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This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-be... See more...
Aliases for RTN3 Gene
Aliases for RTN3 Gene
External Ids for RTN3 Gene
- HGNC: 10469
- NCBI Entrez Gene: 10313
- Ensembl: ENSG00000133318
- OMIM®: 604249
- UniProtKB/Swiss-Prot: O95197
Previous GeneCards Identifiers for RTN3 Gene
- GC11P065970
- GC11P065024
- GC11P063224
- GC11P063205
- GC11P063448
- GC11P059778
Summaries for RTN3 Gene
-
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
GeneCards Summary for RTN3 Gene
RTN3 (Reticulon 3) is a Protein Coding gene. Diseases associated with RTN3 include Extraskeletal Chondroma and Hereditary Sensory And Autonomic Neuropathy Type 1. Among its related pathways are Protein-protein interactions at synapses and SALM protein interactions at the synapses. An important paralog of this gene is RTN4.
UniProtKB/Swiss-Prot Summary for RTN3 Gene
-
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
Additional gene information for RTN3 Gene
- HGNC (10469)
- NCBI Entrez Gene (10313)
- Ensembl (ENSG00000133318)
- OMIM® (604249)
- UniProtKB/Swiss-Prot (O95197)
- Open Targets Platform(ENSG00000133318)
- Search for RTN3 at DataMed
- Search for RTN3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTN3 Gene
Genomics for RTN3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RTN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RTN3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTN3
- Top Transcription factor binding sites by QIAGEN in the RTN3 gene promoter:
-
- ATF6
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
Genomic Locations for RTN3 Gene
Latest Assembly
- chr11:63,681,315-63,759,891
- (GRCh38/hg38)
- Size:
- 78,577 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:63,448,922-63,527,363
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 78,442 bases
- Orientation:
- Plus strand
- chr11:63,448,918-63,527,363
- (GRCh37/hg19 by Ensembl)
- Size:
- 78,446 bases
- Orientation:
- Plus strand
Genomic View for RTN3 Gene
Genes around RTN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
RTN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RTN3 Gene
Proteins for RTN3 Gene
-
Protein details for RTN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95197-RTN3_HUMAN
- Recommended name:
- Reticulon-3
- Protein Accession:
- O95197
- B3KQS2
- B7Z308
- B7Z4M0
- F5H774
- Q147U9
- Q496K2
- Q53GN3
- Q59EP0
- Q5UEP2
- Q6T930
- Q7RTM7
- Q7RTM8
- Q7RTN3
Protein attributes for RTN3 Gene
- Size:
- 1032 amino acids
- Molecular mass:
- 112611 Da
- Quaternary structure:
-
- Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL2. Interacts with TMEM33 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).
- (Microbial infection) Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins (PubMed:17182608).
- (Microbial infection) Interacts with West Nile virus protein NS4A.
- SequenceCaution:
-
- Sequence=BAD93008.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for RTN3 Gene
Post-translational modifications for RTN3 Gene
Other Protein References for RTN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RTN3 / Reticulon 3 Antibody and RTN3 / Reticulon 3 Monoclonal Antibody
- NSJ Bioreagents RTN3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RTN3
- Novus Biologicals Antibodies for RTN3
-
Abcam antibodies for RTN3
- Invitrogen Antibodies for RTN3 (AFLGC-RTN3)
-
Biorbyt antibodies for RTN3
-
Custom Antibody ServicesProSci Antibodies for RTN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RTN3
- Sino Biological Antibodies for RTN3
Protein products for research
-
OriGene Purified Proteins for RTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN3
- Origene Custom Protein Services for RTN3
- antibodies-online: Show 8 available Reticulon 3 Proteins ranked by validation data
- Compare Top Reticulon 3 Proteins
-
Quality Products:
-
Abcam proteins for RTN3
Assay products for research
No data available for DME Specific Peptides for RTN3 Gene
Domains & Families for RTN3 Gene
Gene Families for RTN3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for RTN3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52565, highly similar to Reticulon-3 (B7Z4M0_HUMAN)
- cDNA FLJ59931, highly similar to Reticulon-3 (B7Z4M1_HUMAN)
- Truncated RTN3-A3 (Q7RTN4_HUMAN)
- Neuroendocrine-specific protein-like II (RTN3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RTN3 Gene
Function for RTN3 Gene
Molecular function for RTN3 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
- UniProtKB/Swiss-Prot Induction:
- By endoplasmic reticulum stress (at protein level).
- GENATLAS Biochemistry:
- reticulon 3,neuroendocrine protein,associated with the endoplasmic reticulum,expressed in neural tissues,particularly in the macular region of the retina
Phenotypes From GWAS Catalog for RTN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15286784 |
Phenotypes for RTN3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RTN3 - Starting at $85 >
- * RTN3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RTN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN3
miRNA for RTN3 Gene
- miRTarBase miRNAs that target RTN3
-
- mmu-miR-223-3p (MIRT009745)
- mmu-miR-15a-5p (MIRT011866)
- hsa-miR-155-5p (MIRT020529)
- hsa-miR-760 (MIRT036707)
- hsa-miR-484 (MIRT041723)
- hsa-miR-378a-3p (MIRT043942)
- hsa-miR-106a-5p (MIRT048346)
- hsa-miR-17-5p (MIRT050976)
- hsa-miR-205-5p (MIRT439720)
- hsa-miR-6515-5p (MIRT560660)
- hsa-miR-4443 (MIRT560661)
- hsa-miR-4725-3p (MIRT560662)
- hsa-miR-6780b-5p (MIRT560663)
- hsa-miR-4271 (MIRT560664)
- hsa-miR-6797-5p (MIRT560665)
- hsa-miR-1249-5p (MIRT560666)
- hsa-miR-6783-5p (MIRT560667)
- hsa-miR-671-5p (MIRT560668)
- mmu-miR-5101 (MIRT588982)
- hsa-miR-4511 (MIRT699942)
- hsa-miR-33b-5p (MIRT699943)
- hsa-miR-33a-5p (MIRT699944)
- hsa-miR-4684-3p (MIRT699945)
- hsa-miR-4694-5p (MIRT699946)
- hsa-miR-367-5p (MIRT699947)
- hsa-miR-802 (MIRT699948)
- hsa-miR-522-3p (MIRT699949)
- hsa-miR-224-3p (MIRT699950)
- hsa-miR-4694-3p (MIRT699951)
- hsa-miR-335-3p (MIRT741343)
- hsa-miR-4775 (MIRT748707)
- hsa-miR-5692a (MIRT751215)
- hsa-miR-590-3p (MIRT751575)
- hsa-miR-6793-3p (MIRT756060)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN3
- Browse OriGene Inhibitory RNA Products For RTN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN3
Clone products for research
- Applied Biological Materials (abm): Clones for RTN3 - Starting at $45 >
- * RTN3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211332
- MG219679
- MG219681
- MR211332
- MR211332L3
- MR211332L4
- MR219679
- MR219679L3
- MR219679L4
- MR219681
- MR219681L3
- MR219681L4
- MR228826
- MR230774
- RC217819
- RC217819L1
- RC217819L2
- RC217819L3
- RC217819L4
- RC217864
- RC217864L3
- RC217864L4
- RC217927
- RC217927L3
- RC217927L4
- RC220992
- RC220992L3
- RC220992L4
- RC233461
- RC235038
- RC235130
- RG217819
- RG217864
- RG217927
- RG220992
- RG233461
- RG235038
- RG235130
- RR200210
- RR200210L3
- RR200210L4
- RR200211
- RR200211L3
- RR200211L4
- MR211332L3V
- MR211332L4V
- MR219679L3V
- MR219679L4V
- MR219681L3V
- MR219681L4V
- RC217819L1V
- RC217819L2V
- RC217819L3V
- RC217819L4V
- RC217864L3V
- RC217864L4V
- RC217927L3V
- RC217927L4V
- RC220992L3V
- RC220992L4V
- RR200210L3V
- RR200210L4V
- RR200211L3V
- RR200211L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN3
- Addgene plasmids for RTN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN3
Cell Lines for research
-
Horizon Cell Lines for RTN3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN3 Gene
Localization for RTN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RTN3 Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| extracellular | 4 |
| golgi apparatus | 4 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005615 | extracellular space | TAS | 10331947 |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 15286784 |
| GO:0005789 | endoplasmic reticulum membrane | IEA,IDA | 24262037 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 15286784 |
Pathways & Interactions for RTN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Pathways of neurodegeneration - multiple diseases | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
| 3 | Protein-protein interactions at synapses | ||
| 4 | SALM protein interactions at the synapses | ||
Pathways by source for RTN3 Gene
3 Reactome pathways for RTN3 Gene
1 KEGG pathway for RTN3 Gene
Interacting Proteins for RTN3 Gene
Selected Interacting proteins:
O95197-RTN3_HUMAN
ENSP00000367050
for RTN3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RTN3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
| GO:0071786 | endoplasmic reticulum tubular network organization | IMP | 18779370 |
| GO:0071787 | endoplasmic reticulum tubular network formation | IDA | 25612671 |
No data available for SIGNOR curated interactions for RTN3 Gene
Transcripts for RTN3 Gene
mRNA/cDNA for RTN3 Gene
- 7 REFSEQ mRNAs :
- 35 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000338850 493 nts (view in UCSC)
- ENST00000339997 4886 nts (view in UCSC)
- ENST00000341307 2524 nts (view in UCSC)
- ENST00000354497 1407 nts (view in UCSC)
- ENST00000356000 2645 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RTN3 - Starting at $85 >
- * RTN3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RTN3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN3
- Browse OriGene Inhibitory RNA Products For RTN3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN3
Clone products for research
- Applied Biological Materials (abm): Clones for RTN3 - Starting at $45 >
- * RTN3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211332
- MG219679
- MG219681
- MR211332
- MR211332L3
- MR211332L4
- MR219679
- MR219679L3
- MR219679L4
- MR219681
- MR219681L3
- MR219681L4
- MR228826
- MR230774
- RC217819
- RC217819L1
- RC217819L2
- RC217819L3
- RC217819L4
- RC217864
- RC217864L3
- RC217864L4
- RC217927
- RC217927L3
- RC217927L4
- RC220992
- RC220992L3
- RC220992L4
- RC233461
- RC235038
- RC235130
- RG217819
- RG217864
- RG217927
- RG220992
- RG233461
- RG235038
- RG235130
- RR200210
- RR200210L3
- RR200210L4
- RR200211
- RR200211L3
- RR200211L4
- MR211332L3V
- MR211332L4V
- MR219679L3V
- MR219679L4V
- MR219681L3V
- MR219681L4V
- RC217819L1V
- RC217819L2V
- RC217819L3V
- RC217819L4V
- RC217864L3V
- RC217864L4V
- RC217927L3V
- RC217927L4V
- RC220992L3V
- RC220992L4V
- RR200210L3V
- RR200210L4V
- RR200211L3V
- RR200211L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN3
- Addgene plasmids for RTN3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTN3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - |
Relevant External Links for RTN3 Gene
- GeneLoc Exon Structure for
- RTN3
Expression for RTN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for RTN3 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.7) and Brain - Anterior cingulate cortex (BA24) (x4.2).
This gene is overexpressed in Nasal epithelium (20.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RTN3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTN3
SOURCE GeneReport for Unigene cluster for RTN3 Gene:
Hs.743229mRNA Expression by UniProt/SwissProt for RTN3 Gene:
O95197-RTN3_HUMAN
Tissue specificity:
Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.
Evidence on tissue expression from TISSUES for RTN3 Gene
- Nervous system(5)
- Kidney(4.8)
- Eye(4.8)
- Lung(3.6)
- Blood(3.4)
- Intestine(3.4)
- Skin(3.3)
- Pancreas(3.2)
- Liver(2.3)
- Muscle(2.1)
- Adrenal gland(2)
Primer products for research
-
OriGene qPCR primer pairs for RTN3
-
OriGene qPCR primer pairs and template standards for RTN3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN3 Gene
Orthologs for RTN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RTN3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rtn3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rtn3 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | RTN3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RTN3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RTN3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RTN3 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RTN3 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19053 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.1940 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rtn3 31 31 |
|
OneToMany | |
| zgc56439 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rtnl2 31 |
|
ManyToMany | |
| Rtnl1 31 |
|
ManyToMany | |||
| CG42853 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ret-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10170 31 |
|
OneToMany |
- Species where no ortholog for RTN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RTN3 Gene
- ENSEMBL:
- Gene Tree for RTN3 (if available)
- TreeFam:
- Gene Tree for RTN3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RTN3: view image
Paralogs for RTN3 Gene
(3) SIMAP similar genes for RTN3 Gene using alignment to 6 proteins:
- RTN3_HUMAN
- B7Z4M1_HUMAN
- F5GWG7_HUMAN
- F5H617_HUMAN
- F5H891_HUMAN
- Q7RTN4_HUMAN
Pseudogenes.org Pseudogenes for RTN3 Gene
Variants for RTN3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTN3 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11551949 | Benign: not provided | 63,681,666(+) |
C/T NM_001265589.2(RTN3):c.30C>T (p.Ser10=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs116807490 | Benign: not provided | 63,720,310(+) |
C/T NM_001265589.2(RTN3):c.1808C>T (p.Pro603Leu) |
MISSENSE_VARIANT,INTRON | |
| rs75523067 | Benign: not provided | 63,704,885(+) |
A/C NM_001265589.2(RTN3):c.177A>C (p.Val59=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs11551944 | - |
p.Ala6Glu |
|||
| rs7936660 | - |
p.Asp501His |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2673702 | CNV | deletion | 23128226 |
| esv3626650 | CNV | loss | 21293372 |
| esv3626651 | CNV | loss | 21293372 |
| nsv1145539 | CNV | deletion | 24896259 |
| nsv555180 | CNV | loss | 21841781 |
| nsv825940 | CNV | loss | 20364138 |
| nsv832183 | CNV | loss | 17160897 |
| nsv975941 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
6.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.21;
69.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RTN3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN3 Gene
Disorders for RTN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| extraskeletal chondroma |
|
|
| hereditary sensory and autonomic neuropathy type 1 |
|
|
Search RTN3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RTN3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RTN3 Gene
Publications for RTN3 Gene
- Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. (PMID: 10331947) Moreira EF … Rodriguez IR (Genomics 1999) 2 3 4 23
- Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PMID: 17191123) Wan Q … Liu Y (Apoptosis : an international journal on programmed cell death 2007) 3 4 23
- Tissue specificity and regulation of the N-terminal diversity of reticulon 3. (PMID: 15350194) Di Scala F … Loeffler JP (The Biochemical journal 2005) 3 4 23
- Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain. (PMID: 15946766) Cai Y … Yu L (Brain research. Molecular brain research 2005) 3 4 23
- Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PMID: 12811824) Qi B … Yutsudo M (Journal of cellular physiology 2003) 3 4 23
ExternalLinks
Products for RTN3 Gene
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- Invitrogen Antibodies for RTN3 (AFLGC-RTN3)
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- VectorBuilder Viral vectors for RTN3 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 15 available Reticulon 3 Antibodies ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RTN3
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- Search for RTN3 Proteins at ProSci
- Horizon Cell Lines for RTN3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTN3
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- Biorbyt antibodies for RTN3
Sources for RTN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB