Aliases for RTP5 Gene

Aliases for RTP5 Gene

  • Receptor Transporter Protein 5 (Putative) 2 3 5
  • Z3CXXC5 2 3 4
  • Receptor (Chemosensory) Transporter Protein 5 (Putative) 2 3
  • 3CxxC-Type Zinc Finger Protein 5 3 4
  • CXXC-Type Zinc Finger Protein 11 3 4
  • Receptor-Transporting Protein 5 3 4
  • Zinc Finger, 3CxxC-Type 5 2 3
  • CXXC Finger Protein 11 2 3
  • C2orf85 3 4
  • CXXC11 3 4
  • Chromosome 2 Open Reading Frame 85 2
  • FLJ33590 2
  • RTP5 5

External Ids for RTP5 Gene

Previous HGNC Symbols for RTP5 Gene

  • C2orf85
  • CXXC11

Previous GeneCards Identifiers for RTP5 Gene

  • GC02P242813

Summaries for RTP5 Gene

GeneCards Summary for RTP5 Gene

RTP5 (Receptor Transporter Protein 5 (Putative)) is a Protein Coding gene. Diseases associated with RTP5 include Venous Hemangioma and Pancreas, Annular. Among its related pathways are Signaling by GPCR and Olfactory transduction. An important paralog of this gene is RTP3.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTP5 Gene

Genomics for RTP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RTP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTP5

Genomic Locations for RTP5 Gene

Latest Assembly
chr2:241,869,600-241,873,823
(GRCh38/hg38)
Size:
4,224 bases
Orientation:
Plus strand

Previous Assembly
chr2:242,811,881-242,815,975
(GRCh37/hg19 by Entrez Gene)
Size:
4,095 bases
Orientation:
Plus strand

chr2:242,811,752-242,815,975
(GRCh37/hg19 by Ensembl)
Size:
4,224 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr2(ALT_REF_LOCI_1):81,827-85,921 (+)

Genomic View for RTP5 Gene

Genes around RTP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP5 Gene

Proteins for RTP5 Gene

  • Protein details for RTP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14D33-RTP5_HUMAN
    Recommended name:
    Receptor-transporting protein 5
    Protein Accession:
    Q14D33
    Secondary Accessions:
    • Q8N2A5

    Protein attributes for RTP5 Gene

    Size:
    572 amino acids
    Molecular mass:
    60488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTP5 Gene

Post-translational modifications for RTP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP5 Gene

No data available for DME Specific Peptides for RTP5 Gene

Domains & Families for RTP5 Gene

Gene Families for RTP5 Gene

Protein Domains for RTP5 Gene

genes like me logo Genes that share domains with RTP5: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RTP5 Gene

Function for RTP5 Gene

Phenotypes From GWAS Catalog for RTP5 Gene

Gene Ontology (GO) - Molecular Function for RTP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031849 olfactory receptor binding IBA 21873635
genes like me logo Genes that share ontologies with RTP5: view
genes like me logo Genes that share phenotypes with RTP5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTP5 Gene

Localization for RTP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP5 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP5 gene
Compartment Confidence
cytosol 2
peroxisome 1
nucleus 1
extracellular 0
mitochondrion 0

Gene Ontology (GO) - Cellular Components for RTP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTP5 Gene

Pathways & Interactions for RTP5 Gene

PathCards logo

SuperPathways for RTP5 Gene

genes like me logo Genes that share pathways with RTP5: view

Pathways by source for RTP5 Gene

Gene Ontology (GO) - Biological Process for RTP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA 21873635
GO:0006612 protein targeting to membrane IBA 21873635
GO:0051205 protein insertion into membrane IBA 21873635
genes like me logo Genes that share ontologies with RTP5: view

No data available for SIGNOR curated interactions for RTP5 Gene

Drugs & Compounds for RTP5 Gene

No Compound Related Data Available

Transcripts for RTP5 Gene

mRNA/cDNA for RTP5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP5

Alternative Splicing Database (ASD) splice patterns (SP) for RTP5 Gene

No ASD Table

Relevant External Links for RTP5 Gene

GeneLoc Exon Structure for
RTP5

Expression for RTP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTP5 Gene

mRNA differential expression in normal tissues according to GTEx for RTP5 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.0), Brain - Hippocampus (x7.7), Brain - Amygdala (x7.0), and Brain - Nucleus accumbens (basal ganglia) (x6.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTP5

Evidence on tissue expression from TISSUES for RTP5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RTP5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP5 Gene

Orthologs for RTP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP5 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia CXXC11 29 30
  • 64.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CXXC11 29 30
  • 63.12 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CXXC11 30
  • 28 (a)
OneToOne
Species where no ortholog for RTP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RTP5 Gene

ENSEMBL:
Gene Tree for RTP5 (if available)
TreeFam:
Gene Tree for RTP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTP5: view image
Alliance of Genome Resources:
Additional Orthologs for RTP5

Paralogs for RTP5 Gene

Paralogs for RTP5 Gene

genes like me logo Genes that share paralogs with RTP5: view

Variants for RTP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTP5 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs76064495 Benign: not provided 241,871,734(+) C/T
NM_173821.3(RTP5):c.179C>T (p.Pro60Leu)
MISSENSE
rs7420371 -- p.Gly101Glu
VAR_069402 -- p.Gly412Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RTP5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RTP5 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv2196n106 CNV deletion 24896259
dgv4200n100 CNV loss 25217958
dgv4201n100 CNV gain 25217958
esv3893582 CNV gain 25118596
nsv1002941 CNV gain 25217958
nsv470533 CNV loss 18288195
nsv584991 CNV loss 21841781
nsv955302 CNV deletion 24416366
nsv997984 CNV gain 25217958
nsv998059 CNV loss 25217958

Variation tolerance for RTP5 Gene

Residual Variation Intolerance Score: 81.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.35; 88.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP5
Leiden Open Variation Database (LOVD)
RTP5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP5 Gene

Disorders for RTP5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RTP5 Gene - From: COP

Disorder Aliases PubMed IDs
venous hemangioma
pancreas, annular
  • annular pancreas
duodenal atresia
  • duodenal stenosis
- elite association - COSMIC cancer census association via MalaCards
Search RTP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTP5

genes like me logo Genes that share disorders with RTP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTP5 Gene

Publications for RTP5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for RTP5 Gene

Sources for RTP5 Gene