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Aliases for RWDD4 Gene

Aliases for RWDD4 Gene

  • RWD Domain Containing 4 2 3 5
  • Family With Sequence Similarity 28, Member A 2 3
  • RWD Domain Containing 4A 2 3
  • FAM28A 3 4
  • RWDD4A 3 4
  • RWD Domain-Containing Protein 4A 3
  • RWD Domain-Containing Protein 4 3
  • Protein FAM28A 4

External Ids for RWDD4 Gene

Previous HGNC Symbols for RWDD4 Gene

  • FAM28A
  • RWDD4A

Previous GeneCards Identifiers for RWDD4 Gene

  • GC04M184561

Summaries for RWDD4 Gene

GeneCards Summary for RWDD4 Gene

RWDD4 (RWD Domain Containing 4) is a Protein Coding gene.

Additional gene information for RWDD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD4 Gene

Genomics for RWDD4 Gene

GeneHancer (GH) Regulatory Elements for RWDD4 Gene

Promoters and enhancers for RWDD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I183657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 60 2.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 POLR2B ZNF143 FOS SP3 TRAPPC11 RWDD4 CDKN2AIP RNU6-479P
GH04I183442 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +214.7 214713 3.8 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CDKN2AIP TRAPPC11 RWDD4 LOC100127981
GH04I183617 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.6 +40.0 39953 3.8 FOXA2 MLX ARID4B ZNF48 YY1 TCF12 RXRA SP5 MIER2 PPARG RWDD4 RNU6-479P LOC105377580
GH04I183635 Enhancer 1 Ensembl ENCODE dbSUPER 20 +22.8 22822 3.2 CTCF FOXA2 FOXA3 RAD21 ZNF121 ZNF335 ZFHX2 GATA3 JUND FOSL2 RWDD4 TRAPPC11 RNU6-1053P RNU6-479P LOC105377580
GH04I183468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.7 +189.5 189512 3 SOX13 ZNF211 FOXA2 SAP130 MAX CEBPG RAD21 YY1 ZNF316 NFE2 CDKN2AIP RWDD4 TRAPPC11 ING2 VTI1BP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RWDD4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RWDD4 Gene

Genomic Locations for RWDD4 Gene
chr4:183,639,635-183,659,225
(GRCh38/hg38)
Size:
19,591 bases
Orientation:
Minus strand
chr4:184,560,788-184,580,378
(GRCh37/hg19)

Genomic View for RWDD4 Gene

Genes around RWDD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD4 Gene

Proteins for RWDD4 Gene

  • Protein details for RWDD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NW29-RWDD4_HUMAN
    Recommended name:
    RWD domain-containing protein 4
    Protein Accession:
    Q6NW29
    Secondary Accessions:
    • B2RDE9
    • B4DDP2
    • Q75LA9
    • Q8WVW2

    Protein attributes for RWDD4 Gene

    Size:
    188 amino acids
    Molecular mass:
    21251 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ96848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RWDD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD4 Gene

Post-translational modifications for RWDD4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RWDD4 Gene

Domains & Families for RWDD4 Gene

Gene Families for RWDD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RWDD4 Gene

Suggested Antigen Peptide Sequences for RWDD4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RWDD4: view

No data available for UniProtKB/Swiss-Prot for RWDD4 Gene

Function for RWDD4 Gene

genes like me logo Genes that share phenotypes with RWDD4: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD4 Gene

Localization for RWDD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RWDD4 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RWDD4 Gene

Pathways & Interactions for RWDD4 Gene

SuperPathways for RWDD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RWDD4 Gene

Drugs & Compounds for RWDD4 Gene

No Compound Related Data Available

Transcripts for RWDD4 Gene

Unigene Clusters for RWDD4 Gene

RWD domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for RWDD4 Gene

GeneLoc Exon Structure for
RWDD4
ECgene alternative splicing isoforms for
RWDD4

Expression for RWDD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RWDD4 Gene

Protein differential expression in normal tissues from HIPED for RWDD4 Gene

This gene is overexpressed in Platelet (23.2), Heart (15.9), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RWDD4 Gene



NURSA nuclear receptor signaling pathways regulating expression of RWDD4 Gene:

RWDD4

SOURCE GeneReport for Unigene cluster for RWDD4 Gene:

Hs.133337

Evidence on tissue expression from TISSUES for RWDD4 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RWDD4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RWDD4 Gene

Orthologs for RWDD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD4 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia RWDD4A 34
  • 95 (a)
OneToOne
RWDD4 33
  • 89.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RWDD4 33 34
  • 90.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD4 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd4 33
  • 87.23 (n)
mouse
(Mus musculus)
Mammalia Rwdd4a 33 16 34
  • 85.64 (n)
chicken
(Gallus gallus)
Aves RWDD4 33 34
  • 79.03 (n)
lizard
(Anolis carolinensis)
Reptilia RWDD4 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd4 33
  • 70.39 (n)
Str.10704 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1973 33
zebrafish
(Danio rerio)
Actinopterygii rwdd 33 34
  • 66.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10343 33 34
  • 54.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010019 33
  • 52.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.487 34
  • 47 (a)
OneToOne
Species where no ortholog for RWDD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD4 Gene

ENSEMBL:
Gene Tree for RWDD4 (if available)
TreeFam:
Gene Tree for RWDD4 (if available)

Paralogs for RWDD4 Gene

Pseudogenes.org Pseudogenes for RWDD4 Gene

genes like me logo Genes that share paralogs with RWDD4: view

No data available for Paralogs for RWDD4 Gene

Variants for RWDD4 Gene

Sequence variations from dbSNP and Humsavar for RWDD4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000099024 -- 183,658,427(-) T/C intron_variant
rs10004167 -- 183,657,256(-) A/C intron_variant
rs1000553962 -- 183,655,534(-) T/C intron_variant
rs1000606322 -- 183,655,476(-) G/A intron_variant
rs1000677805 -- 183,643,573(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD4 Gene

Variant ID Type Subtype PubMed ID
nsv830165 CNV loss 17160897
nsv1030766 CNV gain 25217958
nsv1025333 CNV gain 25217958
esv3603445 CNV gain 21293372
esv3603444 CNV loss 21293372
esv2728875 CNV deletion 23290073
esv2728874 CNV deletion 23290073

Variation tolerance for RWDD4 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RWDD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RWDD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD4 Gene

Disorders for RWDD4 Gene

Additional Disease Information for RWDD4

No disorders were found for RWDD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD4 Gene

Publications for RWDD4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for RWDD4 Gene

Sources for RWDD4 Gene

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