Aliases for RXFP1 Gene
External Ids for RXFP1 Gene
Previous HGNC Symbols for RXFP1 Gene
Previous GeneCards Identifiers for RXFP1 Gene
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for RXFP1 Gene
RXFP1 (Relaxin Family Peptide Receptor 1) is a Protein Coding gene. Diseases associated with RXFP1 include Endometriosis and Placenta Accreta. Among its related pathways are Signaling by GPCR and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone binding. An important paralog of this gene is RXFP2.
UniProtKB/Swiss-Prot Summary for RXFP1 Gene
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.