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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
S100A4 (S100 Calcium Binding Protein A4) is a Protein Coding gene. Diseases associated with S100A4 include Bile Duct Adenocarcinoma and Small Intestine Adenocarcinoma. Among its related pathways are Ca, cAMP and Lipid Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is S100A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003779 | actin binding | IEA | -- |
GO:0005509 | calcium ion binding | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 14640694 |
GO:0042802 | identical protein binding | IPI | 20421509 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA | 27068509 |
GO:0005615 | extracellular space | HDA | 22664934 |
GO:0005634 | nucleus | IDA | 12118070 |
GO:0043005 | neuron projection | IEA | -- |
GO:0048471 | perinuclear region of cytoplasm | IDA | 15033494 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ca, cAMP and Lipid Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001837 | epithelial to mesenchymal transition | TAS | 14679171 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | IDA | 15033494 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Trifluoperazine | Approved, Investigational | Pharma | Antagonist, Target, inhibitor | 7 | ||
Copper | Approved, Investigational | Pharma | Target | 249 | ||
Niclosamide | Approved, Investigational, Vet_approved | Pharma | STAT3 inhibitor; also inhibits mTORC1 signaling | 16 | ||
Calcium | Nutra | 6556 | ||||
Anthelmintics | Pharma | 486 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | S100A4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | S100A4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | S100A4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | S100a4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | S100a4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | S100A4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | S100A4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | S100A4 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | icn 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
736033 | Benign: not provided | 153,543,861(-) | G/A | SYNONYMOUS_VARIANT | |
772816 | Benign: not provided | 153,543,882(-) | G/A | SYNONYMOUS_VARIANT | |
777935 | Benign: not provided | 153,543,831(-) | G/A | SYNONYMOUS_VARIANT | |
786858 | Benign: not provided | 153,544,735(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3587584 | CNV | gain | 21293372 |
esv3587591 | CNV | gain | 21293372 |
nsv1002705 | CNV | gain | 25217958 |
nsv831603 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bile duct adenocarcinoma |
|
|
small intestine adenocarcinoma |
|
|
spastic paraplegia 3, autosomal dominant |
|
|
follicular adenoma |
|
|
pleural tuberculosis |
|
|