Aliases for RUNX3 Gene
Aliases for RUNX3 Gene
- Runt Related Transcription Factor 3 2 3 5
- Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit 3 4
- SL3/AKV Core-Binding Factor Alpha C Subunit 3 4
- SL3-3 Enhancer Factor 1 Alpha C Subunit 3 4
- Core-Binding Factor Subunit Alpha-3 3 4
- Runt-Related Transcription Factor 3 2 3
- Acute Myeloid Leukemia 2 Protein 3 4
- Oncogene AML-2 3 4
- CBF-Alpha-3 3 4
- CBFA3 3 4
- AML2 3 4
External Ids for RUNX3 Gene
- HGNC: 10473
- Entrez Gene: 864
- Ensembl: ENSG00000020633
- OMIM: 600210
- UniProtKB: Q13761
Previous HGNC Symbols for RUNX3 Gene
- CBFA3
Previous GeneCards Identifiers for RUNX3 Gene
- GC01M024749
- GC01M024294
- GC01M024205
- GC01M024577
- GC01M024971
- GC01M025098
- GC01M025226
- GC01M023479
Summaries for RUNX3 Gene
-
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for RUNX3 Gene
RUNX3 (Runt Related Transcription Factor 3) is a Protein Coding gene. Diseases associated with RUNX3 include Testicular Yolk Sac Tumor and Cleidocranial Dysplasia. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RUNX2.
UniProtKB/Swiss-Prot for RUNX3 Gene
-
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5-TGTGGT-3, or very rarely, 5-TGCGGT-3, within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
Additional gene information for RUNX3 Gene
- Monarch Initiative
- Search for RUNX3 at DataMed
- Search for RUNX3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNX3 Gene
Genomics for RUNX3 Gene
GeneHancer (GH) Regulatory Elements for RUNX3 Gene
Promoters and enhancers for RUNX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RUNX3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RUNX3 gene promoter:
-
- STAT3
- p300
- STAT2
- STAT1beta
- STAT1alpha
- STAT1
Regulatory Element Products
Genomic Locations for RUNX3 Gene
Genomic Locations for RUNX3 Gene
- chr1:24,899,511-24,965,157
- (GRCh38/hg38)
- Size:
- 65,647 bases
- Orientation:
- Minus strand
- chr1:25,226,002-25,291,612
- (GRCh37/hg19)
- Size:
- 65,611 bases
- Orientation:
- Minus strand
Genomic View for RUNX3 Gene
Genes around RUNX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
- 1p36.11 by Ensembl
RUNX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUNX3 Gene
Proteins for RUNX3 Gene
-
Protein details for RUNX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13761-RUNX3_HUMAN
- Recommended name:
- Runt-related transcription factor 3
- Protein Accession:
- Q13761
- B1AJV5
- Q12969
- Q13760
Protein attributes for RUNX3 Gene
- Size:
- 415 amino acids
- Molecular mass:
- 44356 Da
- Quaternary structure:
-
- Heterodimer with CBFB. RUNX3 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization (By similarity). Interacts with TLE1 and SUV39H1 (PubMed:9751710 and PubMed:16652147). The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain)(PubMed:20100835). Interacts with FYN and LCK (PubMed:20100835). Interacts with FOXP3 (PubMed:17377532). Interacts with ZFHX3 (PubMed:20599712). Interacts with TBX21 (By similarity).
Protein Expression for RUNX3 Gene
Post-translational modifications for RUNX3 Gene
- Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RUNX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
- Novus Biologicals Antibodies for RUNX3
-
Abcam antibodies for RUNX3
- Invitrogen Antibodies for RUNX3
- GeneTex RUNX3 Antibody for RUNX3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
Protein Products
-
OriGene Purified Proteins for RUNX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX3
- Origene Custom Protein Services for RUNX3
- ProSpec Recombinant Proteins for RUNX3
- Search GeneTex for Proteins for RUNX3
-
Abcam proteins for RUNX3
Assay Products
- antibodies-online: Search results for 2 available RUNX3 Elisa Kits ranked by validation data
- Compare Top RUNX3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RUNX3 Gene
Domains & Families for RUNX3 Gene
Gene Families for RUNX3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RUNX3 Gene
Suggested Antigen Peptide Sequences for RUNX3 Gene
Graphical View of Domain Structure for InterPro Entry
Q13761UniProtKB/Swiss-Prot:
RUNX3_HUMAN :- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
- Domain:
-
- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Function for RUNX3 Gene
Molecular function for RUNX3 Gene
- UniProtKB/Swiss-Prot Function:
- Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5-TGTGGT-3, or very rarely, 5-TGCGGT-3, within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
- GENATLAS Biochemistry:
- Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid cells,involved in hematopoiesis and osteogenesis
Phenotypes From GWAS Catalog for RUNX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS,ISS | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 7607690 |
| GO:0005515 | protein binding | IPI | 9751710 |
Phenotypes for RUNX3 Gene
- MGI mutant phenotypes for RUNX3:
-
inferred from 9 alleles
- respiratory system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for RUNX3:
Animal Models for RUNX3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX3
-
CRISPR Products
-
OriGene CRISPR knockouts for RUNX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- Applied Biological Materials CRISPR for RUNX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- GenScript: Design CRISPR guide RNA sequences for RUNX3
miRNA for RUNX3 Gene
- miRTarBase miRNAs that target RUNX3
-
- hsa-mir-532-5p (MIRT000038)
- hsa-mir-130b-3p (MIRT003316)
- hsa-mir-130a-3p (MIRT007055)
- hsa-mir-301a-3p (MIRT007295)
- hsa-mir-148b-3p (MIRT019365)
- hsa-mir-93-5p (MIRT028012)
- hsa-mir-148a-3p (MIRT053518)
- hsa-mir-106a-5p (MIRT053564)
- hsa-mir-106b-5p (MIRT437468)
- hsa-mir-218-5p (MIRT439719)
- hsa-mir-5011-3p (MIRT561630)
- hsa-mir-6894-5p (MIRT561631)
- hsa-mir-765 (MIRT561632)
- hsa-mir-7154-3p (MIRT561633)
- hsa-mir-766-5p (MIRT561634)
- hsa-mir-133a-5p (MIRT561635)
- hsa-mir-4487 (MIRT561636)
- hsa-mir-558 (MIRT561637)
- hsa-mir-3160-3p (MIRT561638)
- hsa-mir-4490 (MIRT561639)
- hsa-mir-4802-5p (MIRT561640)
- hsa-mir-519c-3p (MIRT561641)
- hsa-mir-519b-3p (MIRT561642)
- hsa-mir-519a-3p (MIRT561643)
- hsa-mir-4796-3p (MIRT561644)
- hsa-mir-3609 (MIRT561645)
- hsa-mir-548ah-5p (MIRT561646)
- hsa-mir-519d-3p (MIRT561647)
- hsa-mir-526b-3p (MIRT561648)
- hsa-mir-20b-5p (MIRT561649)
- hsa-mir-20a-5p (MIRT561650)
- hsa-mir-17-5p (MIRT561651)
- hsa-mir-6753-3p (MIRT565938)
- hsa-mir-7107-3p (MIRT565939)
- hsa-mir-20b-3p (MIRT565940)
- hsa-mir-3137 (MIRT565941)
- hsa-mir-6803-5p (MIRT568933)
- hsa-mir-6751-5p (MIRT568934)
- hsa-mir-615-5p (MIRT568935)
- hsa-mir-7110-5p (MIRT568936)
- hsa-mir-6842-5p (MIRT568937)
- hsa-mir-6752-5p (MIRT568938)
- hsa-mir-6835-5p (MIRT568939)
- hsa-mir-6887-5p (MIRT568940)
- hsa-mir-4697-5p (MIRT568941)
- hsa-mir-6795-5p (MIRT568942)
- hsa-mir-4488 (MIRT568943)
- hsa-mir-7111-5p (MIRT568944)
- hsa-mir-1237-5p (MIRT568945)
- hsa-mir-6870-5p (MIRT568946)
- hsa-mir-5698 (MIRT568947)
- hsa-mir-4723-5p (MIRT568948)
- hsa-mir-3175 (MIRT568949)
- hsa-mir-8085 (MIRT568950)
- hsa-mir-6731-5p (MIRT568951)
- hsa-mir-4731-5p (MIRT568952)
- hsa-mir-6805-5p (MIRT568953)
- hsa-mir-637 (MIRT568954)
- hsa-mir-495-3p (MIRT731247)
- hsa-mir-4295 (MIRT734873)
- hsa-mir-375 (MIRT735148)
- hsa-mir-3180-3p (MIRT740786)
- hsa-mir-3180 (MIRT740826)
- hsa-mir-3196 (MIRT741084)
- hsa-mir-6816-5p (MIRT756812)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
- Applied Biological Materials Clones for RUNX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNX3 Gene
Localization for RUNX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUNX3 Gene
- Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269 PubMed:20599712}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISS | -- |
| GO:0005634 | nucleus | IDA | 20100835 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 20100835 |
Pathways & Interactions for RUNX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Wnt / Hedgehog / Notch | ||
| 3 | Dendritic Cells Developmental Lineage Pathway | ||
| 4 | Notch signaling pathway (KEGG) | ||
| 5 | TGF-beta Signaling Pathways | ||
Pathways by source for RUNX3 Gene
3 BioSystems pathways for RUNX3 Gene
1 KEGG pathway for RUNX3 Gene
3 R&D Systems pathways for RUNX3 Gene
1 Cell Signaling Technology pathway for RUNX3 Gene
Interacting Proteins for RUNX3 Gene
Selected Interacting proteins:
Q13761-RUNX3_HUMAN
ENSP00000343477
for RUNX3 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for RUNX3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001503 | ossification | IBA | -- |
| GO:0002062 | chondrocyte differentiation | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 7622058 |
Transcripts for RUNX3 Gene
mRNA/cDNA for RUNX3 Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (168) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000399916 4340 bps (uc001bjr.3)
- ENST00000479341 284 bps (uc057dkr.1)
- ENST00000496967 572 bps (uc057dkq.1)
- ENST00000338888 2629 bps (uc009vrj.4)
- ENST00000308873 3861 bps (uc001bjq.4)
Unigene Clusters for RUNX3 Gene
- Runt-related transcription factor 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RUNX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- Applied Biological Materials CRISPR for RUNX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- GenScript: Design CRISPR guide RNA sequences for RUNX3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
- Applied Biological Materials Clones for RUNX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RUNX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
- Brain (Nervous System)
- Melanocytes (Integumentary System)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- T-Cytotoxic Cells Thymus
- Hematopoietic Bone Marrow
- Limb (Muscoskeletal System)
- Tonsil (Hematopoietic System)
- Epidermis (Integumentary System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dentin
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
- Thymus
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Gut Tube (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Eye (Sensory Organs)
- Adipose (Muscoskeletal System)
- NULL (Integumentary System)
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for RUNX3 Gene
This gene is overexpressed in Whole Blood (x16.1) and Spleen (x4.8).
This gene is overexpressed in NK cells (28.2), Peripheral blood mononuclear cells (15.7), CD8 Tcells (10.1), and CD4 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RUNX3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RUNX3 Gene:
RUNX3SOURCE GeneReport for Unigene cluster for RUNX3 Gene:
Hs.170019mRNA Expression by UniProt/SwissProt for RUNX3 Gene:
Q13761-RUNX3_HUMAN
Tissue specificity:
Expressed in gastric cancer tissues (at protein level).
Evidence on tissue expression from TISSUES for RUNX3 Gene
- Skin(4.3)
- Blood(2.8)
- Intestine(2.6)
- Lymph node(2.6)
- Stomach(2.5)
- Bone marrow(2.4)
- Spleen(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for RUNX3
- genomics-online: primer clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNX3 Gene
Orthologs for RUNX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RUNX3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC487366 33 |
|
||
| RUNX3 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | RUNX3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Runx3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Runx3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | RUNX3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RUNX3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RUNX3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | runx3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | runx3 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1379 35 |
|
|
|
| CG15455 35 |
|
|
|||
| run 34 35 |
|
ManyToMany | |||
| RunxA 34 |
|
ManyToMany | |||
| RunxB 34 |
|
ManyToMany | |||
| lz 34 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rnt-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for RUNX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RUNX3 Gene
- ENSEMBL:
- Gene Tree for RUNX3 (if available)
- TreeFam:
- Gene Tree for RUNX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RUNX3: view image
Paralogs for RUNX3 Gene
(6) SIMAP similar genes for RUNX3 Gene using alignment to 2 proteins:
- RUNX3_HUMAN
- F5H4J4_HUMAN
Variants for RUNX3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000081063 | -- | 24,956,278(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000100250 | -- | 24,918,414(-) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000174179 | -- | 24,902,864(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000295993 | -- | 24,945,474(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000302882 | -- | 24,940,645(-) | G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv508581 | CNV | deletion | 20534489 |
| nsv1136070 | CNV | deletion | 24896259 |
| nsv1077252 | CNV | deletion | 25765185 |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUNX3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNX3 Gene
Disorders for RUNX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| testicular yolk sac tumor |
|
|
| cleidocranial dysplasia |
|
|
| inflammatory bowel disease 7 |
|
|
| atrophic gastritis |
|
|
| gastric cancer |
|
Search RUNX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RUNX3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RUNX3 Gene
Publications for RUNX3 Gene
- Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population. (PMID: 20392673) Guo C … Ding J (Clinical immunology (Orlando, Fla.) 2010) 3 22 44 58
- Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PMID: 20100835) Goh YM … Bae SC (The Journal of biological chemistry 2010) 3 4 22 58
- Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. (PMID: 18684727) Zhang Z … Zhang Z (Carcinogenesis 2008) 3 22 44 58
- [The relationship between RUNX3 gene mutation and keloid]. (PMID: 18717361) Zhang G … Yu Q (Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 2008) 3 22 44 58
- AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. (PMID: 7835892) Levanon D … Groner Y (Genomics 1994) 2 3 4 58
Products for RUNX3 Gene
- R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RUNX3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RUNX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX3
- Origene Custom Protein Services for RUNX3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- OriGene qPCR primer pairs for RUNX3
- OriGene CRISPR knockouts for RUNX3
- OriGene ORF clones in human for RUNX3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RUNX3
- GenScript: Next-day shipping of latest version cDNA ORF clones for RUNX3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RUNX3
- GenScript Custom Assay Services for RUNX3
- GenScript Custom overexpressing Cell Line Services for RUNX3
- GenScript: Design CRISPR guide RNA sequences for RUNX3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RUNX3
- Sino Biological Human cDNA Clone for RUNX3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RUNX3
- Novus Biologicals lysates and proteins for RUNX3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RUNX3
- Abcam proteins for RUNX3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for RUNX3
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 218 available RUNX3 Antibodies ranked by validation data
- Compare Top RUNX3 Antibodies
- antibodies-online: Search results for 2 available RUNX3 Elisa Kits ranked by validation data
- Compare Top RUNX3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 13 available RUNX3 Proteins ranked by validation data
- Compare Top RUNX3 Proteins
- GeneTex RUNX3 Antibody for RUNX3
- Search GeneTex for Proteins for RUNX3
- Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
- Search Santa Cruz Biotechnology (SCBT) for RUNX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- Horizon Cell Lines for RUNX3
- genomics-online: cdna clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- orf clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: primer clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
- GeneCopoeia miRNA 3'UTR Target clone products for RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
Sources for RUNX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt