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Aliases for RSBN1L Gene

Aliases for RSBN1L Gene

  • Round Spermatid Basic Protein 1 Like 2 3 5
  • Round Spermatid Basic Protein 1-Like 2

External Ids for RSBN1L Gene

Previous GeneCards Identifiers for RSBN1L Gene

  • GC07P076970
  • GC07P077163
  • GC07P077325
  • GC07P071928

Summaries for RSBN1L Gene

GeneCards Summary for RSBN1L Gene

RSBN1L (Round Spermatid Basic Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is RSBN1.

Additional gene information for RSBN1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSBN1L Gene

Genomics for RSBN1L Gene

GeneHancer (GH) Regulatory Elements for RSBN1L Gene

Promoters and enhancers for RSBN1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I077694 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 571.7 +0.7 663 5.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 APTR RSBN1L SPDYE18 TMEM60 SPDYE17 PHTF2 FAM185BP PMS2P9 DTX2P1 PTPN12
GH07I077796 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 56.8 +102.5 102500 4.5 HDGF FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TMEM60 PHTF2 RSBN1L SPDYE18 FAM185BP SPDYE17 APTR PMS2P9 LOC100422695 CCDC146
GH07I077535 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 35.1 -157.9 -157924 5.4 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B PTPN12 GC07M077535 RSBN1L FAM185BP PMS2P9 APTR DTX2P1 POMZP3 CCDC146 LOC105375363
GH07I077121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.9 -574.2 -574163 1.7 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CCDC146 FAM185BP GC07M077213 RSBN1L SPDYE18 SPDYE17 ENSG00000213542 POMZP3 UPK3B ENSG00000259628
GH07I077530 Enhancer 1.1 Ensembl ENCODE dbSUPER 17 -165.5 -165493 1.5 PKNOX1 TAF9B ZBTB40 E4F1 RELA NCOR1 ZSCAN29 ZNF639 ZNF407 DPF2 APTR RSBN1L SPDYE17 SPDYE18 PMS2P9 CCDC146 DTX2P1 FAM185BP GC07M077535 PIR61362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RSBN1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RSBN1L gene promoter:

Genomic Locations for RSBN1L Gene

Genomic Locations for RSBN1L Gene
chr7:77,696,426-77,783,022
(GRCh38/hg38)
Size:
86,597 bases
Orientation:
Plus strand
chr7:77,325,743-77,412,339
(GRCh37/hg19)

Genomic View for RSBN1L Gene

Genes around RSBN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSBN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSBN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSBN1L Gene

Proteins for RSBN1L Gene

  • Protein details for RSBN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB5-RSBNL_HUMAN
    Recommended name:
    Round spermatid basic protein 1-like protein
    Protein Accession:
    Q6PCB5
    Secondary Accessions:
    • C9K0P1
    • Q6ZS58
    • Q6ZVI9
    • Q86X48

    Protein attributes for RSBN1L Gene

    Size:
    846 amino acids
    Molecular mass:
    94870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH46353.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC85872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RSBN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSBN1L Gene

Post-translational modifications for RSBN1L Gene

  • Ubiquitination at isoforms=2548
  • Modification sites at PhosphoSitePlus

Other Protein References for RSBN1L Gene

No data available for DME Specific Peptides for RSBN1L Gene

Domains & Families for RSBN1L Gene

Gene Families for RSBN1L Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RSBN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSBN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB5

UniProtKB/Swiss-Prot:

RSBNL_HUMAN :
  • Belongs to the round spermatid basic protein 1 family.
Family:
  • Belongs to the round spermatid basic protein 1 family.
genes like me logo Genes that share domains with RSBN1L: view

Function for RSBN1L Gene

Phenotypes From GWAS Catalog for RSBN1L Gene

genes like me logo Genes that share phenotypes with RSBN1L: view

Animal Model Products

miRNA for RSBN1L Gene

miRTarBase miRNAs that target RSBN1L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSBN1L Gene

Localization for RSBN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSBN1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSBN1L gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RSBN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RSBN1L: view

Pathways & Interactions for RSBN1L Gene

SuperPathways for RSBN1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSBN1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSBN1L Gene

Drugs & Compounds for RSBN1L Gene

No Compound Related Data Available

Transcripts for RSBN1L Gene

Unigene Clusters for RSBN1L Gene

Round spermatid basic protein 1-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSBN1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for RSBN1L Gene

GeneLoc Exon Structure for
RSBN1L
ECgene alternative splicing isoforms for
RSBN1L

Expression for RSBN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSBN1L Gene

Protein differential expression in normal tissues from HIPED for RSBN1L Gene

This gene is overexpressed in Lung (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSBN1L Gene



Protein tissue co-expression partners for RSBN1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSBN1L Gene:

RSBN1L

SOURCE GeneReport for Unigene cluster for RSBN1L Gene:

Hs.592289

Evidence on tissue expression from TISSUES for RSBN1L Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RSBN1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSBN1L Gene

Orthologs for RSBN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for RSBN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSBN1L 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia RSBN1L 33 34
  • 94.51 (n)
cow
(Bos Taurus)
Mammalia RSBN1L 33 34
  • 92.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RSBN1L 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSBN1L 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsbn1l 33 16 34
  • 85.62 (n)
rat
(Rattus norvegicus)
Mammalia Rsbn1l 33
  • 84.83 (n)
chicken
(Gallus gallus)
Aves RSBN1L 33 34
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia RSBN1L 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsbn1l 33
  • 72.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10600 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-21 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.789 34
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8474 33
Species where no ortholog for RSBN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RSBN1L Gene

ENSEMBL:
Gene Tree for RSBN1L (if available)
TreeFam:
Gene Tree for RSBN1L (if available)

Paralogs for RSBN1L Gene

Paralogs for RSBN1L Gene

(1) SIMAP similar genes for RSBN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RSBN1L: view

Variants for RSBN1L Gene

Sequence variations from dbSNP and Humsavar for RSBN1L Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000013903 -- 77,753,297(+) T/C intron_variant
rs1000136615 -- 77,714,652(+) A/G intron_variant
rs1000158627 -- 77,750,476(+) A/G intron_variant
rs1000206422 -- 77,776,543(+) G/A intron_variant
rs1000220392 -- 77,754,408(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RSBN1L Gene

Variant ID Type Subtype PubMed ID
nsv1140809 CNV deletion 24896259
nsv365896 CNV insertion 16902084
nsv831039 CNV gain 17160897

Variation tolerance for RSBN1L Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RSBN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSBN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSBN1L Gene

Disorders for RSBN1L Gene

Additional Disease Information for RSBN1L

No disorders were found for RSBN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSBN1L Gene

Publications for RSBN1L Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 44 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for RSBN1L Gene

Sources for RSBN1L Gene

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