This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the... See more...

Aliases for RSF1 Gene

Aliases for RSF1 Gene

  • Remodeling And Spacing Factor 1 2 3 4 5
  • P325 Subunit Of RSF Chromatin-Remodeling Complex 3 4
  • Hepatitis B Virus X-Associated Protein 3 4
  • HBV PX-Associated Protein 8 3 4
  • HBXAP 3 4
  • XAP8 3 4
  • Hepatitis B Virus X Associated Protein 2
  • RSF-1 3
  • Rsf-1 4
  • P325 3

External Ids for RSF1 Gene

Previous HGNC Symbols for RSF1 Gene

  • HBXAP

Previous GeneCards Identifiers for RSF1 Gene

  • GC11M077055
  • GC11M077371
  • GC11M073675

Summaries for RSF1 Gene

Entrez Gene Summary for RSF1 Gene

  • This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

CIViC Summary for RSF1 Gene

GeneCards Summary for RSF1 Gene

RSF1 (Remodeling And Spacing Factor 1) is a Protein Coding gene. Diseases associated with RSF1 include Hepatitis B and Hepatitis. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include ATPase activity and histone binding. An important paralog of this gene is KAT6B.

UniProtKB/Swiss-Prot Summary for RSF1 Gene

  • Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).

Gene Wiki entry for RSF1 Gene

Additional gene information for RSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RSF1 Gene

Genomics for RSF1 Gene

GeneHancer (GH) Regulatory Elements for RSF1 Gene

Promoters and enhancers for RSF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J077818 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 510.6 +0.1 116 4.6 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 POLR2G SP1 AAMDC RSF1 lnc-INTS4-4 INTS4 LINC02728 ENSG00000241782 ENSG00000255449 ENSG00000254459
GH11J077725 Promoter/Enhancer 1 EPDnew Ensembl 500.2 +94.8 94841 1.2 RELA BCL11A ZNF384 SMARCA5 BATF IRF4 IKZF1 JUNB CUX1 NFIC RSF1 RSF1-IT2 piR-47161-003
GH11J077698 Promoter 0.3 EPDnew 500.1 +122.4 122387 0.1 RSF1 ENSG00000206816 RSF1-IT2
GH11J077469 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.5 +348.3 348253 7.4 HNRNPK ZBTB40 ZNF217 EP300 CTCF ZSCAN5C MYC USF1 PHF8 JUND PAK1 ENSG00000268635 RSF1 GDPD4 ENSG00000241782 ENSG00000254459 AQP11 MYO7A lnc-PAK1-1 lnc-GDPD4-7
GH11J076860 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 20.4 +959.6 959592 2.8 ZNF217 CTCF SIN3A POLR2G SP1 GTF2E2 PHF8 TEAD4 ZFX ZNF354C ACER3 EMSY RSF1 GVQW3 ENSG00000255135 THAP12 ENSG00000254988 piR-43106-038
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RSF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RSF1

Top Transcription factor binding sites by QIAGEN in the RSF1 gene promoter:
  • AML1a
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • c-Myb
  • Nkx2-5
  • p53
  • RSRFC4

Genomic Locations for RSF1 Gene

Genomic Locations for RSF1 Gene
chr11:77,659,996-77,821,017
(GRCh38/hg38)
Size:
161,022 bases
Orientation:
Minus strand
chr11:77,371,041-77,532,063
(GRCh37/hg19)
Size:
161,023 bases
Orientation:
Minus strand

Genomic View for RSF1 Gene

Genes around RSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSF1 Gene

Proteins for RSF1 Gene

  • Protein details for RSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T23-RSF1_HUMAN
    Recommended name:
    Remodeling and spacing factor 1
    Protein Accession:
    Q96T23
    Secondary Accessions:
    • Q86X86
    • Q9H3L8
    • Q9NVZ8
    • Q9NYU0

    Protein attributes for RSF1 Gene

    Size:
    1441 amino acids
    Molecular mass:
    163821 Da
    Quaternary structure:
    • Interacts with SMARCA5/SNF2H to form the RSF complex (PubMed:12972596). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome (PubMed:11944984, PubMed:11788598).
    SequenceCaution:
    • Sequence=AAG43114.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH46124.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK57515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSF1 Gene

Post-translational modifications for RSF1 Gene

  • Ubiquitination at Lys288, Lys89, Lys189, Lys411, Lys215, and Lys463
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSF1 Gene

Domains & Families for RSF1 Gene

Gene Families for RSF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSF1 Gene

Blocks:
  • Zn-finger-like, PHD finger
  • DDT domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSF1 Gene

GenScript: Design optimal peptide antigens:
  • RSF1 protein (Q05DG0_HUMAN)
  • p325 subunit of RSF chromatin-remodeling complex (RSF1_HUMAN)
genes like me logo Genes that share domains with RSF1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RSF1 Gene

Function for RSF1 Gene

Molecular function for RSF1 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).

Phenotypes From GWAS Catalog for RSF1 Gene

Gene Ontology (GO) - Molecular Function for RSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 12972596
GO:0016887 NOT ATPase activity IDA 12972596
GO:0042393 histone binding IDA 12972596
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RSF1: view
genes like me logo Genes that share phenotypes with RSF1: view

Animal Models for RSF1 Gene

MGI Knock Outs for RSF1:
  • Rsf1 Rsf1<tm1b(EUCOMM)Wtsi>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSF1 Gene

Localization for RSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSF1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IBA 21873635
GO:0000790 nuclear chromatin IBA 21873635
GO:0005634 nucleus IDA 11788598
GO:0005654 nucleoplasm TAS,IDA --
GO:0031213 RSF complex IPI,IEA 9836642
genes like me logo Genes that share ontologies with RSF1: view

Pathways & Interactions for RSF1 Gene

genes like me logo Genes that share pathways with RSF1: view

Gene Ontology (GO) - Biological Process for RSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006334 nucleosome assembly IDA 12972596
GO:0006338 chromatin remodeling IDA 9836642
GO:0006352 DNA-templated transcription, initiation IDA 9836642
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RSF1: view

No data available for SIGNOR curated interactions for RSF1 Gene

Drugs & Compounds for RSF1 Gene

(2) Drugs for RSF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RSF1: view

Transcripts for RSF1 Gene

mRNA/cDNA for RSF1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSF1 Gene

No ASD Table

Relevant External Links for RSF1 Gene

GeneLoc Exon Structure for
RSF1

Expression for RSF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RSF1 Gene

Protein differential expression in normal tissues from HIPED for RSF1 Gene

This gene is overexpressed in Adrenal (38.8) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RSF1 Gene



Protein tissue co-expression partners for RSF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RSF1

SOURCE GeneReport for Unigene cluster for RSF1 Gene:

Hs.420229

mRNA Expression by UniProt/SwissProt for RSF1 Gene:

Q96T23-RSF1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RSF1 Gene

  • Liver(4.5)
  • Spleen(4.4)
  • Nervous system(4.4)
  • Lung(2.6)
  • Blood(2.3)
  • Eye(2.1)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with RSF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSF1 Gene

Orthologs for RSF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSF1 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RSF1 31 30
  • 91.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RSF1 31 30
  • 91.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rsf1 17 31 30
  • 85.58 (n)
rat
(Rattus norvegicus)
Mammalia Rsf1 30
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia RSF1 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSF1 31 30
  • 71.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSF1 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5886 30
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21n12.1 30
  • 57.11 (n)
RSF1 (3 of 3) 31
  • 42 (a)
OneToMany
RSF1 (2 of 3) 31
  • 42 (a)
OneToMany
RSF1 (1 of 3) 31
  • 36 (a)
OneToMany
wufi20e01 30
fruit fly
(Drosophila melanogaster)
Insecta CG8677 31
  • 11 (a)
OneToOne
Species where no ortholog for RSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSF1 Gene

ENSEMBL:
Gene Tree for RSF1 (if available)
TreeFam:
Gene Tree for RSF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RSF1: view image

Paralogs for RSF1 Gene

Paralogs for RSF1 Gene

genes like me logo Genes that share paralogs with RSF1: view

Variants for RSF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RSF1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs58758035 - p.Glu304Asp
rs7950873 - p.Ser475Pro

Additional dbSNP identifiers (rs#s) for RSF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RSF1 Gene

Variant ID Type Subtype PubMed ID
dgv1234n100 CNV gain 25217958
esv1937409 CNV deletion 18987734
esv2071392 CNV deletion 18987734
esv2516959 CNV deletion 19546169
esv2562636 CNV deletion 19546169
esv2612929 CNV deletion 19546169
esv2673298 CNV deletion 23128226
esv2744812 CNV deletion 23290073
esv3548030 CNV deletion 23714750
esv3548032 CNV deletion 23714750
nsv1050891 CNV gain 25217958
nsv1070055 CNV deletion 25765185
nsv398 CNV insertion 18451855
nsv468641 CNV gain 19166990
nsv507600 OTHER sequence alteration 20534489
nsv555452 CNV gain 21841781
nsv975951 CNV duplication 23825009
nsv975952 CNV duplication 23825009

Variation tolerance for RSF1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSF1 Gene

Disorders for RSF1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for RSF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
scrotal carcinoma
  • carcinoma of scrotum
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RSF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RSF1

genes like me logo Genes that share disorders with RSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSF1 Gene

Publications for RSF1 Gene

  1. Functional analysis of the subunits of the chromatin assembly factor RSF. (PMID: 12972596) Loyola A … Reinberg D (Molecular and cellular biology 2003) 2 3 4 23 54
  2. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. (PMID: 11788598) Shamay M … Shaul Y (The Journal of biological chemistry 2002) 2 3 4 54
  3. Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. (PMID: 20228782) Sehdev AS … Shih IeM (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010) 3 23 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for RSF1 Gene

Sources for RSF1 Gene