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This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Granulomatosis With Polyangiitis and Myasthenic Syndrome, Congenital, 10. Among its related pathways are Transcriptional misregulation in cancer and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RXRA.
Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 12767074 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 12767074 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | NAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IDA | 7990953 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0042025 | host cell nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
PPAR Pathway
.66
|
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | Gene Expression |
.48
|
|
3 | Nuclear Receptor transcription pathway | ||
4 | Adipocytokine signaling pathway | ||
5 | Gastric cancer |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0030154 | cell differentiation | IBA | 21873635 |
GO:0032526 | response to retinoic acid | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bexarotene | Approved, Investigational | Pharma | Agonist, Target, agonist | Potent and selective RXR agonist, Others | 44 | |
Adapalene | Approved | Pharma | Target, agonist, binder | RAR尾 and RAR纬 agonist | 90 | |
Alitretinoin | Approved, Investigational | Pharma | Agonist, Target, agonist | 17 | ||
Tazarotene | Approved, Investigational | Pharma | Target, agonist, binder | Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor | 48 | |
Tretinoin | Approved, Investigational | Nutra | Agonist, Full agonist, Antagonist, Target, agonist, binder | 273 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Bexarotene | Potent and selective RXR agonist | 153559-49-0 |
CD 3254 | Potent and selective RXRalpha agonist. | 196961-43-0 |
HX 531 | Potent RXR antagonist | 188844-34-0 |
LG 100754 | RXR:PPAR agonist | 180713-37-5 |
Compound | Action | Cas Number |
---|---|---|
Acitretin | Metabolite of etretinate | 55079-83-9 |
Adapalene | RAR尾 and RAR纬 agonist | 106685-40-9 |
Bexarotene | 153559-49-0 | |
Fluorobexarotene | 1190848-23-7 | |
HX 531 | 188844-34-0 | |
HX 630 | 188844-52-2 | |
LG 100754 | 180713-37-5 | |
LG 101506 | 331248-11-4 | |
PA 452 | 457657-34-0 | |
SR 11237 | 146670-40-8 | |
UVI 3003 | 847239-17-2 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RXRB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RXRB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RXRB 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RXRB 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rxrb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rxrb 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | RXRB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rxrb 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rxrba 30 31 |
|
OneToMany | |
rxrbb 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | usp 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | nhr-69 32 |
|
|
|
nhr-14 32 |
|
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
779906 | Benign: not provided | 33,194,833(-) | G/GGGTGGA | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10609n54 | CNV | loss | 21841781 |
nsv1073969 | CNV | deletion | 25765185 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1119076 | CNV | deletion | 24896259 |
nsv522719 | CNV | loss | 19592680 |
nsv830634 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
granulomatosis with polyangiitis |
|
|
myasthenic syndrome, congenital, 10 |
|
|
vasculitis |
|
|
lung cancer |
|
|
neuromuscular junction disease |
|
|