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Aliases for S100A16 Gene

Aliases for S100A16 Gene

  • S100 Calcium Binding Protein A16 2 3 5
  • Aging-Associated Gene 13 Protein 3 4
  • Protein S100-F 3 4
  • S100F 3 4
  • S100 Calcium-Binding Protein A16 4
  • Aging-Associated Protein 13 3
  • Protein S100-A16 3
  • DT1P1A7 3
  • AAG13 3

External Ids for S100A16 Gene

Previous GeneCards Identifiers for S100A16 Gene

  • GC01M9A0123
  • GC01M9A0392
  • GC01M150393
  • GC01M151845
  • GC01M124942

Summaries for S100A16 Gene

GeneCards Summary for S100A16 Gene

S100A16 (S100 Calcium Binding Protein A16) is a Protein Coding gene. Diseases associated with S100A16 include Robinow Syndrome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for S100A16 Gene

  • Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).

Gene Wiki entry for S100A16 Gene

Additional gene information for S100A16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A16 Gene

Genomics for S100A16 Gene

GeneHancer (GH) Regulatory Elements for S100A16 Gene

Promoters and enhancers for S100A16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I153606 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.8 +0.7 686 11.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B S100A16 S100A14 S100A1 SNAPIN ILF2 ENSG00000233222 ENSG00000243613 INTS3 S100A13 ENSG00000272030
GH01I153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +47.6 47584 8.8 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF213 S100A2 S100A6 S100A3 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1
GH01I153539 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +67.6 67614 12 PKNOX1 ARID4B SIN3A DMAP1 CBX5 FOS DEK SP3 SP5 NFYC S100A3 LOC101928034 S100A4 S100A5 S100A16 S100A14 S100A1 CHTOP S100A13 INTS3
GH01I153984 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -373.0 -373027 3.4 HDGF ARID4B SIN3A ZNF2 POLR2B E2F8 ZNF207 ZNF143 FOS SP3 RAB13 S100A4 ILF2 CHTOP S100A16 CREB3L4 CKS1B S100A3 HAX1 GC01P153977
GH01I153355 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 +254.0 254014 7.4 RB1 RAD21 YY1 ARID2 ZNF143 CREM DEK ZNF654 SMARCC1 RXRA S100A9 ENSG00000224784 S100A8 RNU6-160P S100A14 S100A16 S100A12 PGLYRP4 LOC101928009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around S100A16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A16 gene promoter:

Genomic Locations for S100A16 Gene

Genomic Locations for S100A16 Gene
chr1:153,606,886-153,613,145
(GRCh38/hg38)
Size:
6,260 bases
Orientation:
Minus strand
chr1:153,579,362-153,585,621
(GRCh37/hg19)

Genomic View for S100A16 Gene

Genes around S100A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A16 Gene

Proteins for S100A16 Gene

  • Protein details for S100A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FQ6-S10AG_HUMAN
    Recommended name:
    Protein S100-A16
    Protein Accession:
    Q96FQ6
    Secondary Accessions:
    • A8K439
    • D3DV52
    • Q5RHS6

    Protein attributes for S100A16 Gene

    Size:
    103 amino acids
    Molecular mass:
    11801 Da
    Quaternary structure:
    • Homodimer (PubMed:17030513, PubMed:21046186). Interacts with TP53 (By similarity).

    Three dimensional structures from OCA and Proteopedia for S100A16 Gene

neXtProt entry for S100A16 Gene

Post-translational modifications for S100A16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A16 Gene

Antibody Products

  • Abcam antibodies for S100A16
  • Santa Cruz Biotechnology (SCBT) Antibodies for S100A16

No data available for DME Specific Peptides for S100A16 Gene

Domains & Families for S100A16 Gene

Gene Families for S100A16 Gene

Suggested Antigen Peptide Sequences for S100A16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FQ6

UniProtKB/Swiss-Prot:

S10AG_HUMAN :
  • S100A16 proteins, but not other S100 proteins, have only one functional Ca(2+) binding site per monomer. Upon Ca(2+) binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca(2+) -dependent nuclear export. Binds Zn(2+). Ca(2+) and Zn(2+) do not bind to the same site. Does not bind Cu(2+).
  • Belongs to the S-100 family.
Domain:
  • S100A16 proteins, but not other S100 proteins, have only one functional Ca(2+) binding site per monomer. Upon Ca(2+) binding, undergoes conformational changes leading to the exposure of hydrophobic patches which could be implicated in the Ca(2+) -dependent nuclear export. Binds Zn(2+). Ca(2+) and Zn(2+) do not bind to the same site. Does not bind Cu(2+).
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A16: view

Function for S100A16 Gene

Molecular function for S100A16 Gene

UniProtKB/Swiss-Prot Function:
Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).

Phenotypes From GWAS Catalog for S100A16 Gene

Gene Ontology (GO) - Molecular Function for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005509 calcium ion binding IDA 17030513
GO:0005515 protein binding IPI 16189514
GO:0042803 protein homodimerization activity IPI 17030513
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A16: view
genes like me logo Genes that share phenotypes with S100A16: view

Animal Model Products

miRNA for S100A16 Gene

miRTarBase miRNAs that target S100A16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A16 Gene

Localization for S100A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A16 Gene

Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A16 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 21805676
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA 17030513
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 17030513
genes like me logo Genes that share ontologies with S100A16: view

Pathways & Interactions for S100A16 Gene

SuperPathways for S100A16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051592 response to calcium ion IEA --
genes like me logo Genes that share ontologies with S100A16: view

No data available for Pathways by source and SIGNOR curated interactions for S100A16 Gene

Drugs & Compounds for S100A16 Gene

(2) Drugs for S100A16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
genes like me logo Genes that share compounds with S100A16: view

Transcripts for S100A16 Gene

Unigene Clusters for S100A16 Gene

S100 calcium binding protein A16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: -

Relevant External Links for S100A16 Gene

GeneLoc Exon Structure for
S100A16
ECgene alternative splicing isoforms for
S100A16

Expression for S100A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A16 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.5).

Protein differential expression in normal tissues from HIPED for S100A16 Gene

This gene is overexpressed in Nasal epithelium (13.2), Cervix (6.5), and Saliva (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for S100A16 Gene



Protein tissue co-expression partners for S100A16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A16 Gene:

S100A16

SOURCE GeneReport for Unigene cluster for S100A16 Gene:

Hs.515714

mRNA Expression by UniProt/SwissProt for S100A16 Gene:

Q96FQ6-S10AG_HUMAN
Tissue specificity: Ubiquitous (PubMed:14684152). Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary (PubMed:14684152). Expressed in astrocytes (PubMed:17030513).

Evidence on tissue expression from TISSUES for S100A16 Gene

  • Skin(4.8)
  • Nervous system(4.6)
  • Kidney(4.4)
  • Lung(3.3)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with S100A16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A16 Gene

Orthologs for S100A16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A16 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia S100A16 33 34
  • 90.61 (n)
cow
(Bos Taurus)
Mammalia S100A16 33 34
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia S100a16 33
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia S100A16 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia S100a16 33 16 34
  • 83.82 (n)
chicken
(Gallus gallus)
Aves S100A16 33 34
  • 73.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3327 33
Species where no ortholog for S100A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for S100A16 Gene

ENSEMBL:
Gene Tree for S100A16 (if available)
TreeFam:
Gene Tree for S100A16 (if available)

Paralogs for S100A16 Gene

(13) SIMAP similar genes for S100A16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with S100A16: view

No data available for Paralogs for S100A16 Gene

Variants for S100A16 Gene

Sequence variations from dbSNP and Humsavar for S100A16 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000210330 -- 153,609,290(-) C/G 5_prime_UTR_variant, intron_variant
rs1000417429 -- 153,611,234(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000536647 -- 153,610,208(-) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000585430 -- 153,609,084(-) A/G 5_prime_UTR_variant, intron_variant
rs1000679863 -- 153,610,270(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for S100A16 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for S100A16 Gene

Disorders for S100A16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100A16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A16

genes like me logo Genes that share disorders with S100A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A16 Gene

Publications for S100A16 Gene

  1. Structural characterization of human S100A16, a low-affinity calcium binder. (PMID: 21046186) Babini E … Parigi G (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. S100A16, a novel calcium-binding protein of the EF-hand superfamily. (PMID: 17030513) Sturchler E … Heizmann CW (The Journal of biological chemistry 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. S100A16, a ubiquitously expressed EF-hand protein which is up-regulated in tumors. (PMID: 14684152) Marenholz I … Heizmann CW (Biochemical and biophysical research communications 2004) 3 4 58

Products for S100A16 Gene

Sources for S100A16 Gene

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