This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011] See more...

Aliases for S100A14 Gene

Aliases for S100A14 Gene

  • S100 Calcium Binding Protein A14 2 3 5
  • Protein S100-A14 3 4
  • S100A15 3 4
  • S114 3 4
  • Breast Cancer Membrane Protein 84 3
  • S100 Calcium-Binding Protein A14 4
  • BCMP84 3

External Ids for S100A14 Gene

Previous GeneCards Identifiers for S100A14 Gene

  • GC07P101386
  • GC01U900004
  • GC01M9A0130
  • GC01M9A0399
  • GC01M150399
  • GC01M151853
  • GC01M153586
  • GC01M124950

Summaries for S100A14 Gene

Entrez Gene Summary for S100A14 Gene

  • This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

GeneCards Summary for S100A14 Gene

S100A14 (S100 Calcium Binding Protein A14) is a Protein Coding gene. Diseases associated with S100A14 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and chemokine receptor binding. An important paralog of this gene is S100A13.

UniProtKB/Swiss-Prot Summary for S100A14 Gene

  • Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Additional gene information for S100A14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A14 Gene

Genomics for S100A14 Gene

GeneHancer (GH) Regulatory Elements for S100A14 Gene

Promoters and enhancers for S100A14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100A14

Top Transcription factor binding sites by QIAGEN in the S100A14 gene promoter:
  • AREB6
  • Brachyury
  • CREB
  • deltaCREB
  • FOXD1
  • Ik-1
  • LCR-F1
  • MIF-1
  • MyoD
  • STAT5A

Genomic Locations for S100A14 Gene

Genomic Locations for S100A14 Gene
chr1:153,614,255-153,616,986
(GRCh38/hg38)
Size:
2,732 bases
Orientation:
Minus strand
chr1:153,586,731-153,589,462
(GRCh37/hg19)
Size:
2,732 bases
Orientation:
Minus strand

Genomic View for S100A14 Gene

Genes around S100A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A14 Gene

Proteins for S100A14 Gene

  • Protein details for S100A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCY8-S10AE_HUMAN
    Recommended name:
    Protein S100-A14
    Protein Accession:
    Q9HCY8
    Secondary Accessions:
    • Q5RHT0

    Protein attributes for S100A14 Gene

    Size:
    104 amino acids
    Molecular mass:
    11662 Da
    Quaternary structure:
    • Homodimer. Interacts with AGER.

    Three dimensional structures from OCA and Proteopedia for S100A14 Gene

neXtProt entry for S100A14 Gene

Post-translational modifications for S100A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for S100A14 Gene

No data available for DME Specific Peptides for S100A14 Gene

Domains & Families for S100A14 Gene

Gene Families for S100A14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for S100A14 Gene

Blocks:
  • Calcium-binding protein, S-100/ICaBP type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for S100A14 Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium-binding protein A14 (S10AE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCY8

UniProtKB/Swiss-Prot:

S10AE_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A14: view

Function for S100A14 Gene

Molecular function for S100A14 Gene

UniProtKB/Swiss-Prot Function:
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Phenotypes From GWAS Catalog for S100A14 Gene

Gene Ontology (GO) - Molecular Function for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 16682778
GO:0005515 protein binding IPI 16189514
GO:0042379 chemokine receptor binding IMP 18606705
genes like me logo Genes that share ontologies with S100A14: view
genes like me logo Genes that share phenotypes with S100A14: view

Animal Models for S100A14 Gene

MGI Knock Outs for S100A14:
  • S100a14 S100a14<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for S100A14 Gene

miRTarBase miRNAs that target S100A14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A14 Gene

Localization for S100A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A14 gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Cell Junctions (2)
  • Nuclear bodies (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016604 nuclear body IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with S100A14: view

Pathways & Interactions for S100A14 Gene

PathCards logo

SuperPathways for S100A14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for S100A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0032496 response to lipopolysaccharide IEP 17625598
GO:0034142 toll-like receptor 4 signaling pathway IDA 17625598
GO:0042742 defense response to bacterium IEP 17625598
GO:0055074 calcium ion homeostasis NAS 16682778
genes like me logo Genes that share ontologies with S100A14: view

No data available for Pathways by source and SIGNOR curated interactions for S100A14 Gene

Drugs & Compounds for S100A14 Gene

No Compound Related Data Available

Transcripts for S100A14 Gene

mRNA/cDNA for S100A14 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A14 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3:
SP4: -

Relevant External Links for S100A14 Gene

GeneLoc Exon Structure for
S100A14

Expression for S100A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A14 Gene

This gene is overexpressed in Esophagus - Mucosa (x25.3), Vagina (x6.4), Minor Salivary Gland (x4.1), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for S100A14 Gene

This gene is overexpressed in Cervix (31.3), Nasal epithelium (9.0), Saliva (8.2), and Hair follicle (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A14 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100A14

SOURCE GeneReport for Unigene cluster for S100A14 Gene:

Hs.288998

mRNA Expression by UniProt/SwissProt for S100A14 Gene:

Q9HCY8-S10AE_HUMAN
Tissue specificity: Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for S100A14 Gene

  • Pancreas(4.2)
  • Intestine(2.8)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with S100A14: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A14 Gene

Orthologs for S100A14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S100A14 31 30
  • 99.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia S100A14 31 30
  • 91.91 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S100A14 31
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S100A14 31 30
  • 87.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia S100a14 17 31 30
  • 87.79 (n)
zebrafish
(Danio rerio)
Actinopterygii s100a11 31
  • 33 (a)
OneToMany
Species where no ortholog for S100A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A14 Gene

ENSEMBL:
Gene Tree for S100A14 (if available)
TreeFam:
Gene Tree for S100A14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A14: view image

Paralogs for S100A14 Gene

(5) SIMAP similar genes for S100A14 Gene using alignment to 1 proteins:

  • S10AE_HUMAN
genes like me logo Genes that share paralogs with S100A14: view

Variants for S100A14 Gene

Additional dbSNP identifiers (rs#s) for S100A14 Gene

Variation tolerance for S100A14 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A14 Gene

Human Gene Mutation Database (HGMD)
S100A14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for S100A14 Gene

Disorders for S100A14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for S100A14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S100A14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A14 Gene

Publications for S100A14 Gene

  1. Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family. (PMID: 11944983) Pietas A … Petersen I (Genomics 2002) 2 3 4 54
  2. Solution structure and dynamics of human S100A14. (PMID: 23197251) Bertini I … Luchinat C (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2013) 3 4 54
  3. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. (PMID: 22032898) Sapkota D … Ibrahim SO (Oral oncology 2012) 3 4 54
  4. Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. (PMID: 22451655) Chen H … Liu Z (The Journal of biological chemistry 2012) 3 4 54
  5. S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). (PMID: 21559403) Jin Q … Liu Z (PloS one 2011) 3 4 54

Products for S100A14 Gene

  • Biorbyt antibodies for S100A14

Sources for S100A14 Gene