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This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contra... See more...
Aliases for RTKN Gene
External Ids for RTKN Gene
- HGNC: 10466
- Entrez Gene: 6242
- Ensembl: ENSG00000114993
- OMIM: 602288
- UniProtKB: Q9BST9
Previous GeneCards Identifiers for RTKN Gene
- GC02M074790
- GC02M074865
- GC02M074610
- GC02M074627
- GC02M074564
- GC02M074506
- GC02M074653
- GC02M074389
- GC02M074660
- GC02M074667
- GC02M074426
- GC02M074440
- GC02M074446
- GC02M074442
- GC02M074454
- GC02M074427
- GC02M074429
- GC02M074431
- GC02M074433
- GC02M074437
Summaries for RTKN Gene
-
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for RTKN Gene
RTKN (Rhotekin) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include GTP binding and GTP-Rho binding. An important paralog of this gene is RTKN2.
UniProtKB/Swiss-Prot Summary for RTKN Gene
-
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Additional gene information for RTKN Gene
- HGNC(10466)
- Entrez Gene(6242)
- Ensembl(ENSG00000114993)
- OMIM(602288)
- UniProtKB(Q9BST9)
- Open Targets Platform(ENSG00000114993)
- Search for RTKN at DataMed
- Search for RTKN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RTKN Gene
Genomics for RTKN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RTKN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RTKN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RTKN
- Top Transcription factor binding sites by QIAGEN in the RTKN gene promoter:
-
- Cdc5
- GR
- GR-alpha
- p53
- Pax-5
Genomic Locations for RTKN Gene
Genomic Locations for RTKN Gene
- chr2:74,425,835-74,442,422
- (GRCh38/hg38)
- Size:
- 16,588 bases
- Orientation:
- Minus strand
- chr2:74,652,963-74,669,549
- (GRCh37/hg19)
- Size:
- 16,587 bases
- Orientation:
- Minus strand
Genomic View for RTKN Gene
Genes around RTKN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.1 by HGNC
- 2p13.1 by Entrez Gene
- 2p13.1 by Ensembl
RTKN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RTKN Gene
Proteins for RTKN Gene
-
Protein details for RTKN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BST9-RTKN_HUMAN
- Recommended name:
- Rhotekin
- Protein Accession:
- Q9BST9
- H7BXD4
- Q8WVN1
- Q96PT6
- Q9HB05
Protein attributes for RTKN Gene
- Size:
- 563 amino acids
- Molecular mass:
- 62667 Da
- Quaternary structure:
-
- Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity.
- SequenceCaution:
-
- Sequence=AAL16767.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: Incomplete sequence.
Protein Expression for RTKN Gene
Post-translational modifications for RTKN Gene
Other Protein References for RTKN Gene
Antibody Products
- G Biosciences Immunotag™ RTKN Antibody
-
Custom Antibody ServicesOriGene Antibodies for RTKN
- Novus Biologicals Antibodies for RTKN
-
Abcam antibodies for RTKN
- Invitrogen Antibodies for RTKN (AFLGC-RTKN)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RTKN
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RTKN
- Origene Custom Protein Services for RTKN
- antibodies-online: Show 11 available Rhotekin Proteins ranked by validation data
- Compare Top Rhotekin Proteins
-
Quality Products:
-
Abcam proteins for RTKN
Assay Products
-
Abcam assays for RTKN
No data available for DME Specific Peptides for RTKN Gene
Domains & Families for RTKN Gene
Gene Families for RTKN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RTKN Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
- Protein kinase PKN/PRK1, effector
- ProtoNet:
Suggested Antigen Peptide Sequences for RTKN Gene
- GenScript: Design optimal peptide antigens:
-
- Rhotekin (RTKN_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RTKN Gene
Function for RTKN Gene
Molecular function for RTKN Gene
- UniProtKB/Swiss-Prot Function:
- Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
- GENATLAS Biochemistry:
- rhotekin,61kDa,expressed in many tissues including brain,muscle,binding GTP bound form of Rho inhibiting its GTPase activity
Phenotypes From GWAS Catalog for RTKN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005095 | GTPase inhibitor activity | IBA,IDA | 10940294 |
| GO:0005515 | protein binding | IPI | 10940294 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0017048 | Rho GTPase binding | IEA | -- |
Phenotypes for RTKN Gene
- GenomeRNAi human phenotypes for RTKN:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RTKN - Select products 50% OFF >
- * RTKN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RTKN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTKN
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTKN
miRNA for RTKN Gene
- miRTarBase miRNAs that target RTKN
-
- hsa-miR-145-5p (MIRT021499)
- hsa-miR-1296-5p (MIRT036125)
- hsa-miR-320b (MIRT036220)
- hsa-miR-2909 (MIRT489915)
- hsa-miR-7977 (MIRT489916)
- hsa-miR-3162-5p (MIRT489917)
- hsa-miR-629-5p (MIRT489918)
- hsa-miR-6799-5p (MIRT489919)
- hsa-miR-4756-5p (MIRT489920)
- hsa-miR-1225-3p (MIRT489921)
- hsa-miR-4739 (MIRT489922)
- hsa-miR-1321 (MIRT489923)
- hsa-miR-6760-5p (MIRT489924)
- hsa-miR-4323 (MIRT489925)
- hsa-miR-548s (MIRT496910)
- hsa-miR-3926 (MIRT496911)
- hsa-miR-3190-5p (MIRT496912)
- hsa-miR-4494 (MIRT496913)
- hsa-miR-4463 (MIRT496914)
- hsa-miR-4524b-3p (MIRT496915)
- hsa-miR-193b-3p (MIRT496916)
- hsa-miR-193a-3p (MIRT496917)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTKN
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTKN
Clone Products
- Applied Biological Materials (abm): Clones for RTKN - Select products 50% OFF >
- * RTKN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208745
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- RC202548
- RC202548L3
- RC202548L4
- RC204517
- RC204517L1
- RC204517L2
- RC204517L3
- RC204517L4
- RC218810
- RC218810L1
- RC218810L2
- RC218810L3
- RC218810L4
- RG202548
- RG204517
- RG218810
- RR203893
- RR203893L3
- RR203893L4
- MR208745L3V
- MR208745L4V
- MR215049L3V
- MR215049L4V
- RC202548L3V
- RC202548L4V
- RC204517L1V
- RC204517L2V
- RC204517L3V
- RC204517L4V
- RC218810L1V
- RC218810L2V
- RC218810L3V
- RC218810L4V
- RR203893L3V
- RR203893L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTKN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTKN
Cell Line Products
-
Horizon Cell Lines for RTKN
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTKN Gene
Localization for RTKN Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Mitochondria (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005826 | actomyosin contractile ring | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RTKN Gene
Pathways & Interactions for RTKN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Rho GTPases | ||
| 2 | Actin Nucleation by ARP-WASP Complex |
RhoA Pathway
.35
|
|
| 3 | RHO GTPases Activate Rhotekin and Rhophilins | ||
| 4 | Signaling by GPCR | ||
| 5 | G-protein signaling_RhoB regulation pathway |
G-protein signaling_RhoB regulation pathway
-
|
|
Pathways by source for RTKN Gene
1 BioSystems pathway for RTKN Gene
4 Reactome pathways for RTKN Gene
1 GeneGo (Thomson Reuters) pathway for RTKN Gene
- G-protein signaling_RhoB regulation pathway
1 Qiagen pathway for RTKN Gene
- RhoA Pathway
Interacting Proteins for RTKN Gene
Selected Interacting proteins:
Q9BST9-RTKN_HUMAN
ENSP00000272430
for RTKN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RTKN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000281 | mitotic cytokinesis | IBA | 21873635 |
| GO:0000915 | actomyosin contractile ring assembly | IBA | 21873635 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007165 | signal transduction | IDA | 10940294 |
| GO:0007266 | Rho protein signal transduction | IDA | 15480428 |
Drugs & Compounds for RTKN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for RTKN Gene
mRNA/cDNA for RTKN Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000233330 2220 nts (view in UCSC)
- ENST00000272430 2221 nts (view in UCSC)
- ENST00000305557 2646 nts (view in UCSC)
- ENST00000460968 842 nts (view in UCSC)
- ENST00000464094 1266 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RTKN - Select products 50% OFF >
- * RTKN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RTKN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RTKN
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTKN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTKN
- Browse OriGene Inhibitory RNA Products For RTKN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RTKN
Clone Products
- Applied Biological Materials (abm): Clones for RTKN - Select products 50% OFF >
- * RTKN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208745
- MG215049
- MR208745
- MR208745L3
- MR208745L4
- MR215049
- MR215049L3
- MR215049L4
- RC202548
- RC202548L3
- RC202548L4
- RC204517
- RC204517L1
- RC204517L2
- RC204517L3
- RC204517L4
- RC218810
- RC218810L1
- RC218810L2
- RC218810L3
- RC218810L4
- RG202548
- RG204517
- RG218810
- RR203893
- RR203893L3
- RR203893L4
- MR208745L3V
- MR208745L4V
- MR215049L3V
- MR215049L4V
- RC202548L3V
- RC202548L4V
- RC204517L1V
- RC204517L2V
- RC204517L3V
- RC204517L4V
- RC218810L1V
- RC218810L2V
- RC218810L3V
- RC218810L4V
- RR203893L3V
- RR203893L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTKN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RTKN
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - |
| ExUns: | 15b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: |
Relevant External Links for RTKN Gene
- GeneLoc Exon Structure for
- RTKN
Expression for RTKN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for RTKN Gene
This gene is overexpressed in Liver (x5.7) and Brain - Spinal cord (cervical c-1) (x4.2).
This gene is overexpressed in Plasma (32.0), Pancreas (8.6), Islet of Langerhans (7.3), and Pancreatic juice (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RTKN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RTKN
SOURCE GeneReport for Unigene cluster for RTKN Gene:
Hs.192854mRNA Expression by UniProt/SwissProt for RTKN Gene:
Q9BST9-RTKN_HUMAN
Tissue specificity:
Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines.
Evidence on tissue expression from TISSUES for RTKN Gene
- Liver(4.5)
- Nervous system(4.4)
- Kidney(3)
- Skin(2.7)
- Intestine(2.4)
- Heart(2.3)
- Muscle(2.2)
- Blood(2.2)
- Lung(2.2)
- Eye(2)
Primer Products
-
OriGene qPCR primer pairs for RTKN
-
OriGene qPCR primer pairs and template standards for RTKN
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTKN Gene
Orthologs for RTKN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RTKN 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rtkn 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rtkn 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RTKN 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RTKN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rtkn 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-40c11.1 30 |
|
||
| rtkn2b 31 |
|
OneToMany | |||
| RTKN (1 of 2) 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | C07B5.4 31 |
|
OneToMany |
- Species where no ortholog for RTKN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RTKN Gene
- ENSEMBL:
- Gene Tree for RTKN (if available)
- TreeFam:
- Gene Tree for RTKN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RTKN: view image
Paralogs for RTKN Gene
Variants for RTKN Gene
Residual Variation Intolerance Score:
21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.30;
41.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RTKN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RTKN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTKN Gene
Disorders for RTKN Gene
Additional Disease Information for RTKN
No disorders were found for RTKN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTKN Gene
Publications for RTKN Gene
- The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PMID: 10940294) Reynaud C … Jalinot P (The Journal of biological chemistry 2000) 2 3 4 23
- Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. (PMID: 15480428) Liu CA … Chen JY (Oncogene 2004) 3 4 23
- Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286. (PMID: 10873388) Fu Q … Zhao S (Genomics 2000) 3 4 23
- Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. (PMID: 19294487) Nagata K … Asano T (Medical molecular morphology 2009) 3 23
- Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PMID: 16979770) Sudo K … Nagata K (Neuroscience research 2006) 3 23
ExternalLinks
Products for RTKN Gene
- Custom Antibody ServicesOriGene Antibodies for RTKN
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RTKN
- Origene Custom Protein Services for RTKN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTKN
- Browse OriGene Inhibitory RNA Products For RTKN
- OriGene qPCR primer pairs for RTKN
- OriGene qPCR primer pairs and template standards for RTKN
- OriGene CRISPR knockouts for RTKN
- MG208745
- MG215049
- MR208745
- MR208745L3
- MR208745L4
- MR215049
- MR215049L3
- MR215049L4
- RC202548
- RC202548L3
- RC202548L4
- RC204517
- RC204517L1
- RC204517L2
- RC204517L3
- RC204517L4
- RC218810
- RC218810L1
- RC218810L2
- RC218810L3
- RC218810L4
- RG202548
- RG204517
- RG218810
- RR203893
- RR203893L3
- RR203893L4
- MR208745L3V
- MR208745L4V
- MR215049L3V
- MR215049L4V
- RC202548L3V
- RC202548L4V
- RC204517L1V
- RC204517L2V
- RC204517L3V
- RC204517L4V
- RC218810L1V
- RC218810L2V
- RC218810L3V
- RC218810L4V
- RR203893L3V
- RR203893L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 26 available Rhotekin Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for RTKN
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Sources for RTKN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB