Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RTL8A Gene

Aliases for RTL8A Gene

  • Retrotransposon Gag Like 8A 2 3 5
  • Family With Sequence Similarity 127 Member B 2 3
  • Mammalian Retrotransposon Derived Protein 8A 3 4
  • Sushi-Ichi Retrotransposon Homolog 6 2 3
  • Mammalian Retrotransposon-Derived 8A 2 3
  • FAM127B 3 4
  • CXX1b 3 4
  • MAR8A 3 4
  • Family With Sequence Similarity 127, Member B 2
  • Retrotransposon Gag-Like Protein 8A 3
  • Protein FAM127B 3
  • SIRH6 3

External Ids for RTL8A Gene

Previous HGNC Symbols for RTL8A Gene

  • FAM127B

Previous GeneCards Identifiers for RTL8A Gene

  • GC0XM135051
  • GC0XM135053

Summaries for RTL8A Gene

GeneCards Summary for RTL8A Gene

RTL8A (Retrotransposon Gag Like 8A) is a Protein Coding gene. An important paralog of this gene is RTL8B.

Additional gene information for RTL8A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL8A Gene

Genomics for RTL8A Gene

GeneHancer (GH) Regulatory Elements for RTL8A Gene

Promoters and enhancers for RTL8A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI135050 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 275 2 HDGF SIN3A ZNF2 POLR2B ZNF213 SP3 REST ZNF592 ZNF610 SMARCA4 GC0XM135052 GC0XM135055 GC0XM135056 GC0XM135057 RTL8A RTL8B
GH0XI135097 Promoter/Enhancer 1.3 Ensembl ENCODE 10.4 -46.2 -46204 2 PKNOX1 ATF1 ZNF335 EGR1 SCRT2 CREM KLF13 EGR2 SP3 SP5 GC0XM135098 SMIM10L2B ZNF75D ZNF449 RTL8A NCLP2 SMIM10L2B-AS1
GH0XI134965 Enhancer 0.9 Ensembl ENCODE 8 +86.7 86695 0.6 CTCF ZNF384 RAD21 ZNF121 ZNF664 GATA3 GATA2 ZNF143 SMC3 PRDM10 SMIM10 RTL8A HMGB3P31
GH0XI134870 Enhancer 0.4 ENCODE 12.5 +181.6 181560 0.8 ZNF585B TCF7L2 FAM122B RTL8A PHF6 RPL36AP54 GC0XP134864 MOSPD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RTL8A on UCSC Golden Path with GeneCards custom track

Genomic Locations for RTL8A Gene

Genomic Locations for RTL8A Gene
1,265 bases
Minus strand

Genomic View for RTL8A Gene

Genes around RTL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL8A Gene

Proteins for RTL8A Gene

  • Protein details for RTL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retrotransposon Gag-like protein 8A
    Protein Accession:
    Secondary Accessions:
    • A2A2V9
    • Q8TBU2

    Protein attributes for RTL8A Gene

    113 amino acids
    Molecular mass:
    13188 Da
    Quaternary structure:
    No Data Available
    • RTL8A is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.

neXtProt entry for RTL8A Gene

Post-translational modifications for RTL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTL8A Gene

Domains & Families for RTL8A Gene

Gene Families for RTL8A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RTL8A Gene


Suggested Antigen Peptide Sequences for RTL8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM127 family.
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with RTL8A: view

Function for RTL8A Gene

Gene Ontology (GO) - Molecular Function for RTL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RTL8A: view
genes like me logo Genes that share phenotypes with RTL8A: view

Animal Model Products

CRISPR Products

miRNA for RTL8A Gene

miRTarBase miRNAs that target RTL8A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTL8A Gene

Localization for RTL8A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL8A gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RTL8A Gene

Pathways & Interactions for RTL8A Gene

SuperPathways for RTL8A Gene

No Data Available

Interacting Proteins for RTL8A Gene

Gene Ontology (GO) - Biological Process for RTL8A Gene


No data available for Pathways by source and SIGNOR curated interactions for RTL8A Gene

Drugs & Compounds for RTL8A Gene

No Compound Related Data Available

Transcripts for RTL8A Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTL8A Gene

No ASD Table

Relevant External Links for RTL8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTL8A Gene

NURSA nuclear receptor signaling pathways regulating expression of RTL8A Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL8A Gene

Orthologs for RTL8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM127B 33 34
  • 98.53 (n)
(Bos Taurus)
Mammalia FAM127A 34 34 34
  • 88 (a)
(Canis familiaris)
Mammalia -- 34
  • 84 (a)
-- 34
  • 84 (a)
-- 34
  • 84 (a)
-- 34
  • 84 (a)
(Mus musculus)
Mammalia Cxx1a 34
  • 69 (a)
Cxx1b 34
  • 69 (a)
Cxx1c 34
  • 63 (a)
Species where no ortholog for RTL8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL8A Gene

Gene Tree for RTL8A (if available)
Gene Tree for RTL8A (if available)

Paralogs for RTL8A Gene

Paralogs for RTL8A Gene

genes like me logo Genes that share paralogs with RTL8A: view

Variants for RTL8A Gene

Sequence variations from dbSNP and Humsavar for RTL8A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000679334 -- 135,050,683(-) C/T downstream_transcript_variant
rs1004861671 -- 135,051,465(-) C/T 3_prime_UTR_variant, intron_variant
rs1005529590 -- 135,053,538(-) T/C upstream_transcript_variant
rs1005715241 -- 135,052,409(-) G/T upstream_transcript_variant
rs1006914166 -- 135,050,765(-) C/T downstream_transcript_variant

Variation tolerance for RTL8A Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTL8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTL8A Gene

Disorders for RTL8A Gene

No disorders were found for RTL8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTL8A Gene

Publications for RTL8A Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J … Volff JN (Gene 2005) 2 3 58
  2. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J … Volff JN (Cytogenetic and genome research 2005) 3 4 58
  3. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A … Vezzoni P (Genomics 1997) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for RTL8A Gene

Sources for RTL8A Gene

Loading form....