This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the ... See more...

Aliases for RXRB Gene

Aliases for RXRB Gene

  • Retinoid X Receptor Beta 2 3 4 5
  • Nuclear Receptor Subfamily 2 Group B Member 2 2 3 4
  • Retinoic Acid Receptor RXR-Beta 3 4
  • NR2B2 3 4
  • MHC Class I Promoter Binding Protein 3
  • Retinoid X Receptor, Beta 2
  • H-2RIIBP 3
  • DAUDI6 3
  • RCoR-1 3

External Ids for RXRB Gene

Previous GeneCards Identifiers for RXRB Gene

  • GC06M033164
  • GC06M033208
  • GC06M033270
  • GC06M033161
  • GC06M032877

Summaries for RXRB Gene

Entrez Gene Summary for RXRB Gene

  • This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for RXRB Gene

RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Granulomatosis With Polyangiitis and Myasthenic Syndrome, Congenital, 10. Among its related pathways are Signaling by Retinoic Acid and Gastric cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot Summary for RXRB Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Tocris Summary for RXRB Gene

  • Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.

Gene Wiki entry for RXRB Gene

Additional gene information for RXRB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RXRB Gene

Genomics for RXRB Gene

GeneHancer (GH) Regulatory Elements for RXRB Gene

Promoters and enhancers for RXRB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RXRB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RXRB

Top Transcription factor binding sites by QIAGEN in the RXRB gene promoter:
  • Sp1

Genomic Locations for RXRB Gene

Genomic Locations for RXRB Gene
chr6:33,193,585-33,200,853
(GRCh38/hg38)
Size:
7,269 bases
Orientation:
Minus strand
chr6:33,161,365-33,168,630
(GRCh37/hg19)
Size:
7,266 bases
Orientation:
Minus strand

Genomic View for RXRB Gene

Genes around RXRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RXRB Gene

  • Protein details for RXRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28702-RXRB_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-beta
    Protein Accession:
    P28702
    Secondary Accessions:
    • P28703
    • Q59G65
    • Q5JP92
    • Q5STQ1

    Protein attributes for RXRB Gene

    Size:
    533 amino acids
    Molecular mass:
    56922 Da
    Quaternary structure:
    • Homodimer (in vitro) (PubMed:11782480). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:1310259). Interacts with NR1H3 (PubMed:12970175). Interacts with AKAP13 (By similarity).
    SequenceCaution:
    • Sequence=BAD92481.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RXRB Gene

    Alternative splice isoforms for RXRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RXRB Gene

Post-translational modifications for RXRB Gene

  • Ubiquitination at Lys452
  • Modification sites at PhosphoSitePlus

Other Protein References for RXRB Gene

No data available for DME Specific Peptides for RXRB Gene

Domains & Families for RXRB Gene

Gene Families for RXRB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RXRB Gene

Blocks:
  • Retinoic acid receptor signature
  • Steroid hormone receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RXRB Gene

GenScript: Design optimal peptide antigens:
  • Retinoid X receptor, beta (A2ABB0_HUMAN)
  • cDNA FLJ50538, highly similar to Retinoic acid receptor RXR-beta (B7Z3E4_HUMAN)
  • Retinoid X receptor, beta (Q5STP9_HUMAN)
  • Retinoid X receptor beta (RXRB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28702

UniProtKB/Swiss-Prot:

RXRB_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with RXRB: view

Function for RXRB Gene

Molecular function for RXRB Gene

UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
UniProtKB/Swiss-Prot Induction:
Down-regulated by aging.
GENATLAS Biochemistry:
retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily

Phenotypes From GWAS Catalog for RXRB Gene

Gene Ontology (GO) - Molecular Function for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 12767074
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 12767074
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS,IBA 21873635
genes like me logo Genes that share ontologies with RXRB: view
genes like me logo Genes that share phenotypes with RXRB: view

Animal Models for RXRB Gene

MGI Knock Outs for RXRB:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for RXRB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXRB Gene

Localization for RXRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRB Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXRB gene
Compartment Confidence
nucleus 5
mitochondrion 2
peroxisome 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 7990953
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0090575 RNA polymerase II transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with RXRB: view

Pathways & Interactions for RXRB Gene

genes like me logo Genes that share pathways with RXRB: view

Pathways by source for RXRB Gene

1 GeneGo (Thomson Reuters) pathway for RXRB Gene
  • Transcription Sin3 and NuRD in transcription regulation
3 Qiagen pathways for RXRB Gene
  • Nuclear Receptor Activation by Vitamin-A
  • Oct4 in Mammalian ESC Pluripotency
  • PPAR Pathway

SIGNOR curated interactions for RXRB Gene

Gene Ontology (GO) - Biological Process for RXRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030154 cell differentiation IBA 21873635
GO:0032526 response to retinoic acid IBA 21873635
genes like me logo Genes that share ontologies with RXRB: view

Drugs & Compounds for RXRB Gene

(28) Drugs for RXRB Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bexarotene Approved, Investigational Pharma Agonist, agonist, Target Potent and selective RXR agonist, Others 44
Adapalene Approved Pharma binder, Target, agonist RAR尾 and RAR纬 agonist 89
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 31
Alitretinoin Approved, Investigational Pharma Agonist, agonist, Target 17
Tazarotene Approved, Investigational Pharma binder, Target, agonist Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 48

(3) Additional Compounds for RXRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for RXRB Gene

Compound Action Cas Number
Bexarotene Potent and selective RXR agonist 153559-49-0
CD 3254 Potent and selective RXRalpha agonist. 196961-43-0
HX 531 Potent RXR antagonist 188844-34-0
LG 100754 RXR:PPAR agonist 180713-37-5

(11) ApexBio Compounds for RXRB Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Bexarotene 153559-49-0
Fluorobexarotene 1190848-23-7
HX 531 188844-34-0
HX 630 188844-52-2
LG 100754 180713-37-5
LG 101506 331248-11-4
PA 452 457657-34-0
SR 11237 146670-40-8
UVI 3003 847239-17-2
genes like me logo Genes that share compounds with RXRB: view

Drug Products

Transcripts for RXRB Gene

mRNA/cDNA for RXRB Gene

3 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for RXRB

Alternative Splicing Database (ASD) splice patterns (SP) for RXRB Gene

No ASD Table

Relevant External Links for RXRB Gene

GeneLoc Exon Structure for
RXRB

Expression for RXRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RXRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RXRB Gene

This gene is overexpressed in Blymphocyte (27.3), Peripheral blood mononuclear cells (12.2), Placenta (10.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RXRB Gene



Protein tissue co-expression partners for RXRB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RXRB

SOURCE GeneReport for Unigene cluster for RXRB Gene:

Hs.388034

mRNA Expression by UniProt/SwissProt for RXRB Gene:

P28702-RXRB_HUMAN
Tissue specificity: Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines.

Evidence on tissue expression from TISSUES for RXRB Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with RXRB: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXRB Gene

Orthologs for RXRB Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXRB 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RXRB 31 30
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RXRB 31 30
  • 93.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RXRB 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxrb 17 31 30
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Rxrb 30
  • 90.35 (n)
lizard
(Anolis carolinensis)
Reptilia RXRB 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxrb 30
  • 73.24 (n)
zebrafish
(Danio rerio)
Actinopterygii rxrba 31 30
  • 73.12 (n)
OneToMany
rxrbb 31
  • 70 (a)
OneToMany
-- 30
fruit fly
(Drosophila melanogaster)
Insecta usp 31 32
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-69 32
  • 34 (a)
nhr-14 32
  • 33 (a)
Species where no ortholog for RXRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RXRB Gene

ENSEMBL:
Gene Tree for RXRB (if available)
TreeFam:
Gene Tree for RXRB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RXRB: view image

Paralogs for RXRB Gene