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This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]
RTF1 (RTF1 Homolog, Paf1/RNA Polymerase II Complex Component) is a Protein Coding gene. Diseases associated with RTF1 include Immunodeficiency 47 and Hereditary Wilms' Tumor. Among its related pathways are Metabolism of proteins and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003697 | single-stranded DNA binding | IDA | 18184592 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 15923622 |
GO:1990269 | RNA polymerase II C-terminal domain phosphoserine binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IEA | -- |
GO:0016593 | Cdc73/Paf1 complex | IEA,IDA | 20178742 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
2 | Protein ubiquitination | ||
3 | Metabolism of proteins | ||
4 | Chromatin Regulation / Acetylation | ||
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0001711 | endodermal cell fate commitment | IEA,ISS | -- |
GO:0001832 | blastocyst growth | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | TAS | -- |
GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RTF1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RTF1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RTF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RTF1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RTF1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rtf1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RTF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RTF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rtf1 30 |
|
||
Str.16458 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16706 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rtf1 30 31 |
|
OneToOne | |
Dr.15115 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2044 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rtf1 30 31 |
|
OneToMany | |
CG31703 31 |
|
OneToMany | |||
CG31702 31 |
|
OneToMany | |||
CG12498 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F25B3.6 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RTF1 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1372 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2580n100 | CNV | gain | 25217958 |
esv2674168 | CNV | deletion | 23128226 |
esv3636243 | CNV | loss | 21293372 |
esv3636244 | CNV | loss | 21293372 |
nsv1039283 | CNV | gain | 25217958 |
nsv1505 | CNV | insertion | 18451855 |
nsv524476 | CNV | loss | 19592680 |
nsv569232 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 47 |
|
|
hereditary wilms' tumor |
|
|