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This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
RXRG (Retinoid X Receptor Gamma) is a Protein Coding gene. Diseases associated with RXRG include Hyperlipidemia, Familial Combined, 3 and Lung Cancer. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RXRA.
Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J165443 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +0.8 | 848 | 2.7 | ZIC2 SIN3A ZNF189 SCRT1 GLIS1 ZNF560 PKNOX1 ZBTB17 POLR2A EZH2 | RXRG lnc-RXRG-2 lnc-RXRG-3 HSALNG0008134 LMX1A | |
GH01J165527 | Promoter/Enhancer | 0.7 | EPDnew Ensembl | 260.7 | -82.0 | -82046 | 0.8 | SPI1 CTCF | RXRG LRRC52-AS1 MGST3 LRRC52 PRELID1P7 | |
GH01J165446 | Enhancer | 0.2 | Ensembl | 250.7 | -0.7 | -746 | 0.2 | RXRG lnc-RXRG-2 lnc-RXRG-3 LRRC52 | ||
GH01J165482 | Enhancer | 1 | Ensembl ENCODE | 11.4 | -37.0 | -37022 | 0.9 | ZBTB10 FEZF1 IKZF1 ZNF217 ZNF639 CTBP1 ZNF843 KLF9 SP2 FOSL1 | RXRG HSALNG0008140 HSALNG0008138 LRRC52 LRRC52-AS1 | |
GH01J165423 | Promoter/Enhancer | 0.8 | Ensembl ENCODE | 11.5 | +20.5 | 20465 | 2.2 | RXRA RARA HNF4A SP1 NR2F2 | RXRG lnc-RXRG-2 HSALNG0008134 LMX1A |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO:0003707 | steroid hormone receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | ISA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0090575 | RNA polymerase II transcription factor complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
|
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | Gene Expression |
.48
|
|
3 | Nuclear Receptor transcription pathway | ||
4 | Adipocytokine signaling pathway | ||
5 | Gastric cancer |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0030154 | cell differentiation | IBA | 21873635 |
GO:0032526 | response to retinoic acid | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bexarotene | Approved, Investigational | Pharma | Agonist, Target | Potent and selective RXR agonist, Others | 45 | |
Adapalene | Approved | Pharma | Target, agonist, binder | RAR尾 and RAR纬 agonist | 90 | |
Alitretinoin | Approved, Investigational | Pharma | Agonist, Target | 18 | ||
Tretinoin | Approved, Investigational | Nutra | Target, agonist, binder | 286 | ||
Acitretin | Approved | Pharma | Target, agonist | Metabolite of etretinate | 33 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Bexarotene | Potent and selective RXR agonist | 153559-49-0 |
CD 3254 | Potent and selective RXRalpha agonist. | 196961-43-0 |
HX 531 | Potent RXR antagonist | 188844-34-0 |
LG 100754 | RXR:PPAR agonist | 180713-37-5 |
Compound | Action | Cas Number |
---|---|---|
Acitretin | Metabolite of etretinate | 55079-83-9 |
Adapalene | RAR尾 and RAR纬 agonist | 106685-40-9 |
Bexarotene | 153559-49-0 | |
Fluorobexarotene | 1190848-23-7 | |
HX 531 | 188844-34-0 | |
HX 630 | 188844-52-2 | |
LG 100754 | 180713-37-5 | |
LG 101506 | 331248-11-4 | |
PA 452 | 457657-34-0 | |
SR 11237 | 146670-40-8 | |
UVI 3003 | 847239-17-2 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RXRG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RXRG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RXRG 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rxrg 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rxrg 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RXRG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RXRG 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rxrg 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.878 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rxrga 30 |
|
||
rxrgb 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | usp 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10537 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperlipidemia, familial combined, 3 |
|
|
lung cancer |
|
|
cone-rod dystrophy 2 |
|
|
retinitis pigmentosa |
|
|