Aliases for S100A6 Gene
External Ids for S100A6 Gene
Previous HGNC Symbols for S100A6 Gene
Previous GeneCards Identifiers for S100A6 Gene
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
GeneCards Summary for S100A6 Gene
S100A6 (S100 Calcium Binding Protein A6) is a Protein Coding gene. Diseases associated with S100A6 include Melanoma In Congenital Melanocytic Nevus and Pilomatrixoma. Among its related pathways are Gastric Cancer Network 2 and Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100A5.
UniProtKB/Swiss-Prot Summary for S100A6 Gene
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.