs) for S100A7A: view image
Alliance of Genome Resources:
Additional Orthologs for S100A7A

Paralogs for S100A7A Gene

(12) SIMAP similar genes for S100A7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A7A: view

Variants for S100A7A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100A7A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3006414 -- p.Ala84Thr
rs55985140 -- p.Arg23His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for S100A7A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for S100A7A Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958
nsv946398 CNV duplication 23825009
nsv952211 CNV deletion 24416366

Variation tolerance for S100A7A Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A7A Gene

Disorders for S100A7A Gene

MalaCards: The human disease database

(3) MalaCards diseases for S100A7A Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A7A

genes like me logo Genes that share disorders with S100A7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A7A Gene

Publications for S100A7A Gene

  1. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PMID: 12664160) Kulski JK … Bellgard M (Journal of molecular evolution 2003) 3 4 22
  2. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. (PMID: 12923069) Wolf R … Ruzicka T (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 3 4 22
  3. Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding. (PMID: 22747601) Murray JI … Boulanger MJ (BMC structural biology 2012) 3 4
  4. Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (PMID: 17620096) Wolf R … Ruzicka T (Experimental dermatology 2007) 3 22
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for S100A7A Gene

Sources for S100A7A Gene