Aliases for RTN3 Gene
External Ids for RTN3 Gene
Previous GeneCards Identifiers for RTN3 Gene
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
GeneCards Summary for RTN3 Gene
RTN3 (Reticulon 3) is a Protein Coding gene. Diseases associated with RTN3 include Lipodystrophy, Congenital Generalized, Type 4 and Retinitis Pigmentosa 23. Among its related pathways are Transmission across Chemical Synapses and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is RTN4.
UniProtKB/Swiss-Prot Summary for RTN3 Gene
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).