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This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
RSU1 (Ras Suppressor Protein 1) is a Protein Coding gene. Diseases associated with RSU1 include Rigid Spine Muscular Dystrophy 1 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are ERK Signaling and Cell junction organization.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20926685 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005925 | focal adhesion | IDA | 20926685 |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell junction organization | ||
2 | ERK Signaling |
ILK Signaling
.49
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | TAS,IBA | 21873635 |
GO:0010810 | NOT regulation of cell-substrate adhesion | IMP | 20926685 |
GO:0010811 | positive regulation of cell-substrate adhesion | IMP | 20926685 |
GO:0043547 | positive regulation of GTPase activity | IMP | 20926685 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RSU1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RSU1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RSU1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RSU1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RSU1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rsu1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rsu1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RSU1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RSU1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rsu1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8712 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rsu1 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008785 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ics 30 31 |
|
OneToOne | |
BG:BACR48E02.4 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | C34C12.5 32 |
|
|
|
rsu-1 30 31 |
|
OneToOne | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4919 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
757501 | Likely Benign: not provided | 16,695,049(-) | C/T | SYNONYMOUS_VARIANT | |
rs372430392 | Benign: not specified | 16,695,165(-) | G/GA | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2171921 | CNV | deletion | 18987734 |
esv2446889 | CNV | deletion | 19546169 |
esv2661909 | CNV | deletion | 23128226 |
esv2671383 | CNV | deletion | 23128226 |
esv2733595 | CNV | deletion | 23290073 |
esv275522 | CNV | loss | 21479260 |
esv2759735 | CNV | loss | 17122850 |
esv3578656 | CNV | loss | 25503493 |
esv3578657 | CNV | loss | 25503493 |
esv3578658 | CNV | loss | 25503493 |
esv3622474 | CNV | loss | 21293372 |
esv3622477 | CNV | gain | 21293372 |
esv3891765 | CNV | gain | 25118596 |
nsv1046088 | CNV | gain | 25217958 |
nsv1069457 | CNV | deletion | 25765185 |
nsv24610 | CNV | deletion | 16902084 |
nsv466758 | CNV | gain | 19166990 |
nsv470923 | CNV | gain | 18288195 |
nsv550020 | CNV | gain | 21841781 |
nsv831797 | CNV | loss | 17160897 |
nsv831798 | CNV | gain+loss | 17160897 |
nsv831799 | CNV | loss | 17160897 |
nsv831800 | CNV | gain | 17160897 |
nsv947750 | CNV | duplication | 23825009 |
nsv947751 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rigid spine muscular dystrophy 1 |
|
|
amyotrophic lateral sclerosis 1 |
|
|