Aliases for RUNX3 Gene
Aliases for RUNX3 Gene
- Runt Related Transcription Factor 3 2 3 5
- Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit 3 4
- SL3/AKV Core-Binding Factor Alpha C Subunit 3 4
- SL3-3 Enhancer Factor 1 Alpha C Subunit 3 4
- Runt-Related Transcription Factor 3 2 3
- Core-Binding Factor Subunit Alpha-3 3 4
- Acute Myeloid Leukemia 2 Protein 3 4
- Oncogene AML-2 3 4
- CBF-Alpha-3 3 4
- CBFA3 3 4
- AML2 3 4
External Ids for RUNX3 Gene
- HGNC: 10473
- Entrez Gene: 864
- Ensembl: ENSG00000020633
- OMIM: 600210
- UniProtKB: Q13761
Previous HGNC Symbols for RUNX3 Gene
- CBFA3
Previous GeneCards Identifiers for RUNX3 Gene
- GC01M024749
- GC01M024294
- GC01M024205
- GC01M024577
- GC01M024971
- GC01M025098
- GC01M025226
- GC01M023479
Summaries for RUNX3 Gene
-
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for RUNX3 Gene
RUNX3 (Runt Related Transcription Factor 3) is a Protein Coding gene. Diseases associated with RUNX3 include Testicular Yolk Sac Tumor and Esophagus Squamous Cell Carcinoma. Among its related pathways are TGF-beta Receptor Signaling (WikiPathways) and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RUNX2.
UniProtKB/Swiss-Prot for RUNX3 Gene
-
CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Additional gene information for RUNX3 Gene
- Monarch Initiative
- Search for RUNX3 at DataMed
- Search for RUNX3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNX3 Gene
Genomics for RUNX3 Gene
GeneHancer (GH) Regulatory Elements for RUNX3 Gene
Promoters and enhancers for RUNX3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RUNX3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RUNX3 gene promoter:
Regulatory Element Products
Genomic Locations for RUNX3 Gene
Genomic Locations for RUNX3 Gene
- chr1:24,899,511-24,965,157
- (GRCh38/hg38)
- Size:
- 65,647 bases
- Orientation:
- Minus strand
- chr1:25,226,002-25,291,612
- (GRCh37/hg19)
Genomic View for RUNX3 Gene
Genes around RUNX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
RUNX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUNX3 Gene
Proteins for RUNX3 Gene
-
Protein details for RUNX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13761-RUNX3_HUMAN
- Recommended name:
- Runt-related transcription factor 3
- Protein Accession:
- Q13761
- B1AJV5
- Q12969
- Q13760
Protein attributes for RUNX3 Gene
- Size:
- 415 amino acids
- Molecular mass:
- 44356 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. Interacts with FOXP3. Interacts with ZFHX3. Interacts with TBX21 (By similarity).
Protein Expression for RUNX3 Gene
Post-translational modifications for RUNX3 Gene
- Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RUNX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
- Novus Biologicals Antibodies for RUNX3
-
Abcam antibodies for RUNX3
- Invitrogen Antibodies for RUNX3
- GeneTex RUNX3 antibody for RUNX3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
Protein Products
-
OriGene Purified Proteins for RUNX3
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX3
- Origene Custom Protein Services for RUNX3
- ProSpec Recombinant Proteins for RUNX3
- Search GeneTex for Proteins for RUNX3
-
Abcam proteins for RUNX3
Assay Products
-
Cloud-Clone Corp. Assay Kits for RUNX3
- antibodies-online: Search results for 2 available RUNX3 Elisa Kits ranked by validation data
- Compare Top RUNX3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RUNX3 Gene
Domains & Families for RUNX3 Gene
Gene Families for RUNX3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RUNX3 Gene
Suggested Antigen Peptide Sequences for RUNX3 Gene
Graphical View of Domain Structure for InterPro Entry
Q13761UniProtKB/Swiss-Prot:
RUNX3_HUMAN :- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
- Domain:
-
- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Function for RUNX3 Gene
Molecular function for RUNX3 Gene
- GENATLAS Biochemistry:
- Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid cells,involved in hematopoiesis and osteogenesis
- UniProtKB/Swiss-Prot Function:
- CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Phenotypes From GWAS Catalog for RUNX3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 7607690 |
| GO:0005515 | protein binding | IPI | 9751710 |
Phenotypes for RUNX3 Gene
- MGI mutant phenotypes for RUNX3:
-
inferred from 9 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for RUNX3:
Animal Models for RUNX3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RUNX3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX3 gene
- Search ViGene Biosciences for RUNX3
CRISPR Products
-
OriGene CRISPR knockouts for RUNX3
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- Applied Biological Materials CRISPR for RUNX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- GenScript: Design CRISPR guide RNA sequences for RUNX3
miRNA for RUNX3 Gene
- miRTarBase miRNAs that target RUNX3
-
- hsa-mir-532-5p (MIRT000038)
- hsa-mir-130b-3p (MIRT003316)
- hsa-mir-130a-3p (MIRT007055)
- hsa-mir-301a-3p (MIRT007295)
- hsa-mir-148b-3p (MIRT019365)
- hsa-mir-93-5p (MIRT028012)
- hsa-mir-148a-3p (MIRT053518)
- hsa-mir-106a-5p (MIRT053564)
- hsa-mir-106b-5p (MIRT437468)
- hsa-mir-218-5p (MIRT439719)
- hsa-mir-5011-3p (MIRT561630)
- hsa-mir-6894-5p (MIRT561631)
- hsa-mir-765 (MIRT561632)
- hsa-mir-7154-3p (MIRT561633)
- hsa-mir-766-5p (MIRT561634)
- hsa-mir-133a-5p (MIRT561635)
- hsa-mir-4487 (MIRT561636)
- hsa-mir-558 (MIRT561637)
- hsa-mir-3160-3p (MIRT561638)
- hsa-mir-4490 (MIRT561639)
- hsa-mir-4802-5p (MIRT561640)
- hsa-mir-519c-3p (MIRT561641)
- hsa-mir-519b-3p (MIRT561642)
- hsa-mir-519a-3p (MIRT561643)
- hsa-mir-4796-3p (MIRT561644)
- hsa-mir-3609 (MIRT561645)
- hsa-mir-548ah-5p (MIRT561646)
- hsa-mir-519d-3p (MIRT561647)
- hsa-mir-526b-3p (MIRT561648)
- hsa-mir-20b-5p (MIRT561649)
- hsa-mir-20a-5p (MIRT561650)
- hsa-mir-17-5p (MIRT561651)
- hsa-mir-6753-3p (MIRT565938)
- hsa-mir-7107-3p (MIRT565939)
- hsa-mir-20b-3p (MIRT565940)
- hsa-mir-3137 (MIRT565941)
- hsa-mir-6803-5p (MIRT568933)
- hsa-mir-6751-5p (MIRT568934)
- hsa-mir-615-5p (MIRT568935)
- hsa-mir-7110-5p (MIRT568936)
- hsa-mir-6842-5p (MIRT568937)
- hsa-mir-6752-5p (MIRT568938)
- hsa-mir-6835-5p (MIRT568939)
- hsa-mir-6887-5p (MIRT568940)
- hsa-mir-4697-5p (MIRT568941)
- hsa-mir-6795-5p (MIRT568942)
- hsa-mir-4488 (MIRT568943)
- hsa-mir-7111-5p (MIRT568944)
- hsa-mir-1237-5p (MIRT568945)
- hsa-mir-6870-5p (MIRT568946)
- hsa-mir-5698 (MIRT568947)
- hsa-mir-4723-5p (MIRT568948)
- hsa-mir-3175 (MIRT568949)
- hsa-mir-8085 (MIRT568950)
- hsa-mir-6731-5p (MIRT568951)
- hsa-mir-4731-5p (MIRT568952)
- hsa-mir-6805-5p (MIRT568953)
- hsa-mir-637 (MIRT568954)
- hsa-mir-495-3p (MIRT731247)
- hsa-mir-4295 (MIRT734873)
- hsa-mir-375 (MIRT735148)
- hsa-mir-3180-3p (MIRT740786)
- hsa-mir-3180 (MIRT740826)
- hsa-mir-3196 (MIRT741084)
- hsa-mir-6816-5p (MIRT756812)
miRNA Products
- Search ViGene Biosciences for RUNX3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX3 gene
Clone Products
- Sino Biological Human cDNA Clone for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RUNX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RUNX3
-
ViGene Biosciences adenoviral particle packaged cDNA for RUNX3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RUNX3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNX3 Gene
Localization for RUNX3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUNX3 Gene
- Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269 PubMed:20599712}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISS | -- |
| GO:0005634 | nucleus | IDA | 20100835 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 20100835 |
Pathways & Interactions for RUNX3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Wnt / Hedgehog / Notch | ||
| 3 | Dendritic Cells Developmental Lineage Pathway | ||
| 4 | Notch signaling pathway (KEGG) | ||
| 5 | TGF-beta Signaling Pathways | ||
Pathways by source for RUNX3 Gene
3 BioSystems pathways for RUNX3 Gene
1 KEGG pathway for RUNX3 Gene
3 R&D Systems pathways for RUNX3 Gene
1 Cell Signaling Technology pathway for RUNX3 Gene
Interacting Proteins for RUNX3 Gene
Selected Interacting proteins:
ENSP00000343477
Q13761-RUNX3_HUMAN
for RUNX3 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001503 | ossification | IBA | -- |
| GO:0002062 | chondrocyte differentiation | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 7622058 |
Transcripts for RUNX3 Gene
mRNA/cDNA for RUNX3 Gene
- (6) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (168) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RUNX3 Gene
- Runt-related transcription factor 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RUNX3
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- Applied Biological Materials CRISPR for RUNX3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- GenScript: Design CRISPR guide RNA sequences for RUNX3
miRNA Products
- Search ViGene Biosciences for RUNX3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RUNX3
- Browse OriGene Inhibitory RNA Products For RUNX3
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX3 gene
Clone Products
- Sino Biological Human cDNA Clone for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RUNX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RUNX3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Endochondral Facial Bones
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Caudal Facial Endochondral Bones
- Brain (Nervous System)
- Melanocytes (Integumentary System)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- T-Cytotoxic Cells Thymus
- Hematopoietic Bone Marrow
- Limb (Muscoskeletal System)
- Epidermis (Integumentary System)
- Tonsil (Hematopoietic System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dentin
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
- Thymus
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Gut Tube (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Eye (Sensory Organs)
- Adipose (Muscoskeletal System)
- NULL (Integumentary System)
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for RUNX3 Gene
This gene is overexpressed in Whole Blood (x16.1) and Spleen (x4.8).
This gene is overexpressed in NK cells (28.2), Peripheral blood mononuclear cells (15.7), CD8 Tcells (10.1), and CD4 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUNX3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RUNX3 Gene:
RUNX3SOURCE GeneReport for Unigene cluster for RUNX3 Gene:
Hs.170019mRNA Expression by UniProt/SwissProt for RUNX3 Gene:
Q13761-RUNX3_HUMAN
Tissue specificity:
Expressed in gastric cancer tissues (at protein level).
Evidence on tissue expression from TISSUES for RUNX3 Gene
- Skin(4.3)
- Blood(2.8)
- Intestine(2.6)
- Lymph node(2.5)
- Stomach(2.5)
- Bone marrow(2.4)
- Spleen(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for RUNX3
- genomics-online: primer clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNX3 Gene
Orthologs for RUNX3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RUNX3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC487366 33 |
|
||
| RUNX3 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | RUNX3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Runx3 34 16 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Runx3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | RUNX3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RUNX3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RUNX3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | runx3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | runx3 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1379 35 |
|
|
|
| CG15455 35 |
|
|
|||
| run 35 34 |
|
||||
| lz 35 34 |
|
||||
| RunxA 34 |
|
ManyToMany | |||
| RunxB 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rnt-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for RUNX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RUNX3 Gene
(6) SIMAP similar genes for RUNX3 Gene using alignment to 2 proteins:
Variants for RUNX3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000081063 | -- | 24,956,278(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000100250 | -- | 24,918,414(-) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000174179 | -- | 24,902,864(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000295993 | -- | 24,945,474(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000302882 | -- | 24,940,645(-) | G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1077252 | CNV | deletion | 25765185 |
| nsv1136070 | CNV | deletion | 24896259 |
| nsv508581 | CNV | deletion | 20534489 |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUNX3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNX3 Gene
Disorders for RUNX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| testicular yolk sac tumor |
|
|
| esophagus squamous cell carcinoma |
|
|
| gastric cancer |
|
|
| cleidocranial dysplasia |
|
|
| inflammatory bowel disease 7 |
|
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Search RUNX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RUNX3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RUNX3 Gene
Publications for RUNX3 Gene
- Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PMID: 20100835) Goh YM … Bae SC (The Journal of biological chemistry 2010) 3 4 22 58
- Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population. (PMID: 20392673) Guo C … Ding J (Clinical immunology (Orlando, Fla.) 2010) 3 22 44 58
- [The relationship between RUNX3 gene mutation and keloid]. (PMID: 18717361) Zhang G … Yu Q (Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 2008) 3 22 44 58
- Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. (PMID: 18684727) Zhang Z … Zhang Z (Carcinogenesis 2008) 3 22 44 58
- AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. (PMID: 7835892) Levanon D … Groner Y (Genomics 1994) 2 3 4 58
Products for RUNX3 Gene
- R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
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- Custom Antibody ServicesOriGene Antibodies for RUNX3
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- Sino Biological Human cDNA Clone for RUNX3
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- Abcam antibodies for RUNX3
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- ProSpec Recombinant Proteins for RUNX3
- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX3
- VectorBuilder custom plasmid, inducible vectors for RUNX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 218 available RUNX3 Antibodies ranked by validation data
- Compare Top RUNX3 Antibodies
- antibodies-online: Search results for 2 available RUNX3 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 13 available RUNX3 Proteins ranked by validation data
- Compare Top RUNX3 Proteins
- GeneTex RUNX3 antibody for RUNX3
- Search GeneTex for Proteins for RUNX3
- ViGene Biosciences adenoviral particle packaged cDNA for RUNX3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RUNX3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RUNX3 gene
- Search ViGene Biosciences for RUNX3
- Santa Cruz Biotechnology (SCBT) Antibodies for RUNX3
- Search Santa Cruz Biotechnology (SCBT) for RUNX3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUNX3
- Horizon Cell Lines for RUNX3
- genomics-online: cdna clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- orf clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: gRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: primer clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
- genomics-online: shRNA clones - Search results for 88 available RUNX3 gene related products
- Overview of 88 available RUNX3 gene related products
Sources for RUNX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (135) Horizon
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- (139) VectorBuilder
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems