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Aliases for RTN4RL1 Gene
Aliases for RTN4RL1 Gene
External Ids for RTN4RL1 Gene
- HGNC: 21329
- Entrez Gene: 146760
- Ensembl: ENSG00000185924
- OMIM: 610461
- UniProtKB: Q86UN2
Previous GeneCards Identifiers for RTN4RL1 Gene
- GC17M002046
- GC17M001786
- GC17M001734
- GC17M001935
- GC17M001936
- GC17M001945
- GC17M001949
- GC17M001944
- GC17M001943
- GC17M001937
- GC17M001938
- GC17M001939
- GC17M001940
- GC17M001941
Summaries for RTN4RL1 Gene
GeneCards Summary for RTN4RL1 Gene
RTN4RL1 (Reticulon 4 Receptor Like 1) is a Protein Coding gene. Diseases associated with RTN4RL1 include Chromosome 17P13.3, Centromeric, Duplication Syndrome and Microcephaly. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is RTN4RL2.
UniProtKB/Swiss-Prot Summary for RTN4RL1 Gene
-
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Additional gene information for RTN4RL1 Gene
- HGNC(21329)
- Entrez Gene(146760)
- Ensembl(ENSG00000185924)
- OMIM(610461)
- UniProtKB(Q86UN2)
- Open Targets Platform(ENSG00000185924)
- Monarch Initiative
- Search for RTN4RL1 at DataMed
- Search for RTN4RL1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTN4RL1 Gene
Genomics for RTN4RL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RTN4RL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RTN4RL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTN4RL1
- Top Transcription factor binding sites by QIAGEN in the RTN4RL1 gene promoter:
-
- c-Fos
- c-Myc
- Chx10
- GATA-2
- Max1
- NCX
- NF-1
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for RTN4RL1 Gene
Genomic Locations for RTN4RL1 Gene
- chr17:1,934,677-2,025,334
- (GRCh38/hg38)
- Size:
- 90,658 bases
- Orientation:
- Minus strand
- chr17:1,837,971-1,928,639
- (GRCh37/hg19)
- Size:
- 90,669 bases
- Orientation:
- Minus strand
Genomic View for RTN4RL1 Gene
Genes around RTN4RL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
RTN4RL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RTN4RL1 Gene
Proteins for RTN4RL1 Gene
-
Protein details for RTN4RL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UN2-R4RL1_HUMAN
- Recommended name:
- Reticulon-4 receptor-like 1
- Protein Accession:
- Q86UN2
- A1A5E3
- Q8ND46
Protein attributes for RTN4RL1 Gene
- Size:
- 441 amino acids
- Molecular mass:
- 49065 Da
- Quaternary structure:
-
- Identified in a complex that contains RTN4R, RTN4RL1 and NGFR; the interaction depends on the presence of chondroitin sulfate proteoglycans. Does not interact with MAG, OMG and RTN4.
Protein Expression for RTN4RL1 Gene
Post-translational modifications for RTN4RL1 Gene
Other Protein References for RTN4RL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RTN4RL1
- Invitrogen Antibodies for RTN4RL1 (AFLGC-Rtn4rl1)
-
Biorbyt antibodies for RTN4RL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RTN4RL1
Protein Products
- G Biosciences Human NgR3/NgRH2, Lyophilized
-
OriGene Purified Proteins for RTN4RL1
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN4RL1
- Origene Custom Protein Services for RTN4RL1
- Novus Biologicals proteins for RTN4RL1
- Sino Biological Cell Lysates for RTN4RL1
- Sino Biological Recombinant Proteins for RTN4RL1
- antibodies-online: Show 4 available RTN4RL1 Proteins ranked by validation data
- Compare Top RTN4RL1 Proteins
-
Quality Products:
-
Signalway Proteins for RTN4RL1
-
ProSci Proteins for RTN4RL1
-
Abcam proteins for RTN4RL1
Assay Products
- RayBiotech Custom Human NgR3/NgRH2 ELISA
- antibodies-online: Show 2 available RTN4RL1 Elisa Kits ranked by validation data
- Compare Top RTN4RL1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RTN4RL1 Gene
Domains & Families for RTN4RL1 Gene
Gene Families for RTN4RL1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RTN4RL1 Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, N-terminal
- Cysteine-rich flanking region, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for RTN4RL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Nogo-66 receptor-related protein 3 (R4RL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86UN2- Family:
-
- Belongs to the Nogo receptor family.
Function for RTN4RL1 Gene
Molecular function for RTN4RL1 Gene
- UniProtKB/Swiss-Prot Function:
- Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Phenotypes From GWAS Catalog for RTN4RL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008201 | heparin binding | IEA,ISS | -- |
| GO:0035374 | chondroitin sulfate binding | IEA,ISS | -- |
| GO:0038023 | signaling receptor activity | IDA | 12694398 |
Phenotypes for RTN4RL1 Gene
- MGI mutant phenotypes for RTN4RL1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RTN4RL1:
-
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased viability after Maraba virus infection
- Increased hepcidin::fluc mRNA expression
Animal Models for RTN4RL1 Gene
- MGI Knock Outs for RTN4RL1:
-
- Rtn4rl1 Rtn4rl1<tm1.1Rojg>
Animal Model Products
-
Taconic Biosciences Mouse Models for RTN4RL1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RTN4RL1 - Select products 50% OFF >
- * RTN4RL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RTN4RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN4RL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4RL1
miRNA for RTN4RL1 Gene
- miRTarBase miRNAs that target RTN4RL1
-
- mmu-miR-124-3p (MIRT015716)
- hsa-miR-6831-5p (MIRT510829)
- hsa-miR-1277-5p (MIRT510830)
- hsa-miR-190a-3p (MIRT510831)
- hsa-miR-4732-5p (MIRT510832)
- hsa-miR-6832-5p (MIRT510833)
- hsa-miR-574-5p (MIRT510834)
- hsa-miR-3668 (MIRT510835)
- hsa-miR-7852-3p (MIRT510836)
- hsa-miR-5011-5p (MIRT510837)
- hsa-miR-5586-3p (MIRT510838)
- hsa-miR-5010-3p (MIRT521266)
- hsa-miR-223-5p (MIRT521267)
- hsa-miR-1257 (MIRT521268)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN4RL1
- Browse OriGene Inhibitory RNA Products For RTN4RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4RL1
Clone Products
- Applied Biological Materials (abm): Clones for RTN4RL1 - Select products 50% OFF >
- * RTN4RL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RTN4RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN4RL1
Cell Line Products
-
Horizon Cell Lines for RTN4RL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4RL1 Gene
Localization for RTN4RL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL1 Gene
- Cell membrane. Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon. Cell projection. Note=Localized to the surface of neurons, including axons. {ECO:0000250 UniProtKB:Q80WD0}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 0 |
| golgi apparatus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA,IDA | 20463223 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTN4RL1 Gene
Pathways & Interactions for RTN4RL1 Gene
Pathways by source for RTN4RL1 Gene
3 Reactome pathways for RTN4RL1 Gene
Interacting Proteins for RTN4RL1 Gene
Selected Interacting proteins:
Q86UN2-R4RL1_HUMAN
ENSP00000330631
for RTN4RL1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RTN4RL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010977 | negative regulation of neuron projection development | IEA,ISS | -- |
| GO:0022038 | corpus callosum development | IEA | -- |
| GO:0031103 | axon regeneration | TAS | 14664809 |
| GO:0048681 | negative regulation of axon regeneration | IEA,ISS | -- |
No data available for SIGNOR curated interactions for RTN4RL1 Gene
Drugs & Compounds for RTN4RL1 Gene
No Compound Related Data Available
Drug Products
- G Biosciences Human NgR3/NgRH2, Lyophilized
Transcripts for RTN4RL1 Gene
mRNA/cDNA for RTN4RL1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000331238 3614 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RTN4RL1 - Select products 50% OFF >
- * RTN4RL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RTN4RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN4RL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4RL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN4RL1
- Browse OriGene Inhibitory RNA Products For RTN4RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4RL1
Clone Products
- Applied Biological Materials (abm): Clones for RTN4RL1 - Select products 50% OFF >
- * RTN4RL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RTN4RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN4RL1
Relevant External Links for RTN4RL1 Gene
- GeneLoc Exon Structure for
- RTN4RL1
Expression for RTN4RL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Testicular Interstitial Cells Testis Interstitium
-
Eye (Sensory Organs)
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
-
Neurons
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for RTN4RL1 Gene
This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).
This gene is overexpressed in Bone marrow mesenchymal stem cell (49.7) and Seminal vesicle (15.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RTN4RL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTN4RL1
SOURCE GeneReport for Unigene cluster for RTN4RL1 Gene:
Hs.22917mRNA Expression by UniProt/SwissProt for RTN4RL1 Gene:
Q86UN2-R4RL1_HUMAN
Tissue specificity:
Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
Evidence on tissue expression from TISSUES for RTN4RL1 Gene
- Nervous system(4.5)
Primer Products
-
OriGene qPCR primer pairs for RTN4RL1
-
OriGene qPCR primer pairs and template standards for RTN4RL1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4RL1 Gene
Orthologs for RTN4RL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rtn4rl1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rtn4rl1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RTN4RL1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RTN4RL1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RTN4RL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RTN4RL1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rtn4rl1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rtn4rl1b 30 31 |
|
OneToMany | |
| rtn4rl1a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1504 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | lron-12 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RTN4RL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RTN4RL1 Gene
- ENSEMBL:
- Gene Tree for RTN4RL1 (if available)
- TreeFam:
- Gene Tree for RTN4RL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RTN4RL1: view image
Paralogs for RTN4RL1 Gene
Paralogs for RTN4RL1 Gene
Variants for RTN4RL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTN4RL1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709926 | Benign: not provided | 1,937,168(-) | G/A | SYNONYMOUS_VARIANT | |
| 774926 | Benign: not provided | 1,937,383(-) | C/T | MISSENSE_VARIANT | |
| 780389 | Benign: not provided | 1,936,899(-) | G/A | MISSENSE_VARIANT | |
| 790173 | Benign: not provided | 1,936,766(-) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv68n73 | CNV | deletion | 24416366 |
| esv21816 | CNV | loss | 19812545 |
| esv2272299 | CNV | deletion | 18987734 |
| esv23541 | CNV | loss | 19812545 |
| esv2636660 | CNV | deletion | 19546169 |
| esv2658213 | CNV | deletion | 23128226 |
| esv2674942 | CNV | deletion | 23128226 |
| esv2715483 | CNV | deletion | 23290073 |
| esv2715484 | CNV | deletion | 23290073 |
| esv2715486 | CNV | deletion | 23290073 |
| esv2715487 | CNV | deletion | 23290073 |
| esv33335 | CNV | loss | 17666407 |
| esv3368806 | CNV | duplication | 20981092 |
| esv3553992 | CNV | deletion | 23714750 |
| esv3553993 | CNV | deletion | 23714750 |
| esv3582476 | CNV | loss | 25503493 |
| esv3639702 | CNV | loss | 21293372 |
| esv3639703 | CNV | loss | 21293372 |
| nsv1056771 | CNV | gain | 25217958 |
| nsv112398 | CNV | insertion | 16902084 |
| nsv523761 | CNV | loss | 19592680 |
| nsv827857 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RTN4RL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL1 Gene
Disorders for RTN4RL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17p13.3, centromeric, duplication syndrome |
|
|
| microcephaly |
|
|
Search RTN4RL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RTN4RL1
No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4RL1 Gene
Publications for RTN4RL1 Gene
- Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton WA … Nikolov DB (The EMBO journal 2003) 3 4 23
- Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Laurén J … Timmusk T (Molecular and cellular neurosciences 2003) 3 4 23
- Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. (PMID: 12694398) Pignot V … Frentzel S (Journal of neurochemistry 2003) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Overexpression of Nogo receptor 3 (NgR3) correlates with poor prognosis and contributes to the migration of epithelial cells of nasopharyngeal carcinoma patients. (PMID: 29327067) He JY … Zhong Q (Journal of molecular medicine (Berlin, Germany) 2018) 3
ExternalLinks
Products for RTN4RL1 Gene
- View all 5 R&D Systems RTN4RL1 (NgR3/NgRH2) Products
- View all R&D Systems RTN4RL1 (NgR3/NgRH2) Proteins and Enzymes
- View all 3 R&D Systems RTN4RL1 (NgR3/NgRH2) Primary Antibodies
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- Custom Antibody Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN4RL1
- Browse OriGene Inhibitory RNA Products For RTN4RL1
- OriGene qPCR primer pairs for RTN4RL1
- OriGene qPCR primer pairs and template standards for RTN4RL1
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- Browse Primary Antibodies
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- Taconic Biosciences Mouse Models for RTN4RL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RTN4RL1 (AFLGC-Rtn4rl1)
- VectorBuilder Custom and pre-made DNA vectors for RTN4RL1 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for RTN4RL1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RTN4RL1
- antibodies-online: Show 11 available RTN4RL1 Antibodies ranked by validation data
- Compare Top RTN4RL1 Antibodies
- antibodies-online: Show 2 available RTN4RL1 Elisa Kits ranked by validation data
- Compare Top RTN4RL1 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available RTN4RL1 Proteins ranked by validation data
- Compare Top RTN4RL1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RTN4RL1
- Search Santa Cruz Biotechnology (SCBT) for RTN4RL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RTN4RL1
- Search for RTN4RL1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for RTN4RL1
- Horizon Cell Lines for RTN4RL1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN4RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN4RL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RTN4RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4RL1
- Biorbyt antibodies for RTN4RL1
- Signalway Proteins for RTN4RL1
Sources for RTN4RL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB