External Ids for RTKN Gene
Previous GeneCards Identifiers for RTKN Gene
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for RTKN Gene
RTKN (Rhotekin) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and RHO GTPases Activate Rhotekin and Rhophilins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-Rho binding. An important paralog of this gene is RTKN2.
UniProtKB/Swiss-Prot for RTKN Gene
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.