RXRG Gene (Protein Coding)

Retinoid X Receptor Gamma

GC01M165401
GIFtS:
41
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expre... See more...

Aliases for RXRG Gene

Aliases for RXRG Gene

  • Retinoid X Receptor Gamma 2 3 4 5
  • Nuclear Receptor Subfamily 2 Group B Member 3 2 3 4
  • NR2B3 2 3 4
  • Retinoic Acid Receptor RXR-Gamma 3 4
  • Retinoid X Receptor, Gamma 2
  • RXRC 3
  • RXRG 5

External Ids for RXRG Gene

Previous GeneCards Identifiers for RXRG Gene

  • GC01M163005
  • GC01M161021
  • GC01M162066
  • GC01M162557
  • GC01M162102
  • GC01M163636
  • GC01M165370
  • GC01M136616

Summaries for RXRG Gene

Entrez Gene Summary for RXRG Gene

  • This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

GeneCards Summary for RXRG Gene

RXRG (Retinoid X Receptor Gamma) is a Protein Coding gene. Diseases associated with RXRG include Hyperlipidemia, Familial Combined, 3 and Lung Cancer. Among its related pathways are Transcriptional misregulation in cancer and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot Summary for RXRG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Tocris Summary for RXRG Gene

  • Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.

Gene Wiki entry for RXRG Gene

Additional gene information for RXRG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RXRG Gene

Genomics for RXRG Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RXRG Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J165443 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.8 848 2.7 ZIC2 POLR2A ZNF600 SCRT2 ZBTB20 RAD21 ZBTB17 SCRT1 ZBTB11 ZNF189 RXRG lnc-RXRG-2 lnc-RXRG-3 HSALNG0008134 LMX1A
GH01J165527 Promoter 0.3 EPDnew 610.7 -82.3 -82316 0.1 RXRG LRRC52-AS1 LRRC52 ENSG00000230748 lnc-LRRC52-1
GH01J165482 Enhancer 1 Ensembl ENCODE 11.4 -37.0 -37046 0.8 PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 JUND PRDM1 PATZ1 ZNF600 KLF9 RXRG ENSG00000230748 lnc-LRRC52-1 lnc-RXRG-3 LRRC52 LRRC52-AS1
GH01J165423 Promoter/Enhancer 0.8 Ensembl ENCODE 11.5 +20.5 20465 2.2 SP1 NR2F2 RXRA RARA HNF4A RXRG lnc-RXRG-2 HSALNG0008134 LMX1A
GH01J165538 Enhancer 0.8 Ensembl ENCODE 10.4 -94.7 -94730 2.6 RFX1 ZNF639 ZNF10 FOXA2 OSR2 JUN ZBTB17 PKNOX1 JUND NR2F2 MGST3 LRRC52 RXRG lnc-LRRC52-1 LRRC52-AS1 ENSG00000230748
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RXRG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RXRG

Top Transcription factor binding sites by QIAGEN in the RXRG gene promoter:
  • C/EBPalpha
  • Egr-3
  • HSF2
  • IRF-1
  • STAT1

Genomic Locations for RXRG Gene

Genomic Locations for RXRG Gene
chr1:165,400,922-165,445,355
(GRCh38/hg38)
Size:
44,434 bases
Orientation:
Minus strand
chr1:165,370,159-165,414,592
(GRCh37/hg19)
Size:
44,434 bases
Orientation:
Minus strand

Genomic View for RXRG Gene

Genes around RXRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXRG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RXRG Gene

Proteins for RXRG Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RXRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48443-RXRG_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-gamma
    Protein Accession:
    P48443
    Secondary Accessions:
    • A6NIP1
    • Q6IBU7

    Protein attributes for RXRG Gene

    Size:
    463 amino acids
    Molecular mass:
    50871 Da
    Quaternary structure:
    • Homodimer (By similarity). Heterodimer with a RAR molecule (PubMed:28167758). Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:28167758). Interacts with RARA (PubMed:28167758).

    Three dimensional structures from OCA and Proteopedia for RXRG Gene

neXtProt entry for RXRG Gene

Post-translational modifications for RXRG Gene

Other Protein References for RXRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RXRG Gene

Domains & Families for RXRG Gene

Gene Families for RXRG Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Nuclear receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RXRG Gene

InterPro:
Blocks:
  • Steroid hormone receptor signature
  • Retinoic acid receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for RXRG Gene

GenScript: Design optimal peptide antigens:
  • Retinoid X receptor-gamma (B6ZGT6_HUMAN)
  • Retinoid X nuclear receptor gamma variant 1 (F1D8Q7_HUMAN)
  • Retinoic acid receptor RXR-gamma (F1T097_HUMAN)
  • Retinoid X receptor gamma (RXRG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48443

UniProtKB/Swiss-Prot:

RXRG_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with RXRG: view

Function for RXRG Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RXRG Gene

UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
GENATLAS Biochemistry:
retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gamma subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

Phenotypes From GWAS Catalog for RXRG Gene

Gene Ontology (GO) - Molecular Function for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IBA 21873635
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with RXRG: view
genes like me logo Genes that share phenotypes with RXRG: view

Animal Models for RXRG Gene

MGI Knock Outs for RXRG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RXRG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RXRG Gene

Localization for RXRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRG Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXRG gene
Compartment Confidence
nucleus 5
extracellular 2
peroxisome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with RXRG: view

Pathways & Interactions for RXRG Gene

genes like me logo Genes that share pathways with RXRG: view

SIGNOR curated interactions for RXRG Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030154 cell differentiation IBA 21873635
GO:0032526 response to retinoic acid IBA 21873635
genes like me logo Genes that share ontologies with RXRG: view

Drugs & Compounds for RXRG Gene

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  1. Drug

(21) Drugs for RXRG Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bexarotene Approved, Investigational Pharma Agonist, Target, agonist Potent and selective RXR agonist, Others 44
Adapalene Approved Pharma Target, agonist, binder RAR尾 and RAR纬 agonist 90
Alitretinoin Approved, Investigational Pharma Agonist, Target, agonist 17
Tretinoin Approved, Investigational Nutra Agonist, Full agonist, Antagonist, Target, agonist, binder 273
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 33

(4) Additional Compounds for RXRG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for RXRG Gene

Compound Action Cas Number
Bexarotene Potent and selective RXR agonist 153559-49-0
CD 3254 Potent and selective RXRalpha agonist. 196961-43-0
HX 531 Potent RXR antagonist 188844-34-0
LG 100754 RXR:PPAR agonist 180713-37-5

(11) ApexBio Compounds for RXRG Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Bexarotene 153559-49-0
Fluorobexarotene 1190848-23-7
HX 531 188844-34-0
HX 630 188844-52-2
LG 100754 180713-37-5
LG 101506 331248-11-4
PA 452 457657-34-0
SR 11237 146670-40-8
UVI 3003 847239-17-2
genes like me logo Genes that share compounds with RXRG: view

Drug Products

Transcripts for RXRG Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RXRG Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RXRG

Alternative Splicing Database (ASD) splice patterns (SP) for RXRG Gene

No ASD Table

Relevant External Links for RXRG Gene

GeneLoc Exon Structure for
RXRG

Expression for RXRG Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RXRG Gene

mRNA expression in normal human tissues for RXRG Gene
mRNA expression by GTEx for RXRG GenemRNA expression by BioGPS for RXRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RXRG Gene

This gene is overexpressed in Pituitary (x7.3), Brain - Putamen (basal ganglia) (x5.6), Muscle - Skeletal (x5.1), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RXRG

SOURCE GeneReport for Unigene cluster for RXRG Gene:

Hs.26550

mRNA Expression by UniProt/SwissProt for RXRG Gene:

P48443-RXRG_HUMAN
Tissue specificity: Expressed in aortic endothelial cells (at protein level).

Evidence on tissue expression from TISSUES for RXRG Gene

  • Eye(4.5)
  • Heart(4.3)
  • Nervous system(3.3)
  • Muscle(2.9)
  • Thyroid gland(2.5)
  • Liver(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with RXRG: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXRG Gene

Orthologs for RXRG Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RXRG 30 31
  • 99.64 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RXRG 30 31
  • 92.15 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RXRG 30 31
  • 91.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rxrg 30
  • 90.35 (n)
Mouse
(Mus musculus)
 Mammalia Rxrg 30 17 31
  • 90.21 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RXRG 31
  • 89 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RXRG 30 31
  • 78.79 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rxrg 30
  • 71.15 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.878 30
Zebrafish
(Danio rerio)
 Actinopterygii rxrga 30
  • 74.6 (n)
rxrgb 31
  • 73 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta usp 31
  • 36 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10537 31
  • 51 (a)
 OneToMany
Species where no ortholog for RXRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RXRG Gene

ENSEMBL:
Gene Tree for RXRG (if available)
TreeFam:
Gene Tree for RXRG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RXRG: view image

Paralogs for RXRG Gene

Paralogs for RXRG Gene

(30) SIMAP similar genes for RXRG Gene using alignment to 2 proteins:

  • RXRG_HUMAN
  • F1T097_HUMAN
genes like me logo Genes that share paralogs with RXRG: view

Variants for RXRG Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for RXRG Gene

Variation tolerance for RXRG Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RXRG Gene

Human Gene Mutation Database (HGMD)
RXRG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RXRG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RXRG Gene

Disorders for RXRG Gene

MalaCards: The human disease database

(3) MalaCards diseases for RXRG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperlipidemia, familial combined, 3
  • fchl3
lung cancer
  • adenocarcinoma of lung
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards
Search RXRG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RXRG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RXRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RXRG Gene

Publications for RXRG Gene

  1. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt SJ … Elbein SC (Annals of human genetics 2008) 3 23 41
  2. Chromosomal localization of the human retinoid X receptors. (PMID: 8034312) Almasan A … Evans RM (Genomics 1994) 2 3 23
  3. Genome-wide association study of personality traits in bipolar patients. (PMID: 21368711) Alliey-Rodriguez N … Gershon ES (Psychiatric genetics 2011) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41

ExternalLinks

View latest publications for RXRG gene in Mastermind

Products for RXRG Gene

  • Addgene plasmids for RXRG

Sources for RXRG Gene