Aliases for RSF1 Gene
External Ids for RSF1 Gene
Previous HGNC Symbols for RSF1 Gene
Previous GeneCards Identifiers for RSF1 Gene
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
GeneCards Summary for RSF1 Gene
RSF1 (Remodeling And Spacing Factor 1) is a Protein Coding gene. Diseases associated with RSF1 include Hepatitis B and Hepatitis. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include ATPase activity and histone binding.
UniProtKB/Swiss-Prot for RSF1 Gene
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).