Aliases for RTP4 Gene

Aliases for RTP4 Gene

  • Receptor Transporter Protein 4 2 3 5
  • 28 KDa Interferon-Responsive Protein 3 4
  • 3CxxC-Type Zinc Finger Protein 4 3 4
  • Receptor-Transporting Protein 4 3 4
  • Zinc Finger, 3CxxC-Type 4 2 3
  • Z3CXXC4 3 4
  • IFRG28 3 4
  • Receptor (Chemosensory) Transporter Protein 4 3
  • 28kD Interferon Responsive Protein 3

External Ids for RTP4 Gene

Previous GeneCards Identifiers for RTP4 Gene

  • GC03P188569
  • GC03P187086
  • GC03P184491

Summaries for RTP4 Gene

GeneCards Summary for RTP4 Gene

RTP4 (Receptor Transporter Protein 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. An important paralog of this gene is RTP3.

UniProtKB/Swiss-Prot Summary for RTP4 Gene

  • Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

Additional gene information for RTP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTP4 Gene

Genomics for RTP4 Gene

GeneHancer (GH) Regulatory Elements for RTP4 Gene

Promoters and enhancers for RTP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187367 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 524.8 +0.6 580 2.9 ZBTB11 RELA TRIM22 POLR2A ZNF384 SRF IRF1 SPI1 IRF2 ASH2L RTP4 piR-53063-160 piR-50129-168 BCL6 NONHSAG036937.2
GH03J187208 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.3 -158.3 -158292 5 TEAD4 ZBTB11 ZNF623 HES1 CTBP1 RBM25 HDAC3 NR2F2 NCOR1 ZNF585B HSALNG0031410 TBCCD1 MASP1 RTP1 RTP4 LOC101929106 LOC105374260
GH03J187318 Enhancer 0.9 ENCODE CraniofacialAtlas 11.3 -48.8 -48808 1.8 CTCF REST RAD21 TRIM22 SMC3 ESRRA USF1 GABPA CEBPB SPI1 SST MASP1 RTP4 HSALNG0031413 RF00017-4203
GH03J187359 Enhancer 0.4 Ensembl 21.6 -6.9 -6879 4.2 SPI1 POU5F1 NANOG RTP4 piR-50129-168 HSALNG0031413
GH03J187735 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.9 +373.4 373430 13 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 MYC BCL6 ENSG00000285938 ENSG00000228804 RFC4 SNORA4 SNORA63B SNORA81 LPP ST6GAL1 RTP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTP4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTP4

Top Transcription factor binding sites by QIAGEN in the RTP4 gene promoter:
  • ATF6
  • c-Myc
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO3a
  • FOXO3b
  • IRF-1
  • Max
  • Nkx2-5
  • STAT5A

Genomic Locations for RTP4 Gene

Genomic Locations for RTP4 Gene
chr3:187,368,380-187,372,076
(GRCh38/hg38)
Size:
3,697 bases
Orientation:
Plus strand
chr3:187,086,120-187,089,864
(GRCh37/hg19)
Size:
3,745 bases
Orientation:
Plus strand

Genomic View for RTP4 Gene

Genes around RTP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP4 Gene

Proteins for RTP4 Gene

  • Protein details for RTP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX8-RTP4_HUMAN
    Recommended name:
    Receptor-transporting protein 4
    Protein Accession:
    Q96DX8
    Secondary Accessions:
    • Q9H4F3

    Protein attributes for RTP4 Gene

    Size:
    246 amino acids
    Molecular mass:
    27863 Da
    Quaternary structure:
    • Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).

neXtProt entry for RTP4 Gene

Post-translational modifications for RTP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP4 Gene

Domains & Families for RTP4 Gene

Gene Families for RTP4 Gene

Protein Domains for RTP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP4 Gene

GenScript: Design optimal peptide antigens:
  • 28 kDa interferon-responsive protein (RTP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96DX8

UniProtKB/Swiss-Prot:

RTP4_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP4: view

Function for RTP4 Gene

Molecular function for RTP4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
UniProtKB/Swiss-Prot Induction:
By interferons.

Phenotypes From GWAS Catalog for RTP4 Gene

Gene Ontology (GO) - Molecular Function for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16720576
GO:0031849 olfactory receptor binding IBA 21873635
genes like me logo Genes that share ontologies with RTP4: view
genes like me logo Genes that share phenotypes with RTP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTP4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTP4 Gene

Localization for RTP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP4 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP4 gene
Compartment Confidence
cytosol 3
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16720576
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP4: view

Pathways & Interactions for RTP4 Gene

PathCards logo

SuperPathways for RTP4 Gene

genes like me logo Genes that share pathways with RTP4: view

Pathways by source for RTP4 Gene

Gene Ontology (GO) - Biological Process for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0006612 protein targeting to membrane IDA 16720576
GO:0051205 protein insertion into membrane IBA 21873635
GO:0051607 defense response to virus IDA 21478870
genes like me logo Genes that share ontologies with RTP4: view

No data available for SIGNOR curated interactions for RTP4 Gene

Drugs & Compounds for RTP4 Gene

No Compound Related Data Available

Transcripts for RTP4 Gene

mRNA/cDNA for RTP4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP4 Gene

No ASD Table

Relevant External Links for RTP4 Gene

GeneLoc Exon Structure for
RTP4

Expression for RTP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RTP4 Gene

This gene is overexpressed in CD8 Tcells (38.3) and Heart (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RTP4 Gene



Protein tissue co-expression partners for RTP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTP4

SOURCE GeneReport for Unigene cluster for RTP4 Gene:

Hs.43388

mRNA Expression by UniProt/SwissProt for RTP4 Gene:

Q96DX8-RTP4_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.

Evidence on tissue expression from TISSUES for RTP4 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with RTP4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP4 Gene

Orthologs for RTP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTP4 31 30
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC532442 30
  • 76.56 (n)
RTP4 31
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTP4 31 30
  • 71.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtp4 30
  • 65.05 (n)
mouse
(Mus musculus)
Mammalia Rtp4 17 31 30
  • 59.18 (n)
Species where no ortholog for RTP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP4 Gene

ENSEMBL:
Gene Tree for RTP4 (if available)
TreeFam:
Gene Tree for RTP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTP4: view image

Paralogs for RTP4 Gene

Paralogs for RTP4 Gene

(1) SIMAP similar genes for RTP4 Gene using alignment to 1 proteins:

  • RTP4_HUMAN
genes like me logo Genes that share paralogs with RTP4: view

Variants for RTP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTP4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1047584 - p.Thr79Ile
rs35224605 - p.Ser168Asn

Additional dbSNP identifiers (rs#s) for RTP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RTP4 Gene

Variant ID Type Subtype PubMed ID
esv3569169 CNV loss 25503493
nsv1009271 CNV gain 25217958
nsv1014596 CNV gain 25217958

Variation tolerance for RTP4 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.88; 89.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP4 Gene

Disorders for RTP4 Gene

Additional Disease Information for RTP4

No disorders were found for RTP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP4 Gene

Publications for RTP4 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4 54
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4 54
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for RTP4 Gene

Sources for RTP4 Gene