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Aliases for RXFP3 Gene

Aliases for RXFP3 Gene

  • Relaxin/Insulin Like Family Peptide Receptor 3 2 3 5
  • Relaxin Family Peptide Receptor 3 2 3 4
  • G-Protein Coupled Receptor GPCR135 3 4
  • G Protein-Coupled Receptor SALPR 3 4
  • RLN3 Receptor 1 3 4
  • RLN3R1 3 4
  • SALPR 3 4
  • Somatostatin- And Angiotensin-Like Peptide Receptor 4
  • Somatostatin And Angiotensin-Like Peptide Receptor 3
  • G-Protein Coupled Receptor SALPR 3
  • Relaxin 3 Receptor 1 2
  • Relaxin-3 Receptor 1 3
  • GPCR135 3
  • RXFPR3 3

External Ids for RXFP3 Gene

Previous HGNC Symbols for RXFP3 Gene

  • RLN3R1

Summaries for RXFP3 Gene

GeneCards Summary for RXFP3 Gene

RXFP3 (Relaxin/Insulin Like Family Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is RXFP4.

UniProtKB/Swiss-Prot for RXFP3 Gene

  • Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP3 Gene

Additional gene information for RXFP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP3 Gene

Genomics for RXFP3 Gene

GeneHancer (GH) Regulatory Elements for RXFP3 Gene

Promoters and enhancers for RXFP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I033936 Promoter 0.9 Ensembl 550.8 -0.3 -285 0.2 CTCF NRF1 MAX SIN3A MIER2 MNT REST RAD21 MXD3 ZNF143 RXFP3 PIR31924
GH05I033439 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -495.1 -495098 4.3 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000249572 TARS GC05M033441 PIR33729 RPS8P8 LOC643373 RXFP3 GC05P033478
GH05I033435 Enhancer 1 Ensembl ENCODE 11.2 -500.4 -500385 0.4 HDGF CTCF RB1 MZF1 ZNF2 RAD21 RFX5 RELA TEAD3 CC2D1A RXFP3 ENSG00000249572 GC05M033441 PIR33729 GC05M033421
GH05I033432 Enhancer 0.8 ENCODE 10.8 -503.4 -503363 0.6 ELF3 SOX13 FOXA2 SAP130 MAX RARA YY1 ZNF316 HNF4G ATF7 RXFP3 TARS ENSG00000249572 PIR33729 GC05M033441 GC05M033421
GH05I033438 Enhancer 0.6 Ensembl dbSUPER 11.2 -497.5 -497485 0.2 CEBPB FOXA1 ENSG00000249572 GC05M033441 PIR33729 TARS RXFP3 GC05M033421
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RXFP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RXFP3 gene promoter:

Genomic Locations for RXFP3 Gene

Genomic Locations for RXFP3 Gene
2,533 bases
Plus strand

Genomic View for RXFP3 Gene

Genes around RXFP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXFP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP3 Gene

Proteins for RXFP3 Gene

  • Protein details for RXFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Relaxin-3 receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q14DA5

    Protein attributes for RXFP3 Gene

    469 amino acids
    Molecular mass:
    51124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RXFP3 Gene

Post-translational modifications for RXFP3 Gene

  • Glycosylation at posLast=3636 and posLast=4040
  • Modification sites at PhosphoSitePlus

Other Protein References for RXFP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RXFP3 Gene

Domains & Families for RXFP3 Gene

Gene Families for RXFP3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for RXFP3 Gene

Suggested Antigen Peptide Sequences for RXFP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with RXFP3: view

Function for RXFP3 Gene

Molecular function for RXFP3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Ontology (GO) - Molecular Function for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10806363
GO:0004966 galanin receptor activity IBA --
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with RXFP3: view
genes like me logo Genes that share phenotypes with RXFP3: view

Animal Models for RXFP3 Gene

MGI Knock Outs for RXFP3:

miRNA for RXFP3 Gene

miRTarBase miRNAs that target RXFP3

Clone Products

  • Addgene plasmids for RXFP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXFP3 Gene

Localization for RXFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXFP3 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10806363
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RXFP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RXFP3 Gene

Pathways & Interactions for RXFP3 Gene

genes like me logo Genes that share pathways with RXFP3: view

Pathways by source for RXFP3 Gene

Gene Ontology (GO) - Biological Process for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with RXFP3: view

No data available for SIGNOR curated interactions for RXFP3 Gene

Drugs & Compounds for RXFP3 Gene

(10) Drugs for RXFP3 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
[<sup>125</sup>I]H3-B/INSL5 A chimera Pharma Agonist 0
H3 relaxin Pharma Full agonist, Agonist 0
H3 relaxin (B chain) Pharma Full agonist, Agonist 0
H3 relaxin/INSL5 chimera Pharma Full agonist, Agonist 0

(3) Additional Compounds for RXFP3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]H3 relaxin
Full agonist, Agonist
R3(BDelta23-27)R/I5 chimeric peptide
genes like me logo Genes that share compounds with RXFP3: view

Transcripts for RXFP3 Gene

mRNA/cDNA for RXFP3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP3 Gene

Relaxin/insulin-like family peptide receptor 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for RXFP3

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP3 Gene

No ASD Table

Relevant External Links for RXFP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RXFP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RXFP3 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP3 Gene

This gene is overexpressed in Adrenal Gland (x19.3), Brain - Hypothalamus (x7.0), and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for RXFP3 Gene

This gene is overexpressed in Pancreas (60.5) and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RXFP3 Gene

Protein tissue co-expression partners for RXFP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RXFP3 Gene:


SOURCE GeneReport for Unigene cluster for RXFP3 Gene:


mRNA Expression by UniProt/SwissProt for RXFP3 Gene:

Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

Evidence on tissue expression from TISSUES for RXFP3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RXFP3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RXFP3 Gene

Orthologs for RXFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RXFP3 33 34
  • 99.22 (n)
(Bos Taurus)
Mammalia RXFP3 33 34
  • 89.81 (n)
(Canis familiaris)
Mammalia RXFP3 33 34
  • 86.46 (n)
(Mus musculus)
Mammalia Rxfp3 33 16 34
  • 84.86 (n)
(Rattus norvegicus)
Mammalia Rxfp3 33
  • 84.72 (n)
(Monodelphis domestica)
Mammalia RXFP3 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia RXFP3 34
  • 70 (a)
(Gallus gallus)
Aves RXFP3 33 34
  • 74.64 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rxfp3 33
  • 68.92 (n)
(Danio rerio)
Actinopterygii rxfp3 33 34
  • 66.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 34
  • 20 (a)
Species where no ortholog for RXFP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP3 Gene

Gene Tree for RXFP3 (if available)
Gene Tree for RXFP3 (if available)

Paralogs for RXFP3 Gene

Paralogs for RXFP3 Gene

(5) SIMAP similar genes for RXFP3 Gene using alignment to 2 proteins: Pseudogenes for RXFP3 Gene

genes like me logo Genes that share paralogs with RXFP3: view

Variants for RXFP3 Gene

Sequence variations from dbSNP and Humsavar for RXFP3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000332192 -- 33,937,596(+) T/C coding_sequence_variant, missense_variant
rs1000386531 -- 33,939,179(+) C/A downstream_transcript_variant
rs1000668487 -- 33,936,257(+) C/A upstream_transcript_variant
rs1001122669 -- 33,938,584(+) C/T 3_prime_UTR_variant
rs1001173650 -- 33,938,851(+) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RXFP3 Gene

Variant ID Type Subtype PubMed ID
esv3604665 CNV gain 21293372
nsv1019937 CNV loss 25217958
nsv462114 CNV loss 19166990
nsv462115 CNV loss 19166990
nsv522715 CNV gain 19592680
nsv597791 CNV loss 21841781
nsv597792 CNV loss 21841781
nsv597793 CNV loss 21841781
nsv830255 CNV loss 17160897

Variation tolerance for RXFP3 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RXFP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXFP3 Gene

Disorders for RXFP3 Gene

Additional Disease Information for RXFP3

No disorders were found for RXFP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RXFP3 Gene

Publications for RXFP3 Gene

  1. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate RA … Summers RJ (Annals of the New York Academy of Sciences 2005) 2 3 22 58
  2. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PMID: 10806363) Matsumoto M … Furuichi K (Gene 2000) 3 4 22 58
  3. H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). (PMID: 20159943) van der Westhuizen ET … Summers RJ (Molecular pharmacology 2010) 3 22 58
  4. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J … Liu C (European journal of pharmacology 2008) 3 22 58
  5. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PMID: 16507880) Bathgate RA … Summers RJ (Pharmacological reviews 2006) 2 3 58

Products for RXFP3 Gene

  • Addgene plasmids for RXFP3

Sources for RXFP3 Gene

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