Aliases for RSKR Gene

Aliases for RSKR Gene

  • Ribosomal Protein S6 Kinase Related 2 3 5
  • Ribosomal Protein S6 Kinase-Related Protein 3 4
  • Sugen Kinase 494 3 4
  • SGK494 3 4
  • EC 2.7.11.1 4

External Ids for RSKR Gene

Previous GeneCards Identifiers for RSKR Gene

  • GC17M029430
  • GC17M029538
  • GC17M029315

Summaries for RSKR Gene

GeneCards Summary for RSKR Gene

RSKR (Ribosomal Protein S6 Kinase Related) is a Protein Coding gene. An important paralog of this gene is GRK6.

Additional gene information for RSKR Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RSKR Gene

Genomics for RSKR Gene

GeneHancer (GH) Regulatory Elements for RSKR Gene

Promoters and enhancers for RSKR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028614 Promoter 0.6 EPDnew 750.6 0.0 -5 0.1 ZIC2 SUPT5H POLR2A ENSG00000258472 RSKR lnc-KIAA0100-1 RF00017-2324 SPAG5-AS1 RF00017-2319
GH17J028613 Enhancer 0.5 ENCODE 750.6 +0.8 752 0.2 CTCF RAD21 REST TRIM22 ZBTB48 ZNF143 FOS HOMEZ ENSG00000258472 RSKR lnc-KIAA0100-1 lnc-KIAA0100-4 SPAG5-AS1 RF00017-2319
GH17J028615 Promoter/Enhancer 0.5 EPDnew ENCODE 750.6 -2.4 -2352 1.4 RF00017-2324 RSKR KIAA0100 PIGS UNC119 SPAG5-AS1 RF00017-2319
GH17J028612 Enhancer 0.5 Ensembl 750.6 +1.4 1399 0.8 CTCF REST JUND FOS HOMEZ NFATC1 ENSG00000258472 RSKR lnc-KIAA0100-1 lnc-KIAA0100-4 PROCA1 SPAG5-AS1 RF00017-2319
GH17J028616 Promoter 0.3 EPDnew 750.6 -0.6 -594 0.1 ENSG00000258472 RSKR lnc-KIAA0100-1 RF00017-2324 SPAG5-AS1 KIAA0100 RF00017-2319
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RSKR on UCSC Golden Path with GeneCards custom track

Genomic Locations for RSKR Gene

Genomic Locations for RSKR Gene
chr17:28,607,964-28,614,200
(GRCh38/hg38)
Size:
6,237 bases
Orientation:
Minus strand
chr17:26,934,982-26,941,218
(GRCh37/hg19)
Size:
6,237 bases
Orientation:
Minus strand

Genomic View for RSKR Gene

Genes around RSKR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSKR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSKR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSKR Gene

Proteins for RSKR Gene

  • Protein details for RSKR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW2-KS6R_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase-related protein
    Protein Accession:
    Q96LW2
    Secondary Accessions:
    • B4DFP4
    • L7N484
    • Q49A48

    Protein attributes for RSKR Gene

    Size:
    410 amino acids
    Molecular mass:
    46191 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSKR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSKR Gene

Post-translational modifications for RSKR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSKR Gene

No data available for DME Specific Peptides for RSKR Gene

Domains & Families for RSKR Gene

Gene Families for RSKR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSKR Gene

Suggested Antigen Peptide Sequences for RSKR Gene

GenScript: Design optimal peptide antigens:
  • Sugen kinase 494 (SG494_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LW2

UniProtKB/Swiss-Prot:

KS6R_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RSKR: view

Function for RSKR Gene

Molecular function for RSKR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for RSKR Gene

Phenotypes From GWAS Catalog for RSKR Gene

Gene Ontology (GO) - Molecular Function for RSKR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RSKR: view
genes like me logo Genes that share phenotypes with RSKR: view

Animal Models for RSKR Gene

MGI Knock Outs for RSKR:
  • Rskr Rskr<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSKR Gene

Localization for RSKR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSKR gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 0
mitochondrion 0
peroxisome 0
nucleus 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSKR Gene

Pathways & Interactions for RSKR Gene

PathCards logo

SuperPathways for RSKR Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSKR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with RSKR: view

No data available for Pathways by source and SIGNOR curated interactions for RSKR Gene

Drugs & Compounds for RSKR Gene

No Compound Related Data Available

Transcripts for RSKR Gene

mRNA/cDNA for RSKR Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RSKR Gene

No ASD Table

Relevant External Links for RSKR Gene

GeneLoc Exon Structure for
RSKR
ECgene alternative splicing isoforms for
RSKR

Expression for RSKR Gene

SOURCE GeneReport for Unigene cluster for RSKR Gene:

Hs.729077

Evidence on tissue expression from TISSUES for RSKR Gene

  • Nervous system(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSKR Gene

Orthologs for RSKR Gene

This gene was present in the common ancestor of animals.

Orthologs for RSKR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC737514 32
  • 99.11 (n)
-- 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGK494 32
  • 89.28 (n)
-- 33
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGK494 32
  • 88.69 (n)
-- 33
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC030499 33 32
  • 87.66 (n)
OneToOne
Rskr 17
rat
(Rattus norvegicus)
Mammalia Sgk494 32
  • 86.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494554 32
  • 62.57 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883587 32
  • 60.12 (n)
si:dkeyp-118e10.5 33
  • 44 (a)
OneToMany
sgk494b 33
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 33
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F31E3.2 33 32
  • 49 (n)
OneToOne
Species where no ortholog for RSKR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSKR Gene

ENSEMBL:
Gene Tree for RSKR (if available)
TreeFam:
Gene Tree for RSKR (if available)

Paralogs for RSKR Gene

Paralogs for RSKR Gene

genes like me logo Genes that share paralogs with RSKR: view

Variants for RSKR Gene

Sequence variations from dbSNP and Humsavar for RSKR Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000450802 -- 28,609,748(-) A/G 3_prime_UTR_variant
rs1000479887 -- 28,610,299(-) C/T 3_prime_UTR_variant
rs1000783666 -- 28,608,092(-) A/C 3_prime_UTR_variant
rs1000974955 -- 28,614,946(-) C/G/T upstream_transcript_variant
rs1001345139 -- 28,614,690(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RSKR Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv482200 CNV loss 20164927

Variation tolerance for RSKR Gene

Gene Damage Index Score: 2.27; 40.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSKR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSKR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSKR Gene

Disorders for RSKR Gene

No disorders were found for RSKR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RSKR Gene

Publications for RSKR Gene

  1. AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases. (PMID: 23524293) Arencibia JM … Biondi RM (Biochimica et biophysica acta 2013) 2 3 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 56
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56

Products for RSKR Gene

Sources for RSKR Gene