This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alt... See more...

Aliases for RTN4 Gene

Aliases for RTN4 Gene

  • Reticulon 4 2 3 5
  • Neuroendocrine-Specific Protein C Homolog 3 4
  • Neurite Outgrowth Inhibitor 3 4
  • Reticulon-4 3 4
  • Foocen 3 4
  • RTN-X 3 4
  • NOGO 3 4
  • NSP 3 4
  • Neuroendocrine-Specific Protein 4
  • Neurite Growth Inhibitor 220 3
  • My043 Protein 3
  • Nogo Protein 4
  • Human NogoA 3
  • Reticulon 5 3
  • Reticulon-5 4
  • NI220/250 3
  • Nbla00271 3
  • Nbla10545 3
  • KIAA0886 4
  • RTN4-B1 3
  • RTN4-B2 3
  • NSP-CL 3
  • RTN4-A 3
  • RTN4-C 3
  • ASY 3

External Ids for RTN4 Gene

Previous GeneCards Identifiers for RTN4 Gene

  • GC02M055237
  • GC02M055386
  • GC02M055173
  • GC02M055110
  • GC02M055199

Summaries for RTN4 Gene

Entrez Gene Summary for RTN4 Gene

  • This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4 Gene

RTN4 (Reticulon 4) is a Protein Coding gene. Diseases associated with RTN4 include Kleptomania and Epithelial-Stromal Tgfbi Dystrophy. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. An important paralog of this gene is RTN1.

UniProtKB/Swiss-Prot Summary for RTN4 Gene

  • Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).
  • [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity).
  • [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).
  • [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).

Gene Wiki entry for RTN4 Gene

Additional gene information for RTN4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTN4 Gene

Genomics for RTN4 Gene

GeneHancer (GH) Regulatory Elements for RTN4 Gene

Promoters and enhancers for RTN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J055045 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 533.6 +63.8 63843 9.6 EP300 CTCF TCF12 SIN3A MYC NRF1 POLR2G USF1 SP1 NCOR1 RTN4 NONHSAG027791.2 lnc-EML6-7 CLHC1 RNU6-433P PRORSD1P EML6 RF00017-3192
GH02J055231 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.2 -120.7 -120680 5 ZBTB40 ZNF217 EP300 TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 SIX5 CLHC1 RPS27A RTN4 NONHSAG027797.2-001 NONHSAG027797.2-002 lnc-MTIF2-3 PRORSD1P
GH02J055005 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 540.1 +102.7 102657 8.2 HNRNPK USF1 NCOR1 TRIM28 CTCF RFX1 TGIF2 RAD21 TRIM22 POLR2A RTN4 CLHC1 RF00026-544 RNU6-433P RF00017-3191
GH02J054975 Enhancer 1.1 Ensembl ENCODE dbSUPER 44 +134.2 134203 7.6 ZNF217 MEF2C CTBP1 TCF12 ZNF384 ARNT MEF2B NBN JUND ZFHX2 RTN4 EML6 CLHC1 RF00017-3191 lnc-CLHC1-3
GH02J054998 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 39.5 +113.1 113080 1.9 JUND MEF2C MEF2A MXI1 ZNF341 ZNF316 POLR2A ARNT CEBPB MEF2B RTN4 RF00026-544 RNU6-433P RF00017-3191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTN4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTN4

Top Transcription factor binding sites by QIAGEN in the RTN4 gene promoter:
  • C/EBPalpha
  • POU2F1
  • POU2F1a

Genomic Locations for RTN4 Gene

Genomic Locations for RTN4 Gene
chr2:54,972,187-55,112,621
(GRCh38/hg38)
Size:
140,435 bases
Orientation:
Minus strand
chr2:55,199,325-55,339,757
(GRCh37/hg19)
Size:
140,433 bases
Orientation:
Minus strand

Genomic View for RTN4 Gene

Genes around RTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4 Gene

Proteins for RTN4 Gene

  • Protein details for RTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQC3-RTN4_HUMAN
    Recommended name:
    Reticulon-4
    Protein Accession:
    Q9NQC3
    Secondary Accessions:
    • O94962
    • Q7L7Q5
    • Q7L7Q6
    • Q7L7Q8
    • Q8IUA4
    • Q96B16
    • Q9BXG5
    • Q9H212
    • Q9H3I3
    • Q9UQ42
    • Q9Y293
    • Q9Y2Y7
    • Q9Y5U6

    Protein attributes for RTN4 Gene

    Size:
    1192 amino acids
    Molecular mass:
    129931 Da
    Quaternary structure:
    • Binds to RTN4R (PubMed:19052207). Interacts with ATL1 (PubMed:19665976). Interacts with TMEM170A (PubMed:26906412, PubMed:19665976). Interacts with RTN4IP1 (By similarity). Isoform A: interacts in trans with CNTNAP1 (By similarity). Isoform B: homodimerizes (PubMed:27786289). Isoform B: interacts with BAD/Bcl-xl and BCL2. Isoform B: binds to NGBR and RTN3 (PubMed:16835300, PubMed:16979658, PubMed:12811824). Isoform B: interacts with SPTLC1 (By similarity). Isoform B: interacts with GRAMD4 (By similarity). Isoform B: interacts with CDH5 (PubMed:21183689). Isoform B: interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Isoform C: interacts with BACE1 and BACE2 (PubMed:15286784, PubMed:16965550). Isoform C: interacts with TMEM33 (PubMed:25612671).
    SequenceCaution:
    • Sequence=AAD39920.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA74909.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RTN4 Gene

    Alternative splice isoforms for RTN4 Gene

neXtProt entry for RTN4 Gene

Post-translational modifications for RTN4 Gene

  • Ubiquitination at Lys1090, Lys1104, and Lys1171
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RTN4

No data available for DME Specific Peptides for RTN4 Gene

Domains & Families for RTN4 Gene

Gene Families for RTN4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RTN4 Gene

Blocks:
  • Reticulon
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTN4 Gene

GenScript: Design optimal peptide antigens:
  • Reticulon 4, isoform CRA_e (D6W5C2_HUMAN)
  • NOGO-A (Q3LIF1_HUMAN)
  • NOGO-A (Q3LIF4_HUMAN)
  • RTN4 protein (Q6IPN0_HUMAN)
  • Reticulon 4, isoform CRA_d (Q7L7Q5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQC3

UniProtKB/Swiss-Prot:

RTN4_HUMAN :
  • Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
Domain:
  • Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
  • [Isoform B]: N-terminal part, called Am-Nogo-B(1-200), is the functional domain for RTN4B-mediated signaling in endothelial and vascular smooth muscle cells.
genes like me logo Genes that share domains with RTN4: view

Function for RTN4 Gene

Molecular function for RTN4 Gene

UniProtKB/Swiss-Prot Function:
Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).
UniProtKB/Swiss-Prot Function:
[Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).
UniProtKB/Swiss-Prot Function:
[Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).

Phenotypes From GWAS Catalog for RTN4 Gene

Gene Ontology (GO) - Molecular Function for RTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 11126360
GO:0031625 ubiquitin protein ligase binding IPI 27353365
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with RTN4: view
genes like me logo Genes that share phenotypes with RTN4: view

Animal Models for RTN4 Gene

MGI Knock Outs for RTN4:
  • Rtn4 Rtn4<tm2Matl>
  • Rtn4 Rtn4<tm3.1Matl>
  • Rtn4 Rtn4<tm2.1Matl>

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4

Clone Products

  • Addgene plasmids for RTN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4 Gene

Localization for RTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4 Gene

[Isoform A]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Cytoplasmic side. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. {ECO:0000269 PubMed:25612671, ECO:0000269 PubMed:27619977}.
[Isoform B]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Extracellular side. Cell junction. Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (PubMed:21183689). {ECO:0000269 PubMed:21183689, ECO:0000269 PubMed:27786289}.
[Isoform C]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
cytosol 2
golgi apparatus 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005635 nuclear envelope IDA 11126360
GO:0005783 endoplasmic reticulum IEA,NAS 11126360
GO:0005789 endoplasmic reticulum membrane IDA,IEA 25612671
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RTN4: view

Pathways & Interactions for RTN4 Gene

genes like me logo Genes that share pathways with RTN4: view

Pathways by source for RTN4 Gene

1 GeneGo (Thomson Reuters) pathway for RTN4 Gene
  • Development MAG-dependent inhibition of neurite outgrowth
1 Qiagen pathway for RTN4 Gene
  • NgR-p75(NTR)-Mediated Signaling
1 Cell Signaling Technology pathway for RTN4 Gene

SIGNOR curated interactions for RTN4 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for RTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001825 blastocyst formation IEA --
GO:0006915 apoptotic process NAS 11126360
GO:0007399 nervous system development IEA --
GO:0007413 axonal fasciculation ISS --
GO:0010634 positive regulation of epithelial cell migration IMP 27353365
genes like me logo Genes that share ontologies with RTN4: view

Drugs & Compounds for RTN4 Gene

(1) Additional Compounds for RTN4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RTN4: view

Transcripts for RTN4 Gene

mRNA/cDNA for RTN4 Gene

11 REFSEQ mRNAs :
54 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN4

Clone Products

  • Addgene plasmids for RTN4

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - -
SP16:
SP17:
SP18:

ExUns: 17a · 17b · 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RTN4 Gene

GeneLoc Exon Structure for
RTN4

Expression for RTN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RTN4 Gene



Protein tissue co-expression partners for RTN4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTN4

SOURCE GeneReport for Unigene cluster for RTN4 Gene:

Hs.637850

mRNA Expression by UniProt/SwissProt for RTN4 Gene:

Q9NQC3-RTN4_HUMAN
Tissue specificity: Isoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:21183689). Isoform C: is expressed in brain, skeletal muscle and adipocytes. Isoform D is testis-specific.

Evidence on tissue expression from TISSUES for RTN4 Gene

  • Lung(4.3)
  • Pancreas(4.1)
  • Heart(2.8)
  • Adrenal gland(2.6)
  • Intestine(2.4)
  • Bone(2.2)
  • Gall bladder(2.1)
  • Muscle(5)
  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.5)
  • Skin(4.5)
  • Eye(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with RTN4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4 Gene

Orthologs for RTN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RTN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTN4 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTN4 31 30
  • 91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RTN4 31 30
  • 88.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rtn4 17 31 30
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Rtn4 30
  • 83.28 (n)
oppossum
(Monodelphis domestica)
Mammalia RTN4 31
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTN4 31
  • 73 (a)
OneToOne
LOC101749579 30
  • 60.49 (n)
lizard
(Anolis carolinensis)
Reptilia RTN4 31
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4 30
  • 58.06 (n)
Str.386 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68489 30
zebrafish
(Danio rerio)
Actinopterygii rtn4a 31
  • 51 (a)
OneToOne
Dr.24718 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8546 30
fruit fly
(Drosophila melanogaster)
Insecta Rtnl1 31
  • 27 (a)
ManyToMany
Rtnl2 31
  • 22 (a)
ManyToMany
CG42853 31
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ret-1 31
  • 7 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTN2 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 31
  • 33 (a)
OneToMany
Species where no ortholog for RTN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4 Gene

ENSEMBL:
Gene Tree for RTN4 (if available)
TreeFam:
Gene Tree for RTN4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTN4: view image

Paralogs for RTN4 Gene

Paralogs for RTN4 Gene

(6) SIMAP similar genes for RTN4 Gene using alignment to 10 proteins:

  • RTN4_HUMAN
  • C9J685_HUMAN
  • D6W5C2_HUMAN
  • F8W914_HUMAN
  • F8WAM4_HUMAN
  • H7C106_HUMAN
  • Q53R94_HUMAN
  • Q53RF4_HUMAN
  • Q53SY1_HUMAN
  • Q6IPN0_HUMAN
genes like me logo Genes that share paralogs with RTN4: view

Variants for RTN4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTN4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
VAR_035904 A colorectal cancer sample p.Leu429Val
rs11677099 - p.Asp357Val
rs6757519 - p.Glu899Gln
rs6757705 - p.Ser920Cys

Additional dbSNP identifiers (rs#s) for RTN4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RTN4 Gene

Variant ID Type Subtype PubMed ID
esv2474783 CNV deletion 19546169
esv2517082 CNV deletion 19546169
esv2720078 CNV deletion 23290073
esv3340657 CNV insertion 20981092
nsv582029 CNV loss 21841781
nsv834069 CNV loss 17160897
nsv953127 CNV duplication 24416366

Variation tolerance for RTN4 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTN4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4 Gene

Disorders for RTN4 Gene

MalaCards: The human disease database

(59) MalaCards diseases for RTN4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kleptomania
  • pathological stealing
epithelial-stromal tgfbi dystrophy
temporal lobe epilepsy
  • epilepsy, temporal lobe
cholestasis, intrahepatic, of pregnancy 3
  • icp3
anosognosia
- elite association - COSMIC cancer census association via MalaCards
Search RTN4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTN4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RTN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4 Gene

Publications for RTN4 Gene

  1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PMID: 10667797) GrandPré T … Strittmatter SM (Nature 2000) 2 3 4 23 54
  2. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PMID: 18948092) Zhou B … Zhang L (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 41 54
  3. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PMID: 16835300) Miao RQ … Sessa WC (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23 54
  4. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PMID: 15820318) Gregório SP … Dias-Neto E (Schizophrenia research 2005) 3 23 41 54
  5. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PMID: 15661375) Xiong L … Joober R (Brain research. Molecular brain research 2005) 3 23 41 54

Products for RTN4 Gene

  • Addgene plasmids for RTN4

Sources for RTN4 Gene