Aliases for RTP2 Gene

Aliases for RTP2 Gene

  • Receptor Transporter Protein 2 2 3 5
  • Z3CXXC2 2 3 4
  • 3CxxC-Type Zinc Finger Protein 2 3 4
  • Receptor-Transporting Protein 2 3 4
  • Zinc Finger, 3CxxC-Type 2 2 3
  • Receptor (Chemosensory) Transporter Protein 2 3
  • Receptor Transporting Protein 2 2
  • MGC78665 2
  • RTP2 5

External Ids for RTP2 Gene

Previous GeneCards Identifiers for RTP2 Gene

  • GC03M188899
  • GC03M187416
  • GC03M184820

Summaries for RTP2 Gene

GeneCards Summary for RTP2 Gene

RTP2 (Receptor Transporter Protein 2) is a Protein Coding gene. Diseases associated with RTP2 include Ivic Syndrome and Nephronophthisis 3. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP1.

UniProtKB/Swiss-Prot Summary for RTP2 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTP2 Gene

Genomics for RTP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RTP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187715 Enhancer 0.8 ENCODE dbSUPER 250.7 +1.0 1037 0.2 ZNF654 CTCF REST DEK TRIM22 RAD21 RFX5 SMC3 ZBTB48 ZNF2 RTP2 SST LOC100131635
GH03J187679 Enhancer 0.9 Ensembl ENCODE 11.6 +36.0 36025 1.6 ZNF654 MYC ZNF10 CTCF REST DEK TRIM22 SIN3A RAD21 SMC3 LOC100131635 RTP2 SST piR-50443-277 HSALNG0031426
GH03J187670 Promoter/Enhancer 1.2 EPDnew Ensembl 4.7 +45.5 45503 1 KLF9 CEBPA YY1 MXD4 REST KLF11 ZFP64 HOMEZ SIN3A KMT2B SST RTP2 HSALNG0031428 HSALNG0031426 RTP4
GH03J187972 Enhancer 0.2 FANTOM5 15 -257.3 -257281 0 HSALNG0031449 RTP2 lnc-BCL6-7 LINC01991 LPP BCL6
GH03J187942 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -230.4 -230376 7.2 CEBPB EP300 FOXA2 RXRA RARA BCL6 SPI1 HMG20A FOXA1 RAD21 ENSG00000236864 RTP2 LOC105374265 HSALNG0031446 lnc-BCL6-7 BCL6 LPP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTP2

Top Transcription factor binding sites by QIAGEN in the RTP2 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA5
  • MRF-2
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • RFX1

Genomic Locations for RTP2 Gene

Latest Assembly
17,367 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
4,299 bases
Minus strand

(GRCh37/hg19 by Ensembl)
4,299 bases
Minus strand

Genomic View for RTP2 Gene

Genes around RTP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP2 Gene

Proteins for RTP2 Gene

  • Protein details for RTP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-transporting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6NVH4

    Protein attributes for RTP2 Gene

    225 amino acids
    Molecular mass:
    26068 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP2 Gene

Post-translational modifications for RTP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP2 Gene

No data available for DME Specific Peptides for RTP2 Gene

Domains & Families for RTP2 Gene

Gene Families for RTP2 Gene

Protein Domains for RTP2 Gene


Suggested Antigen Peptide Sequences for RTP2 Gene

GenScript: Design optimal peptide antigens:
  • Receptor-transporting protein 2 (RTP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM7 family.
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP2: view

Function for RTP2 Gene

Molecular function for RTP2 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Phenotypes From GWAS Catalog for RTP2 Gene

Gene Ontology (GO) - Molecular Function for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031849 olfactory receptor binding IBA,IMP 15550249
genes like me logo Genes that share ontologies with RTP2: view

Phenotypes for RTP2 Gene

genes like me logo Genes that share phenotypes with RTP2: view

Animal Models for RTP2 Gene

MGI Knock Outs for RTP2:
  • Rtp2 Rtp2<tm1Hmat>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RTP2 Gene

Localization for RTP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP2 Gene

Cell membrane. Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA,IDA 15550249
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTP2 Gene

Pathways & Interactions for RTP2 Gene

PathCards logo

SuperPathways for RTP2 Gene

genes like me logo Genes that share pathways with RTP2: view

Pathways by source for RTP2 Gene

Gene Ontology (GO) - Biological Process for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA 21873635
GO:0006612 protein targeting to membrane IBA 21873635
GO:0051205 protein insertion into membrane IBA,IDA 15550249
genes like me logo Genes that share ontologies with RTP2: view

No data available for SIGNOR curated interactions for RTP2 Gene

Drugs & Compounds for RTP2 Gene

No Compound Related Data Available

Transcripts for RTP2 Gene

mRNA/cDNA for RTP2 Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP2

Alternative Splicing Database (ASD) splice patterns (SP) for RTP2 Gene

No ASD Table

Relevant External Links for RTP2 Gene

GeneLoc Exon Structure for

Expression for RTP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTP2 Gene

mRNA differential expression in normal tissues according to GTEx for RTP2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.8) and Testis (x23.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTP2

SOURCE GeneReport for Unigene cluster for RTP2 Gene:


mRNA Expression by UniProt/SwissProt for RTP2 Gene:

Tissue specificity: Expressed in circumvallate papillae and testis.

Evidence on tissue expression from TISSUES for RTP2 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RTP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP2 Gene

Orthologs for RTP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTP2 29 30
  • 98.22 (n)
(Bos Taurus)
Mammalia RTP2 29 30
  • 91.78 (n)
(Canis familiaris)
Mammalia RTP2 29
  • 89.33 (n)
BCL6 30
  • 87 (a)
(Mus musculus)
Mammalia Rtp2 29 16 30
  • 88.22 (n)
(Rattus norvegicus)
Mammalia Rtp2 29
  • 87.44 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 66 (a)
(Gallus gallus)
Aves LOC101751236 29
  • 53.9 (n)
(Anolis carolinensis)
Reptilia -- 30
  • 35 (a)
-- 30
  • 35 (a)
Species where no ortholog for RTP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RTP2 Gene

Gene Tree for RTP2 (if available)
Gene Tree for RTP2 (if available)
Evolutionary constrained regions (ECRs) for RTP2: view image
Alliance of Genome Resources:
Additional Orthologs for RTP2

Paralogs for RTP2 Gene

Paralogs for RTP2 Gene

(2) SIMAP similar genes for RTP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP2: view

Variants for RTP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTP2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11707167 -- p.Gln82Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RTP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for RTP2 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.64; 93.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTP2 Gene

Disorders for RTP2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RTP2 Gene - From: COP

Disorder Aliases PubMed IDs
ivic syndrome
  • radial ray defects, hearing impairment, external ophthalmoplegia, and thrombocytopenia
nephronophthisis 3
  • nphp3
retinal arteries, tortuosity of
  • rator
interstitial nephritis, karyomegalic
  • kmin
familial glucocorticoid deficiency
  • glucocorticoid deficiency, familial
- elite association - COSMIC cancer census association via MalaCards
Search RTP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTP2

genes like me logo Genes that share disorders with RTP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTP2 Gene

Publications for RTP2 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for RTP2 Gene

Sources for RTP2 Gene