Aliases for RTL10 Gene

Aliases for RTL10 Gene

  • Retrotransposon Gag Like 10 2 3 5
  • BH3-Only Protein 2 3 4
  • BOP 2 3 4
  • Retrotransposon Gag-Like Protein 10 3 4
  • Protein Bop 3 4
  • C22orf29 3 4
  • Chromosome 22 Open Reading Frame 29 2
  • FLJ21125 2
  • RTL10 5

External Ids for RTL10 Gene

Previous HGNC Symbols for RTL10 Gene

  • C22orf29

Summaries for RTL10 Gene

GeneCards Summary for RTL10 Gene

RTL10 (Retrotransposon Gag Like 10) is a Protein Coding gene. Diseases associated with RTL10 include Amyotrophic Lateral Sclerosis 1. An important paralog of this gene is PEG10.

UniProtKB/Swiss-Prot Summary for RTL10 Gene

  • Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTL10 Gene

Genomics for RTL10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RTL10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RTL10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTL10

Genomic Locations for RTL10 Gene

Latest Assembly
chr22:19,846,138-19,854,896
(GRCh38/hg38)
Size:
8,759 bases
Orientation:
Minus strand

Previous Assembly
chr22:19,833,669-19,842,397
(GRCh37/hg19 by Entrez Gene)
Size:
8,729 bases
Orientation:
Minus strand

chr22:19,833,661-19,842,419
(GRCh37/hg19 by Ensembl)
Size:
8,759 bases
Orientation:
Minus strand

Genomic View for RTL10 Gene

Genes around RTL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL10 Gene

Proteins for RTL10 Gene

  • Protein details for RTL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3V2-BOP_HUMAN
    Recommended name:
    Protein Bop
    Protein Accession:
    Q7L3V2
    Secondary Accessions:
    • A8K5E7
    • D3DX21
    • Q6MZM8
    • Q6N000
    • Q9H7A0

    Protein attributes for RTL10 Gene

    Size:
    364 amino acids
    Molecular mass:
    39299 Da
    Quaternary structure:
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    SequenceCaution:
    • Sequence=BAB14998.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for RTL10 Gene

Post-translational modifications for RTL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL10 Gene

No data available for DME Specific Peptides for RTL10 Gene

Domains & Families for RTL10 Gene

Gene Families for RTL10 Gene

Protein Domains for RTL10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L3V2

UniProtKB/Swiss-Prot:

BOP_HUMAN :
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
Domain:
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
genes like me logo Genes that share domains with RTL10: view

No data available for Suggested Antigen Peptide Sequences for RTL10 Gene

Function for RTL10 Gene

Molecular function for RTL10 Gene

UniProtKB/Swiss-Prot Function:
Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.

Phenotypes From GWAS Catalog for RTL10 Gene

Gene Ontology (GO) - Molecular Function for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23055042
genes like me logo Genes that share ontologies with RTL10: view
genes like me logo Genes that share phenotypes with RTL10: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTL10 Gene

Localization for RTL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTL10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL10 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 23055042
genes like me logo Genes that share ontologies with RTL10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTL10 Gene

Pathways & Interactions for RTL10 Gene

PathCards logo

SuperPathways for RTL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0051881 regulation of mitochondrial membrane potential IEA,IMP 23055042
GO:0097345 mitochondrial outer membrane permeabilization IEA,IMP 23055042
genes like me logo Genes that share ontologies with RTL10: view

No data available for Pathways by source and SIGNOR curated interactions for RTL10 Gene

Drugs & Compounds for RTL10 Gene

No Compound Related Data Available

Transcripts for RTL10 Gene

mRNA/cDNA for RTL10 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RTL10 Gene

No ASD Table

Relevant External Links for RTL10 Gene

GeneLoc Exon Structure for
RTL10

Expression for RTL10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTL10

mRNA Expression by UniProt/SwissProt for RTL10 Gene:

Q7L3V2-BOP_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RTL10 Gene

  • Heart(2.5)
  • Nervous system(2.5)
  • Muscle(2.4)
  • Skin(2.3)
  • Pancreas(2.2)
  • Kidney(2.1)
  • Blood(2.1)
  • Lung(2.1)
  • Intestine(2)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL10 Gene

Orthologs for RTL10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C22H22orf29 30
  • 98.63 (n)
C22H22ORF29 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C26H22orf29 30
  • 73.38 (n)
Mouse
(Mus musculus)
Mammalia Gm16314 31
  • 33 (a)
OneToOne
Species where no ortholog for RTL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RTL10 Gene

ENSEMBL:
Gene Tree for RTL10 (if available)
TreeFam:
Gene Tree for RTL10 (if available)

Paralogs for RTL10 Gene

Paralogs for RTL10 Gene

genes like me logo Genes that share paralogs with RTL10: view

Variants for RTL10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RTL10 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs17745302 - p.Arg116His
rs34027839 - p.Asp123Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RTL10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RTL10 Gene

Variant ID Type Subtype PubMed ID
dgv7983n54 CNV gain 21841781
esv3568260 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3647279 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv828949 CNV gain 20364138
nsv834129 CNV loss 17160897
nsv834130 CNV loss 17160897
nsv953024 CNV deletion 24416366

Variation tolerance for RTL10 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTL10 Gene

Disorders for RTL10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RTL10 Gene - From: COP

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search RTL10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTL10

genes like me logo Genes that share disorders with RTL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTL10 Gene

Publications for RTL10 Gene

  1. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PMID: 23055042) Zhang X … Tang H (Protein & cell 2012) 2 3 4
  2. BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL. (PMID: 30185825) Greaves G … Varadarajan S (Cell death and differentiation 2019) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. (PMID: 26760575) Uren PJ … Penalva LO (RNA biology 2016) 3
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3

Products for RTL10 Gene

Sources for RTL10 Gene