Aliases for RUFY1 Gene
Aliases for RUFY1 Gene
External Ids for RUFY1 Gene
- HGNC: 19760
- Entrez Gene: 80230
- Ensembl: ENSG00000176783
- OMIM: 610327
- UniProtKB: Q96T51
Previous GeneCards Identifiers for RUFY1 Gene
- GC00U990921
- GC05P179802
- GC05P179045
- GC05P179090
- GC05P178910
- GC05P178977
- GC05P173702
Summaries for RUFY1 Gene
-
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for RUFY1 Gene
RUFY1 (RUN And FYVE Domain Containing 1) is a Protein Coding gene. Among its related pathways are Metabolism and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and protein transporter activity. An important paralog of this gene is RUFY2.
UniProtKB/Swiss-Prot for RUFY1 Gene
-
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Additional gene information for RUFY1 Gene
- Monarch Initiative
- Search for RUFY1 at DataMed
- Search for RUFY1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY1 Gene
Genomics for RUFY1 Gene
GeneHancer (GH) Regulatory Elements for RUFY1 Gene
Promoters and enhancers for RUFY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RUFY1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RUFY1 Gene
Genomic Locations for RUFY1 Gene
- chr5:179,550,558-179,610,026
- (GRCh38/hg38)
- Size:
- 59,469 bases
- Orientation:
- Plus strand
- chr5:178,977,559-179,037,027
- (GRCh37/hg19)
Genomic View for RUFY1 Gene
Genes around RUFY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
RUFY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RUFY1 Gene
Proteins for RUFY1 Gene
-
Protein details for RUFY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96T51-RUFY1_HUMAN
- Recommended name:
- RUN and FYVE domain-containing protein 1
- Protein Accession:
- Q96T51
- Q59FF3
- Q71S93
- Q9H6I3
Protein attributes for RUFY1 Gene
- Size:
- 708 amino acids
- Molecular mass:
- 79818 Da
- Quaternary structure:
-
- Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.
- SequenceCaution:
-
- Sequence=AAK50771.1; Type=Frameshift; Positions=47, 88; Evidence={ECO:0000305}; Sequence=BAB15276.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RUFY1 Gene
Post-translational modifications for RUFY1 Gene
- Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RUFY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RUFY1
- Invitrogen Antibodies for RUFY1
- GeneTex RUFY1 antibody for RUFY1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RUFY1
Protein Products
-
OriGene Purified Proteins for RUFY1
- Search Origene for MassSpec and Protein Over-expression Lysates for RUFY1
- Origene Custom Protein Services for RUFY1
- antibodies-online: Search results for 6 available RUFY1 Proteins ranked by validation data
- Compare Top RUFY1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for RUFY1
-
Abcam proteins for RUFY1
Assay Products
No data available for DME Specific Peptides for RUFY1 Gene
Domains & Families for RUFY1 Gene
Gene Families for RUFY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RUFY1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RUFY1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96T51UniProtKB/Swiss-Prot:
RUFY1_HUMAN :- The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
- Domain:
-
- The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Function for RUFY1 Gene
Molecular function for RUFY1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Phenotypes From GWAS Catalog for RUFY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21988832 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0008565 | protein transporter activity | IEA | -- |
| GO:0017124 | SH3 domain binding | IPI | 11877430 |
| GO:0042169 | SH2 domain binding | IPI | 11877430 |
Phenotypes for RUFY1 Gene
- GenomeRNAi human phenotypes for RUFY1:
-
- Increased vaccinia virus (VACV) infection
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability after ionizing radiation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RUFY1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RUFY1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUFY1 gene
- Search ViGene Biosciences for RUFY1
CRISPR Products
-
OriGene CRISPR knockouts for RUFY1
- genomics-online: gRNA clones - Search results for available RUFY1 gene related products
- Applied Biological Materials CRISPR for RUFY1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUFY1
- GenScript: Design CRISPR guide RNA sequences for RUFY1
miRNA Products
- Search ViGene Biosciences for RUFY1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RUFY1
- Browse OriGene Inhibitory RNA Products For RUFY1
- genomics-online: shRNA clones - Search results for available RUFY1 gene related products
-
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Clone Products
-
OriGene ORF clones in human for RUFY1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder custom plasmid, inducible vectors for RUFY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUFY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available RUFY1 gene related products
- orf clones - Search results for available RUFY1 gene related products
- Applied Biological Materials Clones for RUFY1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RUFY1
-
ViGene Biosciences adenoviral particle packaged cDNA for RUFY1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RUFY1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RUFY1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RUFY1 Gene
Localization for RUFY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RUFY1 Gene
- Cytoplasm. Early endosome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Vesicles (3)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IDA,IEA | 11877430 |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for RUFY1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | PI Metabolism |
.63
|
|
| 3 | Endocytosis | ||
| 4 | Glycerophospholipid biosynthesis | ||
Pathways by source for RUFY1 Gene
5 Reactome pathways for RUFY1 Gene
1 KEGG pathway for RUFY1 Gene
Interacting Proteins for RUFY1 Gene
Selected Interacting proteins:
Q96T51-RUFY1_HUMAN
ENSP00000325594
for RUFY1 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0030100 | regulation of endocytosis | IPI | 11877430 |
No data available for SIGNOR curated interactions for RUFY1 Gene
Drugs & Compounds for RUFY1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for RUFY1 Gene
mRNA/cDNA for RUFY1 Gene
- (11) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (205) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RUFY1 Gene
- RUN and FYVE domain containing 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RUFY1
- genomics-online: gRNA clones - Search results for available RUFY1 gene related products
- Applied Biological Materials CRISPR for RUFY1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RUFY1
- GenScript: Design CRISPR guide RNA sequences for RUFY1
miRNA Products
- Search ViGene Biosciences for RUFY1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RUFY1
- Browse OriGene Inhibitory RNA Products For RUFY1
- genomics-online: shRNA clones - Search results for available RUFY1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RUFY1 gene
Clone Products
-
OriGene ORF clones in human for RUFY1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RUFY1
- VectorBuilder custom plasmid, inducible vectors for RUFY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RUFY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available RUFY1 gene related products
- orf clones - Search results for available RUFY1 gene related products
- Applied Biological Materials Clones for RUFY1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | - | - | - | ||||||||||
| SP3: | - | - | - | ||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: |
Expression for RUFY1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (17.3), Lymph node (11.1), and Lavage (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUFY1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RUFY1 Gene:
RUFY1SOURCE GeneReport for Unigene cluster for RUFY1 Gene:
Hs.306769mRNA Expression by UniProt/SwissProt for RUFY1 Gene:
Q96T51-RUFY1_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in lung, testis, kidney and brain.
Evidence on tissue expression from TISSUES for RUFY1 Gene
- Nervous system(4.7)
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for RUFY1
-
OriGene qPCR primer pairs and template standards for RUFY1
- genomics-online: primer clones - Search results for available RUFY1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RUFY1 Gene
Orthologs for RUFY1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC462328 33 |
|
||
| RUFY1 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | RUFY1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RUFY1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rufy1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Rufy1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RUFY1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RUFY1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RUFY1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RUFY1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rufy1 33 |
|
||
| Str.16805 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100330077 33 |
|
||
| RUFY1 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG31064 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10485 33 |
|
- Species where no ortholog for RUFY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RUFY1 Gene
(28) SIMAP similar genes for RUFY1 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for RUFY1 Gene
Variants for RUFY1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035985 | A breast cancer sample | p.Cys267Phe | |||
| rs1000015290 | -- | 179,586,692(+) | A/C | intron_variant | |
| rs1000082243 | -- | 179,551,213(+) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000118440 | -- | 179,581,302(+) | C/T | intron_variant | |
| rs1000190325 | -- | 179,592,013(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759397 | CNV | gain | 17122850 |
| esv3429456 | CNV | duplication | 20981092 |
| esv3607747 | CNV | gain | 21293372 |
| esv3607748 | CNV | gain | 21293372 |
| esv3890773 | CNV | gain | 25118596 |
| nsv1022509 | CNV | gain | 25217958 |
| nsv1074895 | CNV | deletion | 25765185 |
| nsv1137049 | CNV | deletion | 24896259 |
| nsv1145083 | CNV | deletion | 24896259 |
| nsv281 | OTHER | inversion | 15895083 |
| nsv477188 | CNV | novel sequence insertion | 20440878 |
| nsv477317 | CNV | novel sequence insertion | 20440878 |
| nsv5159 | CNV | insertion | 18451855 |
| nsv7375 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
7.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.11;
38.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RUFY1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RUFY1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY1 Gene
Disorders for RUFY1 Gene
Additional Disease Information for RUFY1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RUFY1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUFY1 Gene
Publications for RUFY1 Gene
- Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. (PMID: 11877430) Yang J … Qiu Y (The Journal of biological chemistry 2002) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PMID: 14617813) Fouraux MA … Pruijn GJ (Molecular biology of the cell 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for RUFY1 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 52 available RUFY1 Antibodies ranked by validation data
- Compare Top RUFY1 Antibodies
- antibodies-online: Search results for available RUFY1 related products ranked by validation data
- antibodies-online: Search results for 6 available RUFY1 Proteins ranked by validation data
- Compare Top RUFY1 Proteins
- Quality Products:
- GeneTex RUFY1 antibody for RUFY1
- Search GeneTex for Proteins for RUFY1
- ViGene Biosciences adenoviral particle packaged cDNA for RUFY1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RUFY1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RUFY1 gene
- Search ViGene Biosciences for RUFY1
- Santa Cruz Biotechnology (SCBT) Antibodies for RUFY1
- Search Santa Cruz Biotechnology (SCBT) for RUFY1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RUFY1
- Horizon Cell Lines for RUFY1
- genomics-online: cdna clones - Search results for available RUFY1 gene related products
- orf clones - Search results for available RUFY1 gene related products
- genomics-online: gRNA clones - Search results for available RUFY1 gene related products
- genomics-online: primer clones - Search results for available RUFY1 gene related products
- genomics-online: shRNA clones - Search results for available RUFY1 gene related products
Sources for RUFY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems