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Aliases for RSPO2 Gene

Aliases for RSPO2 Gene

  • R-Spondin 2 2 3 5
  • Roof Plate-Specific Spondin-2 3 4
  • R-Spondin 2 Homolog (Xenopus Laevis) 2
  • R-Spondin 2 Homolog 3
  • R-Spondin-2 3
  • CRISTIN2 3
  • HRspo2 4

External Ids for RSPO2 Gene

Previous GeneCards Identifiers for RSPO2 Gene

  • GC08M108981
  • GC08M104233

Summaries for RSPO2 Gene

Entrez Gene Summary for RSPO2 Gene

  • This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for RSPO2 Gene

RSPO2 (R-Spondin 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding and G-protein coupled receptor binding. An important paralog of this gene is RSPO3.

UniProtKB/Swiss-Prot for RSPO2 Gene

  • Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Additional gene information for RSPO2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPO2 Gene

Genomics for RSPO2 Gene

GeneHancer (GH) Regulatory Elements for RSPO2 Gene

Promoters and enhancers for RSPO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I108082 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.4 390 0.6 CTCF MXI1 SIN3A RAD21 ZNF335 FOXM1 CTBP1 ZBTB48 PRDM10 KLF8 RSPO2 NRBF2P4
GH08I108083 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 0.0 -10 0.2 CTCF SIN3A RAD21 ZNF335 FOXM1 CTBP1 ZBTB48 ZNF143 PRDM10 KLF8 RSPO2 AURKBPS1
GH08I108084 Enhancer 0.6 ENCODE 550.8 +1.1 1097 0.2 ZNF777 SUZ12 ZNF335 SP1 GLIS2 ZNF692 GLIS1 PRDM10 ZBTB26 EZH2 RSPO2 EMC2 NRBF2P4
GH08I108442 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.4 -360.3 -360315 3.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 EMC2 LOC105375704 EIF3E NUDCD1 ENY2 RSPO2 GC08M108476
GH08I108467 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.2 -384.9 -384916 2 PKNOX1 NFRKB SIN3A FEZF1 YY1 ZNF335 CTBP1 GATA3 SMARCE1 ELF1 EMC2 RSPO2 GC08M108476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RSPO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RSPO2 gene promoter:

Genomic Locations for RSPO2 Gene

Genomic Locations for RSPO2 Gene
chr8:107,899,316-108,083,685
(GRCh38/hg38)
Size:
184,370 bases
Orientation:
Minus strand
chr8:108,911,544-109,095,913
(GRCh37/hg19)

Genomic View for RSPO2 Gene

Genes around RSPO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSPO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPO2 Gene

Proteins for RSPO2 Gene

  • Protein details for RSPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXX9-RSPO2_HUMAN
    Recommended name:
    R-spondin-2
    Protein Accession:
    Q6UXX9
    Secondary Accessions:
    • B3KVP0
    • Q4G0U4
    • Q8N6X6

    Protein attributes for RSPO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28315 Da
    Quaternary structure:
    • Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6.
    Miscellaneous:
    • Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed:16357527).

    Alternative splice isoforms for RSPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPO2 Gene

Post-translational modifications for RSPO2 Gene

  • Glycosylation at posLast=160160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSPO2 Gene

Domains & Families for RSPO2 Gene

Gene Families for RSPO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for RSPO2 Gene

Suggested Antigen Peptide Sequences for RSPO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXX9

UniProtKB/Swiss-Prot:

RSPO2_HUMAN :
  • The FU repeat is required for activation and stabilization of beta-catenin.
  • Belongs to the R-spondin family.
Domain:
  • The FU repeat is required for activation and stabilization of beta-catenin.
Family:
  • Belongs to the R-spondin family.
genes like me logo Genes that share domains with RSPO2: view

Function for RSPO2 Gene

Molecular function for RSPO2 Gene

UniProtKB/Swiss-Prot Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Phenotypes From GWAS Catalog for RSPO2 Gene

Gene Ontology (GO) - Molecular Function for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 22615920
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RSPO2: view
genes like me logo Genes that share phenotypes with RSPO2: view

Animal Models for RSPO2 Gene

MGI Knock Outs for RSPO2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RSPO2

CRISPR Products

miRNA for RSPO2 Gene

miRTarBase miRNAs that target RSPO2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSPO2 Gene

Localization for RSPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSPO2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSPO2 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,NAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with RSPO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RSPO2 Gene

Pathways & Interactions for RSPO2 Gene

genes like me logo Genes that share pathways with RSPO2: view

SIGNOR curated interactions for RSPO2 Gene

Activates:

Gene Ontology (GO) - Biological Process for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway NAS 24431302
GO:0030282 bone mineralization IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
genes like me logo Genes that share ontologies with RSPO2: view

Drugs & Compounds for RSPO2 Gene

No Compound Related Data Available

Transcripts for RSPO2 Gene

Unigene Clusters for RSPO2 Gene

R-spondin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RSPO2 Gene

GeneLoc Exon Structure for
RSPO2
ECgene alternative splicing isoforms for
RSPO2

Expression for RSPO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RSPO2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x6.6), Brain - Frontal Cortex (BA9) (x6.4), Colon - Sigmoid (x5.6), Brain - Cortex (x4.6), Brain - Hypothalamus (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for RSPO2 Gene

This gene is overexpressed in Esophagus (29.1), Colon muscle (25.7), and Breast (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RSPO2 Gene



Protein tissue co-expression partners for RSPO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RSPO2 Gene:

RSPO2

SOURCE GeneReport for Unigene cluster for RSPO2 Gene:

Hs.444834

Evidence on tissue expression from TISSUES for RSPO2 Gene

  • Nervous system(4.5)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with RSPO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSPO2 Gene

Orthologs for RSPO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSPO2 33 34
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia RSPO2 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPO2 33 34
  • 94.92 (n)
cow
(Bos Taurus)
Mammalia RSPO2 33 34
  • 94.65 (n)
rat
(Rattus norvegicus)
Mammalia Rspo2 33
  • 93.85 (n)
mouse
(Mus musculus)
Mammalia Rspo2 33 16 34
  • 92.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RSPO2 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSPO2 33 34
  • 80.32 (n)
lizard
(Anolis carolinensis)
Reptilia RSPO2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rspo2 33
  • 78.05 (n)
zebrafish
(Danio rerio)
Actinopterygii rspo2 34
  • 71 (a)
OneToOne
LOC566054 33
  • 70.23 (n)
Species where no ortholog for RSPO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPO2 Gene

ENSEMBL:
Gene Tree for RSPO2 (if available)
TreeFam:
Gene Tree for RSPO2 (if available)

Paralogs for RSPO2 Gene

Paralogs for RSPO2 Gene

(3) SIMAP similar genes for RSPO2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RSPO2 Gene

genes like me logo Genes that share paralogs with RSPO2: view

Variants for RSPO2 Gene

Sequence variations from dbSNP and Humsavar for RSPO2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000019993 -- 107,964,754(-) C/G intron_variant
rs1000023527 -- 107,907,230(-) T/C intron_variant
rs1000023825 -- 107,995,564(-) C/T intron_variant
rs1000052999 -- 108,013,689(-) T/C intron_variant
rs1000053275 -- 108,042,507(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RSPO2 Gene

Variant ID Type Subtype PubMed ID
esv2737420 CNV deletion 23290073
esv2737421 CNV deletion 23290073
esv3618341 CNV loss 21293372
nsv528821 CNV loss 19592680
nsv951462 CNV duplication 24416366
nsv971693 CNV duplication 23825009

Variation tolerance for RSPO2 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.24; 96.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSPO2 Gene

Human Gene Mutation Database (HGMD)
RSPO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSPO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPO2 Gene

Disorders for RSPO2 Gene

Additional Disease Information for RSPO2

No disorders were found for RSPO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSPO2 Gene

Publications for RSPO2 Gene

  1. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. (PMID: 22615920) Gong X … Liu Q (PloS one 2012) 3 4 58
  2. R-Spondin proteins: a novel link to beta-catenin activation. (PMID: 16357527) Kim KA … Funk WD (Cell cycle (Georgetown, Tex.) 2006) 3 4 58
  3. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. (PMID: 15469841) Kazanskaya O … Wu W (Developmental cell 2004) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for RSPO2 Gene

Sources for RSPO2 Gene

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