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Aliases for RTP2 Gene

Aliases for RTP2 Gene

  • Receptor Transporter Protein 2 2 3 5
  • 3CxxC-Type Zinc Finger Protein 2 3 4
  • Zinc Finger, 3CxxC-Type 2 2 3
  • Z3CXXC2 3 4
  • Receptor (Chemosensory) Transporter Protein 2 3
  • Receptor Transporting Protein 2 2
  • Receptor-Transporting Protein 2 3

External Ids for RTP2 Gene

Previous GeneCards Identifiers for RTP2 Gene

  • GC03M188899
  • GC03M187416
  • GC03M184820

Summaries for RTP2 Gene

GeneCards Summary for RTP2 Gene

RTP2 (Receptor Transporter Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP1.

UniProtKB/Swiss-Prot for RTP2 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Additional gene information for RTP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP2 Gene

Genomics for RTP2 Gene

GeneHancer (GH) Regulatory Elements for RTP2 Gene

Promoters and enhancers for RTP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I187717 Enhancer 0.2 dbSUPER 550.8 -1.3 -1342 0.7 RTP2 LOC100131635 SST BCL6-AS1 GC03P187680
GH03I187972 Enhancer 0.2 FANTOM5 15 -256.2 -256186 0 RTP2 LINC01991 LOC105374265
GH03I188032 Enhancer 0.2 FANTOM5 11.4 -315.4 -315364 0 RTP2 LPP ENSG00000225058 ENSG00000234238
GH03I187954 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.4 -238.5 -238535 2.3 FOXA2 BRCA1 RAD21 RARA RFX5 YY1 SMARCC2 RCOR1 FOS SMARCC1 BCL6 BCL6-AS1 LPP RTP2 LOC105374265 LINC01991
GH03I187715 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.8 +2.1 2119 0.4 CTCF RB1 ZNF133 ARID4B ZNF384 ZNF2 RAD21 RFX5 TEAD3 CC2D1A SST RTP2 LOC100131635 GC03P187680
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RTP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RTP2 gene promoter:

Genomic Locations for RTP2 Gene

Genomic Locations for RTP2 Gene
18,462 bases
Minus strand

Genomic View for RTP2 Gene

Genes around RTP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP2 Gene

Proteins for RTP2 Gene

  • Protein details for RTP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-transporting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6NVH4

    Protein attributes for RTP2 Gene

    225 amino acids
    Molecular mass:
    26068 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP2 Gene

Post-translational modifications for RTP2 Gene

No Post-translational modifications

Other Protein References for RTP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP2 Gene

Domains & Families for RTP2 Gene

Gene Families for RTP2 Gene

Protein Domains for RTP2 Gene


Suggested Antigen Peptide Sequences for RTP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM7 family.
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP2: view

Function for RTP2 Gene

Molecular function for RTP2 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Phenotypes From GWAS Catalog for RTP2 Gene

Gene Ontology (GO) - Molecular Function for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031849 olfactory receptor binding IMP 15550249
genes like me logo Genes that share ontologies with RTP2: view

Phenotypes for RTP2 Gene

MGI mutant phenotypes for RTP2:
inferred from 1 alleles
GenomeRNAi human phenotypes for RTP2:
genes like me logo Genes that share phenotypes with RTP2: view

Animal Models for RTP2 Gene

MGI Knock Outs for RTP2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RTP2 Gene

Localization for RTP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP2 Gene

Cell membrane; Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 15550249
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTP2 Gene

Pathways & Interactions for RTP2 Gene

genes like me logo Genes that share pathways with RTP2: view

Pathways by source for RTP2 Gene

Interacting Proteins for RTP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350976 Q5QGT7-RTP2_HUMAN for RTP2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA --
GO:0006612 protein targeting to membrane IBA --
GO:0051205 protein insertion into membrane IDA 15550249
genes like me logo Genes that share ontologies with RTP2: view

No data available for SIGNOR curated interactions for RTP2 Gene

Drugs & Compounds for RTP2 Gene

No Compound Related Data Available

Transcripts for RTP2 Gene

mRNA/cDNA for RTP2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP2 Gene

Receptor (chemosensory) transporter protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP2 Gene

No ASD Table

Relevant External Links for RTP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTP2 Gene

mRNA differential expression in normal tissues according to GTEx for RTP2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.8) and Testis (x23.2).

NURSA nuclear receptor signaling pathways regulating expression of RTP2 Gene:


SOURCE GeneReport for Unigene cluster for RTP2 Gene:


mRNA Expression by UniProt/SwissProt for RTP2 Gene:

Tissue specificity: Expressed in circumvallate papillae and testis.
genes like me logo Genes that share expression patterns with RTP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP2 Gene

Orthologs for RTP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTP2 33 34
  • 98.22 (n)
(Bos Taurus)
Mammalia RTP2 33 34
  • 91.78 (n)
(Canis familiaris)
Mammalia RTP2 33
  • 89.33 (n)
BCL6 34
  • 87 (a)
(Mus musculus)
Mammalia Rtp2 33 16 34
  • 88.22 (n)
(Rattus norvegicus)
Mammalia Rtp2 33
  • 87.44 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
(Gallus gallus)
Aves LOC101751236 33
  • 53.9 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
-- 34
  • 35 (a)
Species where no ortholog for RTP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP2 Gene

Gene Tree for RTP2 (if available)
Gene Tree for RTP2 (if available)

Paralogs for RTP2 Gene

Paralogs for RTP2 Gene

(2) SIMAP similar genes for RTP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP2: view

Variants for RTP2 Gene

Sequence variations from dbSNP and Humsavar for RTP2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000245521 -- 187,713,696(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000437584 -- 187,707,736(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000512330 -- 187,708,655(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000578139 -- 187,714,853(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000619301 -- 187,703,334(-) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for RTP2 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.64; 93.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTP2 Gene

Disorders for RTP2 Gene

Additional Disease Information for RTP2

No disorders were found for RTP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP2 Gene

Publications for RTP2 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4 58
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4 58
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors. (PMID: 28586385) Yu T … Zhuang H (PloS one 2017) 3 58

Products for RTP2 Gene

Sources for RTP2 Gene

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