Aliases for RSRC2 Gene

Aliases for RSRC2 Gene

  • Arginine And Serine Rich Coiled-Coil 2 2 3 5
  • Arginine/Serine-Rich Coiled-Coil Protein 2 3 4
  • Arginine/Serine-Rich Coiled-Coil 2 2 3

External Ids for RSRC2 Gene

Previous GeneCards Identifiers for RSRC2 Gene

  • GC12M121555
  • GC12M122989
  • GC12M119950

Summaries for RSRC2 Gene

GeneCards Summary for RSRC2 Gene

RSRC2 (Arginine And Serine Rich Coiled-Coil 2) is a Protein Coding gene. Diseases associated with RSRC2 include Strabismus. An important paralog of this gene is SRSF4.

Additional gene information for RSRC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RSRC2 Gene

Genomics for RSRC2 Gene

GeneHancer (GH) Regulatory Elements for RSRC2 Gene

Promoters and enhancers for RSRC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RSRC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RSRC2

Top Transcription factor binding sites by QIAGEN in the RSRC2 gene promoter:
  • c-Myc
  • Elk-1
  • Lmo2
  • Max1
  • Pax-4a

Genomic Locations for RSRC2 Gene

Genomic Locations for RSRC2 Gene
chr12:122,503,454-122,527,013
(GRCh38/hg38)
Size:
23,560 bases
Orientation:
Minus strand
chr12:122,989,190-123,011,560
(GRCh37/hg19)
Size:
22,371 bases
Orientation:
Minus strand

Genomic View for RSRC2 Gene

Genes around RSRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSRC2 Gene

Proteins for RSRC2 Gene

  • Protein details for RSRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4I2-RSRC2_HUMAN
    Recommended name:
    Arginine/serine-rich coiled-coil protein 2
    Protein Accession:
    Q7L4I2
    Secondary Accessions:
    • Q6N040
    • Q6NW16
    • Q9H864

    Protein attributes for RSRC2 Gene

    Size:
    434 amino acids
    Molecular mass:
    50560 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW98327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RSRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSRC2 Gene

Post-translational modifications for RSRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RSRC2 Gene

Domains & Families for RSRC2 Gene

Gene Families for RSRC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSRC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSRC2 Gene

GenScript: Design optimal peptide antigens:
  • Arginine/serine-rich coiled-coil protein 2 (RSRC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L4I2

UniProtKB/Swiss-Prot:

RSRC2_HUMAN :
  • Belongs to the RSRC2 family.
Family:
  • Belongs to the RSRC2 family.
genes like me logo Genes that share domains with RSRC2: view

Function for RSRC2 Gene

Phenotypes From GWAS Catalog for RSRC2 Gene

Gene Ontology (GO) - Molecular Function for RSRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with RSRC2: view
genes like me logo Genes that share phenotypes with RSRC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RSRC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSRC2 Gene

Localization for RSRC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSRC2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSRC2 Gene

Pathways & Interactions for RSRC2 Gene

PathCards logo

SuperPathways for RSRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSRC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSRC2 Gene

Drugs & Compounds for RSRC2 Gene

No Compound Related Data Available

Transcripts for RSRC2 Gene

mRNA/cDNA for RSRC2 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RSRC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSRC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - -
SP14: - - - - - -

ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RSRC2 Gene

GeneLoc Exon Structure for
RSRC2

Expression for RSRC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RSRC2 Gene

Protein differential expression in normal tissues from HIPED for RSRC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Testis (8.8), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RSRC2 Gene



Protein tissue co-expression partners for RSRC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RSRC2

SOURCE GeneReport for Unigene cluster for RSRC2 Gene:

Hs.432996

Evidence on tissue expression from TISSUES for RSRC2 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Lung(2.8)
  • Bone marrow(2.3)
  • Spleen(2.1)
  • Heart(2)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RSRC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSRC2 Gene

Orthologs for RSRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSRC2 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSRC2 31
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSRC2 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSRC2 31
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSRC2 31
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsrc2 31
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSRC2 31
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSRC2 31
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj11021-prov 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10041 30
zebrafish
(Danio rerio)
Actinopterygii rsrc2 31
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6340 31
  • 23 (a)
OneToOne
Species where no ortholog for RSRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSRC2 Gene

ENSEMBL:
Gene Tree for RSRC2 (if available)
TreeFam:
Gene Tree for RSRC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RSRC2: view image

Paralogs for RSRC2 Gene

Paralogs for RSRC2 Gene

(1) SIMAP similar genes for RSRC2 Gene using alignment to 6 proteins:

  • RSRC2_HUMAN
  • E1B6W4_HUMAN
  • E9PI52_HUMAN
  • F5GYD2_HUMAN
  • F5H1Z2_HUMAN
  • H0YGP9_HUMAN

Pseudogenes.org Pseudogenes for RSRC2 Gene

genes like me logo Genes that share paralogs with RSRC2: view

Variants for RSRC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RSRC2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs752134549 Likely Pathogenic: Strabismus; Myopia; Autistic behavior; Seizures; Global developmental delay; Obesity 122,517,404(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs17886684 - p.His88Arg

Additional dbSNP identifiers (rs#s) for RSRC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RSRC2 Gene

Variant ID Type Subtype PubMed ID
esv1004502 CNV deletion 20482838
esv1035767 CNV deletion 17803354
esv2279643 CNV deletion 18987734
esv2501949 CNV deletion 19546169
esv2574323 CNV deletion 19546169
esv2746498 CNV deletion 23290073
esv3250940 CNV deletion 24192839
esv3549910 CNV deletion 23714750
esv5088 CNV loss 18987735
esv9727 CNV loss 19470904
esv993685 CNV deletion 20482838
nsv1041677 CNV gain 25217958
nsv1070136 CNV deletion 25765185
nsv1113531 CNV deletion 24896259
nsv1150175 CNV deletion 26484159
nsv53703 CNV deletion 16902084
nsv958634 CNV deletion 24416366

Variation tolerance for RSRC2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSRC2 Gene

Human Gene Mutation Database (HGMD)
RSRC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSRC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSRC2 Gene

Disorders for RSRC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RSRC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
strabismus
  • strabismus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search RSRC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RSRC2

genes like me logo Genes that share disorders with RSRC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSRC2 Gene

Publications for RSRC2 Gene

  1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. (PMID: 17203224) Kurehara H … Kuwabara Y (International journal of oncology 2007) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for RSRC2 Gene

Sources for RSRC2 Gene