Aliases for RWDD2A Gene

Aliases for RWDD2A Gene

  • RWD Domain Containing 2A 2 3 5
  • RWD Domain-Containing Protein 2A 3 4
  • RWD Domain Containing 2 2 3
  • RWDD2 3 4
  • DJ747H23.2 3

External Ids for RWDD2A Gene

Previous HGNC Symbols for RWDD2A Gene

  • RWDD2

Previous GeneCards Identifiers for RWDD2A Gene

  • GC06P083959
  • GC06P081131
  • GC06P083903

Summaries for RWDD2A Gene

GeneCards Summary for RWDD2A Gene

RWDD2A (RWD Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is RWDD2B.

Additional gene information for RWDD2A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RWDD2A Gene

Genomics for RWDD2A Gene

GeneHancer (GH) Regulatory Elements for RWDD2A Gene

Promoters and enhancers for RWDD2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J083190 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 768.2 -0.7 -687 5.2 SP1 ZBTB40 MLX POLR2A ZNF362 MYC NFYC ELF1 L3MBTL2 DACH1 RWDD2A PGM3 lnc-ME1-1 DOP1A ME1 lnc-ME1-2 RF00017-5643
GH06J083065 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15 -125.0 -124991 9 ZNF785 ZNF24 SP1 CTCF ZBTB6 RBPJ POLR2A USF2 NR2F6 CREB1 DOP1A UBE3D RWDD2A SNAP91 RF00017-5643 lnc-PGM3-1
GH06J082259 Enhancer 1.1 Ensembl ENCODE 12 -932.3 -932261 4.9 ZBTB6 CTBP1 ZNF362 ZNF121 BCL6B ZNF384 SP7 ZSCAN21 PRDM1 KLF14 DOP1A UBE3D IBTK LOC100132659 TPBG RWDD2A PGM3 lnc-IBTK-4 lnc-TPBG-8
GH06J082875 Enhancer 1 Ensembl ENCODE 12 -316.7 -316712 3.2 BCL6B MAFK SP7 ZSCAN21 FOSL2 PKNOX1 ZIC2 POLR2A ZBTB8A PRDM10 RWDD2A DOP1A RF00017-5642 lnc-PGM3-3
GH06J083215 Enhancer 0.9 Ensembl ENCODE 12.1 +22.3 22318 1.2 CTCF CC2D1A HLF RAD21 TEAD4 CEBPG SP7 CEBPA REST TRIM22 PRSS35 PGM3 RWDD2A DOP1A UBE3D HE855980 piR-52294-121 ME1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RWDD2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RWDD2A gene promoter:
  • AML1a
  • ATF6
  • Msx-1
  • MyoD
  • Pax-2
  • Pax-2a
  • POU3F2
  • RORalpha1
  • Sox9
  • YY1

Genomic Locations for RWDD2A Gene

Genomic Locations for RWDD2A Gene
chr6:83,193,313-83,198,935
(GRCh38/hg38)
Size:
5,623 bases
Orientation:
Plus strand
chr6:83,903,032-83,908,651
(GRCh37/hg19)
Size:
5,620 bases
Orientation:
Plus strand

Genomic View for RWDD2A Gene

Genes around RWDD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD2A Gene

Proteins for RWDD2A Gene

  • Protein details for RWDD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIY3-RWD2A_HUMAN
    Recommended name:
    RWD domain-containing protein 2A
    Protein Accession:
    Q9UIY3
    Secondary Accessions:
    • B4DIQ3
    • E1P548
    • Q2M3R3
    • Q96FH1

    Protein attributes for RWDD2A Gene

    Size:
    292 amino acids
    Molecular mass:
    33893 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RWDD2A Gene

    Alternative splice isoforms for RWDD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD2A Gene

Post-translational modifications for RWDD2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RWDD2A Gene

No data available for DME Specific Peptides for RWDD2A Gene

Domains & Families for RWDD2A Gene

Gene Families for RWDD2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RWDD2A Gene

Suggested Antigen Peptide Sequences for RWDD2A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58360, highly similar to RWD domain-containing protein 2 (B4DIQ3_HUMAN)
  • RWD domain-containing protein 2A (RWD2A_HUMAN)
genes like me logo Genes that share domains with RWDD2A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RWDD2A Gene

Function for RWDD2A Gene

Phenotypes From GWAS Catalog for RWDD2A Gene

genes like me logo Genes that share phenotypes with RWDD2A: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD2A Gene

Localization for RWDD2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RWDD2A gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RWDD2A Gene

Pathways & Interactions for RWDD2A Gene

PathCards logo

SuperPathways for RWDD2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RWDD2A Gene

Drugs & Compounds for RWDD2A Gene

No Compound Related Data Available

Transcripts for RWDD2A Gene

mRNA/cDNA for RWDD2A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:
SP2: - -
SP3: -

Relevant External Links for RWDD2A Gene

GeneLoc Exon Structure for
RWDD2A
ECgene alternative splicing isoforms for
RWDD2A

Expression for RWDD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RWDD2A Gene

Protein differential expression in normal tissues from HIPED for RWDD2A Gene

This gene is overexpressed in Retina (44.7), Frontal cortex (15.6), and Spinal cord (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RWDD2A Gene



Protein tissue co-expression partners for RWDD2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RWDD2A Gene:

RWDD2A

SOURCE GeneReport for Unigene cluster for RWDD2A Gene:

Hs.709686

Evidence on tissue expression from TISSUES for RWDD2A Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with RWDD2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RWDD2A Gene

Orthologs for RWDD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD2A 33 32
  • 99.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RWDD2A 33 32
  • 92.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RWDD2A 33 32
  • 89.84 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd2a 32
  • 87.33 (n)
mouse
(Mus musculus)
Mammalia Rwdd2a 17 33 32
  • 86.99 (n)
oppossum
(Monodelphis domestica)
Mammalia RWDD2A 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD2A 33 32
  • 67.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RWDD2A 33
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd2a 32
  • 65.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011898 32
  • 45.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30338 33 32
  • 45.56 (n)
OneToMany
Species where no ortholog for RWDD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RWDD2A Gene

ENSEMBL:
Gene Tree for RWDD2A (if available)
TreeFam:
Gene Tree for RWDD2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RWDD2A: view image

Paralogs for RWDD2A Gene

Paralogs for RWDD2A Gene

(1) SIMAP similar genes for RWDD2A Gene using alignment to 2 proteins:

  • RWD2A_HUMAN
  • B4DIQ3_HUMAN
genes like me logo Genes that share paralogs with RWDD2A: view

Variants for RWDD2A Gene

Sequence variations from dbSNP and Humsavar for RWDD2A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000012132 -- 83,192,683(+) T/C upstream_transcript_variant
rs1000123695 -- 83,198,869(+) G/T 3_prime_UTR_variant
rs1000848297 -- 83,197,677(+) T/C 3_prime_UTR_variant
rs1000972192 -- 83,193,351(+) C/A/T upstream_transcript_variant
rs1001152535 -- 83,191,738(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD2A Gene

Variant ID Type Subtype PubMed ID
nsv1026095 CNV gain 25217958

Variation tolerance for RWDD2A Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RWDD2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RWDD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD2A Gene

Disorders for RWDD2A Gene

Additional Disease Information for RWDD2A

No disorders were found for RWDD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD2A Gene

Publications for RWDD2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56

Products for RWDD2A Gene

Sources for RWDD2A Gene