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This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants... See more...
Aliases for RXFP1 Gene
Aliases for RXFP1 Gene
External Ids for RXFP1 Gene
- HGNC: 19718
- NCBI Entrez Gene: 59350
- Ensembl: ENSG00000171509
- OMIM®: 606654
- UniProtKB/Swiss-Prot: Q9HBX9
Previous HGNC Symbols for RXFP1 Gene
- LGR7
Previous GeneCards Identifiers for RXFP1 Gene
- GC04P159655
- GC04P159435
- GC04P159236
- GC04P155192
Summaries for RXFP1 Gene
-
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for RXFP1 Gene
RXFP1 (Relaxin Family Peptide Receptor 1) is a Protein Coding gene. Diseases associated with RXFP1 include Endometriosis and Placenta Accreta. Among its related pathways are Signaling by GPCR and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone binding. An important paralog of this gene is RXFP2.
UniProtKB/Swiss-Prot Summary for RXFP1 Gene
-
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Additional gene information for RXFP1 Gene
- HGNC (19718)
- NCBI Entrez Gene (59350)
- Ensembl (ENSG00000171509)
- OMIM® (606654)
- UniProtKB/Swiss-Prot (Q9HBX9)
- Open Targets Platform(ENSG00000171509)
- Monarch Initiative
- Search for RXFP1 at DataMed
- Search for RXFP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RXFP1 Gene
Genomics for RXFP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RXFP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J158521 | Promoter | 0.8 | EPDnew Ensembl | 250.1 | +206.4 | 206390 | 0.6 | NRF1 | NONHSAG039215.2 RXFP1 ENSG00000249901 ETFDH | |
| GH04J158312 | Enhancer | 0.7 | Ensembl ENCODE | 250.7 | -0.2 | -210 | 5 | CEBPB EP300 JUND BHLHE40 SPI1 IKZF2 FOS RUNX3 | RXFP1 AIDAP2 TMEM144 PPID FAM198B-AS1 HSALNG0038165 HSALNG0038162 | |
| GH04J158590 | Promoter | 0.3 | EPDnew | 250.1 | +275.6 | 275616 | 0.1 | RXFP1 RF00017-4435 piR-30449-124 NONHSAG039215.2 ETFDH | ||
| GH04J158371 | Enhancer | 0.6 | Ensembl ENCODE | 14.6 | +55.9 | 55890 | 2 | CEBPB EP300 FOS | RXFP1 RNU4-79P HSALNG0038166 LOC105377510 HSALNG0038162 ETFDH | |
| GH04J158273 | Enhancer | 0.2 | Ensembl | 10.5 | -41.2 | -41210 | 1 | RXFP1 AIDAP2 MN298144 lnc-TMEM144-3 TMEM144 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RXFP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RXFP1
- Top Transcription factor binding sites by QIAGEN in the RXFP1 gene promoter:
-
- aMEF-2
- E47
- Lhx3a
- LHX3b
- MEF-2A
- MZF-1
- STAT3
- STAT5B
- Tal-1beta
- TBP
Genomic Locations for RXFP1 Gene
Latest Assembly
- chr4:158,315,311-158,653,372
- (GRCh38/hg38)
- Size:
- 338,062 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:159,442,866-159,574,524
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 131,659 bases
- Orientation:
- Plus strand
- chr4:159,236,463-159,574,524
- (GRCh37/hg19 by Ensembl)
- Size:
- 338,062 bases
- Orientation:
- Plus strand
Genomic View for RXFP1 Gene
Genes around RXFP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q32.1 by HGNC
- 4q32.1 by Entrez Gene
- 4q32.1 by Ensembl
RXFP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RXFP1 Gene
Proteins for RXFP1 Gene
-
Protein details for RXFP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBX9-RXFP1_HUMAN
- Recommended name:
- Relaxin receptor 1
- Protein Accession:
- Q9HBX9
- B4DHD1
- B4DTV2
- Q2M215
- Q3KU24
- Q3KU25
- Q3KU26
Protein attributes for RXFP1 Gene
- Size:
- 757 amino acids
- Molecular mass:
- 86975 Da
- Quaternary structure:
-
- Interacts with C1QTNF8.
Protein Expression for RXFP1 Gene
Post-translational modifications for RXFP1 Gene
Other Protein References for RXFP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011530476.1
- XP_011530477.1
- XP_011530478.1
- XP_011530481.1
- XP_016864006.1
- XP_016864007.1
- XP_016864008.1
- XP_016864009.1
- XP_016864011.1
- XP_016864012.1
- XP_016864013.1
- XP_016864014.1
- XP_016864015.1
- NP_001240656.1
- NP_001240657.1
- NP_001240658.1
- NP_001240659.1
- NP_001240661.1
- NP_001240662.1
- NP_001350705.1
- NP_067647.2
Antibodies for research
- LifeSpan BioSciences RXFP1/ LGR7 Antibody (LS-A561) and RXFP1/ LGR7 Antibody (LS-A566)
- G Biosciences Immunotag™ RXFP1 Antibody
- GeneTex Anti-LGR7 antibody [C3-2], C-term and Anti-LGR7 antibody
-
Custom Antibody ServicesOriGene Antibodies for RXFP1
- Novus Biologicals Antibodies for RXFP1
-
Abcam antibodies for RXFP1
- Invitrogen Antibodies for RXFP1 (AFLGC-RXFP1)
-
Biorbyt antibodies for RXFP1
-
Boster Bio Antibodies for RXFP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RXFP1
Protein products for research
-
OriGene Purified Proteins for RXFP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RXFP1
- Origene Custom Protein Services for RXFP1
-
Abcam proteins for RXFP1
No data available for DME Specific Peptides for RXFP1 Gene
Domains & Families for RXFP1 Gene
Gene Families for RXFP1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for RXFP1 Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, N-terminal
- Low density lipoprotein-receptor, class A
- Relaxin receptor family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for RXFP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61255, highly similar to Relaxin receptor 1 (B4DHD1_HUMAN)
- Relaxin family peptide receptor 1 (RXFP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HBX9- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for RXFP1 Gene
Molecular function for RXFP1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Phenotypes From GWAS Catalog for RXFP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA,IDA | 11809971 |
| GO:0005515 | protein binding | IEA,IPI | 20664520 |
| GO:0008528 | G protein-coupled peptide receptor activity | IBA | 21873635 |
| GO:0042562 | hormone binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RXFP1 Gene
- MGI mutant phenotypes for RXFP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RXFP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Increased homologous recombination repair frequency
Animal Models for research
-
Taconic Biosciences Mouse Models for RXFP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RXFP1 - Starting at $85 >
- * RXFP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RXFP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RXFP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RXFP1
miRNA for RXFP1 Gene
- miRTarBase miRNAs that target RXFP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RXFP1
- Browse OriGene Inhibitory RNA Products For RXFP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RXFP1
Clone products for research
- Applied Biological Materials (abm): Clones for RXFP1 - Starting at $45 >
- * RXFP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223089
- MR223089
- MR223089L1
- MR223089L2
- MR223089L3
- MR223089L4
- RC211338
- RC211338L1
- RC211338L2
- RC211338L3
- RC211338L4
- RC233002
- RC233024
- RC233096
- RC233102
- RC234877
- RC239141
- RG211338
- RG233002
- RG233024
- RG233096
- RG233102
- RG234877
- RR205689
- RR205689L3
- RR205689L4
- MR223089L1V
- MR223089L2V
- MR223089L3V
- MR223089L4V
- RC211338L1V
- RC211338L2V
- RC211338L3V
- RC211338L4V
- RR205689L3V
- RR205689L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RXFP1
- Addgene plasmids for RXFP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RXFP1
Cell Lines for research
-
Horizon Cell Lines for RXFP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXFP1 Gene
Localization for RXFP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RXFP1 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RXFP1 Gene
Pathways & Interactions for RXFP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Relaxin signaling pathway | ||
| 4 | CREB Pathway |
Activation of PKC through GPCR
.63
|
|
| 5 | G-Beta Gamma Signaling |
Relaxin Pathway
.37
|
|
Pathways by source for RXFP1 Gene
2 BioSystems pathways for RXFP1 Gene
8 Reactome pathways for RXFP1 Gene
2 KEGG pathways for RXFP1 Gene
2 Qiagen pathways for RXFP1 Gene
- Activation of PKC through GPCR
- Relaxin Pathway
Interacting Proteins for RXFP1 Gene
Selected Interacting proteins:
Q9HBX9-RXFP1_HUMAN
ENSP00000405841
for RXFP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RXFP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0007190 | activation of adenylate cyclase activity | IBA | 21873635 |
Drugs & Compounds for RXFP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>33</sup>P]H2 relaxin |
|
Agonist, Full agonist |
|
Transcripts for RXFP1 Gene
mRNA/cDNA for RXFP1 Gene
- 8 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307765 3686 nts (view in UCSC)
- ENST00000342048 3676 nts (view in UCSC)
- ENST00000343542 2130 nts (view in UCSC)
- ENST00000423548 3930 nts (view in UCSC)
- ENST00000448688 3861 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RXFP1 - Starting at $85 >
- * RXFP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RXFP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RXFP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RXFP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RXFP1
- Browse OriGene Inhibitory RNA Products For RXFP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RXFP1
Clone products for research
- Applied Biological Materials (abm): Clones for RXFP1 - Starting at $45 >
- * RXFP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223089
- MR223089
- MR223089L1
- MR223089L2
- MR223089L3
- MR223089L4
- RC211338
- RC211338L1
- RC211338L2
- RC211338L3
- RC211338L4
- RC233002
- RC233024
- RC233096
- RC233102
- RC234877
- RC239141
- RG211338
- RG233002
- RG233024
- RG233096
- RG233102
- RG234877
- RR205689
- RR205689L3
- RR205689L4
- MR223089L1V
- MR223089L2V
- MR223089L3V
- MR223089L4V
- RC211338L1V
- RC211338L2V
- RC211338L3V
- RC211338L4V
- RR205689L3V
- RR205689L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RXFP1
- Addgene plasmids for RXFP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RXFP1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for RXFP1 Gene
- GeneLoc Exon Structure for
- RXFP1
Expression for RXFP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
mRNA differential expression in normal tissues according to GTEx for RXFP1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.5), Brain - Anterior cingulate cortex (BA24) (x9.4), and Brain - Cortex (x8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RXFP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RXFP1
SOURCE GeneReport for Unigene cluster for RXFP1 Gene:
Hs.591686mRNA Expression by UniProt/SwissProt for RXFP1 Gene:
Q9HBX9-RXFP1_HUMAN
Tissue specificity:
Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
Evidence on tissue expression from TISSUES for RXFP1 Gene
- Nervous system(4.7)
Primer products for research
-
OriGene qPCR primer pairs for RXFP1
-
OriGene qPCR primer pairs and template standards for RXFP1
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXFP1 Gene
Orthologs for RXFP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RXFP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RXFP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RXFP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RXFP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Rxfp1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rxfp1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | RXFP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RXFP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rxfp1 30 |
|
||
| Str.18185 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | rxfp1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG34411 30 31 |
|
ManyToMany | |
| Lgr3 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GPRGPH 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for RXFP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RXFP1 Gene
- ENSEMBL:
- Gene Tree for RXFP1 (if available)
- TreeFam:
- Gene Tree for RXFP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RXFP1: view image
Paralogs for RXFP1 Gene
Paralogs for RXFP1 Gene
(4) SIMAP similar genes for RXFP1 Gene using alignment to 4 proteins:
- RXFP1_HUMAN
- B4DHD1_HUMAN
- E9PCA3_HUMAN
- E9PIF0_HUMAN
Variants for RXFP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RXFP1 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 974730 | Uncertain Significance: Aganglionic megacolon | 158,620,033(+) |
ACTCAGATTTTACAAC
NG_031835.1(PPID):g.103322_138659del |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1536e212 | CNV | loss | 25503493 |
| esv2669435 | CNV | deletion | 23128226 |
| esv2728610 | CNV | deletion | 23290073 |
| esv3569762 | CNV | loss | 25503493 |
| esv3569766 | CNV | loss | 25503493 |
| esv3602833 | CNV | gain | 21293372 |
| nsv830124 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.15;
39.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RXFP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RXFP1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXFP1 Gene
Disorders for RXFP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| endometriosis |
|
|
| placenta accreta |
|
|
| radiation cystitis |
|
|
| acrocallosal syndrome |
|
|
| cryptorchidism, unilateral or bilateral |
|
|
Search RXFP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RXFP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RXFP1 Gene
Publications for RXFP1 Gene
- Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function. (PMID: 18533687) Yan Y … Bathgate RA (Biochemistry 2008) 3 4 23
- The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation. (PMID: 17148455) Hopkins EJ … Gooley PR (The Journal of biological chemistry 2007) 3 4 23
- Receptors for relaxin family peptides. (PMID: 15956688) Bathgate RA … Summers RJ (Annals of the New York Academy of Sciences 2005) 2 3 23
- H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. (PMID: 12506116) Sudo S … Hsueh AJ (The Journal of biological chemistry 2003) 3 4 23
- C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (PMID: 24014093) Glogowska A … Klonisch T (The Journal of pathology 2013) 3 4
ExternalLinks
Products for RXFP1 Gene
- View all 10 R&D Systems RXFP1 (Relaxin R1) Products
- View all R&D Systems RXFP1 (Relaxin R1) Proteins and Enzymes
- View all 8 R&D Systems RXFP1 (Relaxin R1) Primary Antibodies
- View all R&D Systems RXFP1 (Relaxin R1) cDNA Clones
- Learn more about R&D Systems custom RXFP1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for RXFP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RXFP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RXFP1
- Origene Custom Protein Services for RXFP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RXFP1
- Browse OriGene Inhibitory RNA Products For RXFP1
- OriGene qPCR primer pairs for RXFP1
- OriGene qPCR primer pairs and template standards for RXFP1
- OriGene CRISPR knockouts for RXFP1
- MG223089
- MR223089
- MR223089L1
- MR223089L2
- MR223089L3
- MR223089L4
- RC211338
- RC211338L1
- RC211338L2
- RC211338L3
- RC211338L4
- RC233002
- RC233024
- RC233096
- RC233102
- RC234877
- RC239141
- RG211338
- RG233002
- RG233024
- RG233096
- RG233102
- RG234877
- RR205689
- RR205689L3
- RR205689L4
- MR223089L1V
- MR223089L2V
- MR223089L3V
- MR223089L4V
- RC211338L1V
- RC211338L2V
- RC211338L3V
- RC211338L4V
- RR205689L3V
- RR205689L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RXFP1
- Sino Biological Human cDNA Clone for RXFP1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RXFP1
- Novus Biologicals proteins and lysates for RXFP1
- Novus Biologicals ELISA Kits for RXFP1
- Browse Antibodies
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- Abcam antibodies for RXFP1
- Abcam proteins for RXFP1
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- Taconic Biosciences Mouse Models for RXFP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RXFP1 (AFLGC-RXFP1)
- VectorBuilder Custom and pre-made DNA vectors for RXFP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RXFP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RXFP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RXFP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RXFP1
- Addgene plasmids for RXFP1
- antibodies-online: Show 26 available RXFP1 Antibodies ranked by validation data
- Compare Top RXFP1 Antibodies
- antibodies-online: Show 31 available RXFP1 Elisa Kits ranked by validation data
- Compare Top RXFP1 Elisa Kits
- antibodies-online: Show 8 available RXFP1 Proteins ranked by validation data
- Compare Top RXFP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RXFP1
- Search Santa Cruz Biotechnology (SCBT) for RXFP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RXFP1
- Horizon Cell Lines for RXFP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RXFP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RXFP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RXFP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RXFP1
- Boster Bio Antibodies for RXFP1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for RXFP1
Sources for RXFP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
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- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB