Aliases for RRP8 Gene
External Ids for RRP8 Gene
Previous HGNC Symbols for RRP8 Gene
Previous GeneCards Identifiers for RRP8 Gene
GeneCards Summary for RRP8 Gene
RRP8 (Ribosomal RNA Processing 8) is a Protein Coding gene. Diseases associated with RRP8 include Powassan Encephalitis and Allergic Urticaria. Among its related pathways are Chromatin Regulation / Acetylation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include methylated histone binding.
UniProtKB/Swiss-Prot Summary for RRP8 Gene
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.