The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located... See more...

Aliases for S100A10 Gene

Aliases for S100A10 Gene

  • S100 Calcium Binding Protein A10 2 3 5
  • CLP11 2 3 4
  • P11 2 3 4
  • Annexin II Tetramer (AIIt) P11 Subunit 2 3
  • Cellular Ligand Of Annexin II 3 4
  • Calpactin I Light Chain 3 4
  • Calpactin-1 Light Chain 3 4
  • Protein S100-A10 3 4
  • ANX2LG 3 4
  • CAL1L 3 4
  • 42C 2 3
  • S100 Calcium-Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 2
  • S100 Calcium Binding Protein A10 (Annexin II Ligand, Calpactin I, Light Polypeptide (P11)) 3
  • Annexin II Ligand, Calpactin I, Light Polypeptide 3
  • S100 Calcium-Binding Protein A10 4
  • Calpactin I 2
  • P10 Protein 4
  • S100A10 5
  • ANX2L 3
  • Ca[1] 3
  • GP11 3
  • P10 3

External Ids for S100A10 Gene

Previous HGNC Symbols for S100A10 Gene

  • ANX2LG
  • CAL1L

Previous GeneCards Identifiers for S100A10 Gene

  • GC01M149796
  • GC01M147738
  • GC01M148730
  • GC01M149171
  • GC01M148768
  • GC01M150224
  • GC01M123333

Summaries for S100A10 Gene

Entrez Gene Summary for S100A10 Gene

  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for S100A10 Gene

S100A10 (S100 Calcium Binding Protein A10) is a Protein Coding gene. Diseases associated with S100A10 include Trachea Leiomyoma and Barrett's Adenocarcinoma. Among its related pathways are Dissolution of Fibrin Clot and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is S100A1.

UniProtKB/Swiss-Prot Summary for S100A10 Gene

  • Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Gene Wiki entry for S100A10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S100A10 Gene

Genomics for S100A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for S100A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S100A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S100A10

Top Transcription factor binding sites by QIAGEN in the S100A10 gene promoter:
  • AML1a
  • AP-4
  • ATF-2
  • Bach2
  • E47
  • FOXF2
  • FOXO4
  • Hand1
  • NF-kappaB1
  • Sox5

Genomic Locations for S100A10 Gene

Genomic Locations for S100A10 Gene
chr1:151,982,915-151,993,859
(GRCh38/hg38)
Size:
10,945 bases
Orientation:
Minus strand
chr1:151,955,386-151,966,866
(GRCh37/hg19)
Size:
11,481 bases
Orientation:
Minus strand

Genomic View for S100A10 Gene

Genes around S100A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S100A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S100A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S100A10 Gene

Proteins for S100A10 Gene

  • Protein details for S100A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60903-S10AA_HUMAN
    Recommended name:
    Protein S100-A10
    Protein Accession:
    P60903
    Secondary Accessions:
    • A8K4V8
    • P08206
    • Q5T1C5

    Protein attributes for S100A10 Gene

    Size:
    97 amino acids
    Molecular mass:
    11203 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).
    Miscellaneous:
    • Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

    Three dimensional structures from OCA and Proteopedia for S100A10 Gene

neXtProt entry for S100A10 Gene

Post-translational modifications for S100A10 Gene

  • Ubiquitination at Lys18, Lys37, Lys47, Lys54, and Lys57
  • Modification sites at PhosphoSitePlus

Other Protein References for S100A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S100A10 Gene

Domains & Families for S100A10 Gene

Gene Families for S100A10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for S100A10 Gene

InterPro:
Blocks:
  • Calcium-binding protein, S-100/ICaBP type
ProtoNet:

Suggested Antigen Peptide Sequences for S100A10 Gene

GenScript: Design optimal peptide antigens:
  • S100 calcium binding protein A10 (Annexin II ligand, calpactin I, light polypeptide (P11)), isoform CRA_b (D3DV26_HUMAN)
  • S100A10 protein (Q6FGE5_HUMAN)
  • p11 (S10AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60903

UniProtKB/Swiss-Prot:

S10AA_HUMAN :
  • Belongs to the S-100 family.
Family:
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with S100A10: view

Function for S100A10 Gene

Molecular function for S100A10 Gene

UniProtKB/Swiss-Prot Function:
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
GENATLAS Biochemistry:
S100 calcium binding protein A10,epidermal differentiation complex

Phenotypes From GWAS Catalog for S100A10 Gene

Gene Ontology (GO) - Molecular Function for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 14699089
GO:0008289 NOT lipid binding IDA 23861394
GO:0042803 protein homodimerization activity IDA 23091277
GO:0044325 ion channel binding IPI 12198146
genes like me logo Genes that share ontologies with S100A10: view
genes like me logo Genes that share phenotypes with S100A10: view

Animal Models for S100A10 Gene

MGI Knock Outs for S100A10:

Animal Model Products

CRISPR Products

miRNA for S100A10 Gene

miRTarBase miRNAs that target S100A10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S100A10 Gene

Localization for S100A10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S100A10 gene
Compartment Confidence
extracellular 4
cytosol 4
plasma membrane 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
cytoskeleton 2
endosome 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005783 endoplasmic reticulum IEA --
GO:0019897 extrinsic component of plasma membrane IEA --
GO:0045121 colocalizes_with membrane raft IDA 14699089
GO:0062023 collagen-containing extracellular matrix HDA 28675934
genes like me logo Genes that share ontologies with S100A10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for S100A10 Gene

Pathways & Interactions for S100A10 Gene

genes like me logo Genes that share pathways with S100A10: view

Pathways by source for S100A10 Gene

1 BioSystems pathway for S100A10 Gene
2 Reactome pathways for S100A10 Gene
1 KEGG pathway for S100A10 Gene
1 GeneGo (Thomson Reuters) pathway for S100A10 Gene
  • Regulation of CFTR activity (norm and CF)

SIGNOR curated interactions for S100A10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for S100A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IDA 23861394
GO:0006900 vesicle budding from membrane IDA 23861394
GO:0042493 response to drug IEA --
GO:0043547 positive regulation of GTPase activity IMP 23129259
GO:0051099 positive regulation of binding IEA --
genes like me logo Genes that share ontologies with S100A10: view

Drugs & Compounds for S100A10 Gene

(5) Drugs for S100A10 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
Calcium Nutra 6556

(1) Additional Compounds for S100A10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with S100A10: view

Transcripts for S100A10 Gene

mRNA/cDNA for S100A10 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S100A10

Alternative Splicing Database (ASD) splice patterns (SP) for S100A10 Gene

No ASD Table

Relevant External Links for S100A10 Gene

GeneLoc Exon Structure for
S100A10

Expression for S100A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S100A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S100A10 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for S100A10 Gene

This gene is overexpressed in Nasopharynx (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for S100A10 Gene



Protein tissue co-expression partners for S100A10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S100A10

SOURCE GeneReport for Unigene cluster for S100A10 Gene:

Hs.143873

Evidence on tissue expression from TISSUES for S100A10 Gene

  • Nervous system(4.7)
  • Skin(4.7)
  • Liver(4.7)
  • Intestine(4.1)
  • Lung(4)
  • Blood(3.5)
  • Heart(3.5)
  • Kidney(3.2)
  • Spleen(2.9)
  • Muscle(2.9)
  • Adrenal gland(2.9)
  • Pancreas(2.9)
  • Lymph node(2.8)
  • Eye(2.8)
  • Stomach(2.7)
  • Bone marrow(2.7)
  • Thyroid gland(2.5)
  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with S100A10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S100A10 Gene

Orthologs for S100A10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S100A10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia S100A10 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia S100A10 30 31
  • 94.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia S100A10 30
  • 92.78 (n)
-- 31
  • 92 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia S100a10 30
  • 90.07 (n)
Mouse
(Mus musculus)
Mammalia S100a10 30 17 31
  • 89.69 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia S100A10 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves S100A10 30 31
  • 78.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia S100A10 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11404 30
Zebrafish
(Danio rerio)
Actinopterygii s100a10b 30 31
  • 57.39 (n)
ManyToMany
s100a10a 31
  • 47 (a)
ManyToMany
Species where no ortholog for S100A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for S100A10 Gene

ENSEMBL:
Gene Tree for S100A10 (if available)
TreeFam:
Gene Tree for S100A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S100A10: view image

Paralogs for S100A10 Gene

(24) SIMAP similar genes for S100A10 Gene using alignment to 3 proteins:

  • S10AA_HUMAN
  • D3DV26_HUMAN
  • Q6FGE5_HUMAN

Pseudogenes.org Pseudogenes for S100A10 Gene

genes like me logo Genes that share paralogs with S100A10: view

Variants for S100A10 Gene

Additional dbSNP identifiers (rs#s) for S100A10 Gene

Structural Variations from Database of Genomic Variants (DGV) for S100A10 Gene

Variant ID Type Subtype PubMed ID
nsv1007097 CNV gain 25217958
nsv2855 CNV deletion 18451855

Variation tolerance for S100A10 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S100A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S100A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S100A10 Gene

Disorders for S100A10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for S100A10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trachea leiomyoma
  • leiomyoma of the trachea
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
cannabis dependence
  • marijuana abuse
conjunctival intraepithelial neoplasm
  • intraepithelial neoplasia of conjunctiva
rectum adenoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for S100A10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with S100A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S100A10 Gene

Publications for S100A10 Gene

  1. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. (PMID: 18838110) Tzang RF … Tsai SJ (Neuroscience letters 2008) 3 23 41
  2. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. (PMID: 8276421) Volz A … Mischke D (Genomics 1993) 2 3 23
  3. cDNA sequence of human p11 calpactin I light chain. (PMID: 1386341) Dooley TP … Simon M (Genomics 1992) 3 4 23
  4. Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. (PMID: 1533380) Harder T … Gerke V (Gene 1992) 3 4 23
  5. Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II. (PMID: 1831433) Kube E … Gerke V (Gene 1991) 3 4 23

Products for S100A10 Gene

Sources for S100A10 Gene