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Aliases for RTP3 Gene

Aliases for RTP3 Gene

  • Receptor Transporter Protein 3 2 3 5
  • TMEM7 2 3 4
  • 3CxxC-Type Zinc Finger Protein 3 3 4
  • Zinc Finger, 3CxxC-Type 3 2 3
  • Transmembrane Protein 7 3 4
  • Z3CXXC3 3 4
  • Receptor (Chemosensory) Transporter Protein 3 3
  • Receptor-Transporting Protein 3 3
  • LTM1 3

External Ids for RTP3 Gene

Previous HGNC Symbols for RTP3 Gene

  • TMEM7

Previous GeneCards Identifiers for RTP3 Gene

  • GC03P046515

Summaries for RTP3 Gene

GeneCards Summary for RTP3 Gene

RTP3 (Receptor Transporter Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. An important paralog of this gene is RTP4.

UniProtKB/Swiss-Prot for RTP3 Gene

  • Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.

Additional gene information for RTP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP3 Gene

Genomics for RTP3 Gene

GeneHancer (GH) Regulatory Elements for RTP3 Gene

Promoters and enhancers for RTP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046495 Enhancer 0.9 Ensembl ENCODE 550.8 -1.0 -983 1.7 CTCF PKNOX1 RAD21 BRD9 SCRT2 ZNF143 FOS PRDM10 RXRA NRF1 RTP3 LTF LRRC2-AS1
GH03I046497 Promoter 0.8 EPDnew 550.8 +0.5 476 0.1 JUND RXRA TAF1 HNF4G MAX HNF4A YY1 RTP3 LRRC2 LOC105377070
GH03I046404 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -90.9 -90893 4.8 HDGF PKNOX1 SMAD1 ARNT IRF4 POLR2B ZNF766 CBX5 FOS ZNF592 CCRL2 LOC102724297 CCR1 CCR2 RTP3 CCR5 LIMD1 LRRC2 TDGF1 PRSS45
GH03I046564 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 11.4 +68.5 68519 2.8 PKNOX1 FOXA2 MLX ARID4B ZNF48 RAD21 YY1 ZNF335 RCOR1 FOS LRRC2 LTF RTP3 PRSS50 PRSS46P CCRL2 SCAP TDGF1 LRRC2-AS1
GH03I046556 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 12.2 +60.5 60513 3.8 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B DMAP1 IRF4 YY1 POLR2B LRRC2-AS1 LRRC2 RTP3 LTF SETD2 PTPN23 CCR2 TDGF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RTP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RTP3 gene promoter:

Genomic Locations for RTP3 Gene

Genomic Locations for RTP3 Gene
3,459 bases
Plus strand

Genomic View for RTP3 Gene

Genes around RTP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP3 Gene

Proteins for RTP3 Gene

  • Protein details for RTP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-transporting protein 3
    Protein Accession:
    Secondary Accessions:
    • A2RRP6

    Protein attributes for RTP3 Gene

    232 amino acids
    Molecular mass:
    27031 Da
    Quaternary structure:
    • Interacts with TAS2R16.

neXtProt entry for RTP3 Gene

Post-translational modifications for RTP3 Gene

No Post-translational modifications

Other Protein References for RTP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP3 Gene

Domains & Families for RTP3 Gene

Gene Families for RTP3 Gene

Protein Domains for RTP3 Gene


Suggested Antigen Peptide Sequences for RTP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM7 family.
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP3: view

Function for RTP3 Gene

Molecular function for RTP3 Gene

UniProtKB/Swiss-Prot Function:
Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.

Phenotypes From GWAS Catalog for RTP3 Gene

Gene Ontology (GO) - Molecular Function for RTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16720576
GO:0031849 olfactory receptor binding IBA --
genes like me logo Genes that share ontologies with RTP3: view
genes like me logo Genes that share phenotypes with RTP3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTP3 Gene

Localization for RTP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP3 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP3 gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16720576
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP3: view

Pathways & Interactions for RTP3 Gene

genes like me logo Genes that share pathways with RTP3: view

Pathways by source for RTP3 Gene

Interacting Proteins for RTP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296142 Q9BQQ7-RTP3_HUMAN for RTP3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0006612 protein targeting to membrane IDA 16720576
GO:0051205 protein insertion into membrane IBA --
genes like me logo Genes that share ontologies with RTP3: view

No data available for SIGNOR curated interactions for RTP3 Gene

Drugs & Compounds for RTP3 Gene

No Compound Related Data Available

Transcripts for RTP3 Gene

mRNA/cDNA for RTP3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP3 Gene

Receptor (chemosensory) transporter protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP3 Gene

No ASD Table

Relevant External Links for RTP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTP3 Gene

mRNA differential expression in normal tissues according to GTEx for RTP3 Gene

This gene is overexpressed in Liver (x45.6).

Protein differential expression in normal tissues from HIPED for RTP3 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTP3 Gene

Protein tissue co-expression partners for RTP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTP3 Gene:


SOURCE GeneReport for Unigene cluster for RTP3 Gene:


mRNA Expression by UniProt/SwissProt for RTP3 Gene:

Tissue specificity: Expressed predominantly in adult liver (PubMed:11896456, PubMed:17693185). Expressed in testis (PubMed:16720576, PubMed:17693185). Also expressed in kidney, lung and fetal liver (PubMed:17693185). Low levels in heart, thyroid, adrenal gland, pancreas, ovary, prostate, skin, plasma leukocytes, bone marrow and fetal brain (PubMed:17693185). Not detected in brain, spleen, colon, small intestine, skeletal muscle, stomach, placenta, salivary gland and uterus (PubMed:17693185).
genes like me logo Genes that share expression patterns with RTP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP3 Gene

Orthologs for RTP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTP3 33 34
  • 99.53 (n)
(Bos Taurus)
Mammalia RTP3 33 34
  • 82.82 (n)
(Canis familiaris)
Mammalia RTP3 33 34
  • 80.57 (n)
(Mus musculus)
Mammalia Rtp3 34
  • 24 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496614 33
  • 53.12 (n)
(Danio rerio)
Actinopterygii si:ch211-276k2.2 33
  • 47.58 (n)
Species where no ortholog for RTP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RTP3 Gene

Gene Tree for RTP3 (if available)
Gene Tree for RTP3 (if available)

Paralogs for RTP3 Gene

Paralogs for RTP3 Gene

(4) SIMAP similar genes for RTP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP3: view

Variants for RTP3 Gene

Sequence variations from dbSNP and Humsavar for RTP3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000433942 -- 46,496,880(+) A/G upstream_transcript_variant
rs1001407635 -- 46,499,377(+) A/G intron_variant
rs1002002127 -- 46,500,793(+) T/C coding_sequence_variant, missense_variant
rs1002086287 -- 46,496,117(+) T/C upstream_transcript_variant
rs1002121092 -- 46,501,394(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RTP3 Gene

Variant ID Type Subtype PubMed ID
nsv1013306 CNV gain 25217958
nsv1014624 CNV loss 25217958

Variation tolerance for RTP3 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP3 Gene

Disorders for RTP3 Gene

Additional Disease Information for RTP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RTP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP3 Gene

Publications for RTP3 Gene

  1. Genome-wide association study for femoral neck bone geometry. (PMID: 20175129) Zhao LJ … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010) 3 22 44 58
  2. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4 58
  3. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4 58
  4. The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3. (PMID: 11896456) Kiss H … Dumanski JP (European journal of human genetics : EJHG 2002) 3 4 22 58
  5. The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. (PMID: 17693185) Zhou X … Imreh S (Cancer genetics and cytogenetics 2007) 3 4 58

Products for RTP3 Gene

Sources for RTP3 Gene

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