Aliases for RUNX1 Gene
Aliases for RUNX1 Gene
- Runt Related Transcription Factor 1 2 3 5
- Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit 3 4
- SL3/AKV Core-Binding Factor Alpha B Subunit 3 4
- SL3-3 Enhancer Factor 1 Alpha B Subunit 3 4
- Runt-Related Transcription Factor 1 2 3
- Acute Myeloid Leukemia 1 Protein 3 4
- Oncogene AML-1 3 4
- PEBP2-Alpha B 3 4
- PEA2-Alpha B 3 4
- CBFA2 3 4
- AML1 3 4
- Core-Binding Factor, Runt Domain, Alpha Subunit 2 3
External Ids for RUNX1 Gene
- HGNC: 10471
- Entrez Gene: 861
- Ensembl: ENSG00000159216
- OMIM: 151385
- UniProtKB: Q01196
Previous HGNC Symbols for RUNX1 Gene
- AML1
- CBFA2
Previous GeneCards Identifiers for RUNX1 Gene
- GC21M032737
- GC21M035080
- GC21M035081
- GC21M036160
- GC21M021639
Summaries for RUNX1 Gene
-
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
-
RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.
GeneCards Summary for RUNX1 Gene
RUNX1 (Runt Related Transcription Factor 1) is a Protein Coding gene. Diseases associated with RUNX1 include Platelet Disorder, Familial, With Associated Myeloid Malignancy and Isolated Delta-Storage Pool Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is RUNX2.
UniProtKB/Swiss-Prot for RUNX1 Gene
-
CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
Additional gene information for RUNX1 Gene
- Monarch Initiative
- Search for RUNX1 at DataMed
- Search for RUNX1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNX1 Gene
Genomics for RUNX1 Gene
GeneHancer (GH) Regulatory Elements for RUNX1 Gene
Promoters and enhancers for RUNX1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21I035040 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 558 | +958.0 | 958043 | 11.8 | HDGF PKNOX1 ARID4B FEZF1 ZNF2 IRF4 ZNF766 CBX5 ZNF302 ZNF143 | RUNX1 SMIM11A RPL23AP3 C21orf140 RUNX1-IT1 GC21M035098 | |
| GH21I035953 | Enhancer | 0.9 | ENCODE | 11.6 | +50.9 | 50897 | 1.2 | FOXA2 MLX ARID4B DMAP1 ETS1 TCF12 SP5 MXD4 MIER2 PPARG | RUNX1 LINC01436 CBR1 PIR44766 MTND2P1 | |
| GH21I035924 | Enhancer | 0.9 | Ensembl ENCODE | 11.3 | +79.4 | 79393 | 1.5 | PKNOX1 LEF1 USF1 FOXA2 ZNF473 ZBTB21 MAX CEBPG ZIC2 HIC1 | SETD4 RIMKLBP1 RUNX1 MORC3 MTND2P1 PIR44766 | |
| GH21I035593 | Enhancer | 1 | ENCODE dbSUPER | 10 | +411.5 | 411499 | 0.2 | INSM2 MZF1 FEZF1 ZEB1 ZNF213 ZNF366 ZNF391 FOS KLF13 CEBPB | RUNX1 PPP1R2P2 EZH2P1 LOC100506403 | |
| GH21I035849 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE | 10.5 | +154.2 | 154242 | 1.4 | ZNF316 MAFG FOS ZIC2 MAFK EMSY | PPP1R2P2 RUNX1 MORC3 PIR34429 PIR44073 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RUNX1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RUNX1 gene promoter:
Regulatory Element Products
Genomic Locations for RUNX1 Gene
Genomic Locations for RUNX1 Gene
- chr21:34,787,801-36,004,667
- (GRCh38/hg38)
- Size:
- 1,216,867 bases
- Orientation:
- Minus strand
- chr21:36,160,098-37,376,965
- (GRCh37/hg19)
Genomic View for RUNX1 Gene
Genes around RUNX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.12 by Ensembl
- 21q22.12 by Entrez Gene
- 21q22.12 by HGNC
RUNX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUNX1 Gene
Proteins for RUNX1 Gene
-
Protein details for RUNX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01196-RUNX1_HUMAN
- Recommended name:
- Runt-related transcription factor 1
- Protein Accession:
- Q01196
- A8MV94
- B2RMS4
- D3DSG1
- O60472
- O60473
- O76047
- O76089
- Q13081
- Q13755
- Q13756
- Q13757
- Q13758
- Q13759
- Q15341
- Q15343
- Q16122
- Q16284
- Q16285
- Q16286
- Q16346
- Q16347
- Q92479
Protein attributes for RUNX1 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 48737 Da
- Quaternary structure:
-
- Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and ALYREF/THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1. Interacts with YAP1. Interacts with HIPK2 (By similarity). Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity. Found in a complex with PRMT5, RUNX1 AND CBFB. Interacts with FOXP3. Interacts with TBX21 (By similarity).
- SequenceCaution:
-
- Sequence=AAC05246.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05247.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for RUNX1 Gene
Protein Expression for RUNX1 Gene
Post-translational modifications for RUNX1 Gene
- Methylated.
- Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
- Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.
- Ubiquitination at posLast=2424 and isoforms=2, 3, 4, 5, 6, 7, 8, 9, 10, 11125
Other Protein References for RUNX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RUNX1 (RUNX1/CBFA2)
- Cell Signaling Technology (CST) Antibodies for RUNX1 (AML1)
- Novus Biologicals Antibodies for RUNX1
-
Abcam antibodies for RUNX1
-
Cloud-Clone Corp. Antibodies for RUNX1
- Invitrogen Antibodies for RUNX1
- GeneTex RUNX1 antibody for RUNX1
-
Custom Antibody ServicesProSci Antibodies for RUNX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUNX1
Protein Products
-
OriGene Purified Proteins for RUNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX1
- Origene Custom Protein Services for RUNX1
-
Cloud-Clone Corp. Proteins for RUNX1
- Search GeneTex for Proteins for RUNX1
-
Abcam proteins for RUNX1
Assay Products
-
Abcam assays for RUNX1
No data available for DME Specific Peptides for RUNX1 Gene
Domains & Families for RUNX1 Gene
Gene Families for RUNX1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RUNX1 Gene
Suggested Antigen Peptide Sequences for RUNX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q01196UniProtKB/Swiss-Prot:
RUNX1_HUMAN :- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
- Domain:
-
- A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
Function for RUNX1 Gene
Molecular function for RUNX1 Gene
- GENATLAS Biochemistry:
- Drosophila Runt pair rule-related transcription factor 1,binding to the enhancer of T cell receptor genes,involved in hematopoiesis and osteogenesis,rearranged in acute myeloid leukemia with t(8;21)(q22;q22),often associated with prior therapy t(17;21)(q11.2;q22) and others;myelodsyplasia syndrome with t(3;21)(q26;q22);acute lymphoblastic leukemia with t(12;21)(p13;q22)
- UniProtKB/Swiss-Prot Function:
- CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
Phenotypes From GWAS Catalog for RUNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 9199349 |
| GO:0001047 | core promoter binding | IDA | 17377532 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IMP | 9199349 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for RUNX1 Gene
- MGI mutant phenotypes for RUNX1:
-
inferred from 41 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RUNX1:
Animal Models for RUNX1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RUNX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX1 gene
- Search ViGene Biosciences for RUNX1
CRISPR Products
-
OriGene CRISPR knockouts for RUNX1
- genomics-online: gRNA clones - Search results for 123 available RUNX1 gene related products
- Overview of 123 available RUNX1 gene related products
- Applied Biological Materials CRISPR for RUNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
- GenScript: Design CRISPR guide RNA sequences for RUNX1
miRNA for RUNX1 Gene
- miRTarBase miRNAs that target RUNX1
-
- hsa-mir-27a-3p (MIRT000107)
- hsa-mir-17-5p (MIRT003741)
- hsa-mir-20a-5p (MIRT003742)
- hsa-mir-106a-5p (MIRT003743)
- hsa-mir-423-5p (MIRT038069)
- hsa-mir-675-5p (MIRT053591)
- hsa-mir-8485 (MIRT203374)
- hsa-mir-221-3p (MIRT438218)
- hsa-mir-7111-3p (MIRT534539)
- hsa-mir-4792 (MIRT534540)
- hsa-mir-6721-5p (MIRT534541)
- hsa-mir-6860 (MIRT534542)
- hsa-mir-612 (MIRT534543)
- hsa-mir-5189-5p (MIRT534544)
- hsa-mir-3187-5p (MIRT534545)
- hsa-mir-1285-3p (MIRT534546)
- hsa-mir-939-3p (MIRT534547)
- hsa-mir-6769b-3p (MIRT534548)
- hsa-mir-4723-3p (MIRT534549)
- hsa-mir-3183 (MIRT534550)
- hsa-mir-6791-5p (MIRT534551)
- hsa-mir-4292 (MIRT534552)
- hsa-mir-4308 (MIRT534553)
- hsa-mir-4762-5p (MIRT534554)
- hsa-mir-605-5p (MIRT534555)
- hsa-mir-551b-5p (MIRT534556)
- hsa-mir-4417 (MIRT569539)
- hsa-mir-4467 (MIRT569540)
- hsa-mir-6853-5p (MIRT569541)
- hsa-mir-8072 (MIRT569542)
- hsa-mir-4530 (MIRT569543)
- hsa-mir-3960 (MIRT569544)
- hsa-mir-922 (MIRT569545)
- hsa-mir-4789-3p (MIRT612533)
- hsa-mir-335-3p (MIRT622381)
- hsa-mir-5096 (MIRT622382)
- hsa-mir-377-3p (MIRT622383)
- hsa-mir-6885-3p (MIRT699881)
- hsa-mir-4446-5p (MIRT699882)
- hsa-mir-7152-5p (MIRT699883)
- hsa-mir-5006-3p (MIRT699884)
- hsa-mir-4755-5p (MIRT699885)
- hsa-mir-3180-5p (MIRT699886)
- hsa-mir-4639-5p (MIRT699887)
- hsa-mir-4497 (MIRT699888)
- hsa-mir-642a-5p (MIRT699889)
- hsa-mir-513a-5p (MIRT699890)
- hsa-mir-3160-5p (MIRT699891)
- hsa-mir-1266-3p (MIRT699892)
- hsa-mir-4667-3p (MIRT699893)
- hsa-mir-1470 (MIRT699894)
- hsa-mir-7157-5p (MIRT699895)
- hsa-mir-4310 (MIRT699896)
- hsa-mir-141-5p (MIRT699897)
- hsa-mir-2115-3p (MIRT699898)
- hsa-mir-1179 (MIRT699899)
- hsa-mir-27b-3p (MIRT699900)
- hsa-mir-128-3p (MIRT699901)
- hsa-mir-216a-3p (MIRT699902)
- hsa-mir-3681-3p (MIRT699903)
- hsa-mir-18a-5p (MIRT731126)
- ssc-mir-27b-3p (MIRT731370)
- hsa-mir-215-5p (MIRT732121)
- hsa-mir-9-5p (MIRT733692)
- hsa-mir-101-3p (MIRT734125)
- hsa-mir-144-5p (MIRT734389)
- hsa-mir-181a-5p (MIRT734590)
- hsa-mir-378a-3p (MIRT734686)
Transcription Factor Targets for RUNX1 Gene
Targeted motifs for RUNX1 Gene
HOMER Transcription Factor Regulatory Elements motif RUNX1
- Consensus sequence: AAACCACAAA Submotif: canonical Cell Type: Jurkat GEO ID: GSE29180
miRNA Products
- Search ViGene Biosciences for RUNX1
Inhibitory RNA Products
- Origene shrna products in human, mouse, rat for RUNX1
- Browse OriGene Inhibitory RNA Products For RUNX1
- genomics-online: shRNA clones - Search results for 123 available RUNX1 gene related products
- Overview of 123 available RUNX1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX1 gene
Clone Products
-
OriGene ORF clones in human for RUNX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RUNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RUNX1
- Applied Biological Materials Clones for RUNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RUNX1
-
ViGene Biosciences adenoviral particle packaged cDNA for RUNX1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RUNX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX1 gene
No data available for Enzyme Numbers (IUBMB) for RUNX1 Gene
Localization for RUNX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUNX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
- Nucleoplasm (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 7862156 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for RUNX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 2 | Endometrial cancer | ||
| 3 | Chronic myeloid leukemia | ||
| 4 | Pathways in cancer | ||
| 5 | Th17 cell differentiation | ||
Pathways by source for RUNX1 Gene
1 Cell Signaling Technology pathway for RUNX1 Gene
2 BioSystems pathways for RUNX1 Gene
6 KEGG pathways for RUNX1 Gene
Interacting Proteins for RUNX1 Gene
Selected Interacting proteins:
ENSP00000300305
Q01196-RUNX1_HUMAN
for RUNX1 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for RUNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001503 | ossification | IBA | -- |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | TAS | -- |
| GO:0002062 | chondrocyte differentiation | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for RUNX1 Gene
mRNA/cDNA for RUNX1 Gene
- (10) REFSEQ mRNAs :
- (34) Additional mRNA sequences :
- (184) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RUNX1 Gene
- Runt-related transcription factor 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RUNX1
- genomics-online: gRNA clones - Search results for 123 available RUNX1 gene related products
- Overview of 123 available RUNX1 gene related products
- Applied Biological Materials CRISPR for RUNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
- GenScript: Design CRISPR guide RNA sequences for RUNX1
miRNA Products
- Search ViGene Biosciences for RUNX1
Inhibitory RNA Products
- Origene shrna products in human, mouse, rat for RUNX1
- Browse OriGene Inhibitory RNA Products For RUNX1
- genomics-online: shRNA clones - Search results for 123 available RUNX1 gene related products
- Overview of 123 available RUNX1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RUNX1 gene
Clone Products
-
OriGene ORF clones in human for RUNX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RUNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RUNX1
- Applied Biological Materials Clones for RUNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - |
Expression for RUNX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Rib
- Prehypertrophic Chondrocytes Stylopod Growth Plate
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Vertebrae
- Prehypertrophic Chondrocytes Rib
- Prehypertrophic Chondrocytes Stylopod Growth Plate
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Primitive Erythrocytes Extraembryonic Blood Islands
- Hematopoietic Stem Cells Liver Bud
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Spinal Cord (Nervous System)
- Lateral Neurons Of The LMC Rostral Brachial Lateral Motor Division
- Lateral Neurons Of The LMC Caudal Brachial Lateral Motor Division
- Scapulohumeralis Posterior Muscle Motor Neurons Rostral Brachial Lateral Motor Division
- Lateral Neurons of the LMC Lumbar Lateral Motor Division
-
Neurons
- Lateral Neurons Of The LMC Rostral Brachial Lateral Motor Division
- Lateral Neurons Of The LMC Caudal Brachial Lateral Motor Division
- Scapulohumeralis Posterior Muscle Motor Neurons Rostral Brachial Lateral Motor Division
- Lateral Neurons of the LMC Lumbar Lateral Motor Division
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Tooth (Integumentary System)
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Ameloblasts Dental Enamel
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Erythroid Progenitor Cells Definitive Yolk Sac
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Oviduct
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Primitive Erythrocytes Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Epithelial Cells
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Eye (Sensory Organs)
- Umbilical Cord (Extraembryonic Tissues)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Heart (Cardiovascular System)
- Cardiac Crescent Cells Cardiac Crescent
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Epiblast (Early Embryonic Tissues)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for RUNX1 Gene
This gene is overexpressed in Minor Salivary Gland (x5.4).
This gene is overexpressed in Peripheral blood mononuclear cells (28.0), CD8 Tcells (16.3), CD4 Tcells (12.5), and Blymphocyte (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUNX1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RUNX1 Gene:
RUNX1SOURCE GeneReport for Unigene cluster for RUNX1 Gene:
Hs.149261mRNA Expression by UniProt/SwissProt for RUNX1 Gene:
Q01196-RUNX1_HUMAN
Tissue specificity:
Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Evidence on tissue expression from TISSUES for RUNX1 Gene
- Blood(4.6)
- Liver(4.3)
- Bone marrow(3.5)
- Nervous system(2.6)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNX1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
Regions:
Head and neck:
- face
- head
- neck
- nose
Abdomen:
- adrenal gland
- kidney
Pelvis:
- pelvis
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for RUNX1
-
OriGene qPCR primer pairs and template standards for RUNX1
- genomics-online: primer clones - Search results for 123 available RUNX1 gene related products
- Overview of 123 available RUNX1 gene related products
Orthologs for RUNX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RUNX1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RUNX1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RUNX1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Runx1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Runx1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RUNX1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RUNX1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RUNX1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RUNX1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | runx1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69003 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RUNX1 (2 of 2) 34 |
|
OneToMany | |
| runx1 33 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1379 35 |
|
|
|
| CG15455 35 |
|
|
|||
| run 35 34 |
|
||||
| lz 35 34 |
|
||||
| RunxA 34 |
|
ManyToMany | |||
| RunxB 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rnt-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for RUNX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RUNX1 Gene
(6) SIMAP similar genes for RUNX1 Gene using alignment to 9 proteins:
Variants for RUNX1 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1017287894 | uncertain-significance, Familial platelet disorder with associated myeloid malignancy | 34,792,496(-) | G/A/C | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1026501675 | uncertain-significance, Familial platelet disorder with associated myeloid malignancy | 34,789,769(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1056623039 | uncertain-significance, Familial platelet disorder with associated myeloid malignancy | 34,799,419(-) | C/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1057519748 | likely-pathogenic, Acute myeloid leukemia | 34,859,486(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, stop_gained | |
| rs1057519749 | likely-pathogenic, Acute myeloid leukemia | 34,880,579(-) | C/A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.98;
36.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUNX1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNX1 Gene
Disorders for RUNX1 Gene
(36) MalaCards diseases for RUNX1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| platelet disorder, familial, with associated myeloid malignancy |
|
|
| isolated delta-storage pool disease |
|
|
| acute myeloid leukemia with t(8;21)(q22;q22) translocation |
|
|
| leukemia, acute myeloid |
|
|
| leukemia, acute lymphoblastic 3 |
|
|
Search RUNX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RUNX1_HUMAN- Familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia. {ECO:0000269 PubMed:10508512}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving RUNX1 is found in acute leukemia. Translocation t(11,21)(q13;q22) that forms a MACROD1-RUNX1 fusion protein.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP or MECOM.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of M2 type acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1T1.
- Note=A chromosomal aberration involving RUNX1/AML1 is a cause of therapy-related myelodysplastic syndrome (T-MDS). Translocation t(3;21)(q26;q22) with EAP or MECOM.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in acute myeloid leukemia. Translocation t(20;21)(q11;q22) with CBFA2T2. {ECO:0000269 PubMed:20520637}.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3-end of TEL to the alternate 5-exon of AML-1H.
- Note=A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Additional Disease Information for RUNX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RUNX1 Gene
Publications for RUNX1 Gene
- Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. (PMID: 17431401) Fujimoto T … Nerlov C (The EMBO journal 2007) 3 4 22 58
- LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). (PMID: 17532767) Imagama S … Naoe T (European journal of haematology 2007) 3 4 22 58
- Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PMID: 14970218) Cho JY … Libermann TA (The Journal of biological chemistry 2004) 3 4 22 58
- A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells. (PMID: 9199349) Zhang YW … Ito Y (Molecular and cellular biology 1997) 3 4 22 58
- Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. (PMID: 8313895) Mitani K … Hirai H (The EMBO journal 1994) 3 4 22 58
Products for RUNX1 Gene
- R&D Systems Antibodies for RUNX1 (RUNX1/CBFA2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RUNX1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RUNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for RUNX1
- Origene Custom Protein Services for RUNX1
- Origene shrna products in human, mouse, rat for RUNX1
- Browse OriGene Inhibitory RNA Products For RUNX1
- OriGene qPCR primer pairs and template standards for RUNX1
- OriGene qPCR primer pairs for RUNX1
- OriGene CRISPR knockouts for RUNX1
- OriGene ORF clones in human for RUNX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RUNX1
- GenScript: Next-day shipping of latest version cDNA ORF clones for RUNX1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RUNX1
- GenScript Custom Assay Services for RUNX1
- GenScript Custom overexpressing Cell Line Services for RUNX1
- GenScript: Design CRISPR guide RNA sequences for RUNX1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RUNX1
- Cell Signaling Technology (CST) Antibodies for RUNX1 (AML1)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for RUNX1
- Novus Biologicals lysates and proteins for RUNX1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RUNX1
- Abcam proteins for RUNX1
- Abcam assays for RUNX1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for RUNX1
- Cloud-Clone Corp. Proteins for RUNX1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for RUNX1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUNX1
- VectorBuilder custom plasmid, inducible vectors for RUNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUNX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RUNX1
- antibodies-online: Search results for 284 available MECOM Antibodies ranked by validation data
- Compare Top MECOM Antibodies
- antibodies-online: Search results for 14 available MECOM Elisa Kits ranked by validation data
- Compare Top MECOM Elisa Kits
- Quality Products:
- antibodies-online: Search results for 8 available MECOM Proteins ranked by validation data
- Compare Top MECOM Proteins
- GeneTex RUNX1 antibody for RUNX1
- Search GeneTex for Proteins for RUNX1
- ViGene Biosciences adenoviral particle packaged cDNA for RUNX1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RUNX1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RUNX1 gene
- Search ViGene Biosciences for RUNX1
- Santa Cruz Biotechnology (SCBT) Antibodies for RUNX1
- Search Santa Cruz Biotechnology (SCBT) for RUNX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUNX1
- Custom Antibody ServicesProSci Antibodies for RUNX1
- Search for RUNX1 Proteins at ProSci
- Horizon Cell Lines for RUNX1
- genomics-online: cdna clones - Search results for 123 available MECOM gene related products
- Overview of 123 available MECOM gene related products
- orf clones - Search results for 123 available MECOM gene related products
- Overview of 123 available MECOM gene related products
- genomics-online: gRNA clones - Search results for 123 available MECOM gene related products
- Overview of 123 available MECOM gene related products
- genomics-online: primer clones - Search results for 123 available MECOM gene related products
- Overview of 123 available MECOM gene related products
- genomics-online: shRNA clones - Search results for 123 available MECOM gene related products
- Overview of 123 available MECOM gene related products
Sources for RUNX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142)