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Aliases for RSL24D1 Gene

Aliases for RSL24D1 Gene

  • Ribosomal L24 Domain Containing 1 2 3 5
  • Ribosomal L24 Domain-Containing Protein 1 3 4
  • C15orf15 3 4
  • RPL24L 3 4
  • Homolog Of Yeast Ribosomal Like Protein 24 3
  • Probable Ribosome Biogenesis Protein RLP24 3
  • Chromosome 15 Open Reading Frame 15 2
  • 60S Ribosomal Protein L30 Isolog 3
  • Ribosomal Protein L24-Like 4
  • My024 Protein 3
  • HRP-L30-Iso 3
  • RLP24 3
  • RPL24 3
  • TVAS3 3
  • L30 3

External Ids for RSL24D1 Gene

Previous HGNC Symbols for RSL24D1 Gene

  • C15orf15

Previous GeneCards Identifiers for RSL24D1 Gene

  • GC15M053261
  • GC15M055473
  • GC15M032299

Summaries for RSL24D1 Gene

Entrez Gene Summary for RSL24D1 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012]

GeneCards Summary for RSL24D1 Gene

RSL24D1 (Ribosomal L24 Domain Containing 1) is a Protein Coding gene. Diseases associated with RSL24D1 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RSL24D1 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).

Gene Wiki entry for RSL24D1 Gene

Additional gene information for RSL24D1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSL24D1 Gene

Genomics for RSL24D1 Gene

GeneHancer (GH) Regulatory Elements for RSL24D1 Gene

Promoters and enhancers for RSL24D1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I055194 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 559.8 +0.5 455 3.4 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B E2F8 RSL24D1 PIGB PIGBOS1 RAB27A C15orf65 ENSG00000279145 GC15M057438
GH15I055401 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.8 -208.5 -208492 7.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B C15orf65 CCPG1 RSL24D1 NEDD4 PYGO1 DNAAF4 PIGBOS1 PIGB GC15M057427 DNAAF4-CCPG1
GH15I056037 Enhancer 1.5 FANTOM5 Ensembl ENCODE 23.8 -843.9 -843914 6.5 PKNOX1 CLOCK FOXA2 MLX FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF280D RSL24D1 TEX9 PYGO1 PRTG RFX7 MNS1 TCF12 PIGBOS1 RN7SL568P
GH15I055497 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 13.5 -301.3 -301303 1.5 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GTF3C2 ZNF143 MXD4 ZNF518A DNAAF4 DNAAF4-CCPG1 RSL24D1 PYGO1 C15orf65 PIGB LOC100420711
GH15I055275 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -84.1 -84102 10.4 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF766 FOS JUNB REST ZNF592 PIGB RSL24D1 RAB27A GC15P055286 GC15M057438
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RSL24D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RSL24D1 gene promoter:

Genomic Locations for RSL24D1 Gene

Genomic Locations for RSL24D1 Gene
16,262 bases
Minus strand

Genomic View for RSL24D1 Gene

Genes around RSL24D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSL24D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSL24D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSL24D1 Gene

Proteins for RSL24D1 Gene

  • Protein details for RSL24D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ribosome biogenesis protein RLP24
    Protein Accession:
    Secondary Accessions:
    • B2RD72
    • Q561V8
    • Q8N6S8
    • Q96B04
    • Q96C76
    • Q96HJ1

    Protein attributes for RSL24D1 Gene

    163 amino acids
    Molecular mass:
    19621 Da
    Quaternary structure:
    • Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).

neXtProt entry for RSL24D1 Gene

Post-translational modifications for RSL24D1 Gene

  • Ubiquitination at posLast=2727, isoforms=73, and isoforms=88
  • Modification sites at PhosphoSitePlus

Other Protein References for RSL24D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSL24D1 Gene

Domains & Families for RSL24D1 Gene

Gene Families for RSL24D1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RSL24D1 Gene

Suggested Antigen Peptide Sequences for RSL24D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL24 family.
  • Belongs to the eukaryotic ribosomal protein eL24 family.
genes like me logo Genes that share domains with RSL24D1: view

Function for RSL24D1 Gene

Molecular function for RSL24D1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).

Phenotypes From GWAS Catalog for RSL24D1 Gene

Gene Ontology (GO) - Molecular Function for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RSL24D1: view
genes like me logo Genes that share phenotypes with RSL24D1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSL24D1 Gene

Localization for RSL24D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSL24D1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSL24D1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA,IEA --
GO:0005840 ribosome IEA --
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RSL24D1: view

Pathways & Interactions for RSL24D1 Gene

SuperPathways for RSL24D1 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
genes like me logo Genes that share pathways with RSL24D1: view

Pathways by source for RSL24D1 Gene

1 KEGG pathway for RSL24D1 Gene

Gene Ontology (GO) - Biological Process for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IEA,IBA --
GO:0042254 ribosome biogenesis IEA --
GO:1902626 assembly of large subunit precursor of preribosome IBA --
genes like me logo Genes that share ontologies with RSL24D1: view

No data available for SIGNOR curated interactions for RSL24D1 Gene

Drugs & Compounds for RSL24D1 Gene

(3) Drugs for RSL24D1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RSL24D1: view

Transcripts for RSL24D1 Gene

Unigene Clusters for RSL24D1 Gene

Ribosomal L24 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSL24D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -

Relevant External Links for RSL24D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSL24D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSL24D1 Gene

Protein differential expression in normal tissues from HIPED for RSL24D1 Gene

This gene is overexpressed in Lung (52.8) and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSL24D1 Gene

Protein tissue co-expression partners for RSL24D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSL24D1 Gene:


SOURCE GeneReport for Unigene cluster for RSL24D1 Gene:


Evidence on tissue expression from TISSUES for RSL24D1 Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Liver(4.5)
  • Blood(4.3)
  • Bone marrow(4.3)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Skin(3.3)
  • Kidney(2.7)
  • Muscle(2.6)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with RSL24D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSL24D1 Gene

Orthologs for RSL24D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RSL24D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RSL24D1 34 33
  • 99.59 (n)
(Monodelphis domestica)
Mammalia RSL24D1 34
  • 93 (a)
(Canis familiaris)
Mammalia RSL24D1 34 33
  • 92.96 (n)
(Bos Taurus)
Mammalia RSL24D1 34 33
  • 90.95 (n)
(Mus musculus)
Mammalia Rsl24d1 34 16 33
  • 87.86 (n)
(Rattus norvegicus)
Mammalia Rsl24d1 33
  • 87.86 (n)
(Ornithorhynchus anatinus)
Mammalia RSL24D1 34
  • 82 (a)
(Gallus gallus)
Aves LOC768911 33
  • 80.95 (n)
(Anolis carolinensis)
Reptilia RSL24D1 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rsl24d1 33
  • 79.63 (n)
(Danio rerio)
Actinopterygii rsl24d1 34 33
  • 74.95 (n)
wufa95d02 33
fruit fly
(Drosophila melanogaster)
Insecta RpL24-like 34 33
  • 58.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001545 33
  • 58.02 (n)
(Caenorhabditis elegans)
Secernentea rpl-24.2 33 34
  • 57.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLP24 33 34 36
  • 58.02 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR346W 33
  • 56.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09439g 33
  • 54.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44860 33
  • 59.91 (n)
(Oryza sativa)
Liliopsida Os01g0514000 33
  • 55.28 (n)
Os.2120 33
(Hordeum vulgare)
Liliopsida Hv.3722 33
(Zea mays)
Liliopsida Zm.7161 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8868 34
  • 57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05235 33
  • 51.47 (n)
Species where no ortholog for RSL24D1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSL24D1 Gene

Gene Tree for RSL24D1 (if available)
Gene Tree for RSL24D1 (if available)

Paralogs for RSL24D1 Gene

No data available for Paralogs for RSL24D1 Gene

Variants for RSL24D1 Gene

Sequence variations from dbSNP and Humsavar for RSL24D1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000007114 -- 55,194,943(-) A/T intron_variant
rs1000354723 -- 55,189,111(-) T/C intron_variant
rs1000405235 -- 55,191,790(-) T/C intron_variant
rs1000419426 -- 55,186,017(-) T/C intron_variant
rs1000455958 -- 55,185,619(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RSL24D1 Gene

Variant ID Type Subtype PubMed ID
esv2761899 CNV gain+loss 21179565
nsv1039471 CNV gain 25217958
nsv1043789 CNV gain 25217958
nsv525768 CNV loss 19592680
nsv976937 CNV duplication 23825009
nsv984073 CNV duplication 23825009

Variation tolerance for RSL24D1 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSL24D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSL24D1 Gene

Disorders for RSL24D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RSL24D1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RSL24D1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RSL24D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSL24D1 Gene

Publications for RSL24D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Sequential protein association with nascent 60S ribosomal particles. (PMID: 12808088) Saveanu C … Fromont-Racine M (Molecular and cellular biology 2003) 2 3 58
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  5. Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. (PMID: 11707418) Saveanu C … Fromont-Racine M (The EMBO journal 2001) 2 3 58

Products for RSL24D1 Gene

Sources for RSL24D1 Gene

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