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Aliases for RUNDC1 Gene

Aliases for RUNDC1 Gene

  • RUN Domain Containing 1 2 3 5

External Ids for RUNDC1 Gene

Previous GeneCards Identifiers for RUNDC1 Gene

  • GC17P041506
  • GC17P038386
  • GC17P041132
  • GC17P036898
  • GC17P042981
  • GC17P043060
  • GC17P043142
  • GC17P043146
  • GC17P043180
  • GC17P043256
  • GC17P043318

Summaries for RUNDC1 Gene

Entrez Gene Summary for RUNDC1 Gene

  • This gene encodes a protein that contains a RUN (RPIP8, UNC-14 and NESCA) domain and a coiled coil domain. The encoded protein may negatively regulate p53 transcriptional activity. This gene is a potential candidate gene for predisposition to glioma in humans. [provided by RefSeq, May 2017]

GeneCards Summary for RUNDC1 Gene

RUNDC1 (RUN Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RUNDC1 Gene

  • May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Additional gene information for RUNDC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC1 Gene

Genomics for RUNDC1 Gene

GeneHancer (GH) Regulatory Elements for RUNDC1 Gene

Promoters and enhancers for RUNDC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042979 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 52 2.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 SP3 PTGES3L PTGES3L-AARSD1 RUNDC1 HMGN2P15 RPL27 IFI35 AARSD1 PIR51537
GH17I042982 Enhancer 0.5 ENCODE 550.8 +1.8 1773 0.4 GATA3 ZNF189 DPF2 FOXA1 PTGES3L PTGES3L-AARSD1 RUNDC1 NBR2 IFI35 PIR51537
GH17I042823 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -156.4 -156433 1.7 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B PSME3 MIR6781 BECN1 COA3 CNTD1 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2
GH17I042576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 -402.3 -402326 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC17P042577 GC17P042580 PSMC3IP DHX8 HMGN1P29 ENSG00000267758 TUBG2 NBR2 MLX STAT5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RUNDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RUNDC1 gene promoter:

Genomic Locations for RUNDC1 Gene

Genomic Locations for RUNDC1 Gene
13,187 bases
Plus strand

Genomic View for RUNDC1 Gene

Genes around RUNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC1 Gene

Proteins for RUNDC1 Gene

  • Protein details for RUNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUN domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6Y2K8
    • Q8IXT9
    • Q8N3W1

    Protein attributes for RUNDC1 Gene

    613 amino acids
    Molecular mass:
    67643 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14873.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO86728.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC1 Gene


neXtProt entry for RUNDC1 Gene

Post-translational modifications for RUNDC1 Gene

  • Ubiquitination at isoforms=2383
  • Modification sites at PhosphoSitePlus

Other Protein References for RUNDC1 Gene

No data available for DME Specific Peptides for RUNDC1 Gene

Domains & Families for RUNDC1 Gene

Gene Families for RUNDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RUNDC1 Gene


Suggested Antigen Peptide Sequences for RUNDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RUNDC1: view

No data available for UniProtKB/Swiss-Prot for RUNDC1 Gene

Function for RUNDC1 Gene

Molecular function for RUNDC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Gene Ontology (GO) - Molecular Function for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RUNDC1: view
genes like me logo Genes that share phenotypes with RUNDC1: view

Animal Models for RUNDC1 Gene

MGI Knock Outs for RUNDC1:

Animal Model Products

CRISPR Products

miRNA for RUNDC1 Gene

miRTarBase miRNAs that target RUNDC1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNDC1 Gene

Localization for RUNDC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RUNDC1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RUNDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RUNDC1 Gene

Pathways & Interactions for RUNDC1 Gene

SuperPathways for RUNDC1 Gene

No Data Available

Interacting Proteins for RUNDC1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96C34-RUND1_HUMAN ENSP00000354622 for RUNDC1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RUNDC1: view

No data available for Pathways by source and SIGNOR curated interactions for RUNDC1 Gene

Drugs & Compounds for RUNDC1 Gene

No Compound Related Data Available

Transcripts for RUNDC1 Gene

Unigene Clusters for RUNDC1 Gene

RUN domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC1 Gene

No ASD Table

Relevant External Links for RUNDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUNDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RUNDC1 Gene

Protein differential expression in normal tissues from HIPED for RUNDC1 Gene

This gene is overexpressed in Monocytes (56.8) and Islet of Langerhans (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUNDC1 Gene

Protein tissue co-expression partners for RUNDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RUNDC1 Gene:


SOURCE GeneReport for Unigene cluster for RUNDC1 Gene:


Evidence on tissue expression from TISSUES for RUNDC1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RUNDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNDC1 Gene

Orthologs for RUNDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RUNDC1 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia RUNDC1 33 34
  • 90.76 (n)
(Bos Taurus)
Mammalia RUNDC1 33 34
  • 89.42 (n)
(Mus musculus)
Mammalia Rundc1 33 16 34
  • 87.35 (n)
(Rattus norvegicus)
Mammalia Rundc1 33
  • 86.86 (n)
(Monodelphis domestica)
Mammalia RUNDC1 34
  • 81 (a)
(Gallus gallus)
Aves RUNDC1 34
  • 75 (a)
(Anolis carolinensis)
Reptilia RUNDC1 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rundc1 33
  • 68.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2440 33
(Danio rerio)
Actinopterygii LOC100537899 33
  • 67.28 (n)
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12801 33
fruit fly
(Drosophila melanogaster)
Insecta CG3703 33 34
  • 48.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004080 33
  • 47.9 (n)
(Caenorhabditis elegans)
Secernentea T19D7.4 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2174 34
  • 29 (a)
Species where no ortholog for RUNDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RUNDC1 Gene

Gene Tree for RUNDC1 (if available)
Gene Tree for RUNDC1 (if available)

Paralogs for RUNDC1 Gene Pseudogenes for RUNDC1 Gene

genes like me logo Genes that share paralogs with RUNDC1: view

No data available for Paralogs for RUNDC1 Gene

Variants for RUNDC1 Gene

Sequence variations from dbSNP and Humsavar for RUNDC1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs864622034 uncertain-significance, Malignant tumor of prostate 42,990,326(+) G/C coding_sequence_variant, missense_variant
rs1000245006 -- 42,983,944(+) A/G intron_variant
rs1000443307 -- 42,992,837(+) G/T 3_prime_UTR_variant
rs1000585429 -- 42,985,463(+) G/A intron_variant
rs1000617736 -- 42,988,473(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC1 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457742 CNV loss 19166990
nsv483009 CNV gain 15286789
nsv575052 CNV loss 21841781

Variation tolerance for RUNDC1 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RUNDC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC1 Gene

Disorders for RUNDC1 Gene

Additional Disease Information for RUNDC1

No disorders were found for RUNDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC1 Gene

Publications for RUNDC1 Gene

  1. A high-throughput loss-of-function screening identifies novel p53 regulators. (PMID: 16929179) Llanos S … Serrano M (Cell cycle (Georgetown, Tex.) 2006) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium. (PMID: 25652157) Jalali A … Bondy ML (Scientific reports 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for RUNDC1 Gene

Sources for RUNDC1 Gene

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