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Aliases for RTP4 Gene

Aliases for RTP4 Gene

  • Receptor Transporter Protein 4 2 3 5
  • 28 KDa Interferon-Responsive Protein 3 4
  • 3CxxC-Type Zinc Finger Protein 4 3 4
  • Zinc Finger, 3CxxC-Type 4 2 3
  • Z3CXXC4 3 4
  • IFRG28 3 4
  • Receptor (Chemosensory) Transporter Protein 4 3
  • 28kD Interferon Responsive Protein 3
  • Receptor-Transporting Protein 4 3

External Ids for RTP4 Gene

Previous GeneCards Identifiers for RTP4 Gene

  • GC03P188569
  • GC03P187086
  • GC03P184491

Summaries for RTP4 Gene

GeneCards Summary for RTP4 Gene

RTP4 (Receptor Transporter Protein 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. An important paralog of this gene is RTP3.

UniProtKB/Swiss-Prot for RTP4 Gene

  • Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

Additional gene information for RTP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP4 Gene

Genomics for RTP4 Gene

GeneHancer (GH) Regulatory Elements for RTP4 Gene

Promoters and enhancers for RTP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187367 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 674.9 +0.5 520 2.7 ZNF639 SRF IRF2 STAT1 TAF1 ZBTB11 TRIM22 RELA YY1 SP1 RTP4 BCL6 ENSG00000280270
GH03J187318 Enhancer 0.9 Ensembl ENCODE 11.3 -48.8 -48760 1.8 CTCF ESRRA MAX ERF ZNF384 ZNF2 RAD21 RFX5 ZNF335 CC2D1A SST MASP1 RTP4
GH03J187209 Enhancer 1 Ensembl ENCODE 9.3 -157.8 -157803 1.3 HDAC1 MEIS2 TEAD4 TAL1 ZNF644 FOSL1 CCNT2 TCF12 CTBP1 ZNF766 MASP1 RTP4 RTP1 LOC101929106 LOC105374260
GH03J187735 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 +373.5 373478 13 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 MEF2D SSRP1 ZNF610 BCL6 LOC100131635 SNORA4 RFC4 SNORA63B LPP SNORA81 ST6GAL1 RTP4 RTP2
GH03J187403 Enhancer 0.9 Ensembl ENCODE 7.2 +35.6 35585 1.7 MXI1 JUN MAX BRCA1 ZNF507 RFX5 HIC1 ZNF366 SMC3 RCOR1 RTP4 ENSG00000239093 ENSG00000280270
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RTP4 gene promoter:
  • IRF-1
  • STAT5A
  • ATF6
  • FOXJ2 (long isoform)
  • FOXJ2
  • c-Myc
  • Max
  • Nkx2-5
  • FOXO3b
  • FOXO3a

Genomic Locations for RTP4 Gene

Genomic Locations for RTP4 Gene
chr3:187,368,332-187,372,076
(GRCh38/hg38)
Size:
3,745 bases
Orientation:
Plus strand
chr3:187,086,120-187,089,864
(GRCh37/hg19)
Size:
3,745 bases
Orientation:
Plus strand

Genomic View for RTP4 Gene

Genes around RTP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP4 Gene

Proteins for RTP4 Gene

  • Protein details for RTP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX8-RTP4_HUMAN
    Recommended name:
    Receptor-transporting protein 4
    Protein Accession:
    Q96DX8
    Secondary Accessions:
    • Q9H4F3

    Protein attributes for RTP4 Gene

    Size:
    246 amino acids
    Molecular mass:
    27863 Da
    Quaternary structure:
    • Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).

neXtProt entry for RTP4 Gene

Post-translational modifications for RTP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP4 Gene

Domains & Families for RTP4 Gene

Gene Families for RTP4 Gene

Protein Domains for RTP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DX8

UniProtKB/Swiss-Prot:

RTP4_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP4: view

Function for RTP4 Gene

Molecular function for RTP4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
UniProtKB/Swiss-Prot Induction:
By interferons.

Phenotypes From GWAS Catalog for RTP4 Gene

Gene Ontology (GO) - Molecular Function for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16720576
GO:0031849 olfactory receptor binding IBA --
genes like me logo Genes that share ontologies with RTP4: view
genes like me logo Genes that share phenotypes with RTP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTP4 Gene

Localization for RTP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP4 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP4 gene
Compartment Confidence
cytosol 3
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16720576
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP4: view

Pathways & Interactions for RTP4 Gene

genes like me logo Genes that share pathways with RTP4: view

Pathways by source for RTP4 Gene

Interacting Proteins for RTP4 Gene

Gene Ontology (GO) - Biological Process for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0006612 protein targeting to membrane IDA 16720576
GO:0051205 protein insertion into membrane IBA --
GO:0051607 defense response to virus IDA 21478870
genes like me logo Genes that share ontologies with RTP4: view

No data available for SIGNOR curated interactions for RTP4 Gene

Drugs & Compounds for RTP4 Gene

No Compound Related Data Available

Transcripts for RTP4 Gene

mRNA/cDNA for RTP4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP4 Gene

Receptor (chemosensory) transporter protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP4 Gene

No ASD Table

Relevant External Links for RTP4 Gene

GeneLoc Exon Structure for
RTP4
ECgene alternative splicing isoforms for
RTP4

Expression for RTP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RTP4 Gene

This gene is overexpressed in CD8 Tcells (38.3) and Heart (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RTP4 Gene



Protein tissue co-expression partners for RTP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RTP4 Gene:

RTP4

SOURCE GeneReport for Unigene cluster for RTP4 Gene:

Hs.43388

mRNA Expression by UniProt/SwissProt for RTP4 Gene:

Q96DX8-RTP4_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.

Evidence on tissue expression from TISSUES for RTP4 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with RTP4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP4 Gene

Orthologs for RTP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTP4 34 33
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC532442 33
  • 76.56 (n)
RTP4 34
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTP4 34 33
  • 71.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtp4 33
  • 65.05 (n)
mouse
(Mus musculus)
Mammalia Rtp4 16 34 33
  • 59.18 (n)
Species where no ortholog for RTP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP4 Gene

ENSEMBL:
Gene Tree for RTP4 (if available)
TreeFam:
Gene Tree for RTP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTP4: view image

Paralogs for RTP4 Gene

Paralogs for RTP4 Gene

(1) SIMAP similar genes for RTP4 Gene using alignment to 1 proteins:

  • RTP4_HUMAN
genes like me logo Genes that share paralogs with RTP4: view

Variants for RTP4 Gene

Sequence variations from dbSNP and Humsavar for RTP4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000412394 -- 187,368,028(+) G/A upstream_transcript_variant
rs1000685460 -- 187,367,921(+) A/C upstream_transcript_variant
rs1000688214 -- 187,369,094(+) T/C intron_variant
rs1000741574 -- 187,369,522(+) T/C intron_variant
rs1001205774 -- 187,368,082(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RTP4 Gene

Variant ID Type Subtype PubMed ID
esv3569169 CNV loss 25503493
nsv1009271 CNV gain 25217958
nsv1014596 CNV gain 25217958

Variation tolerance for RTP4 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.88; 89.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP4 Gene

Disorders for RTP4 Gene

Additional Disease Information for RTP4

No disorders were found for RTP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP4 Gene

Publications for RTP4 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4 58
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4 58
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 58

Products for RTP4 Gene

Sources for RTP4 Gene

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