Aliases for RTP1 Gene

Aliases for RTP1 Gene

  • Receptor Transporter Protein 1 2 3 5
  • Z3CXXC1 2 3 4
  • 3CxxC-Type Zinc Finger Protein 1 3 4
  • Receptor-Transporting Protein 1 3 4
  • Zinc Finger, 3CxxC-Type 1 2 3
  • Receptor (Chemosensory) Transporter Protein 1 3
  • Receptor Transporting Protein 1 2
  • MGC35450 2
  • RTP1 5

External Ids for RTP1 Gene

Previous GeneCards Identifiers for RTP1 Gene

  • GC03P188398
  • GC03P186915
  • GC03P184319

Summaries for RTP1 Gene

GeneCards Summary for RTP1 Gene

RTP1 (Receptor Transporter Protein 1) is a Protein Coding gene. Diseases associated with RTP1 include Ivic Syndrome and Schopf-Schulz-Passarge Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP2.

UniProtKB/Swiss-Prot Summary for RTP1 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTP1 Gene

Genomics for RTP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RTP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J187197 Promoter/Enhancer 0.7 EPDnew Ensembl 266.2 -0.1 -85 0.8 RFX1 MNT BMI1 RTP1 piR-38716-108 LOC101929106 RPL39L
GH03J187180 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 17.4 -18.2 -18184 5.8 ETS1 POU5F1 NANOG POLR2A MG598801-017 RPL39L piR-48950-134 RTP1 CRYGS piR-37567-130 ST6GAL1
GH03J187208 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.6 +12.8 12802 5.4 NCOR1 NFIC HES1 ZBTB7B ZNF623 ZNF585B TAL1 STAT5A FOXM1 HDAC2 HSALNG0031410-001 HSALNG0031410-002 LOC101929106 TBCCD1 MASP1 RTP1 RTP4 LOC105374260
GH03J187182 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 12.1 -14.2 -14183 1.5 EBF1 MAFK ZNF664 SPI1 POLR2A PRDM10 ZFHX2 SCRT2 piR-38716-108 piR-36098-008 piR-58557-061 RTP1 RPL39L
GH03J187184 Enhancer 0.9 ENCODE dbSUPER 10.2 -11.3 -11295 3.4 ZNF600 BRCA1 POLR2A ZIC2 REST EP300 ZNF316 YY1 TBP TCF7L2 piR-38716-108 piR-58557-061 RTP1 RPL39L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTP1

Top Transcription factor binding sites by QIAGEN in the RTP1 gene promoter:
  • AML1a
  • C/EBPalpha
  • NF-1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for RTP1 Gene

Latest Assembly
chr3:187,197,486-187,201,462
(GRCh38/hg38)
Size:
3,977 bases
Orientation:
Plus strand

Previous Assembly
chr3:186,915,274-186,919,250
(GRCh37/hg19 by Entrez Gene)
Size:
3,977 bases
Orientation:
Plus strand

chr3:186,915,274-186,919,253
(GRCh37/hg19 by Ensembl)
Size:
3,980 bases
Orientation:
Plus strand

Genomic View for RTP1 Gene

Genes around RTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP1 Gene

Proteins for RTP1 Gene

  • Protein details for RTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59025-RTP1_HUMAN
    Recommended name:
    Receptor-transporting protein 1
    Protein Accession:
    P59025

    Protein attributes for RTP1 Gene

    Size:
    263 amino acids
    Molecular mass:
    30913 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP1 Gene

Post-translational modifications for RTP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP1 Gene

Domains & Families for RTP1 Gene

Gene Families for RTP1 Gene

Protein Domains for RTP1 Gene

Suggested Antigen Peptide Sequences for RTP1 Gene

GenScript: Design optimal peptide antigens:
  • Receptor-transporting protein 1 (RTP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59025

UniProtKB/Swiss-Prot:

RTP1_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP1: view

Function for RTP1 Gene

Molecular function for RTP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Phenotypes From GWAS Catalog for RTP1 Gene

Gene Ontology (GO) - Molecular Function for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031849 olfactory receptor binding IBA,IMP 15550249
genes like me logo Genes that share ontologies with RTP1: view
genes like me logo Genes that share phenotypes with RTP1: view

Animal Models for RTP1 Gene

MGI Knock Outs for RTP1:
  • Rtp1 Rtp1<tm1.1Hmat>

miRNA for RTP1 Gene

miRTarBase miRNAs that target RTP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTP1 Gene

Localization for RTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP1 Gene

Cell membrane. Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP1 gene
Compartment Confidence
plasma membrane 4
mitochondrion 3
cytosol 2
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA,IDA 15550249
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTP1 Gene

Pathways & Interactions for RTP1 Gene

PathCards logo

SuperPathways for RTP1 Gene

genes like me logo Genes that share pathways with RTP1: view

Pathways by source for RTP1 Gene

Gene Ontology (GO) - Biological Process for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA 21873635
GO:0006612 protein targeting to membrane IBA 21873635
GO:0051205 protein insertion into membrane IBA,IDA 15550249
genes like me logo Genes that share ontologies with RTP1: view

No data available for SIGNOR curated interactions for RTP1 Gene

Drugs & Compounds for RTP1 Gene

No Compound Related Data Available

Transcripts for RTP1 Gene

mRNA/cDNA for RTP1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTP1

Alternative Splicing Database (ASD) splice patterns (SP) for RTP1 Gene

No ASD Table

Relevant External Links for RTP1 Gene

GeneLoc Exon Structure for
RTP1

Expression for RTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTP1 Gene

This gene is overexpressed in Brain - Cortex (x10.7), Brain - Frontal Cortex (BA9) (x9.1), Brain - Anterior cingulate cortex (BA24) (x8.2), and Brain - Hypothalamus (x7.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTP1

SOURCE GeneReport for Unigene cluster for RTP1 Gene:

Hs.518480

mRNA Expression by UniProt/SwissProt for RTP1 Gene:

P59025-RTP1_HUMAN
Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for RTP1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RTP1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP1 Gene

Orthologs for RTP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RTP1 29 30
  • 99.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RTP1 29 30
  • 92.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RTP1 29 30
  • 92.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rtp1 29
  • 88.72 (n)
Mouse
(Mus musculus)
Mammalia Rtp1 29 16 30
  • 87.83 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 83 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 79 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 36 (a)
ManyToMany
-- 30
  • 35 (a)
ManyToMany
Species where no ortholog for RTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RTP1 Gene

ENSEMBL:
Gene Tree for RTP1 (if available)
TreeFam:
Gene Tree for RTP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTP1: view image
Alliance of Genome Resources:
Additional Orthologs for RTP1

Paralogs for RTP1 Gene

Paralogs for RTP1 Gene

(2) SIMAP similar genes for RTP1 Gene using alignment to 1 proteins:

  • RTP1_HUMAN
genes like me logo Genes that share paralogs with RTP1: view

Variants for RTP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTP1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
VAR_036122 A breast cancer sample p.Arg124Ser
rs35053281 -- p.Ala212Gly
rs6764714 -- p.Gln229Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RTP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RTP1 Gene

Variant ID Type Subtype PubMed ID
esv23875 CNV gain 19812545
nsv1004008 CNV gain 25217958
nsv1014596 CNV gain 25217958
nsv4158 CNV insertion 18451855
nsv508264 CNV deletion 20534489
nsv592710 CNV loss 21841781

Variation tolerance for RTP1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP1 Gene

Human Gene Mutation Database (HGMD)
RTP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP1
Leiden Open Variation Database (LOVD)
RTP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP1 Gene

Disorders for RTP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RTP1 Gene - From: COP

Disorder Aliases PubMed IDs
ivic syndrome
  • radial ray defects, hearing impairment, external ophthalmoplegia, and thrombocytopenia
schopf-schulz-passarge syndrome
  • ssps
glycoproteinosis
  • mucolipidosis type i
interstitial nephritis, karyomegalic
  • kmin
familial glucocorticoid deficiency
  • glucocorticoid deficiency, familial
- elite association - COSMIC cancer census association via MalaCards
Search RTP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTP1

genes like me logo Genes that share disorders with RTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTP1 Gene

Publications for RTP1 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4
  3. Synergism of accessory factors in functional expression of mammalian odorant receptors. (PMID: 17387175) Zhuang H … Matsunami H (The Journal of biological chemistry 2007) 3 22
  4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RTP1 Gene

Sources for RTP1 Gene