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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several ty... See more...
Aliases for RUNX1 Gene
Aliases for RUNX1 Gene
- RUNX Family Transcription Factor 1 2 3 5
- Runt-Related Transcription Factor 1 2 3 4
- Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit 3 4
- SL3/AKV Core-Binding Factor Alpha B Subunit 3 4
- SL3-3 Enhancer Factor 1 Alpha B Subunit 3 4
- Runt Related Transcription Factor 1 2 3
- Acute Myeloid Leukemia 1 Protein 3 4
- Oncogene AML-1 3 4
- PEBP2-Alpha B 3 4
- PEA2-Alpha B 3 4
- AMLCR1 2 3
- CBFA2 3 4
- AML1 3 4
External Ids for RUNX1 Gene
- HGNC: 10471
- Entrez Gene: 861
- Ensembl: ENSG00000159216
- OMIM: 151385
- UniProtKB: Q01196
Previous HGNC Symbols for RUNX1 Gene
- AML1
- CBFA2
Previous GeneCards Identifiers for RUNX1 Gene
- GC21M032737
- GC21M035080
- GC21M035081
- GC21M036160
- GC21M021639
Summaries for RUNX1 Gene
-
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
-
RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.
GeneCards Summary for RUNX1 Gene
RUNX1 (RUNX Family Transcription Factor 1) is a Protein Coding gene. Diseases associated with RUNX1 include Platelet Disorder, Familial, With Associated Myeloid Malignancy and Leukemia, Acute Myeloid. Among its related pathways are Transcriptional misregulation in cancer and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is RUNX2.
UniProtKB/Swiss-Prot Summary for RUNX1 Gene
-
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
-
Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation.
-
Isoform AML-1L interferes with the transactivation activity of RUNX1.
Additional gene information for RUNX1 Gene
- HGNC(10471)
- Entrez Gene(861)
- Ensembl(ENSG00000159216)
- OMIM(151385)
- UniProtKB(Q01196)
- Open Targets Platform(ENSG00000159216)
- Monarch Initiative
- Search for RUNX1 at DataMed
- Search for RUNX1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RUNX1 Gene
Genomics for RUNX1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RUNX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RUNX1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RUNX1
- Top Transcription factor binding sites by QIAGEN in the RUNX1 gene promoter:
-
- AML1a
- C/EBPalpha
Genomic Locations for RUNX1 Gene
Genomic Locations for RUNX1 Gene
- chr21:34,787,801-36,004,667
- (GRCh38/hg38)
- Size:
- 1,216,867 bases
- Orientation:
- Minus strand
- chr21:36,160,098-37,376,965
- (GRCh37/hg19)
- Size:
- 1,216,868 bases
- Orientation:
- Minus strand
Genomic View for RUNX1 Gene
Genes around RUNX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.12 by HGNC
- 21q22.12 by Entrez Gene
- 21q22.12 by Ensembl
RUNX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUNX1 Gene
Proteins for RUNX1 Gene
-
Protein details for RUNX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01196-RUNX1_HUMAN
- Recommended name:
- Runt-related transcription factor 1
- Protein Accession:
- Q01196
- A8MV94
- B2RMS4
- D3DSG1
- O60472
- O60473
- O76047
- O76089
- Q13081
- Q13755
- Q13756
- Q13757
- Q13758
- Q13759
- Q15341
- Q15343
- Q16122
- Q16284
- Q16285
- Q16286
- Q16346
- Q16347
- Q92479
Protein attributes for RUNX1 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 48737 Da
- Quaternary structure:
-
- Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and ALYREF/THOC4 (PubMed:9119228, PubMed:9751710). Interacts with ELF1, ELF2 and SPI1 (PubMed:10207087). Interacts via its Runt domain with the ELF4 N-terminal region (PubMed:10207087). Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation (PubMed:14970218). Interacts with KAT6A and KAT6B (PubMed:11742995, PubMed:11965546). Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1 (PubMed:12917624, PubMed:16652147). Interacts with YAP1 (PubMed:18280240). Interacts with HIPK2 (By similarity). Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity. Found in a complex with PRMT5, RUNX1 and CBFB. Interacts with FOXP3 (PubMed:17377532). Interacts with TBX21 (By similarity). Interacts with DPF2 (PubMed:28533407).
- SequenceCaution:
-
- Sequence=AAC05246.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAC05247.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for RUNX1 Gene
Protein Expression for RUNX1 Gene
Post-translational modifications for RUNX1 Gene
- Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
- Methylated.
- Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
-
Ubiquitination at Lys125, Lys24, and Lys43
- NX_Q01196 (NX_Q01196-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RUNX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents RUNX1 Antibody
- Novus Biologicals Antibodies for RUNX1
-
Abcam antibodies for RUNX1
- Invitrogen Antibodies for RUNX1 (AFLGC-RUNX1)
-
Boster Bio Antibodies for RUNX1
-
Custom Antibody ServicesProSci Antibodies for RUNX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUNX1
- Sino Biological Antibodies for RUNX1
Protein Products
-
OriGene Purified Proteins for RUNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX1
- Origene Custom Protein Services for RUNX1
- antibodies-online: Show 9 available RUNX1 Proteins ranked by validation data
- Compare Top RUNX1 Proteins
-
Quality Products:
-
Signalway Proteins for RUNX1
-
Abcam proteins for RUNX1
Assay Products
- antibodies-online: Show 11 available RUNX1 Elisa Kits ranked by validation data
- Compare Top RUNX1 Elisa Kits
-
Quality Products:
-
Abcam assays for RUNX1
No data available for DME Specific Peptides for RUNX1 Gene
Domains & Families for RUNX1 Gene
Gene Families for RUNX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RUNX1 Gene
- InterPro:
- Blocks:
-
- Acute myeloid leukemia 1 protein signature
- Runx inhibition
- ProtoNet:
Suggested Antigen Peptide Sequences for RUNX1 Gene
- GenScript: Design optimal peptide antigens:
-
- Aml1 protein (Q15342_HUMAN)
- Aml1 protein (Q15344_HUMAN)
- RUNX1 protein (Q2TAM6_HUMAN)
- SL3/AKV core-binding factor alpha B subunit (RUNX1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01196UniProtKB/Swiss-Prot:
RUNX1_HUMAN :- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
- Domain:
-
- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Function for RUNX1 Gene
Molecular function for RUNX1 Gene
- UniProtKB/Swiss-Prot Function:
- Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation.
- UniProtKB/Swiss-Prot Function:
- Isoform AML-1L interferes with the transactivation activity of RUNX1.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by phorbol myristate acetate (PMA).
- GENATLAS Biochemistry:
- Drosophila Runt pair rule-related transcription factor 1,binding to the enhancer of T cell receptor genes,involved in hematopoiesis and osteogenesis,rearranged in acute myeloid leukemia with t(8;21)(q22;q22),often associated with prior therapy t(17;21)(q11.2;q22) and others;myelodsyplasia syndrome with t(3;21)(q26;q22);acute lymphoblastic leukemia with t(12;21)(p13;q22)
Phenotypes From GWAS Catalog for RUNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 21873977 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 9199349 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 17377532 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 9199349 |
Phenotypes for RUNX1 Gene
- MGI mutant phenotypes for RUNX1:
-
inferred from 41 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RUNX1:
Animal Models for RUNX1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RUNX1 - Select products 50% OFF >
- * RUNX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RUNX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
miRNA for RUNX1 Gene
- miRTarBase miRNAs that target RUNX1
-
- hsa-miR-27a-3p (MIRT000107)
- mmu-miR-27b-3p (MIRT001078)
- mmu-miR-27a-3p (MIRT001079)
- hsa-miR-17-5p (MIRT003741)
- hsa-miR-20a-5p (MIRT003742)
- hsa-miR-106a-5p (MIRT003743)
- mmu-miR-30c-5p (MIRT003793)
- mmu-miR-18a-5p (MIRT003794)
- mmu-miR-9-5p (MIRT003796)
- mmu-miR-181a-5p (MIRT003910)
- mmu-miR-126a-3p (MIRT005730)
- mmu-miR-126a-5p (MIRT005735)
- mmu-miR-199a-3p (MIRT006578)
- hsa-miR-423-5p (MIRT038069)
- hsa-miR-675-5p (MIRT053591)
- mmu-miR-128-3p (MIRT054072)
- hsa-miR-8485 (MIRT203374)
- hsa-miR-221-3p (MIRT438218)
- mmu-miR-181d-5p (MIRT438767)
- hsa-miR-7111-3p (MIRT534539)
- hsa-miR-4792 (MIRT534540)
- hsa-miR-6721-5p (MIRT534541)
- hsa-miR-6860 (MIRT534542)
- hsa-miR-612 (MIRT534543)
- hsa-miR-5189-5p (MIRT534544)
- hsa-miR-3187-5p (MIRT534545)
- hsa-miR-1285-3p (MIRT534546)
- hsa-miR-939-3p (MIRT534547)
- hsa-miR-6769b-3p (MIRT534548)
- hsa-miR-4723-3p (MIRT534549)
- hsa-miR-3183 (MIRT534550)
- hsa-miR-6791-5p (MIRT534551)
- hsa-miR-4292 (MIRT534552)
- hsa-miR-4308 (MIRT534553)
- hsa-miR-4762-5p (MIRT534554)
- hsa-miR-605-5p (MIRT534555)
- hsa-miR-551b-5p (MIRT534556)
- hsa-miR-4417 (MIRT569539)
- hsa-miR-4467 (MIRT569540)
- hsa-miR-6853-5p (MIRT569541)
- hsa-miR-8072 (MIRT569542)
- hsa-miR-4530 (MIRT569543)
- hsa-miR-3960 (MIRT569544)
- hsa-miR-922 (MIRT569545)
- mmu-miR-466l-5p (MIRT588976)
- mmu-miR-452-5p (MIRT588977)
- mmu-miR-450b-5p (MIRT588978)
- mmu-miR-466i-5p (MIRT588979)
- mmu-miR-466k (MIRT588980)
- mmu-miR-466d-5p (MIRT588981)
- mmu-miR-1198-5p (MIRT592463)
- mmu-miR-511-3p (MIRT592464)
- mmu-miR-466p-5p (MIRT592465)
- mmu-miR-466e-5p (MIRT592466)
- mmu-miR-466a-5p (MIRT592467)
- mmu-miR-1187 (MIRT592468)
- hsa-miR-4789-3p (MIRT612533)
- hsa-miR-335-3p (MIRT622381)
- hsa-miR-5096 (MIRT622382)
- hsa-miR-377-3p (MIRT622383)
- hsa-miR-6885-3p (MIRT699881)
- hsa-miR-4446-5p (MIRT699882)
- hsa-miR-7152-5p (MIRT699883)
- hsa-miR-5006-3p (MIRT699884)
- hsa-miR-4755-5p (MIRT699885)
- hsa-miR-3180-5p (MIRT699886)
- hsa-miR-4639-5p (MIRT699887)
- hsa-miR-4497 (MIRT699888)
- hsa-miR-642a-5p (MIRT699889)
- hsa-miR-513a-5p (MIRT699890)
- hsa-miR-3160-5p (MIRT699891)
- hsa-miR-1266-3p (MIRT699892)
- hsa-miR-4667-3p (MIRT699893)
- hsa-miR-1470 (MIRT699894)
- hsa-miR-7157-5p (MIRT699895)
- hsa-miR-4310 (MIRT699896)
- hsa-miR-141-5p (MIRT699897)
- hsa-miR-2115-3p (MIRT699898)
- hsa-miR-1179 (MIRT699899)
- hsa-miR-27b-3p (MIRT699900)
- hsa-miR-128-3p (MIRT699901)
- hsa-miR-216a-3p (MIRT699902)
- hsa-miR-3681-3p (MIRT699903)
- hsa-miR-18a-5p (MIRT731126)
- ssc-miR-27b-3p (MIRT731370)
- hsa-miR-215-5p (MIRT732121)
- hsa-miR-9-5p (MIRT733692)
- hsa-miR-101-3p (MIRT734125)
- hsa-miR-144-5p (MIRT734389)
- hsa-miR-181a-5p (MIRT734590)
- hsa-miR-378a-3p (MIRT734686)
Transcription Factor Targets for RUNX1 Gene
Targeted motifs for RUNX1 Gene
HOMER Transcription Factor Regulatory Elements motif RUNX1
- Consensus sequence: AAACCACAAA Submotif: canonical Cell Type: Jurkat GEO ID: GSE29180
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX1
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Clone Products
- Applied Biological Materials (abm): Clones for RUNX1 - Select products 50% OFF >
- * RUNX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206993
- MG226250
- MG226252
- MG226256
- MR206993
- MR206993L3
- MR206993L4
- MR226250
- MR226250L3
- MR226250L4
- MR226252
- MR226252L3
- MR226252L4
- MR226256
- MR226256L3
- MR226256L4
- RC223809
- RC223809L1
- RC223809L2
- RC223809L3
- RC223809L4
- RC223854
- RC223854L1
- RC223854L2
- RC223854L3
- RC223854L4
- RC225321
- RC225321L1
- RC225321L2
- RC225321L3
- RC225321L4
- RG223809
- RG223854
- RG225321
- RR206224
- RR206224L3
- RR206224L4
- MR206993L3V
- MR206993L4V
- MR226250L3V
- MR226250L4V
- MR226252L3V
- MR226252L4V
- MR226256L3V
- MR226256L4V
- RC223809L1V
- RC223809L2V
- RC223809L3V
- RC223809L4V
- RC223854L1V
- RC223854L2V
- RC223854L3V
- RC223854L4V
- RC225321L1V
- RC225321L2V
- RC225321L3V
- RC225321L4V
- RR206224L3V
- RR206224L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RUNX1
- Addgene plasmids for RUNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX1
Cell Line Products
-
Horizon Cell Lines for RUNX1
No data available for Enzyme Numbers (IUBMB) for RUNX1 Gene
Localization for RUNX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUNX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 7862156 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016513 | core-binding factor complex | TAS | 18258917 |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for RUNX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Endometrial cancer | ||
| 3 | NF-kappaB Signaling | ||
| 4 | Pathways in cancer | ||
| 5 | Th17 cell differentiation | ||
Pathways by source for RUNX1 Gene
2 BioSystems pathways for RUNX1 Gene
5 Reactome pathways for RUNX1 Gene
6 KEGG pathways for RUNX1 Gene
3 R&D Systems pathways for RUNX1 Gene
1 Cell Signaling Technology pathway for RUNX1 Gene
Interacting Proteins for RUNX1 Gene
Selected Interacting proteins:
Q01196-RUNX1_HUMAN
ENSP00000300305
for RUNX1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RUNX1
SIGNOR curated interactions for RUNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001503 | ossification | IBA | 21873635 |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | TAS | -- |
| GO:0002062 | chondrocyte differentiation | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for RUNX1 Gene
mRNA/cDNA for RUNX1 Gene
- 3 REFSEQ mRNAs :
- 38 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300305 6222 nts (view in UCSC)
- ENST00000344691 7274 nts (view in UCSC)
- ENST00000358356 2720 nts (view in UCSC)
- ENST00000399237 822 nts (view in UCSC)
- ENST00000399240 1590 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RUNX1 - Select products 50% OFF >
- * RUNX1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RUNX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX1
- Browse OriGene Inhibitory RNA Products For RUNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX1
Clone Products
- Applied Biological Materials (abm): Clones for RUNX1 - Select products 50% OFF >
- * RUNX1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206993
- MG226250
- MG226252
- MG226256
- MR206993
- MR206993L3
- MR206993L4
- MR226250
- MR226250L3
- MR226250L4
- MR226252
- MR226252L3
- MR226252L4
- MR226256
- MR226256L3
- MR226256L4
- RC223809
- RC223809L1
- RC223809L2
- RC223809L3
- RC223809L4
- RC223854
- RC223854L1
- RC223854L2
- RC223854L3
- RC223854L4
- RC225321
- RC225321L1
- RC225321L2
- RC225321L3
- RC225321L4
- RG223809
- RG223854
- RG225321
- RR206224
- RR206224L3
- RR206224L4
- MR206993L3V
- MR206993L4V
- MR226250L3V
- MR226250L4V
- MR226252L3V
- MR226252L4V
- MR226256L3V
- MR226256L4V
- RC223809L1V
- RC223809L2V
- RC223809L3V
- RC223809L4V
- RC223854L1V
- RC223854L2V
- RC223854L3V
- RC223854L4V
- RC225321L1V
- RC225321L2V
- RC225321L3V
- RC225321L4V
- RR206224L3V
- RR206224L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RUNX1
- Addgene plasmids for RUNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - |
Relevant External Links for RUNX1 Gene
- GeneLoc Exon Structure for
- RUNX1
Expression for RUNX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Rib
- Prehypertrophic Chondrocytes Stylopod Growth Plate
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Rib
- Prehypertrophic Chondrocytes Stylopod Growth Plate
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Primitive Erythrocytes Extraembryonic Blood Islands
- Hematopoietic Stem Cells Liver Bud
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Spinal Cord (Nervous System)
- Lateral Neurons Of The LMC Rostral Brachial Lateral Motor Division
- Lateral Neurons Of The LMC Caudal Brachial Lateral Motor Division
- Scapulohumeralis Posterior Muscle Motor Neurons Rostral Brachial Lateral Motor Division
- Lateral Neurons of the LMC Lumbar Lateral Motor Division
-
Neurons
- Lateral Neurons Of The LMC Rostral Brachial Lateral Motor Division
- Lateral Neurons Of The LMC Caudal Brachial Lateral Motor Division
- Scapulohumeralis Posterior Muscle Motor Neurons Rostral Brachial Lateral Motor Division
- Lateral Neurons of the LMC Lumbar Lateral Motor Division
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Tooth (Integumentary System)
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Ameloblasts Dental Enamel
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Oviduct
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Erythrocytes Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Epithelial Cells
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Eye (Sensory Organs)
- Umbilical Cord (Extraembryonic Tissues)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Epiblast (Early Embryonic Tissues)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for RUNX1 Gene
This gene is overexpressed in Minor Salivary Gland (x5.4).
This gene is overexpressed in Peripheral blood mononuclear cells (28.0), CD8 Tcells (16.3), CD4 Tcells (12.5), and Blymphocyte (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RUNX1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RUNX1
SOURCE GeneReport for Unigene cluster for RUNX1 Gene:
Hs.149261mRNA Expression by UniProt/SwissProt for RUNX1 Gene:
Q01196-RUNX1_HUMAN
Tissue specificity:
Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Evidence on tissue expression from TISSUES for RUNX1 Gene
- Blood(4.5)
- Liver(4.4)
- Bone marrow(3)
- Nervous system(2.6)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNX1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- face
- head
- neck
- nose
Abdomen:
- adrenal gland
- kidney
Pelvis:
- pelvis
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for RUNX1
-
OriGene qPCR primer pairs and template standards for RUNX1
Gene Expression Assay Products
Orthologs for RUNX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RUNX1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RUNX1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RUNX1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Runx1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Runx1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RUNX1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RUNX1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RUNX1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RUNX1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | runx1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69003 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | RUNX1 (2 of 2) 31 |
|
OneToMany | |
| runx1 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1379 32 |
|
|
|
| CG15455 32 |
|
|
|||
| run 31 32 |
|
ManyToMany | |||
| RunxA 31 |
|
ManyToMany | |||
| RunxB 31 |
|
ManyToMany | |||
| lz 31 32 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | rnt-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RUNX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RUNX1 Gene
- ENSEMBL:
- Gene Tree for RUNX1 (if available)
- TreeFam:
- Gene Tree for RUNX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RUNX1: view image
Paralogs for RUNX1 Gene
(6) SIMAP similar genes for RUNX1 Gene using alignment to 9 proteins:
- RUNX1_HUMAN
- A8MZI9_HUMAN
- C9JWM1_HUMAN
- F5H139_HUMAN
- H9KVB1_HUMAN
- Q2TAM6_HUMAN
- U5P039_HUMAN
- V9GYT3_HUMAN
- V9GYT5_HUMAN
Variants for RUNX1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RUNX1 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 627081 | Likely Pathogenic: Pancytopenia | 34,880,563(-) | C/A | NONSENSE | |
| 627100 | Likely Pathogenic: Thrombocytopenia | 34,859,509(-) | A/T | MISSENSE_VARIANT | |
| 627101 | Likely Pathogenic: Storage pool disease of platelets | 34,834,593(-) | G/A | NONSENSE | |
| 627152 | Likely Pathogenic: Thrombocytopenia | 34,799,407(-) | G/C | NONSENSE | |
| 627342 | Likely Pathogenic: Thrombocytopenia; Familial platelet disorder with associated myeloid malignancy | 34,859,494(-) | T/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.98;
36.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUNX1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNX1 Gene
Disorders for RUNX1 Gene
(39) MalaCards diseases for RUNX1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| platelet disorder, familial, with associated myeloid malignancy |
|
|
| leukemia, acute myeloid |
|
|
| acute myeloid leukemia with t(8;21)(q22;q22) translocation |
|
|
| isolated delta-storage pool disease |
|
|
| aggressive systemic mastocytosis |
|
|
Search RUNX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RUNX1_HUMAN- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of M2 type acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1T1.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of therapy-related myelodysplastic syndrome (T-MDS). Translocation t(3;21)(q26;q22) with EAP or MECOM.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP or MECOM.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.
- Note=A chromosomal aberration involving RUNX1 is found in acute leukemia. Translocation t(11,21)(q13;q22) that forms a MACROD1-RUNX1 fusion protein.
- Familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia. {ECO:0000269 PubMed:10508512}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in acute myeloid leukemia. Translocation t(20;21)(q11;q22) with CBFA2T2. {ECO:0000269 PubMed:20520637}.
Additional Disease Information for RUNX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for RUNX1 Gene
Publications for RUNX1 Gene
- LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). (PMID: 17532767) Imagama S … Naoe T (European journal of haematology 2007) 3 4 23
- Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PMID: 17431401) Fujimoto T … Nerlov C (The EMBO journal 2007) 3 4 23
- Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PMID: 14970218) Cho JY … Libermann TA (The Journal of biological chemistry 2004) 3 4 23
- MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. (PMID: 11965546) Pelletier N … Yang XJ (Oncogene 2002) 3 4 23
- The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. (PMID: 12217689) Bäckström S … Sauer UH (Journal of molecular biology 2002) 3 4 23
ExternalLinks
Products for RUNX1 Gene
- Custom Antibody ServicesOriGene Antibodies for RUNX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RUNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX1
- Origene Custom Protein Services for RUNX1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RUNX1
- Browse OriGene Inhibitory RNA Products For RUNX1
- OriGene qPCR primer pairs for RUNX1
- OriGene qPCR primer pairs and template standards for RUNX1
- OriGene CRISPR knockouts for RUNX1
- MG206993
- MG226250
- MG226252
- MG226256
- MR206993
- MR206993L3
- MR206993L4
- MR226250
- MR226250L3
- MR226250L4
- MR226252
- MR226252L3
- MR226252L4
- MR226256
- MR226256L3
- MR226256L4
- RC223809
- RC223809L1
- RC223809L2
- RC223809L3
- RC223809L4
- RC223854
- RC223854L1
- RC223854L2
- RC223854L3
- RC223854L4
- RC225321
- RC225321L1
- RC225321L2
- RC225321L3
- RC225321L4
- RG223809
- RG223854
- RG225321
- RR206224
- RR206224L3
- RR206224L4
- MR206993L3V
- MR206993L4V
- MR226250L3V
- MR226250L4V
- MR226252L3V
- MR226252L4V
- MR226256L3V
- MR226256L4V
- RC223809L1V
- RC223809L2V
- RC223809L3V
- RC223809L4V
- RC223854L1V
- RC223854L2V
- RC223854L3V
- RC223854L4V
- RC225321L1V
- RC225321L2V
- RC225321L3V
- RC225321L4V
- RR206224L3V
- RR206224L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RUNX1
- Sino Biological Human cDNA Clone for RUNX1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for RUNX1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RUNX1
- Novus Biologicals proteins and lysates for RUNX1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RUNX1
- Abcam proteins for RUNX1
- Abcam assays for RUNX1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for RUNX1 (AFLGC-RUNX1)
- VectorBuilder Custom and pre-made DNA vectors for RUNX1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RUNX1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RUNX1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RUNX1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RUNX1
- Addgene plasmids for RUNX1
- antibodies-online: Show 100 available RUNX1 Antibodies ranked by validation data
- Compare Top RUNX1 Antibodies
- antibodies-online: Show 11 available RUNX1 Elisa Kits ranked by validation data
- Compare Top RUNX1 Elisa Kits
- Quality Products:
- antibodies-online: Show 9 available RUNX1 Proteins ranked by validation data
- Compare Top RUNX1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RUNX1
- Search Santa Cruz Biotechnology (SCBT) for RUNX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
- Custom Antibody ServicesProSci Antibodies for RUNX1
- Search for RUNX1 Proteins at ProSci
- Horizon Cell Lines for RUNX1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RUNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RUNX1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RUNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RUNX1
- Boster Bio Antibodies for RUNX1
- Signalway Proteins for RUNX1
Sources for RUNX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119)