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This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
RTKN (Rhotekin) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-Rho binding. An important paralog of this gene is RTKN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005095 | GTPase inhibitor activity | IBA,IDA | 10940294 |
GO:0005515 | protein binding | IPI | 10940294 |
GO:0005525 | GTP binding | IEA | -- |
GO:0017048 | Rho GTPase binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005826 | actomyosin contractile ring | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by Rho GTPases | ||
2 | Actin Nucleation by ARP-WASP Complex |
RhoA Pathway
.35
|
|
3 | RHO GTPases Activate Rhotekin and Rhophilins | ||
4 | Signaling by GPCR | ||
5 | G-protein signaling_RhoB regulation pathway |
G-protein signaling_RhoB regulation pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000281 | mitotic cytokinesis | IBA | 21873635 |
GO:0000915 | actomyosin contractile ring assembly | IBA | 21873635 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007165 | signal transduction | IDA | 10940294 |
GO:0007266 | Rho protein signal transduction | IDA | 15480428 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - |
ExUns: | 15b |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: | |
SP8: | |
SP9: | |
SP10: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rtkn 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rtkn 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RTKN 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RTKN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rtkn 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-40c11.1 30 |
|
||
rtkn2b 31 |
|
OneToMany | |||
RTKN (1 of 2) 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | C07B5.4 31 |
|
OneToMany |
No disorders were found for RTKN Gene.