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Aliases for RWDD2A Gene

Aliases for RWDD2A Gene

  • RWD Domain Containing 2A 2 3 5
  • RWD Domain Containing 2 2 3
  • RWDD2 3 4
  • RWD Domain-Containing Protein 2A 3
  • DJ747H23.2 3

External Ids for RWDD2A Gene

Previous HGNC Symbols for RWDD2A Gene

  • RWDD2

Previous GeneCards Identifiers for RWDD2A Gene

  • GC06P083959
  • GC06P081131
  • GC06P083903

Summaries for RWDD2A Gene

GeneCards Summary for RWDD2A Gene

RWDD2A (RWD Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is RWDD2B.

Additional gene information for RWDD2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD2A Gene

Genomics for RWDD2A Gene

GeneHancer (GH) Regulatory Elements for RWDD2A Gene

Promoters and enhancers for RWDD2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I083192 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558 +0.1 96 2.4 HDGF SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 RWDD2A PGM3 DOPEY1 ME1 GC06M083097
GH06I083866 Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.8 +674.6 674609 2.3 PKNOX1 FEZF1 ZNF2 CBX5 ZNF213 ZNF302 ZNF416 ZNF143 ZNF548 FOS CEP162 DOPEY1 UBE3D RWDD2A RIPPLY2 CYB5R4 PIR41363 GC06P083900
GH06I083215 Enhancer 1 Ensembl ENCODE 12.1 +22.4 22395 1 RB1 INSM2 ARID4B ZNF2 RAD21 YY1 ZNF143 RCOR1 BCLAF1 RUNX3 PRSS35 PGM3 RWDD2A DOPEY1 UBE3D GC06M083097 GC06P083243 ME1
GH06I083064 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.6 -127.7 -127693 1.7 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 UBE3D RWDD2A PIR40475 GC06M083015
GH06I083221 Enhancer 0.6 FANTOM5 12.8 +28.5 28461 0.2 CTCF ZNF362 ZNF512B KLF16 ZNF512 PRDM1 PRSS35 PGM3 RWDD2A UBE3D GC06M083097 GC06P083243 ME1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RWDD2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RWDD2A gene promoter:

Genomic Locations for RWDD2A Gene

Genomic Locations for RWDD2A Gene
chr6:83,193,313-83,198,932
(GRCh38/hg38)
Size:
5,620 bases
Orientation:
Plus strand
chr6:83,903,032-83,908,651
(GRCh37/hg19)

Genomic View for RWDD2A Gene

Genes around RWDD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD2A Gene

Proteins for RWDD2A Gene

  • Protein details for RWDD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIY3-RWD2A_HUMAN
    Recommended name:
    RWD domain-containing protein 2A
    Protein Accession:
    Q9UIY3
    Secondary Accessions:
    • B4DIQ3
    • E1P548
    • Q2M3R3
    • Q96FH1

    Protein attributes for RWDD2A Gene

    Size:
    292 amino acids
    Molecular mass:
    33893 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RWDD2A Gene

    Alternative splice isoforms for RWDD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD2A Gene

Post-translational modifications for RWDD2A Gene

No Post-translational modifications

Other Protein References for RWDD2A Gene

No data available for DME Specific Peptides for RWDD2A Gene

Domains & Families for RWDD2A Gene

Gene Families for RWDD2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RWDD2A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RWDD2A: view

No data available for UniProtKB/Swiss-Prot for RWDD2A Gene

Function for RWDD2A Gene

Phenotypes From GWAS Catalog for RWDD2A Gene

genes like me logo Genes that share phenotypes with RWDD2A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD2A Gene

Localization for RWDD2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RWDD2A gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
plasma membrane 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RWDD2A Gene

Pathways & Interactions for RWDD2A Gene

SuperPathways for RWDD2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RWDD2A Gene

Drugs & Compounds for RWDD2A Gene

No Compound Related Data Available

Transcripts for RWDD2A Gene

Unigene Clusters for RWDD2A Gene

RWD domain containing 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:
SP2: - -
SP3: -

Relevant External Links for RWDD2A Gene

GeneLoc Exon Structure for
RWDD2A
ECgene alternative splicing isoforms for
RWDD2A

Expression for RWDD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RWDD2A Gene

Protein differential expression in normal tissues from HIPED for RWDD2A Gene

This gene is overexpressed in Retina (44.7), Frontal cortex (15.6), and Spinal cord (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RWDD2A Gene



Protein tissue co-expression partners for RWDD2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RWDD2A Gene:

RWDD2A

SOURCE GeneReport for Unigene cluster for RWDD2A Gene:

Hs.709686

Evidence on tissue expression from TISSUES for RWDD2A Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with RWDD2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RWDD2A Gene

Orthologs for RWDD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD2A 33 34
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia RWDD2A 33 34
  • 92.92 (n)
cow
(Bos Taurus)
Mammalia RWDD2A 33 34
  • 89.84 (n)
rat
(Rattus norvegicus)
Mammalia Rwdd2a 33
  • 87.33 (n)
mouse
(Mus musculus)
Mammalia Rwdd2a 33 16 34
  • 86.99 (n)
oppossum
(Monodelphis domestica)
Mammalia RWDD2A 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD2A 33 34
  • 67.82 (n)
lizard
(Anolis carolinensis)
Reptilia RWDD2A 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd2a 33
  • 65.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011898 33
  • 45.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30338 33 34
  • 45.56 (n)
Species where no ortholog for RWDD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RWDD2A Gene

ENSEMBL:
Gene Tree for RWDD2A (if available)
TreeFam:
Gene Tree for RWDD2A (if available)

Paralogs for RWDD2A Gene

Paralogs for RWDD2A Gene

(1) SIMAP similar genes for RWDD2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RWDD2A: view

Variants for RWDD2A Gene

Sequence variations from dbSNP and Humsavar for RWDD2A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000012132 -- 83,192,683(+) T/C upstream_transcript_variant
rs1000123695 -- 83,198,869(+) G/T 3_prime_UTR_variant
rs1000848297 -- 83,197,677(+) T/C 3_prime_UTR_variant
rs1000972192 -- 83,193,351(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001152535 -- 83,191,738(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD2A Gene

Variant ID Type Subtype PubMed ID
nsv1026095 CNV gain 25217958

Variation tolerance for RWDD2A Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RWDD2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RWDD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD2A Gene

Disorders for RWDD2A Gene

Additional Disease Information for RWDD2A

No disorders were found for RWDD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD2A Gene

Publications for RWDD2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for RWDD2A Gene

Sources for RWDD2A Gene

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