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This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor s... See more...
Aliases for RUNX3 Gene
Aliases for RUNX3 Gene
- RUNX Family Transcription Factor 3 2 3 5
- Runt-Related Transcription Factor 3 2 3 4
- AML2 2 3 4
- Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit 3 4
- SL3/AKV Core-Binding Factor Alpha C Subunit 3 4
- SL3-3 Enhancer Factor 1 Alpha C Subunit 3 4
- Runt Related Transcription Factor 3 2 3
- Core-Binding Factor Subunit Alpha-3 3 4
- Acute Myeloid Leukemia 2 Protein 3 4
- Oncogene AML-2 3 4
- CBF-Alpha-3 3 4
External Ids for RUNX3 Gene
- HGNC: 10473
- NCBI Entrez Gene: 864
- Ensembl: ENSG00000020633
- OMIM®: 600210
- UniProtKB/Swiss-Prot: Q13761
Previous HGNC Symbols for RUNX3 Gene
- CBFA3
Previous GeneCards Identifiers for RUNX3 Gene
- GC01M024749
- GC01M024294
- GC01M024205
- GC01M024577
- GC01M024971
- GC01M025098
- GC01M025226
- GC01M023479
Summaries for RUNX3 Gene
-
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for RUNX3 Gene
RUNX3 (RUNX Family Transcription Factor 3) is a Protein Coding gene. Diseases associated with RUNX3 include Testicular Yolk Sac Tumor and Cleidocranial Dysplasia. Among its related pathways are Endochondral Ossification and Measles. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RUNX1.
UniProtKB/Swiss-Prot Summary for RUNX3 Gene
-
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
Additional gene information for RUNX3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RUNX3 Gene
Genomics for RUNX3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RUNX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RUNX3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RUNX3
- Top Transcription factor binding sites by QIAGEN in the RUNX3 gene promoter:
-
- p300
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
Genomic Locations for RUNX3 Gene
Latest Assembly
- chr1:24,899,511-24,965,158
- (GRCh38/hg38)
- Size:
- 65,648 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:25,226,002-25,291,501
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 65,500 bases
- Orientation:
- Minus strand
Genomic View for RUNX3 Gene
Genes around RUNX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by HGNC
- 1p36.11 by Entrez Gene
- 1p36.11 by Ensembl
RUNX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUNX3 Gene
Proteins for RUNX3 Gene
-
Protein details for RUNX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13761-RUNX3_HUMAN
- Recommended name:
- Runt-related transcription factor 3
- Protein Accession:
- Q13761
- B1AJV5
- Q12969
- Q13760
Protein attributes for RUNX3 Gene
- Size:
- 415 amino acids
- Molecular mass:
- 44356 Da
- Quaternary structure:
-
- Heterodimer with CBFB. RUNX3 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization (By similarity). Interacts with TLE1 and SUV39H1 (PubMed:9751710 and PubMed:16652147). The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain)(PubMed:20100835). Interacts with FYN and LCK (PubMed:20100835). Interacts with FOXP3 (PubMed:17377532). Interacts with ZFHX3 (PubMed:20599712). Interacts with TBX21 (By similarity).
Protein Expression for RUNX3 Gene
Post-translational modifications for RUNX3 Gene
- Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RUNX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RUNX3 Monoclonal Antibody and RUNX3 Antibody
- NSJ Bioreagents RUNX3 Antibody
- Novus Biologicals Antibodies for RUNX3
-
Abcam antibodies for RUNX3
- Invitrogen Antibodies for RUNX3 (AFLGC-RUNX3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
- Sino Biological Antibodies for RUNX3
Protein products for research
-
OriGene Purified Proteins for RUNX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX3
- Origene Custom Protein Services for RUNX3
- ProSpec Recombinant Proteins for RUNX3
- antibodies-online: Show 12 available RUNX3 Proteins ranked by validation data
- Compare Top RUNX3 Proteins
-
Quality Products:
-
Abcam proteins for RUNX3
Assay products for research
- antibodies-online: Show 5 available RUNX3 Elisa Kits ranked by validation data
- Compare Top RUNX3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RUNX3 Gene
Domains & Families for RUNX3 Gene
Gene Families for RUNX3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RUNX3 Gene
- InterPro:
- Blocks:
-
- Acute myeloid leukemia 1 protein signature
- Runx inhibition
Suggested Antigen Peptide Sequences for RUNX3 Gene
- GenScript: Design optimal peptide antigens:
-
- Runt-related transcription factor 3, isoform CRA_b (B1AJV5_HUMAN)
- Transcription factor AML2 (O14814_HUMAN)
- Core binding factor alpha 3 subunit (Q9Y3R8_HUMAN)
- SL3/AKV core-binding factor alpha C subunit (RUNX3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13761UniProtKB/Swiss-Prot:
RUNX3_HUMAN :- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
- Domain:
-
- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Function for RUNX3 Gene
Molecular function for RUNX3 Gene
- UniProtKB/Swiss-Prot Function:
- Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
- GENATLAS Biochemistry:
- Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid cells,involved in hematopoiesis and osteogenesis
Phenotypes From GWAS Catalog for RUNX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 7607690 |
Phenotypes for RUNX3 Gene
- MGI mutant phenotypes for RUNX3:
-
inferred from 11 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- integument phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RUNX3:
Animal Models for RUNX3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RUNX3 - Starting at $85 >
- * RUNX3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RUNX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
miRNA for RUNX3 Gene
- miRTarBase miRNAs that target RUNX3
-
- hsa-miR-532-5p (MIRT000038)
- hsa-miR-130b-3p (MIRT003316)
- hsa-miR-130a-3p (MIRT007055)
- hsa-miR-301a-3p (MIRT007295)
- hsa-miR-148b-3p (MIRT019365)
- hsa-miR-93-5p (MIRT028012)
- hsa-miR-148a-3p (MIRT053518)
- hsa-miR-106a-5p (MIRT053564)
- hsa-miR-106b-5p (MIRT437468)
- hsa-miR-218-5p (MIRT439719)
- hsa-miR-5011-3p (MIRT561630)
- hsa-miR-6894-5p (MIRT561631)
- hsa-miR-765 (MIRT561632)
- hsa-miR-7154-3p (MIRT561633)
- hsa-miR-766-5p (MIRT561634)
- hsa-miR-133a-5p (MIRT561635)
- hsa-miR-4487 (MIRT561636)
- hsa-miR-558 (MIRT561637)
- hsa-miR-3160-3p (MIRT561638)
- hsa-miR-4490 (MIRT561639)
- hsa-miR-4802-5p (MIRT561640)
- hsa-miR-519c-3p (MIRT561641)
- hsa-miR-519b-3p (MIRT561642)
- hsa-miR-519a-3p (MIRT561643)
- hsa-miR-4796-3p (MIRT561644)
- hsa-miR-3609 (MIRT561645)
- hsa-miR-548ah-5p (MIRT561646)
- hsa-miR-519d-3p (MIRT561647)
- hsa-miR-526b-3p (MIRT561648)
- hsa-miR-20b-5p (MIRT561649)
- hsa-miR-20a-5p (MIRT561650)
- hsa-miR-17-5p (MIRT561651)
- hsa-miR-6753-3p (MIRT565938)
- hsa-miR-7107-3p (MIRT565939)
- hsa-miR-20b-3p (MIRT565940)
- hsa-miR-3137 (MIRT565941)
- hsa-miR-6803-5p (MIRT568933)
- hsa-miR-6751-5p (MIRT568934)
- hsa-miR-615-5p (MIRT568935)
- hsa-miR-7110-5p (MIRT568936)
- hsa-miR-6842-5p (MIRT568937)
- hsa-miR-6752-5p (MIRT568938)
- hsa-miR-6835-5p (MIRT568939)
- hsa-miR-6887-5p (MIRT568940)
- hsa-miR-4697-5p (MIRT568941)
- hsa-miR-6795-5p (MIRT568942)
- hsa-miR-4488 (MIRT568943)
- hsa-miR-7111-5p (MIRT568944)
- hsa-miR-1237-5p (MIRT568945)
- hsa-miR-6870-5p (MIRT568946)
- hsa-miR-5698 (MIRT568947)
- hsa-miR-4723-5p (MIRT568948)
- hsa-miR-3175 (MIRT568949)
- hsa-miR-8085 (MIRT568950)
- hsa-miR-6731-5p (MIRT568951)
- hsa-miR-4731-5p (MIRT568952)
- hsa-miR-6805-5p (MIRT568953)
- hsa-miR-637 (MIRT568954)
- mmu-miR-466l-5p (MIRT592126)
- mmu-miR-466i-5p (MIRT592127)
- mmu-miR-466d-5p (MIRT592128)
- mmu-miR-466k (MIRT592129)
- mmu-miR-1943-5p (MIRT593023)
- mmu-miR-185-5p (MIRT597379)
- mmu-miR-3473a (MIRT597380)
- mmu-miR-882 (MIRT597381)
- hsa-miR-495-3p (MIRT731247)
- mmu-miR-210-3p (MIRT732826)
- hsa-miR-4295 (MIRT734873)
- hsa-miR-375 (MIRT735148)
- hsa-miR-3180-3p (MIRT740786)
- hsa-miR-3180 (MIRT740826)
- hsa-miR-3196 (MIRT741084)
- hsa-miR-6816-5p (MIRT756812)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
Clone products for research
- Applied Biological Materials (abm): Clones for RUNX3 - Starting at $45 >
- * RUNX3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RUNX3
- Addgene plasmids for RUNX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
Cell Lines for research
-
Horizon Cell Lines for RUNX3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNX3 Gene
Localization for RUNX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUNX3 Gene
- Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269 PubMed:20599712}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISS | -- |
| GO:0005634 | nucleus | IDA | 20100835 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 20100835 |
Pathways & Interactions for RUNX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Wnt / Hedgehog / Notch | ||
| 2 | Measles | ||
| 3 | Th17 cell differentiation | ||
| 4 | Dendritic Cells Developmental Lineage Pathway | ||
| 5 | Notch Signaling Pathway (WikiPathways) | ||
Pathways by source for RUNX3 Gene
3 BioSystems pathways for RUNX3 Gene
2 KEGG pathways for RUNX3 Gene
3 R&D Systems pathways for RUNX3 Gene
1 Cell Signaling Technology pathway for RUNX3 Gene
Interacting Proteins for RUNX3 Gene
Selected Interacting proteins:
Q13761-RUNX3_HUMAN
ENSP00000382800
for RUNX3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RUNX3
SIGNOR curated interactions for RUNX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001503 | ossification | IBA | 21873635 |
| GO:0002062 | chondrocyte differentiation | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 7622058 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
Transcripts for RUNX3 Gene
mRNA/cDNA for RUNX3 Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308873 4267 nts (view in UCSC)
- ENST00000338888 2629 nts (view in UCSC)
- ENST00000399916 4340 nts (view in UCSC)
- ENST00000479341 284 nts (view in UCSC)
- ENST00000496967 572 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RUNX3 - Starting at $85 >
- * RUNX3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RUNX3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
Clone products for research
- Applied Biological Materials (abm): Clones for RUNX3 - Starting at $45 >
- * RUNX3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RUNX3
- Addgene plasmids for RUNX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
Relevant External Links for RUNX3 Gene
- GeneLoc Exon Structure for
- RUNX3
Expression for RUNX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
- Brain (Nervous System)
- Melanocytes (Integumentary System)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- T-Cytotoxic Cells Thymus
- Hematopoietic Bone Marrow
- Limb (Muscoskeletal System)
- Tonsil (Hematopoietic System)
- Epidermis (Integumentary System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dentin
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
- Thymus
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Gut Tube (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Eye (Sensory Organs)
- NULL (Integumentary System)
- Epithelial Cells (Uncategorized)
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for RUNX3 Gene
This gene is overexpressed in Whole Blood (x16.1) and Spleen (x4.8).
This gene is overexpressed in NK cells (28.2), Peripheral blood mononuclear cells (15.7), CD8 Tcells (10.1), and CD4 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RUNX3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RUNX3
SOURCE GeneReport for Unigene cluster for RUNX3 Gene:
Hs.170019mRNA Expression by UniProt/SwissProt for RUNX3 Gene:
Q13761-RUNX3_HUMAN
Tissue specificity:
Expressed in gastric cancer tissues (at protein level).
Evidence on tissue expression from TISSUES for RUNX3 Gene
- Skin(4.5)
- Blood(3.1)
- Lymph node(2.9)
- Intestine(2.9)
- Bone marrow(2.8)
- Spleen(2.8)
- Stomach(2.6)
- Lung(2.3)
- Muscle(2.1)
- Liver(2.1)
- Nervous system(2)
Primer products for research
-
OriGene qPCR primer pairs for RUNX3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNX3 Gene
Orthologs for RUNX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RUNX3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC487366 29 |
|
||
| RUNX3 30 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | RUNX3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Runx3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Runx3 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | RUNX3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RUNX3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RUNX3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | runx3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | runx3 29 30 |
|
OneToOne | |
| -- 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1379 31 |
|
|
|
| CG15455 31 |
|
|
|||
| run 30 31 |
|
ManyToMany | |||
| RunxA 30 |
|
ManyToMany | |||
| RunxB 30 |
|
ManyToMany | |||
| lz 30 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | rnt-1 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for RUNX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RUNX3 Gene
- ENSEMBL:
- Gene Tree for RUNX3 (if available)
- TreeFam:
- Gene Tree for RUNX3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RUNX3: view image
- Alliance of Genome Resources:
- Additional Orthologs for RUNX3
Paralogs for RUNX3 Gene
(6) SIMAP similar genes for RUNX3 Gene using alignment to 2 proteins:
- RUNX3_HUMAN
- F5H4J4_HUMAN
Variants for RUNX3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RUNX3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114583699 | Benign: not provided | 24,927,713(-) |
G/A NM_004350.3(RUNX3):c.300C>T (p.Asp100=) |
SYNONYMOUS | |
| rs143410594 | Benign: not provided | 24,964,515(-) |
G/T NM_001031680.2(RUNX3):c.57C>A (p.Arg19=) |
SYNONYMOUS | |
| rs573389125 | Benign: not provided | 24,902,248(-) |
G/A NM_004350.3(RUNX3):c.1122C>T (p.Gly374=) |
SYNONYMOUS | |
| rs771649356 | Likely Benign: not provided | 24,907,249(-) |
C/T NM_004350.3(RUNX3):c.703+10G>A |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1077252 | CNV | deletion | 25765185 |
| nsv1136070 | CNV | deletion | 24896259 |
| nsv508581 | CNV | deletion | 20534489 |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUNX3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNX3 Gene
Disorders for RUNX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| testicular yolk sac tumor |
|
|
| cleidocranial dysplasia |
|
|
| leukemia |
|
|
| myeloid leukemia |
|
|
| gastric cancer |
|
|
Search RUNX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RUNX3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RUNX3 Gene
Publications for RUNX3 Gene
- Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PMID: 20100835) Goh YM … Bae SC (The Journal of biological chemistry 2010) 3 4 22
- Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population. (PMID: 20392673) Guo C … Ding J (Clinical immunology (Orlando, Fla.) 2010) 3 22 40
- Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. (PMID: 18684727) Zhang Z … Zhang Z (Carcinogenesis 2008) 3 22 40
- [The relationship between RUNX3 gene mutation and keloid]. (PMID: 18717361) Zhang G … Yu Q (Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 2008) 3 22 40
- AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. (PMID: 7835892) Levanon D … Groner Y (Genomics 1994) 2 3 4
ExternalLinks
Products for RUNX3 Gene
- Custom Antibody ServicesOriGene Antibodies for RUNX3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RUNX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX3
- Origene Custom Protein Services for RUNX3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- OriGene qPCR primer pairs for RUNX3
- OriGene CRISPR knockouts for RUNX3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RUNX3
- Sino Biological Human cDNA Clone for RUNX3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for RUNX3
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RUNX3
- Novus Biologicals proteins and lysates for RUNX3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RUNX3
- Abcam proteins for RUNX3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for RUNX3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RUNX3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RUNX3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RUNX3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RUNX3
- Addgene plasmids for RUNX3
- antibodies-online: Show 38 available RUNX3 Antibodies ranked by validation data
- Compare Top RUNX3 Antibodies
- antibodies-online: Show 5 available RUNX3 Elisa Kits ranked by validation data
- Compare Top RUNX3 Elisa Kits
- Quality Products:
- antibodies-online: Show 12 available RUNX3 Proteins ranked by validation data
- Compare Top RUNX3 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
- Search Santa Cruz Biotechnology (SCBT) for RUNX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- Horizon Cell Lines for RUNX3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RUNX3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX3
Sources for RUNX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources