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RTN4RL1 (Reticulon 4 Receptor Like 1) is a Protein Coding gene. Diseases associated with RTN4RL1 include Chromosome 17P13.3, Centromeric, Duplication Syndrome and Microcephaly. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is RTN4RL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008201 | heparin binding | IEA,ISS | -- |
GO:0035374 | chondroitin sulfate binding | IEA,ISS | -- |
GO:0038023 | signaling receptor activity | IDA | 12694398 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0009986 | cell surface | IEA,IDA | 20463223 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010977 | negative regulation of neuron projection development | IEA,ISS | -- |
GO:0022038 | corpus callosum development | IEA | -- |
GO:0031103 | axon regeneration | TAS | 14664809 |
GO:0048681 | negative regulation of axon regeneration | IEA,ISS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RTN4RL1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rtn4rl1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rtn4rl1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RTN4RL1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RTN4RL1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RTN4RL1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RTN4RL1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rtn4rl1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rtn4rl1b 30 31 |
|
OneToMany | |
rtn4rl1a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1504 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | lron-12 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709926 | Benign: not provided | 1,937,168(-) | G/A | SYNONYMOUS_VARIANT | |
774926 | Benign: not provided | 1,937,383(-) | C/T | MISSENSE_VARIANT | |
780389 | Benign: not provided | 1,936,899(-) | G/A | MISSENSE_VARIANT | |
790173 | Benign: not provided | 1,936,766(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv68n73 | CNV | deletion | 24416366 |
esv21816 | CNV | loss | 19812545 |
esv2272299 | CNV | deletion | 18987734 |
esv23541 | CNV | loss | 19812545 |
esv2636660 | CNV | deletion | 19546169 |
esv2658213 | CNV | deletion | 23128226 |
esv2674942 | CNV | deletion | 23128226 |
esv2715483 | CNV | deletion | 23290073 |
esv2715484 | CNV | deletion | 23290073 |
esv2715486 | CNV | deletion | 23290073 |
esv2715487 | CNV | deletion | 23290073 |
esv33335 | CNV | loss | 17666407 |
esv3368806 | CNV | duplication | 20981092 |
esv3553992 | CNV | deletion | 23714750 |
esv3553993 | CNV | deletion | 23714750 |
esv3582476 | CNV | loss | 25503493 |
esv3639702 | CNV | loss | 21293372 |
esv3639703 | CNV | loss | 21293372 |
nsv1056771 | CNV | gain | 25217958 |
nsv112398 | CNV | insertion | 16902084 |
nsv523761 | CNV | loss | 19592680 |
nsv827857 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 17p13.3, centromeric, duplication syndrome |
|
|
microcephaly |
|
|