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Aliases for RTL8C Gene

Aliases for RTL8C Gene

  • Retrotransposon Gag Like 8C 2 3 5
  • Mammalian Retrotransposon Derived Protein 8C 3 4
  • Family With Sequence Similarity 127 Member A 2 3
  • Sushi-Ichi Retrotransposon Homolog 5 2 3
  • Mammalian Retrotransposon-Derived 8C 2 3
  • CAAX Box 1 2 3
  • FAM127A 3 4
  • MAR8C 3 4
  • CXX1 3 4
  • Family With Sequence Similarity 127, Member A 2
  • Retrotransposon Gag-Like Protein 8B 3
  • Cerebral Protein 5 4
  • Protein FAM127A 3
  • MART8C 3
  • Mart8 3
  • SIRH5 3
  • MART8 4
  • Mar8 3
  • MAR8 4

External Ids for RTL8C Gene

Previous HGNC Symbols for RTL8C Gene

  • CXX1
  • FAM127A

Summaries for RTL8C Gene

GeneCards Summary for RTL8C Gene

RTL8C (Retrotransposon Gag Like 8C) is a Protein Coding gene. An important paralog of this gene is RTL8A.

Gene Wiki entry for RTL8C Gene

Additional gene information for RTL8C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL8C Gene

Genomics for RTL8C Gene

GeneHancer (GH) Regulatory Elements for RTL8C Gene

Promoters and enhancers for RTL8C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ135031 Promoter/Enhancer 1.4 Ensembl ENCODE 650.7 +0.4 377 2.2 HDGF ATF1 SIN3A DMAP1 GLI4 ZNF2 YY1 POLR2B GLIS2 ATF7 GC0XM135032 GC0XM135033 GC0XM135034 GC0XM135035 RTL8C RTL8B ZNF75D FAM122B INTS6L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTL8C on UCSC Golden Path with GeneCards custom track

Genomic Locations for RTL8C Gene

Genomic Locations for RTL8C Gene
chrX:135,032,303-135,033,546
(GRCh38/hg38)
Size:
1,244 bases
Orientation:
Plus strand
chrX:134,166,333-134,167,576
(GRCh37/hg19)
Size:
1,244 bases
Orientation:
Plus strand

Genomic View for RTL8C Gene

Genes around RTL8C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL8C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL8C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL8C Gene

Proteins for RTL8C Gene

  • Protein details for RTL8C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15255-CXX1_HUMAN
    Recommended name:
    CAAX box protein 1
    Protein Accession:
    O15255
    Secondary Accessions:
    • Q6IBF1

    Protein attributes for RTL8C Gene

    Size:
    209 amino acids
    Molecular mass:
    22278 Da
    Quaternary structure:
    No Data Available
  • Protein details for RTL8C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ZKI3-RTL8C_HUMAN
    Recommended name:
    Retrotransposon Gag-like protein 8B
    Protein Accession:
    A6ZKI3

    Protein attributes for RTL8C Gene

    Size:
    113 amino acids
    Molecular mass:
    13171 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • RTL8C is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.

neXtProt entry for RTL8C Gene

Post-translational modifications for RTL8C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL8C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTL8C Gene

Domains & Families for RTL8C Gene

Gene Families for RTL8C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RTL8C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTL8C Gene

Graphical View of Domain Structure for InterPro Entry

A6ZKI3

UniProtKB/Swiss-Prot:

RTL8C_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with RTL8C: view

Function for RTL8C Gene

genes like me logo Genes that share phenotypes with RTL8C: view

Animal Model Products

CRISPR Products

miRNA for RTL8C Gene

miRTarBase miRNAs that target RTL8C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTL8C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTL8C Gene

Localization for RTL8C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTL8C Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL8C gene
Compartment Confidence
mitochondrion 2
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RTL8C Gene

Pathways & Interactions for RTL8C Gene

SuperPathways for RTL8C Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTL8C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RTL8C Gene

Drugs & Compounds for RTL8C Gene

No Compound Related Data Available

Transcripts for RTL8C Gene

mRNA/cDNA for RTL8C Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTL8C

Alternative Splicing Database (ASD) splice patterns (SP) for RTL8C Gene

No ASD Table

Relevant External Links for RTL8C Gene

GeneLoc Exon Structure for
RTL8C
ECgene alternative splicing isoforms for
RTL8C

Expression for RTL8C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RTL8C Gene:

RTL8C

mRNA Expression by UniProt/SwissProt for RTL8C Gene:

O15255-CXX1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RTL8C Gene

  • Nervous system(3.8)
  • Muscle(2.9)
  • Lung(2.7)
  • Heart(2.5)
  • Skin(2.5)
  • Eye(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RTL8C: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL8C Gene

Orthologs for RTL8C Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL8C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127A 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102152178 33
  • 91.45 (n)
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia FAM127A 34 34 34
  • 90 (a)
ManyToMany
LOC783730 33
  • 89.68 (n)
mouse
(Mus musculus)
Mammalia Cxx1c 33
  • 73.57 (n)
Cxx1b 34
  • 71 (a)
ManyToMany
Rtl8c 16
Species where no ortholog for RTL8C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL8C Gene

ENSEMBL:
Gene Tree for RTL8C (if available)
TreeFam:
Gene Tree for RTL8C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RTL8C: view image

Paralogs for RTL8C Gene

Paralogs for RTL8C Gene

genes like me logo Genes that share paralogs with RTL8C: view

Variants for RTL8C Gene

Sequence variations from dbSNP and Humsavar for RTL8C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002500077 -- 135,032,061(+) T/C upstream_transcript_variant
rs1005620804 -- 135,033,979(+) T/C downstream_transcript_variant
rs1006304346 -- 135,031,980(+) G/C/T upstream_transcript_variant
rs1006397701 -- 135,031,373(+) A/G upstream_transcript_variant
rs1007148345 -- 135,032,811(+) C/T 3_prime_UTR_variant

Variation tolerance for RTL8C Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTL8C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL8C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTL8C Gene

Disorders for RTL8C Gene

No disorders were found for RTL8C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTL8C Gene

Publications for RTL8C Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J … Volff JN (Gene 2005) 2 3 4 58
  2. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J … Volff JN (Cytogenetic and genome research 2005) 2 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A … Vezzoni P (Genomics 1997) 2 3 58

Products for RTL8C Gene

Sources for RTL8C Gene

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