RTN4R Gene (Protein Coding)

Reticulon 4 Receptor

GCID:: GC22M020234

GIFtS:: 44

Genes Participants

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008] See more...

Aliases for RTN4R Gene

Reticulon 4 Receptor ² ³ ⁵
Reticulon-4 Receptor ³ ⁴
Nogo-66 Receptor ³ ⁴
Nogo Receptor ³ ⁴
NOGOR ³ ⁴
UNQ330/PRO526 ³
NOGO Receptor ²
NGR ³
NgR ⁴

External Ids for RTN4R Gene

HGNC: 18601
Entrez Gene: 65078
Ensembl: ENSG00000040608
OMIM: 605566
UniProtKB: Q9BZR6

Previous GeneCards Identifiers for RTN4R Gene

GC22M017169
GC22M018603
GC22M003848

Search aliases for RTN4R gene in PubMed and other databases

Summaries for RTN4R Gene

Entrez Gene Summary for RTN4R Gene

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4R Gene

RTN4R (Reticulon 4 Receptor) is a Protein Coding gene. Diseases associated with RTN4R include Schizophrenia and Leukemia, Acute Lymphoblastic. Among its related pathways are Spinal Cord Injury and NgR-p75(NTR)-Mediated Signaling. An important paralog of this gene is RTN4RL1.

UniProtKB/Swiss-Prot Summary for RTN4R Gene

Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
- RTN4R_HUMAN,Q9BZR6

Tocris Summary for RTN4R Gene

Gene Wiki entry for RTN4R Gene

Additional gene information for RTN4R Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTN4R Gene

Genomics for RTN4R Gene

GeneHancer (GH) Regulatory Elements for RTN4R Gene

Promoters and enhancers for RTN4R Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH22J020267	Promoter/Enhancer	2.3	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	500.4	+15.4	15407	2.5	HNRNPK CTCF NRF1 TEAD4 ZIC2 ZBTB10 GABPA ZBTB26 TARDBP REST	RTN4R TRMT2A THAP7-AS1 THAP7 DGCR8 LZTR1 ENSG00000215493 UFD1 RANBP1 ZDHHC8
GH22J020282	Enhancer	0.4	Ensembl dbSUPER	500.7	+0.5	545	0.6	BHLHE40	RTN4R lnc-RTN4R-2 MIR1286
GH22J020180	Enhancer	0.9	Ensembl ENCODE	12.5	+100.5	100482	5.5	EP300 CTCF ZBTB10 ZNF341 KDM5B RBM14 USF1 MAX HIC1 ZBTB7A	TRMT2A DGCR8 LZTR1 THAP7 RTN4R ENSG00000215493 RPL8P5 RANBP1 THAP7-AS1 ZDHHC8
GH22J020221	Enhancer	0.8	Ensembl dbSUPER	12.7	+60.7	60745	1.8	ZIC2 MYC TARDBP NR2F2 ZBTB5 SETDB1 RAD21 RXRA GLIS1 HNF4A	RTN4R LOC284865 LOC105372863 HSALNG0134115
GH22J020217	Enhancer	0.7	Ensembl dbSUPER	12.7	+65.8	65845	0.8	FOXA1 RXRA ZFP64 CEBPB HNF4A KLF1 ZNF184 FOXA2 ZBTB20 ATF7	HSALNG0134115 RTN4R LOC284865 piR-49311

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTN4R on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTN4R

Top Transcription factor binding sites by QIAGEN in the RTN4R gene promoter:

AREB6
STAT1
STAT1alpha
STAT1beta
STAT2
STAT3
STAT4
STAT5A
STAT5B
STAT6

Genomic Locations for RTN4R Gene

chr22:20,241,415-20,283,246: (GRCh38/hg38)

Size:: 41,832 bases
Orientation:: Minus strand

chr22:20,228,938-20,270,769: (GRCh37/hg19)

Size:: 41,832 bases
Orientation:: Minus strand

Genomic View for RTN4R Gene

Genes around RTN4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

22q11.21 by HGNC
22q11.21 by Entrez Gene
22q11.21 by Ensembl

RTN4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for RTN4R Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RTN4R Gene

NC_000022.11

Proteins for RTN4R Gene

Protein details for RTN4R Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q9BZR6-RTN4R_HUMAN

Recommended name:

Reticulon-4 receptor

Protein Accession:

Q9BZR6

Secondary Accessions:
- D3DX28
Protein attributes for RTN4R Gene
Size:

473 amino acids

Molecular mass:

50708 Da
Quaternary structure:
Homodimer (PubMed:18411262). Interacts with MAG (PubMed:12089450, PubMed:12839991, PubMed:18411262, PubMed:19052207). Interacts with RTN4 (PubMed:12839991, PubMed:19052207). Interacts with NGFR (PubMed:12426574, PubMed:18411262, PubMed:19052207). Interacts with LINGO1 (PubMed:14966521, PubMed:19052207). Interacts with KIAA0319L (PubMed:20697954). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity). Interacts with OMG (PubMed:12068310, PubMed:12839991, PubMed:19052207).
Three dimensional structures from OCA and Proteopedia for RTN4R Gene
- 1OZN (3D)
- 1P8T (3D)

neXtProt entry for RTN4R Gene

Protein Expression for RTN4R Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RTN4R Gene

N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
- Q9BZR6-RTN4R_HUMAN
Glycosylation at Asn82, Asn179, and Asn372
- NX_Q9BZR6 (NX_Q9BZR6-1)
Modification sites at PhosphoSitePlus
- Q9BZR6

Other Protein References for RTN4R Gene

ENSEMBL proteins:

REFSEQ proteins:

NP_075380.1

Antibody Products

Creative Diagnostics Anti-RTN4R monoclonal antibody, clone FQS22260

Creative Biolabs

Alomone Labs, Ltd. Anti-Nogo Receptor (extracellular) Antibody

OriGene Antibodies for RTN4R
- DM3592P
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- TA351454
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Novus Biologicals Antibodies for RTN4R

Abcam antibodies for RTN4R
- Nogo Receptor

Invitrogen Antibodies for RTN4R (AFLGC-RTN4R)

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Sino Biological Antibodies for RTN4R

Protein Products

G Biosciences Human Nogo Receptor/NgR, Lyophilized

Recombinant Human Nogo Receptor Fc Chimera Protein, CF (1208-NG)

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Novus Biologicals lysates for RTN4R

Sino Biological Recombinant Proteins for RTN4R
Sino Biological Cell Lysates for RTN4R

ProSpec Recombinant Proteins for RTN4R

antibodies-online: Show 17 available RTN4R Proteins ranked by validation data
Compare Top RTN4R Proteins

Signalway Proteins for RTN4R
- AP75289
- GP10641

ProSci Proteins for RTN4R

Abcam proteins for RTN4R
- Nogo Receptor

Assay Products

RayBiotech Human Nogo Receptor/Reticulon-4 Receptor ELISA

Aviva Systems Biology RTN4R ELISA Kit (Human) (OKCD01887)

OriGene ELISA Kits for RTN4R
- EA102743
Custom Assay Services

antibodies-online: Show 8 available RTN4R Elisa Kits ranked by validation data
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Quality Products:

Boster Bio ELISA Kits for RTN4R
- EK2066

Signalway ELISA kits for RTN4R
- EK7501

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No data available for DME Specific Peptides for RTN4R Gene

Domains & Families for RTN4R Gene

Gene Families for RTN4R Gene

HGNC:

MicroRNA protein coding host genes

Human Protein Atlas (HPA):

Disease related genes
Predicted membrane proteins

Protein Domains for RTN4R Gene

Blocks:

Cysteine-rich flanking region, C-terminal
Leucine-rich repeat signature
Cysteine-rich flanking region, N-terminal

InterPro:

ProtoNet:

Q9BZR6

Suggested Antigen Peptide Sequences for RTN4R Gene

GenScript: Design optimal peptide antigens:

Nogo-66 receptor (RTN4R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZR6

UniProtKB/Swiss-Prot:

RTN4R_HUMAN :

Belongs to the Nogo receptor family.

Family:

Belongs to the Nogo receptor family.

Function for RTN4R Gene

Molecular function for RTN4R Gene

UniProtKB/Swiss-Prot Function:

Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).

RTN4R_HUMAN,Q9BZR6

Phenotypes From GWAS Catalog for RTN4R Gene

Gene Ontology (GO) - Molecular Function for RTN4R Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	20463223
GO:0008201	heparin binding	ISS,IEA	--
GO:0008289	lipid binding	IEA	--
GO:0035374	chondroitin sulfate binding	ISS,IEA	--
GO:0038023	signaling receptor activity	NAS,IEA	11201742

Phenotypes for RTN4R Gene

MGI mutant phenotypes for RTN4R:

inferred from 10 alleles

GenomeRNAi human phenotypes for RTN4R:

Human Phenotype Ontology for RTN4R Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for RTN4R Gene

MGI Knock Outs for RTN4R:

Rtn4r ^{Rtn4r<tm1Matl>}
Rtn4r ^{Rtn4r<tm2.2Stmr>}
Rtn4r ^{Rtn4r<tm1.1Pado>}
Rtn4r ^{Rtn4r<tm1Stmr>}
Rtn4r ^{Rtn4r<tm1b(KOMP)Wtsi>}
Rtn4r ^{Rtn4r<tm1Gogo>}
Rtn4r ^{Rtn4r<tm1Mrc>}

Animal Model Products

Taconic Biosciences Mouse Models for RTN4R
- Rtn4r

CRISPR Products

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OriGene CRISPR knockouts for RTN4R
- GA112230
- GA206506
- KN404073
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genomics-online: gRNA clones - Search for available RTN4R gRNA products
Overview of 125 available RTN4R gene related products
Recommended
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Santa Cruz Biotechnology (SCBT) CRISPR for RTN4R

miRNA for RTN4R Gene

miRTarBase miRNAs that target RTN4R

miRNA Products

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Inhibitory RNA Products

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Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4R

genomics-online: shRNA clones - Search for available RTN4R shRNA products
Overview of 125 available RTN4R gene related products
Recommended
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- pPM-C-His
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- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
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- pENTR221
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Search Santa Cruz Biotechnology (SCBT) for RTN4R siRNA/shRNA

Clone Products

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OriGene clones in human,mouse,rat for RTN4R
- SC203936
- MC205180
- RN201439
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OriGene ORF clones in human,mouse,rat for RTN4R
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Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for RTN4R

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Overview of 125 available RTN4R gene related products
Recommended
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orf clones - Search for available RTN4R ORF products
Overview of 125 available RTN4R gene related products
Recommended
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Human Nogo Receptor/NgR (NP_075380) VersaClone cDNA (RDC2191)

Cell Line Products

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VectorBuilder Stable cell line generation for RTN4R

Horizon Cell Lines for RTN4R
- RTN4R knockout cell line

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RTN4R Gene

Localization for RTN4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4R Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250 UniProtKB:Q99PI8}.

Q9BZR6-RTN4R_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
plasma membrane	5
endoplasmic reticulum	4
extracellular	3
cytoskeleton	3
mitochondrion	2
nucleus	2
endosome	2
cytosol	2
peroxisome	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Focal adhesion sites (3)
Plasma membrane (3)
Actin filaments (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for RTN4R Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IEA,ISS	--
GO:0009986	cell surface	IDA,IEA	16712417
GO:0016020	membrane	IEA	--

Pathways & Interactions for RTN4R Gene

SuperPathways for RTN4R Gene

	SuperPathway	Contained pathways
1	Guidance Cues and Growth Cone Motility	Guidance Cues and Growth Cone Motility -
2	NgR-p75(NTR)-Mediated Signaling	NgR-p75(NTR)-Mediated Signaling -
3	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	Development MAG-dependent inhibition of neurite outgrowth .42
4	p75(NTR)-mediated signaling	p75(NTR)-mediated signaling -
5	Spinal Cord Injury	Spinal Cord Injury -

Pathways by source for RTN4R Gene

2 BioSystems pathways for RTN4R Gene

1 GeneGo (Thomson Reuters) pathway for RTN4R Gene

Development MAG-dependent inhibition of neurite outgrowth

2 Qiagen pathways for RTN4R Gene

Guidance Cues and Growth Cone Motility
NgR-p75(NTR)-Mediated Signaling

Interacting Proteins for RTN4R Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q9BZR6-RTN4R_HUMAN ENSP00000043402 for RTN4R Gene via UniProtKB STRING IID

Symbol	External ID(s)	Details
KIAA0319L	Q8IZA0 ⁴ ¹²⁷ ENSP00000318406 ²¹	EBI-5240240, EBI-5240269 STRING: ENSP00000318406 IID: # exp=1
ARHGEF25	ENSP00000335560 ²¹ Q86VW2 ¹²⁷	STRING: ENSP00000335560 IID: # exp=1
CNTN4	ENSP00000380602 ²¹ Q8IWV2 ¹²⁷	STRING: ENSP00000380602 IID: # pred=1
EPHA7	ENSP00000358309 ²¹ Q15375 ¹²⁷	STRING: ENSP00000358309 IID: # pred=1
F2	ENSP00000308541 ²¹ P00734 ¹²⁷	STRING: ENSP00000308541 IID: # pred=1

GPS-Prot Interaction Network for RTN4R

;

Gene Ontology (GO) - Biological Process for RTN4R Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor signaling pathway	ISS,IEA	--
GO:0007409	axonogenesis	IEA	--
GO:0010977	negative regulation of neuron projection development	IEA,ISS	--
GO:0022038	corpus callosum development	IEA,ISS	--
GO:0023041	neuronal signal transduction	IEA,ISS	--

No data available for SIGNOR curated interactions for RTN4R Gene

Drugs & Compounds for RTN4R Gene

(3) Drugs for RTN4R Gene - From: Tocris and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
MOG (35-55)		MalaCards Medline Plus	Pharma		Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment	0

(4) Additional Compounds for RTN4R Gene - From: Tocris

Name	CAS Number	PubChem IDs
B2	MalaCards Medline Plus	115687-05-3
Nogo-66 (1-40)	MalaCards Medline Plus	475221-20-6
PLP (139-151)	MalaCards Medline Plus	122018-58-0
TCS PrP Inhibitor 13	MalaCards Medline Plus	34320-83-7

(5) Tocris Compounds for RTN4R Gene

Compound	Action	Cas Number
B2	Promotes inclusion formation in Huntington's and Parkinson's diseases	115687-05-3
MOG (35-55)	Encephalitogenic myelin oligodendrocyte glycoprotein fragment	149635-73-4
Nogo-66 (1-40)	Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration	475221-20-6
PLP (139-151)	Encephalitogenic myelin proteolipid fragment	122018-58-0
TCS PrP Inhibitor 13	Antiprion agent; potently inhibits PrP-res accumulation	34320-83-7

Drug Products

G Biosciences Human Nogo Receptor/NgR, Lyophilized

Tocris compounds for RTN4R

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Transcripts for RTN4R Gene

mRNA/cDNA for RTN4R Gene

1 REFSEQ mRNAs :

NM_023004.6

6 NCBI additional mRNA sequence :

6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000043402 1944 bps (ENST00000043402.8)
ENST00000416372 1777 bps (ENST00000416372.5)
ENST00000425986 1973 bps (ENST00000425986.1)
ENST00000463936 458 bps (ENST00000463936.1)
ENST00000469601 672 bps (ENST00000469601.1)

CRISPR Products

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OriGene CRISPR knockouts for RTN4R
- GA112230
- GA206506
- KN404073
- KN515193

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN4R

genomics-online: gRNA clones - Search for available RTN4R gRNA products
Overview of 125 available RTN4R gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pMD18-T Simple
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pENTR223
- pENTR221
- pENTR201

Santa Cruz Biotechnology (SCBT) CRISPR for RTN4R

miRNA Products

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Inhibitory RNA Products

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genomics-online: shRNA clones - Search for available RTN4R shRNA products
Overview of 125 available RTN4R gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pMD18-T Simple
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pENTR223
- pENTR221
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Search Santa Cruz Biotechnology (SCBT) for RTN4R siRNA/shRNA

Clone Products

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OriGene clones in human,mouse,rat for RTN4R
- SC203936
- MC205180
- RN201439
- SC126683
OriGene ORF clones in human,mouse,rat for RTN4R
- MG207571
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Search Addgene for plasmids for RTN4R

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN4R

genomics-online: cdna clones - Search for available RTN4R CDNA products
Overview of 125 available RTN4R gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pMD18-T Simple
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pENTR223
- pENTR221
- pENTR201
orf clones - Search for available RTN4R ORF products
Overview of 125 available RTN4R gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pMD18-T Simple
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pENTR223
- pENTR221
- pENTR201

Human Nogo Receptor/NgR (NP_075380) VersaClone cDNA (RDC2191)

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4R Gene

No ASD Table

Relevant External Links for RTN4R Gene

GeneLoc Exon Structure for: RTN4R

Expression for RTN4R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN4R Gene

mRNA expression in normal human tissues for RTN4R Gene

mRNA differential expression in normal tissues according to GTEx for RTN4R Gene

This gene is overexpressed in Brain - Cerebellum (x7.3), Brain - Cerebellar Hemisphere (x6.8), Brain - Cortex (x6.8), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for RTN4R Gene

This gene is overexpressed in Cerebrospinal fluid (54.3) and Fetal Brain (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RTN4R Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RTN4R Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for RTN4R Gene

Protein tissue co-expression partners for RTN4R Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTN4R

SOURCE GeneReport for Unigene cluster for RTN4R Gene:

Hs.30868

mRNA Expression by UniProt/SwissProt for RTN4R Gene:

Q9BZR6-RTN4R_HUMAN

Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).

Evidence on tissue expression from TISSUES for RTN4R Gene

Nervous system(4.8)
Lung(4.2)

Primer Products

OriGene qPCR primer pairs for RTN4R
- HP214617
- MP212673
OriGene qPCR primer pairs and template standards for RTN4R
- HK206476
- MK204359

genomics-online: primer clones - Search for available RTN4R Primer products
Overview of 125 available RTN4R gene related products
Recommended
- pCMV-SPORT6
- pOTB7
- pMD18-T Simple
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pENTR223
- pENTR221
- pENTR201

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for RTN4R

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4R Gene

Orthologs for RTN4R Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4R Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	RTN4R ³¹ ³⁰	99.28 (n)	OneToOne	22:18680939-18682336 458663 XM_514992.3 XP_514992.2
dog (Canis familiaris)	Mammalia	RTN4R ³⁰	85.61 (n)		486414 XM_005636657.1 XP_005636714.1
cow (Bos Taurus)	Mammalia	RTN4R ³¹ ³⁰	84.11 (n)	OneToOne	17:75103302-75104723 100299284 XM_005218315.1 XP_005218372.1
mouse (Mus musculus)	Mammalia	Rtn4r ¹⁷ ³¹ ³⁰	82.66 (n)		18127642 16:18127642-18152408 65079 NM_022982.2 NP_075358.1
rat (Rattus norvegicus)	Mammalia	Rtn4r ³⁰	82.52 (n)		113912 NM_053613.1 NP_446065.1
oppossum (Monodelphis domestica)	Mammalia	RTN4R ³¹	57 (a)	OneToOne	3:509118146-509119657
platypus (Ornithorhynchus anatinus)	Mammalia	-- ³¹	26 (a)	ManyToMany	Contig273:256214-257197
chicken (Gallus gallus)	Aves	RTN4R ³¹ ³⁰	59.74 (n)	OneToOne	15:10338375-10405782 417001 XM_415292.4 XP_415292.4
lizard (Anolis carolinensis)	Reptilia	RTN4R ³¹	45 (a)	OneToOne	GL343417.1:594131-652448
tropical clawed frog (Silurana tropicalis)	Amphibia	LOC100485966 ³⁰	49.65 (n)		100485966 XM_002932103.2 XP_002932149.2
zebrafish (Danio rerio)	Actinopterygii	LOC100332374 ³⁰	54.34 (n)		100332374 XM_002661960.2 XP_002662006.1
zebrafish (Danio rerio)	Actinopterygii	rtn4r ³¹ ³¹	44 (a)	OneToMany	5:11525552-11526970 5:11761444-11763156
fruit fly (Drosophila melanogaster)	Insecta	CG1504 ³¹	20 (a)	OneToMany	X:20181336-20186734
worm (Caenorhabditis elegans)	Secernentea	lron-12 ³¹	16 (a)	OneToMany	III:12114564-12118470
sea squirt (Ciona savignyi)	Ascidiacea	-- ³¹	26 (a)	OneToMany	reftig_30:2703219-2713416

Species where no ortholog for RTN4R was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)

Evolution for RTN4R Gene

ENSEMBL:: Gene Tree for RTN4R (if available)
TreeFam:: Gene Tree for RTN4R (if available)
Aminode:: Evolutionary constrained regions (ECRs) for RTN4R: view image

Paralogs for RTN4R Gene

RTN4RL1 ⁵
RTN4RL2 ⁵
FLRT1 ⁵
NYX ⁵
LRRTM3 ⁵
LRRTM4 ⁵
FLRT2 ⁵
LRRC4 ⁵
FLRT3 ⁵
LRRC4B ⁵
LRRC15 ⁵
PODNL1 ⁵
LRRC4C ⁵
LRRTM1 ⁵
PODN ⁵
GP1BA ⁵
LRTM1 ⁵
LRRC66 ⁵
DCN ⁵
BGN ⁵
ASPN ⁵
LRRC19 ⁵

(3) SIMAP similar genes for RTN4R Gene using alignment to 3 proteins:

RTN4R_HUMAN
H7C0V4_HUMAN
H7C215_HUMAN

Variants for RTN4R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTN4R Gene

SNP ID	Clinical significance and condition	Chr 22 pos	Variation	Type
rs1432033565	Schizophrenia (SCZD) [MIM:181500]		p.Arg292His
rs200119628	Schizophrenia (SCZD) [MIM:181500]		p.Arg399Trp
rs74315508	Risk Factor: Schizophrenia, susceptibility to. Schizophrenia (SCZD) [MIM:181500]	20,242,778(-)	G/Ap.Arg119Trp	MISSENSE_VARIANT
rs74315509	Risk Factor: Schizophrenia, susceptibility to. Schizophrenia (SCZD) [MIM:181500]	20,242,546(-)	C/Tp.Arg196His	MISSENSE_VARIANT
rs748655075	Schizophrenia (SCZD) [MIM:181500]		p.Arg377Trp

Additional dbSNP identifiers (rs#s) for RTN4R Gene

Structural Variations from Database of Genomic Variants (DGV) for RTN4R Gene

Variant ID	Type	Subtype	PubMed ID
dgv4480n100	CNV	gain	25217958
dgv4481n100	CNV	gain	25217958
dgv4482n100	CNV	gain	25217958
dgv726n67	CNV	gain	20364138
dgv7983n54	CNV	gain	21841781
dgv7986n54	CNV	loss	21841781
esv1003446	CNV	deletion	20482838
esv2758825	CNV	loss	17122850
esv3310500	CNV	novel sequence insertion	20981092
esv3441142	CNV	duplication	20981092
esv3893434	CNV	gain	25118596
esv3893435	CNV	gain	25118596
nsv1060294	CNV	gain	25217958
nsv1064701	CNV	gain	25217958
nsv1117315	CNV	tandem duplication	24896259
nsv471183	CNV	loss	18288195
nsv828938	CNV	gain	20364138
nsv828939	CNV	loss	20364138
nsv834134	CNV	loss	17160897
nsv953027	CNV	deletion	24416366

Variation tolerance for RTN4R Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTN4R Gene

Human Gene Mutation Database (HGMD): RTN4R
SNPedia medical, phenotypic, and genealogical associations of SNPs for: RTN4R

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for RTN4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4R Gene

Disorders for RTN4R Gene

(9) MalaCards diseases for RTN4R Gene - From: UniProtKB/Swiss-Prot, LncRNADisease, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
schizophrenia	sczd	15532024
leukemia, acute lymphoblastic	all	27650541
spinal cord injury	spinal cord injuries
psychotic disorder	mental or behavioural disorder
basidiobolomycosis	infection by basidiobolus

- elite association - COSMIC cancer census association via MalaCards

Search RTN4R in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RTN4R_HUMAN

Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:15532024, ECO:0000269 PubMed:19052207, ECO:0000269 PubMed:28892071}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for RTN4R

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for RTN4R gene in PubMed and other databases

No data available for Genatlas for RTN4R Gene

Publications for RTN4R Gene

Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. (PMID: 19052207) Budel S … Strittmatter SM (The Journal of neuroscience : the official journal of the Society for Neuroscience 2008) ³ ⁴ ²³ ⁴¹ ⁵⁴
Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. (PMID: 15532024) Sinibaldi L … Dallapiccola B (Human mutation 2004) ³ ⁴ ²³ ⁴¹ ⁵⁴
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PMID: 11201742) Fournier AE … Strittmatter SM (Nature 2001) ² ³ ⁴ ²³ ⁵⁴
No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. (PMID: 16897606) Meng J … He L (Journal of neural transmission (Vienna, Austria : 1996) 2007) ³ ²³ ⁴¹ ⁵⁴
A high-content screening assay for the Nogo receptor based on cellular Rho activation. (PMID: 16712417) Teusch N … Kiefer C (Assay and drug development technologies 2006) ³ ⁴ ²³ ⁵⁴