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Aliases for S100A11 Gene

Aliases for S100A11 Gene

  • S100 Calcium Binding Protein A11 2 3 5
  • Calgizzarin 2 3 4
  • Metastatic Lymph Node Gene 70 Protein 3 4
  • Protein S100-C 3 4
  • MLN 70 3 4
  • MLN70 3 4
  • S100C 3 4
  • S100 Calcium-Binding Protein A11 (Calgizzarin) 2
  • Epididymis Secretory Protein Li 43 3
  • S100 Calcium-Binding Protein A11 4
  • Protein S100-A11 3
  • HEL-S-43 3

External Ids for S100A11 Gene

Previous GeneCards Identifiers for S100A11 Gene

  • GC01M149845
  • GC01M147787
  • GC01M148780
  • GC01M149221
  • GC01M148818
  • GC01M150271
  • GC01M152004
  • GC01M123382

Summaries for S100A11 Gene

Entrez Gene Summary for S100A11 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A11 Gene

S100A11 (S100 Calcium Binding Protein A11) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is S100P.

UniProtKB/Swiss-Prot for S100A11 Gene

  • Facilitates the differentiation and the cornification of keratinocytes.

Gene Wiki entry for S100A11 Gene

Additional gene information for S100A11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S100A11 Gene

Genomics for S100A11 Gene

GeneHancer (GH) Regulatory Elements for S100A11 Gene

Promoters and enhancers for S100A11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152045 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.3 -0.7 -697 6.6 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A YBX1 FEZF1 DMAP1 S100A11 LOC101927949 PI4KB ZNF687 PIP5K1A MRPL9 ENSG00000229021 FLG-AS1 GABPB2 RPS10P6
GH01J152032 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.4 +11.9 11903 6.4 PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 POLR2B S100A11 PI4KB RPS10P6 THEM4 ZNF687 PIP5K1A MRPL9 GABPB2 PSMB4 RN7SL444P
GH01J151986 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 +53.4 53424 16.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ENSG00000229021 S100A10 THEM4 S100A11 THEM5 FLG-AS1 MLLT11 LOC105371441
GH01J151971 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +75.0 74951 2.8 PKNOX1 CLOCK ATF1 FEZF1 ZNF2 GLIS2 ZNF213 ZNF143 ZFP91 FOS ENSG00000229021 THEM4 S100A10 S100A11 THEM5 ENSG00000252840 CGN LINGO4 TUFT1 LOC105371441
GH01J151974 Enhancer 1.1 ENCODE dbSUPER 9.9 +71.4 71405 3.7 FOXA2 ARNT FEZF1 YY1 TCF12 FOS ATF7 ZNF263 RXRA NCOA1 THEM4 PI4KB ZNF687 GABPB2 POGZ PIP5K1A MRPL9 THEM5 LOC100132111 C2CD4D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S100A11 gene promoter:
  • Sp1
  • AREB6
  • NF-1
  • LCR-F1
  • deltaCREB
  • CREB
  • RORalpha2
  • E4BP4

Genomic Locations for S100A11 Gene

Genomic Locations for S100A11 Gene
15,402 bases
Minus strand
15,402 bases
Minus strand

Genomic View for S100A11 Gene

Genes around S100A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A11 Gene

Proteins for S100A11 Gene

  • Protein details for S100A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein S100-A11
    Protein Accession:
    Secondary Accessions:
    • Q5VTK0

    Protein attributes for S100A11 Gene

    105 amino acids
    Molecular mass:
    11740 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    • Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.

    Three dimensional structures from OCA and Proteopedia for S100A11 Gene

neXtProt entry for S100A11 Gene

Post-translational modifications for S100A11 Gene

  • Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.
  • Ubiquitination at posLast=5555
  • Modification sites at PhosphoSitePlus

Other Protein References for S100A11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A11 Gene

Domains & Families for S100A11 Gene

Gene Families for S100A11 Gene

Suggested Antigen Peptide Sequences for S100A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A11: view

Function for S100A11 Gene

Molecular function for S100A11 Gene

UniProtKB/Swiss-Prot Function:
Facilitates the differentiation and the cornification of keratinocytes.
GENATLAS Biochemistry:
S100 calcium-binding protein A11,bovine CAAF1 homolog,expressed in polynuclear leukocytes,esophagus,epidermal diffentiation complex

Phenotypes From GWAS Catalog for S100A11 Gene

Gene Ontology (GO) - Molecular Function for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10913138
GO:0042803 protein homodimerization activity IDA 10913138
GO:0044548 S100 protein binding IPI 10913138
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with S100A11: view
genes like me logo Genes that share phenotypes with S100A11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for S100A11 Gene

Localization for S100A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S100A11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1
endosome 1

Gene Ontology (GO) - Cellular Components for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 10913138
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus TAS,IDA 10913138
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with S100A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for S100A11 Gene

Pathways & Interactions for S100A11 Gene

genes like me logo Genes that share pathways with S100A11: view

Pathways by source for S100A11 Gene

3 Reactome pathways for S100A11 Gene

Gene Ontology (GO) - Biological Process for S100A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 16130169
GO:0008156 negative regulation of DNA replication TAS 10851017
GO:0008285 negative regulation of cell proliferation TAS 10851017
GO:0042127 regulation of cell proliferation IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with S100A11: view

No data available for SIGNOR curated interactions for S100A11 Gene

Drugs & Compounds for S100A11 Gene

(3) Drugs for S100A11 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Phosphonothreonine Experimental Pharma Target 0

(1) Additional Compounds for S100A11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A11: view

Transcripts for S100A11 Gene

mRNA/cDNA for S100A11 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(774) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S100A11 Gene

S100 calcium binding protein A11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for S100A11 Gene

No ASD Table

Relevant External Links for S100A11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for S100A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S100A11 Gene

mRNA differential expression in normal tissues according to GTEx for S100A11 Gene

This gene is overexpressed in Whole Blood (x17.4) and Esophagus - Mucosa (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A11 Gene

Protein tissue co-expression partners for S100A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of S100A11 Gene:


SOURCE GeneReport for Unigene cluster for S100A11 Gene:


Evidence on tissue expression from TISSUES for S100A11 Gene

  • Lung(4.8)
  • Skin(4.7)
  • Nervous system(4.5)
  • Liver(4.4)
  • Intestine(3.8)
  • Pancreas(3.1)
  • Blood(2.9)
  • Kidney(2.5)
  • Muscle(2.5)
  • Gall bladder(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Heart(2.3)
  • Spleen(2.2)
  • Bone marrow(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with S100A11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A11 Gene

Orthologs for S100A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia S100A11 34 33
  • 99.05 (n)
(Canis familiaris)
Mammalia S100A11 34 33
  • 89.46 (n)
(Mus musculus)
Mammalia S100a11 34
  • 87 (a)
Gm5068 33
  • 81.25 (n)
S100a11-ps 16
(Bos Taurus)
Mammalia S100A11 34 33
  • 85.76 (n)
(Rattus norvegicus)
Mammalia S100a11 33
  • 84.72 (n)
(Ornithorhynchus anatinus)
Mammalia S100A11 34
  • 81 (a)
(Monodelphis domestica)
Mammalia S100A11 34
  • 64 (a)
(Gallus gallus)
Aves S100A11 34 33
  • 71.04 (n)
(Anolis carolinensis)
Reptilia S100A11 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia s100a11 33
  • 62.15 (n)
(Danio rerio)
Actinopterygii s100a10a 34
  • 44 (a)
s100a10b 34
  • 41 (a)
Species where no ortholog for S100A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S100A11 Gene

Gene Tree for S100A11 (if available)
Gene Tree for S100A11 (if available)
Evolutionary constrained regions (ECRs) for S100A11: view image

Paralogs for S100A11 Gene

Variants for S100A11 Gene

Sequence variations from dbSNP and Humsavar for S100A11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000079027 -- 152,032,301(-) A/G downstream_transcript_variant
rs1000514775 -- 152,036,995(-) G/A 5_prime_UTR_variant
rs1000733583 -- 152,037,210(-) T/A/C upstream_transcript_variant
rs1001401570 -- 152,035,811(-) A/T intron_variant
rs1001665367 -- 152,036,415(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S100A11 Gene

Variant ID Type Subtype PubMed ID
nsv1007097 CNV gain 25217958
nsv547853 CNV gain 21841781

Variation tolerance for S100A11 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S100A11 Gene

Disorders for S100A11 Gene

Additional Disease Information for S100A11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for S100A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S100A11 Gene

Publications for S100A11 Gene

  1. The structure of S100A11 fragment explains a local structural change induced by phosphorylation. (PMID: 18618420) Kouno T … Kawano K (Journal of peptide science : an official publication of the European Peptide Society 2008) 3 4 22 58
  2. Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. (PMID: 8985590) Wicki R … Heizmann CW (Cell calcium 1996) 2 3 22 58
  3. Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. (PMID: 7889529) Tanaka M … Itakura M (Cancer letters 1995) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain. (PMID: 19577285) Bin L … Leung DY (The Journal of allergy and clinical immunology 2009) 3 22 58

Products for S100A11 Gene

Sources for S100A11 Gene

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