Aliases for RXRB Gene
Aliases for RXRB Gene
External Ids for RXRB Gene
- HGNC: 10478
- Entrez Gene: 6257
- Ensembl: ENSG00000204231
- OMIM: 180246
- UniProtKB: P28702
Previous GeneCards Identifiers for RXRB Gene
- GC06M033164
- GC06M033208
- GC06M033270
- GC06M033161
- GC06M032877
Summaries for RXRB Gene
-
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for RXRB Gene
RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Wegener Granulomatosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RXRA.
UniProtKB/Swiss-Prot for RXRB Gene
-
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
-
Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXRB Gene
Genomics for RXRB Gene
GeneHancer (GH) Regulatory Elements for RXRB Gene
Promoters and enhancers for RXRB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RXRB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RXRB gene promoter:
Regulatory Element Products
Genomic Locations for RXRB Gene
Genomic Locations for RXRB Gene
- chr6:33,193,585-33,200,853
- (GRCh38/hg38)
- Size:
- 7,269 bases
- Orientation:
- Minus strand
- chr6:33,161,365-33,168,630
- (GRCh37/hg19)
Genomic View for RXRB Gene
Genes around RXRB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
RXRB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RXRB Gene
Proteins for RXRB Gene
-
Protein details for RXRB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28702-RXRB_HUMAN
- Recommended name:
- Retinoic acid receptor RXR-beta
- Protein Accession:
- P28702
- P28703
- Q59G65
- Q5JP92
- Q5STQ1
Protein attributes for RXRB Gene
- Size:
- 533 amino acids
- Molecular mass:
- 56922 Da
- Quaternary structure:
-
- Homodimer (in vitro) (PubMed:11782480). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:1310259). Interacts with NR1H3 (PubMed:12970175). Interacts with AKAP13 (By similarity).
- SequenceCaution:
-
- Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for RXRB Gene
Protein Expression for RXRB Gene
Post-translational modifications for RXRB Gene
- Ubiquitination at posLast=452452
Other Protein References for RXRB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RXRB (RXR beta/NR2B2)
- Cell Signaling Technology (CST) Antibodies for RXRB (RXRB)
-
Custom Antibody ServicesOriGene Antibodies for RXRB
- Novus Biologicals Antibodies for RXRB
-
Abcam antibodies for RXRB
- Invitrogen Antibodies for RXRB
- GeneTex RXRB antibody for RXRB
-
Santa Cruz Biotechnology (SCBT) Antibodies for RXRB
Protein Products
-
OriGene Purified Proteins for RXRB
- Search Origene for MassSpec and Protein Over-expression Lysates for RXRB
- Origene Custom Protein Services for RXRB
- Search GeneTex for Proteins for RXRB
-
Abcam proteins for RXRB
Assay Products
No data available for DME Specific Peptides for RXRB Gene
Domains & Families for RXRB Gene
Gene Families for RXRB Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RXRB Gene
Suggested Antigen Peptide Sequences for RXRB Gene
Graphical View of Domain Structure for InterPro Entry
P28702UniProtKB/Swiss-Prot:
RXRB_HUMAN :- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
- Domain:
-
- Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for RXRB Gene
Molecular function for RXRB Gene
- GENATLAS Biochemistry:
- retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),beta subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
- UniProtKB/Swiss-Prot Function:
- Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
Phenotypes From GWAS Catalog for RXRB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 12767074 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 12767074 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | NAS | 1662118 |
| GO:0003707 | steroid hormone receptor activity | IEA | -- |
Phenotypes for RXRB Gene
- MGI mutant phenotypes for RXRB:
-
inferred from 4 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for RXRB:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased G1 DNA content
- G0/1 arrest
- Decreased viability
- Upregulation of Wnt pathway
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RXRB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RXRB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RXRB gene
- Search ViGene Biosciences for RXRB
CRISPR Products
-
OriGene CRISPR knockouts for RXRB
- Applied Biological Materials CRISPR for RXRB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RXRB
- GenScript: Design CRISPR guide RNA sequences for RXRB
miRNA for RXRB Gene
- miRTarBase miRNAs that target RXRB
-
- hsa-mir-197-3p (MIRT004176)
- hsa-mir-346 (MIRT004235)
- hsa-mir-335-5p (MIRT016771)
- hsa-mir-26b-5p (MIRT028819)
- hsa-mir-484 (MIRT042213)
- hsa-mir-92a-3p (MIRT049481)
- hsa-let-7b-5p (MIRT051998)
- hsa-mir-573 (MIRT455413)
- hsa-mir-6851-5p (MIRT455414)
- hsa-mir-3616-5p (MIRT455415)
- hsa-mir-3689d (MIRT455416)
- hsa-mir-298 (MIRT455417)
- hsa-mir-7854-3p (MIRT455418)
- hsa-mir-5002-3p (MIRT455419)
- hsa-mir-4795-5p (MIRT455420)
- hsa-mir-3158-5p (MIRT455421)
- hsa-mir-509-5p (MIRT455422)
- hsa-mir-509-3-5p (MIRT455423)
- hsa-mir-4418 (MIRT455424)
- hsa-mir-6891-5p (MIRT455425)
- hsa-mir-3173-3p (MIRT455426)
- hsa-mir-4278 (MIRT487984)
- hsa-mir-6885-5p (MIRT487985)
- hsa-mir-328-5p (MIRT487986)
- hsa-mir-4697-5p (MIRT487987)
- hsa-mir-4488 (MIRT487988)
- hsa-mir-1237-5p (MIRT487989)
- hsa-mir-3196 (MIRT487990)
- hsa-mir-6816-5p (MIRT487991)
- hsa-mir-3180-3p (MIRT487992)
- hsa-mir-3180 (MIRT487993)
- hsa-mir-4467 (MIRT487994)
- hsa-mir-6077 (MIRT487995)
- hsa-mir-8072 (MIRT487996)
- hsa-mir-3960 (MIRT487997)
- hsa-mir-6732-5p (MIRT487998)
- hsa-mir-6805-5p (MIRT487999)
- hsa-mir-6794-5p (MIRT488000)
- hsa-mir-4716-3p (MIRT488001)
- hsa-mir-4524b-3p (MIRT488002)
- hsa-mir-320e (MIRT488003)
- hsa-mir-6083 (MIRT610401)
- hsa-mir-6754-3p (MIRT610402)
- hsa-mir-412-3p (MIRT610403)
- hsa-mir-6756-3p (MIRT610404)
- hsa-mir-3127-3p (MIRT610405)
- hsa-mir-6769a-3p (MIRT628659)
miRNA Products
- Search ViGene Biosciences for RXRB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RXRB
- Browse OriGene Inhibitory RNA Products For RXRB
-
ViGene Biosciences ready-to-package AAV shRNAs for RXRB gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RXRB in any vector
- XM_005272855.1
- XM_005275008.1
- XM_005275150.1
- XM_005275277.1
- XM_005275439.1
- XM_011514796.1
- NM_001291989.1
- XM_011547269.1
- XM_011547672.1
- XM_011547899.1
- XM_011548071.1
- XM_011548260.1
- XM_005249278.1
- NM_001270401.1
- XM_005272854.1
- XM_005275007.1
- XM_005275149.1
- XM_005275276.1
- XM_005275438.1
- NM_021976.4
- XM_005249279.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RXRB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RXRB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RXRB
- genomics-online: cdna clones - Search results for 119 available Retinoid X Receptor beta gene related products
- Overview of 119 available Retinoid X Receptor beta gene related products
- orf clones - Search results for 119 available Retinoid X Receptor beta gene related products
- Overview of 119 available Retinoid X Receptor beta gene related products
- Applied Biological Materials Clones for RXRB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RXRB
-
ViGene Biosciences adenoviral particle packaged cDNA for RXRB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RXRB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RXRB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXRB Gene
Localization for RXRB Gene
Subcellular locations from UniProtKB/Swiss-Prot for RXRB Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| peroxisome | 2 |
| cytosol | 2 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 7990953 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for RXRB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endometrial cancer |
.36
|
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.66
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Nuclear Receptor transcription pathway | ||
| 5 | Adipocytokine signaling pathway | ||
Pathways by source for RXRB Gene
3 BioSystems pathways for RXRB Gene
5 Reactome pathways for RXRB Gene
10 KEGG pathways for RXRB Gene
1 GeneGo (Thomson Reuters) pathway for RXRB Gene
3 Qiagen pathways for RXRB Gene
Interacting Proteins for RXRB Gene
Selected Interacting proteins:
ENSP00000363812
P28702-RXRB_HUMAN
for RXRB Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for RXRB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0030522 | intracellular receptor signaling pathway | IEA | -- |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA | -- |
Drugs & Compounds for RXRB Gene
(29) Drugs for RXRB Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bexarotene | Approved, Investigational | Pharma | Agonist, Target, agonist | Potent and selective RXR agonist, Others | 44 | |
| Adapalene | Approved | Pharma | Target, agonist, binder | RAR尾 and RAR纬 agonist | 78 | |
| Tazarotene | Approved, Investigational | Pharma | Target, agonist, binder | Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor | 46 | |
| Acitretin | Approved | Pharma | Target, agonist | Metabolite of etretinate | 30 | |
| Alitretinoin | Approved, Investigational | Pharma | Target, agonist | 17 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 9-cis-retinoic acid |
|
Agonist |
|
|||
| all-trans-retinoic acid |
|
Full agonist, Agonist | 302-79-4 |
|
(4) Tocris Compounds for RXRB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bexarotene | Potent and selective RXR agonist | 153559-49-0 |
| CD 3254 | Potent and selective RXRalpha agonist. | 196961-43-0 |
| HX 531 | Potent RXR antagonist | 188844-34-0 |
| LG 100754 | RXR:PPAR agonist | 180713-37-5 |
(11) ApexBio Compounds for RXRB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Acitretin | Metabolite of etretinate | 55079-83-9 |
| Adapalene | RAR尾 and RAR纬 agonist | 106685-40-9 |
| Bexarotene | 153559-49-0 | |
| Fluorobexarotene | 1190848-23-7 | |
| HX 531 | 188844-34-0 | |
| HX 630 | 188844-52-2 | |
| LG 100754 | 180713-37-5 | |
| LG 101506 | 331248-11-4 | |
| PA 452 | 457657-34-0 | |
| SR 11237 | 146670-40-8 | |
| UVI 3003 | 847239-17-2 |
Transcripts for RXRB Gene
mRNA/cDNA for RXRB Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (297) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RXRB Gene
- Retinoid X receptor, beta:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RXRB
- Applied Biological Materials CRISPR for RXRB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RXRB
- GenScript: Design CRISPR guide RNA sequences for RXRB
miRNA Products
- Search ViGene Biosciences for RXRB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RXRB
- Browse OriGene Inhibitory RNA Products For RXRB
-
ViGene Biosciences ready-to-package AAV shRNAs for RXRB gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RXRB in any vector
- XM_005272855.1
- XM_005275008.1
- XM_005275150.1
- XM_005275277.1
- XM_005275439.1
- XM_011514796.1
- NM_001291989.1
- XM_011547269.1
- XM_011547672.1
- XM_011547899.1
- XM_011548071.1
- XM_011548260.1
- XM_005249278.1
- NM_001270401.1
- XM_005272854.1
- XM_005275007.1
- XM_005275149.1
- XM_005275276.1
- XM_005275438.1
- NM_021976.4
- XM_005249279.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RXRB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RXRB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RXRB
- genomics-online: cdna clones - Search results for 119 available Retinoid X Receptor beta gene related products
- Overview of 119 available Retinoid X Receptor beta gene related products
- orf clones - Search results for 119 available Retinoid X Receptor beta gene related products
- Overview of 119 available Retinoid X Receptor beta gene related products
- Applied Biological Materials Clones for RXRB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RXRB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dentin
- Ameloblasts Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Inner Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Outer Enamel Epithelial Cells Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Dental Placode Cells Dental Placode
- Early Ameloblasts Dental Enamel
This gene is overexpressed in Blymphocyte (27.3), Peripheral blood mononuclear cells (12.2), Placenta (10.6), and Ovary (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RXRB Gene
NURSA nuclear receptor signaling pathways regulating expression of RXRB Gene:
RXRBSOURCE GeneReport for Unigene cluster for RXRB Gene:
Hs.388034mRNA Expression by UniProt/SwissProt for RXRB Gene:
P28702-RXRB_HUMAN
Tissue specificity:
Expressed in a variety of tumor cell lines.
Evidence on tissue expression from TISSUES for RXRB Gene
- Nervous system(4.8)
- Liver(4.2)
- Thyroid gland(2.5)
Primer Products
-
OriGene qPCR primer pairs for RXRB
-
OriGene qPCR primer pairs and template standards for RXRB
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXRB Gene
Orthologs for RXRB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RXRB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RXRB 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RXRB 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RXRB 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rxrb 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rxrb 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RXRB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rxrb 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rxrba 33 34 |
|
||
| rxrbb 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | usp 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | nhr-69 35 |
|
|
|
| nhr-14 35 |
|
|
- Species where no ortholog for RXRB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RXRB Gene
Paralogs for RXRB Gene
(46) SIMAP similar genes for RXRB Gene using alignment to 6 proteins:
Variants for RXRB Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000491541 | -- | 33,194,538(-) | G/C | 3_prime_UTR_variant | |
| rs1000612226 | -- | 33,194,223(-) | A/G | 3_prime_UTR_variant | |
| rs1001539000 | -- | 33,195,886(-) | A/G | intron_variant | |
| rs1001951266 | -- | 33,201,835(-) | C/G | upstream_transcript_variant | |
| rs1002841616 | -- | 33,200,610(-) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv830634 | CNV | loss | 17160897 |
| nsv522719 | CNV | loss | 19592680 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1073969 | CNV | deletion | 25765185 |
| dgv10609n54 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.02;
37.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RXRB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXRB Gene
Disorders for RXRB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wegener granulomatosis |
|
Search RXRB in MalaCards
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Additional Disease Information for RXRB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RXRB Gene
Publications for RXRB Gene
- Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients. (PMID: 19811264) Kälsch AI … Yard BA (Autoimmunity 2009) 3 22 44 58
- Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (PMID: 11840500) Ishiguro H … Arinami T (American journal of medical genetics 2002) 3 22 44 58
- Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals. (PMID: 8381386) Fleischhauer K … Yang SY (Human genetics 1993) 3 4 22 58
- Mapping of RXRB to human chromosome 6p21.3. (PMID: 8257090) Fitzgibbon J … Povey S (Annals of human genetics 1993) 2 3 22 58
- Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta. (PMID: 1315958) Fleischhauer K … Yang SY (Nucleic acids research 1992) 3 4 22 58
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