This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-be... See more...

Aliases for RTN3 Gene

Aliases for RTN3 Gene

  • Reticulon 3 2 3 5
  • Neuroendocrine-Specific Protein-Like 2 2 3 4
  • Homolog Of ASY Protein 2 3 4
  • NSP-Like Protein II 2 3 4
  • NSPLII 2 3 4
  • ASYIP 2 3 4
  • NSPL2 2 3 4
  • HAP 2 3 4
  • Neuroendocrine-Specific Protein-Like II 3 4
  • ASY Interacting Protein 2 3
  • NSP-Like Protein 2 3 4
  • Reticulon-3 3 4
  • RTN3-A1 2 3
  • Isoforme III 2
  • RTN3 5

External Ids for RTN3 Gene

Previous GeneCards Identifiers for RTN3 Gene

  • GC11P065970
  • GC11P065024
  • GC11P063224
  • GC11P063205
  • GC11P063448
  • GC11P059778

Summaries for RTN3 Gene

Entrez Gene Summary for RTN3 Gene

  • This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

GeneCards Summary for RTN3 Gene

RTN3 (Reticulon 3) is a Protein Coding gene. Diseases associated with RTN3 include Extraskeletal Chondroma and Hereditary Sensory And Autonomic Neuropathy Type 1. Among its related pathways are Protein-protein interactions at synapses and SALM protein interactions at the synapses. An important paralog of this gene is RTN4.

UniProtKB/Swiss-Prot Summary for RTN3 Gene

  • May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).

Gene Wiki entry for RTN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTN3 Gene

Genomics for RTN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RTN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063680 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.1 1088 4 TBP SP1 ZBTB10 FEZF1 CEBPA MNT IKZF1 SMAD5 HES1 MBD2 RTN3 ATL3 IMMP1LP1 HSALNG0084710 ZFTA
GH11J063679 Enhancer 0.4 Ensembl 250.7 -1.3 -1315 0.4 ZNF316 MAFK ZNF512 RTN3 ATL3
GH11J062851 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.4 -823.6 -823555 13.4 BCL11A SP1 MXD4 FEZF1 CEBPA MNT DEK IKZF1 SMAD5 ETS1 SNHG1 NXF1 SLC3A2 piR-40154-030 piR-40163-016 piR-52261-046 CSKMT MTA2 LOC105369332 GANAB
GH11J063837 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 +159.3 159251 6.5 NR2C1 MNT DEK IKZF1 SMAD5 POLR2A CTCF ELF1 NONO THAP11 MARK2 MK280054 SF1 KCNK4 SNHG1 RTN3 NRXN2 NAA40 RNU6-1306P PLCB3
GH11J063937 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.9 +257.6 257584 2.8 TBP ZBTB10 SP1 MXD4 NR2C1 IKZF1 MBD2 ZNF217 POLR2A BRCA1 HSALNG0084729 NAA40 lnc-RCOR2-2 KCNK4 RTN3 NRXN2 SF1 SLC22A6 PPP2R5B FLRT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTN3

Top Transcription factor binding sites by QIAGEN in the RTN3 gene promoter:
  • ATF6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for RTN3 Gene

Latest Assembly
chr11:63,681,315-63,759,891
(GRCh38/hg38)
Size:
78,577 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,448,922-63,527,363
(GRCh37/hg19 by Entrez Gene)
Size:
78,442 bases
Orientation:
Plus strand

chr11:63,448,918-63,527,363
(GRCh37/hg19 by Ensembl)
Size:
78,446 bases
Orientation:
Plus strand

Genomic View for RTN3 Gene

Genes around RTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN3 Gene

Proteins for RTN3 Gene

  • Protein details for RTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95197-RTN3_HUMAN
    Recommended name:
    Reticulon-3
    Protein Accession:
    O95197
    Secondary Accessions:
    • B3KQS2
    • B7Z308
    • B7Z4M0
    • F5H774
    • Q147U9
    • Q496K2
    • Q53GN3
    • Q59EP0
    • Q5UEP2
    • Q6T930
    • Q7RTM7
    • Q7RTM8
    • Q7RTN3

    Protein attributes for RTN3 Gene

    Size:
    1032 amino acids
    Molecular mass:
    112611 Da
    Quaternary structure:
    • Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL2. Interacts with TMEM33 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).
    • (Microbial infection) Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins (PubMed:17182608).
    • (Microbial infection) Interacts with West Nile virus protein NS4A.
    SequenceCaution:
    • Sequence=BAD93008.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RTN3 Gene

    Alternative splice isoforms for RTN3 Gene

neXtProt entry for RTN3 Gene

Post-translational modifications for RTN3 Gene

  • Ubiquitination at Lys998 and Lys1018
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for RTN3
  • Santa Cruz Biotechnology (SCBT) Antibodies for RTN3

No data available for DME Specific Peptides for RTN3 Gene

Domains & Families for RTN3 Gene

Gene Families for RTN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RTN3 Gene

InterPro:
Blocks:
  • Reticulon
ProtoNet:

Suggested Antigen Peptide Sequences for RTN3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52565, highly similar to Reticulon-3 (B7Z4M0_HUMAN)
  • cDNA FLJ59931, highly similar to Reticulon-3 (B7Z4M1_HUMAN)
  • Truncated RTN3-A3 (Q7RTN4_HUMAN)
  • Neuroendocrine-specific protein-like II (RTN3_HUMAN)
genes like me logo Genes that share domains with RTN3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RTN3 Gene

Function for RTN3 Gene

Molecular function for RTN3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress (at protein level).
GENATLAS Biochemistry:
reticulon 3,neuroendocrine protein,associated with the endoplasmic reticulum,expressed in neural tissues,particularly in the macular region of the retina

Phenotypes From GWAS Catalog for RTN3 Gene

Gene Ontology (GO) - Molecular Function for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15286784
genes like me logo Genes that share ontologies with RTN3: view
genes like me logo Genes that share phenotypes with RTN3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN3

Clone products for research

  • Addgene plasmids for RTN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN3 Gene

Localization for RTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN3 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 4
golgi apparatus 4
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space TAS 10331947
GO:0005783 endoplasmic reticulum IEA,IDA 15286784
GO:0005789 endoplasmic reticulum membrane IEA,IDA 24262037
GO:0005794 Golgi apparatus IEA,IDA 15286784
genes like me logo Genes that share ontologies with RTN3: view

Pathways & Interactions for RTN3 Gene

genes like me logo Genes that share pathways with RTN3: view

Pathways by source for RTN3 Gene

Gene Ontology (GO) - Biological Process for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016032 viral process IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0071786 endoplasmic reticulum tubular network organization IMP 18779370
GO:0071787 endoplasmic reticulum tubular network formation IDA 25612671
genes like me logo Genes that share ontologies with RTN3: view

No data available for SIGNOR curated interactions for RTN3 Gene

Drugs & Compounds for RTN3 Gene

No Compound Related Data Available

Transcripts for RTN3 Gene

mRNA/cDNA for RTN3 Gene

7 REFSEQ mRNAs :
35 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTN3

Clone products for research

  • Addgene plasmids for RTN3

Alternative Splicing Database (ASD) splice patterns (SP) for RTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - -
SP8:
SP9: - - - -
SP10: - -
SP11: - - -

Relevant External Links for RTN3 Gene

GeneLoc Exon Structure for
RTN3

Expression for RTN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.7) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RTN3 Gene

This gene is overexpressed in Nasal epithelium (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RTN3 Gene



Protein tissue co-expression partners for RTN3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTN3

SOURCE GeneReport for Unigene cluster for RTN3 Gene:

Hs.743229

mRNA Expression by UniProt/SwissProt for RTN3 Gene:

O95197-RTN3_HUMAN
Tissue specificity: Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.

Evidence on tissue expression from TISSUES for RTN3 Gene

  • Nervous system(5)
  • Kidney(4.8)
  • Eye(4.8)
  • Lung(3.6)
  • Blood(3.4)
  • Intestine(3.4)
  • Skin(3.3)
  • Pancreas(3.2)
  • Liver(2.3)
  • Muscle(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with RTN3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN3 Gene

Orthologs for RTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RTN3 30 31
  • 99.34 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rtn3 30 17 31
  • 80.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rtn3 30
  • 78.72 (n)
Cow
(Bos Taurus)
Mammalia RTN3 31
  • 75 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RTN3 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RTN3 31
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RTN3 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RTN3 31
  • 39 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19053 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.1940 30
Zebrafish
(Danio rerio)
Actinopterygii rtn3 31 31
  • 65 (a)
OneToMany
zgc56439 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rtnl2 31
  • 26 (a)
ManyToMany
Rtnl1 31
  • 24 (a)
ManyToMany
CG42853 31
  • 16 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ret-1 31
  • 6 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10170 31
  • 29 (a)
OneToMany
Species where no ortholog for RTN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RTN3 Gene

ENSEMBL:
Gene Tree for RTN3 (if available)
TreeFam:
Gene Tree for RTN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTN3: view image

Paralogs for RTN3 Gene

Paralogs for RTN3 Gene

(3) SIMAP similar genes for RTN3 Gene using alignment to 6 proteins:

  • RTN3_HUMAN
  • B7Z4M1_HUMAN
  • F5GWG7_HUMAN
  • F5H617_HUMAN
  • F5H891_HUMAN
  • Q7RTN4_HUMAN

Pseudogenes.org Pseudogenes for RTN3 Gene

genes like me logo Genes that share paralogs with RTN3: view

Variants for RTN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTN3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11551949 Benign: not provided 63,681,666(+) C/T
NM_001265589.2(RTN3):c.30C>T (p.Ser10=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs116807490 Benign: not provided 63,720,310(+) C/T
NM_001265589.2(RTN3):c.1808C>T (p.Pro603Leu)
MISSENSE_VARIANT,INTRON
rs75523067 Benign: not provided 63,704,885(+) A/C
NM_001265589.2(RTN3):c.177A>C (p.Val59=)
SYNONYMOUS_VARIANT,INTRON
rs11551944 - p.Ala6Glu
rs7936660 - p.Asp501His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RTN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RTN3 Gene

Variant ID Type Subtype PubMed ID
esv2673702 CNV deletion 23128226
esv3626650 CNV loss 21293372
esv3626651 CNV loss 21293372
nsv1145539 CNV deletion 24896259
nsv555180 CNV loss 21841781
nsv825940 CNV loss 20364138
nsv832183 CNV loss 17160897
nsv975941 CNV duplication 23825009

Variation tolerance for RTN3 Gene

Residual Variation Intolerance Score: 6.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTN3 Gene

Human Gene Mutation Database (HGMD)
RTN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN3 Gene

Disorders for RTN3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RTN3 Gene - From: COP

Disorder Aliases PubMed IDs
extraskeletal chondroma
  • soft tissue chondroma
hereditary sensory and autonomic neuropathy type 1
  • hereditary sensory and autonomic neuropathy type i
- elite association - COSMIC cancer census association via MalaCards
Search RTN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTN3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RTN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN3 Gene

Publications for RTN3 Gene

  1. Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. (PMID: 10331947) Moreira EF … Rodriguez IR (Genomics 1999) 2 3 4 23
  2. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PMID: 17191123) Wan Q … Liu Y (Apoptosis : an international journal on programmed cell death 2007) 3 4 23
  3. Tissue specificity and regulation of the N-terminal diversity of reticulon 3. (PMID: 15350194) Di Scala F … Loeffler JP (The Biochemical journal 2005) 3 4 23
  4. Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain. (PMID: 15946766) Cai Y … Yu L (Brain research. Molecular brain research 2005) 3 4 23
  5. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PMID: 12811824) Qi B … Yutsudo M (Journal of cellular physiology 2003) 3 4 23

Products for RTN3 Gene

Sources for RTN3 Gene