The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located... See more...

Aliases for S100A7 Gene

Aliases for S100A7 Gene

  • S100 Calcium Binding Protein A7 2 3 5
  • Protein S100-A7 3 4
  • PSOR1 3 4
  • S100 Calcium-Binding Protein A7 (Psoriasin 1) 2
  • S100 Calcium Binding Protein A7 (Psoriasin 1) 2
  • S100 Calcium-Binding Protein A7 4
  • Psoriasin 1 3
  • Psoriasin 4
  • S100A7c 3
  • S100A7C 4

External Ids for S100A7 Gene

Previous HGNC Symbols for S100A7 Gene

  • PSOR1

Previous GeneCards Identifiers for S100A7 Gene

  • GC01M151246
  • GC01M149212
  • GC01M150205
  • GC01M150646
  • GC01M150243
  • GC01M151696
  • GC01M153430
  • GC01M124793

Summaries for S100A7 Gene

Entrez Gene Summary for S100A7 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

GeneCards Summary for S100A7 Gene

S100A7 (S100 Calcium Binding Protein A7) is a Protein Coding gene. Diseases associated with S100A7 include Bladder Squamous Cell Carcinoma and Anal Fistula. Among its related pathways are Innate Immune System and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding. An important paralog of this gene is S100A7A.

Gene Wiki entry for S100A7 Gene

Additional gene information for S100A7 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A7 Gene

Genomics for S100A7 Gene

GeneHancer (GH) Regulatory Elements for S100A7 Gene

Promoters and enhancers for S100A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153531 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.2 -74.5 -74469 8.2 CTCF TCF12 POLR2G USF1 NCOR1 PHF8 JUND FOS POLR2A SAP30 ENSG00000238279 S100A6 lnc-S100A5-1 piR-48636 S100A7 S100A3 RN7SL44P S100A7L2 PGLYRP3 SLC39A1
GH01J153460 Promoter 0.3 EPDnew 500.7 0.0 -8 0.1 S100A7 lnc-S100A7A-1
GH01J153447 Enhancer 0.3 Ensembl 0.4 +12.9 12861 0.8 FOS S100A9 RNU6-160P ENSG00000233222 ENSG00000243613 S100A3 S100A7P2 S100A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100A7

Top Transcription factor binding sites by QIAGEN in the S100A7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • LUN-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • STAT3

Genomic Locations for S100A7 Gene

Genomic Locations for S100A7 Gene
chr1:153,457,744-153,460,661
(GRCh38/hg38)
Size:
2,918 bases
Orientation:
Minus strand
chr1:153,430,220-153,433,177
(GRCh37/hg19)
Size:
2,958 bases
Orientation:
Minus strand

Genomic View for S100A7 Gene

Genes around S100A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A7 Gene

Proteins for S100A7 Gene

  • Protein details for S100A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31151-S10A7_HUMAN
    Recommended name:
    Protein S100-A7
    Protein Accession:
    P31151
    Secondary Accessions:
    • Q5SY67
    • Q6FGE3
    • Q9H1E2

    Protein attributes for S100A7 Gene

    Size:
    101 amino acids
    Molecular mass:
    11471 Da
    Quaternary structure:
    • Interacts with RANBP9.

    Three dimensional structures from OCA and Proteopedia for S100A7 Gene

neXtProt entry for S100A7 Gene

Post-translational modifications for S100A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A7 Gene

Domains & Families for S100A7 Gene

Gene Families for S100A7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for S100A7 Gene

Blocks:
  • Calcium-binding protein, S-100/ICaBP type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for S100A7 Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein A7 (S10A7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31151

UniProtKB/Swiss-Prot:

S10A7_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A7: view

Function for S100A7 Gene

Molecular function for S100A7 Gene

GENATLAS Biochemistry:
S100 calcium binding protein A7,epidermal diffentiation complex,acting as a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes,upregulated in psoriasis but not involved in psoriasis susceptibility

Phenotypes From GWAS Catalog for S100A7 Gene

Gene Ontology (GO) - Molecular Function for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 8077703
GO:0005515 protein binding IPI 12421467
GO:0008270 zinc ion binding NAS 10026247
GO:0046872 metal ion binding IEA --
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A7: view
genes like me logo Genes that share phenotypes with S100A7: view

miRNA for S100A7 Gene

miRTarBase miRNAs that target S100A7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A7 Gene

Localization for S100A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A7 Gene

Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A7 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
lysosome 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9693957
GO:0005615 extracellular space IDA 21805676
GO:0005634 nucleus IDA 10595935
GO:0005737 cytoplasm TAS 9693957
GO:0005783 endoplasmic reticulum IDA 12839573
genes like me logo Genes that share ontologies with S100A7: view

Pathways & Interactions for S100A7 Gene

genes like me logo Genes that share pathways with S100A7: view

Pathways by source for S100A7 Gene

Gene Ontology (GO) - Biological Process for S100A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species IDA 16082188
GO:0001525 angiogenesis NAS 16357139
GO:0008544 epidermis development TAS 1940442
GO:0010820 positive regulation of T cell chemotaxis IDA 18606705
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with S100A7: view

No data available for SIGNOR curated interactions for S100A7 Gene

Drugs & Compounds for S100A7 Gene

(9) Drugs for S100A7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2822
Dexibuprofen Approved, Investigational Pharma Target 0
Ibuprofen Approved Pharma Channel blocker, Inhibition, Inhibitor, Target, inducer 677
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0

(3) Additional Compounds for S100A7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A7: view

Transcripts for S100A7 Gene

mRNA/cDNA for S100A7 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A7 Gene

No ASD Table

Relevant External Links for S100A7 Gene

GeneLoc Exon Structure for
S100A7

Expression for S100A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A7 Gene

mRNA differential expression in normal tissues according to GTEx for S100A7 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.2), Vagina (x16.4), Minor Salivary Gland (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for S100A7 Gene

This gene is overexpressed in Oral epithelium (24.2), Stomach (13.3), and Esophagus (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100A7

SOURCE GeneReport for Unigene cluster for S100A7 Gene:

Hs.112408

mRNA Expression by UniProt/SwissProt for S100A7 Gene:

P31151-S10A7_HUMAN
Tissue specificity: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.

Evidence on tissue expression from TISSUES for S100A7 Gene

  • Skin(4.7)
genes like me logo Genes that share expression patterns with S100A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A7 Gene

Orthologs for S100A7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for S100A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A7 31 30
  • 97.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia S100A7 31 30
  • 79.87 (n)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
OneToMany
Species where no ortholog for S100A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A7 Gene

ENSEMBL:
Gene Tree for S100A7 (if available)
TreeFam:
Gene Tree for S100A7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A7: view image

Paralogs for S100A7 Gene

(7) SIMAP similar genes for S100A7 Gene using alignment to 1 proteins:

  • S10A7_HUMAN
genes like me logo Genes that share paralogs with S100A7: view

Variants for S100A7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100A7 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3014837 - p.Glu28Asp

Additional dbSNP identifiers (rs#s) for S100A7 Gene

Structural Variations from Database of Genomic Variants (DGV) for S100A7 Gene

Variant ID Type Subtype PubMed ID
nsv1002705 CNV gain 25217958
nsv831603 CNV gain 17160897
nsv946399 CNV duplication 23825009

Variation tolerance for S100A7 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A7 Gene

Disorders for S100A7 Gene

MalaCards: The human disease database

(17) MalaCards diseases for S100A7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
anal fistula
  • rectal fistula
psoriasis
squamous cell carcinoma
  • epidermoid carcinoma
porokeratosis
  • porokeratosis of mibelli
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A7 Gene

Publications for S100A7 Gene

  1. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. (PMID: 1940442) Madsen P … Basse B (The Journal of investigative dermatology 1991) 2 3 4 23 54
  2. Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis. (PMID: 18373864) Bryborn M … Cardell LO (Respiratory research 2008) 3 23 41 54
  3. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. (PMID: 12664160) Kulski JK … Bellgard M (Journal of molecular evolution 2003) 3 4 23 54
  4. Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states. (PMID: 10026247) Brodersen DE … Kjeldgaard M (Biochemistry 1999) 3 4 23 54
  5. EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing. (PMID: 9562557) Brodersen DE … Kjeldgaard M (Structure (London, England : 1993) 1998) 3 4 23 54

Products for S100A7 Gene

Sources for S100A7 Gene